204
Views
7
CrossRef citations to date
0
Altmetric
Review

Inhibitors of the renal outer medullary potassium channel: a patent review

, PhD (Researcher in Pharmacology) , , PhD (Researcher in Pharmacology) , (Full professor in Pharmacology) & , PhD (Associate professor in Pharmacology)

Bibliography

  • Palmer LG. Potassium secretion and the regulation of distal nephron K channels. Am J Physiol Renal Physiol 1999;277:F821-5
  • Palmer LG, Choe H, Frindt G. Is the secretory K channel in the rat CCT ROMK? Am J Physiol Renal Physiol 1997;273:F404-10
  • Wang WH, Herbert SC, Giebisch G. Renal K channels: structure and function. Ann Rev Physiol 1997;59:413-36
  • Hebert SC, Desir G, Giebisch G, et al. Molecular diversity and regulation of renal potassium channels. Physiol Rev 2005;85(1):319-71
  • Rieg T, Vallon V, Sausbier M, et al. The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion. Kidney Int 2007;72:566-73
  • Xu ZC, Yang Y, Hebert SC. Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase. J Biol Chem 1996;271:9313-19
  • Huang CL, Feng S, Hilgemann DW. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature 1998;391:803-6
  • Wang W, Giebisch G. Dual modulation of renal ATP-sensitive K channel by protein kinases A and C. Proc Natl Acad Sci USA 1991;88:9722-5
  • Lu M, Leng Q, Egan ME, et al. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest 2006;116:797-807
  • McNicholas CM, MacGregor GG, Islas LD, et al. pH-dependent modulation of the cloned renal K+ channel ROMK. Am J Physiol Renal Physiol 1998;275:F972-81
  • Garcia ML, Priest BT, Alonso-Galicia M, et al. Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis. J Pharmacol Exp Ther 2014;348(1):153-64
  • Simon D, Karet F, Rodriguez-Soriano J, et al. Genetic heterogeneity of Bartter’s syndrome revealed by mutation in the K+ channel, ROMK. Nat Genet 1997;14:152-6
  • Ji W, Foo JN, O’Roak BJ, et al. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 2008;40:592-9
  • Jin W, Lu Z. A novel high-affinity inhibitor for inward-rectifier K+ channels. Biochemistry 1998;37:13291-9
  • Felix JP, Liu J, Schmalhofer WA, et al. Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin. Biochemistry 2006;45:10129-39
  • Lewis LM, Bhave G, Chauder BA, et al. High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol Pharmacol 2009;76:1094-103
  • Bhave G, Chauder BA, Liu W, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol 2011;79:42-50
  • Rampe D, Roy ML, Dennis A, Brown AM. A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS Lett 1997;417(1):28-32
  • Tang H, Walsh SP, Yan Y, et al. Discovery of selective small molecule ROMK inihibitors as potential new mechanism diuretics. ACS Med Chem Lett 2012;3:367-72
  • Garcia ML, Kaczorowski GJ. Targeting the inward-rectifier potassium channel ROMK in cardiovascular disease. Curr Opin Pharmacol 2014;15:1-6
  • Tang H, de Jesus RK, Walsh SP, et al. Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one. Bioorg Med Chem Lett 2013;23:5829-32
  • Garcia ML, Priest BT, Alonso-Galicia M, et al. Pharmacological inhibition of the renal outer medullary potessium channel causes diuresis and natriuresis in the absence of kaliuresis. J Pharmacol Exp Ther 2014;348:153-64
  • Raphemot R, Weaver CD, Denton JS. High-throughput screening for small-molecule modulators of inward rectifier potassium channels. J Vis Exp 2013;71:e4209
  • Felix JP, Priest BT, Solly et al. The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors. Assay Drug Dev Technol 2012;10:417-31
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2012058134 A1; 2012
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2013039802 A1; 2013
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2013062900 A1; 2013
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2013062892 A1; 2013
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2012058116; 2012
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2014015495 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. US20140031349 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2010129379; 2010
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. US20140142115 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2014085210 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2013028474 A1; 2013
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2014099633 A2; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2014126944 A2; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. US20140336177; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. US20140309213 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. U2014S0288042 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. US20140275020 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2014150132 A1; 2014
  • Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel. WO2015017305 A1; 2015
  • Swale DR, Sheehan JH, Banerjee S, et al. Computational and functional analyses of a small-molecule binding site in ROMK. Biophys J 2015;108:1094-103
  • Kithas PA, Supiano MA. Hypertension in the geriatric population: a patient-centered approach. Med Clin N Am 2015;99:379-89

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.