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Original Article

N-Hydroxyureas as 5-lipoxygenase inhibitors: Patent Evaluation

Pages 187-189 | Published online: 03 Mar 2008

Key References

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  • FORD-HUTCHINSON AW: Evidence for the involvement of leukotrienes and other lipoxyge-nase products in disease states. In: Leukotrienes and Lipoxygenases: Chemical, Biological and Clinical Aspects. (1989) Rokach J (Ed), Elsevier Science pp405–420.
  • MASAMUNE H, MELVIN LS JR: Novel applications of leukotriene intervention. Annu. Rep. Med. Chem. (1989) 24:71.
  • HUI KP, TAYLOR IK, TAYLOR GW, RUBIN P, KES'TERSON J, BARNES NC, BARNES PJ: Effects of a 5-lipoxygenase inhibitor on leukotriene generation and airway response after allergen challenge in asthmatic patients. Thorax (1991) 46:184.
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  • CARTER GW, YOUNG PR, ALBERT DH, BouskA J, DYER R, BELL RL, BOUSKA J, SUMMERS JB, BROOKS DW: 5-Lipoxygenase inhibitory activity of zileuton. J. Pharmacol Exp. Ther. (1991) 256:929.
  • GARLAND LG, SALMON JA: Hydroxamic acids and hydroxyureas as inhibitors of arachidonate 5-lipoxygenase. Drugs Fut. (1991) 16:547.
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