References to primary literature
- LIPPMAN ME, ALLEGRA JC: Current concepts in cancer. Receptors in breast cancer. N. Eng. J. Med. (1978) 299:930.
- SANIEN RJ: Clinical use of aromatase in-hibitors: current data and future perspec-tives. J. Enzyme Inhibition (1990) 4:79–99.
- A review article on aromatase inhibitors used in the clinic.
- MEANS GD, MAHENDROO MS, CORBIN Cl, MATHIS JM, POWELL FE, MENDELSON CR, SIMPSON ER: Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for oestrogen biosynthesis. J. Biol. Chem. (1989) 264(32): 19385–19391.
- BANTING L, NICHOLLS P1, SHAW MA, SMTTH HJ: Recent development in aromatase in-hibition as a potential treatment for oestrogen-dependent breast cancer. In: Progress in Medicinal Chemistry. (1989) Elles GP, West GS (Eds), Elsevier Science Publishers, Vol 26, pp253–298.
- SANTEN RJ, MANNI A, HARVEY H, REDMOND ssC: Endocrine treatment of breast cancer inwomen. Endocrine Reviews (1990) 11(2):221–265.
- A thorough review on the subject.
- LONNING PE, JOHANNESSEN DC: Treatment of breast cancer with aromatase inhibitors.Drugs of Today (1991) 27(2):117–132.
- A critical review on the aromatase inhibitors presently un-dergoing clinical trials.
- COLE PA, ROBINSON CH: Mechanism and in-hibition of cytochrome P-450 aromatase. J. Med. Chem. (1990) 33(11):2933–2942.
- A classification of aromatase inhibitors according to their type of inhibition.
- AICHTAR M, WRIGHT JN: A unified mecha-nistic view of oxidative reactions catalysed by P-450 and related Fe-containing enzyme. Natural Products Reports (1991) 527–551.
- A detailed mechanistic account of reactions catalysed by cytochrome P-450 enzymes.
- ORTIZ DE MONTELLANO PR, REICH NO: Inhibition of cytochrome P-450 enzymes. Structure, Mechanism and Biochemistry. (1986) Plenum Press, New York, London, Chapter 8.
- BRUGGEMEffiR RW, Li P-K, SNIDER CE, DARBY MV, KATLIC NE: 7a-substituted androstenediones as effective in vitro and in vivo inhibitors of aromatase. Steroids (1987) 50:163.
- FURTH PS, ROSENBERGER JG, MARCOTTE PA, ROBINSON CH: Synthesis of 2,2-dimethy1-4-hydroxy-4-androstene-3,17-dione as an in-hibitor of aromatase. J. Enzyme Inhibition (1990) 4:131–135.
- GRITZ DE MONTELLANO PR: The inactivationof cytochrome P450. In: Annual Reports in Medicinal Chemistry, Section V: Topics in Bi-ology. (1984) Egan RW (Ed), Academic Press Inc, Chapter 20.
- BRODIE AMH, GARRIT WM, HENDRICKSON JR, Tsm-MoRRis C-H, MARCO'TIB PA, ROBIN-SON CH: Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sus-tained effects in vivo. Steroids (1981) 38:693–702.
- One of the first papers on aromatase inhibitors.
- DI SALLE E, Gnanci D, ORNATI G, Biu ATICO G, D'ALEssio R, VILLA V, LOMBARDI P: 4-aminoandrostenedione derivatives. A novel class of irreversible aromatase in-
- GIUDICI D. ORNATI G. BmncoG, BummF, LOMBARDPI, DI SALLEE : 6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304). A new irreversible aromatase inhibitor. J. SteroidBiochem. (1988) 30:391–394.
- HENDERSOND, NOSBIRATWG, KERB U l-Methyl-l,4-Androstadiene3, 17-dione (SH 489): characterisation of an irreversible inhibitor of oestrogen biosynthesis. J. SteroidBiochem. (1986) 24(1):303–306.
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- BURICHART JP, PEET NP, WRIGHT CW, JOHN-STON JO: Novel time-dependent inhibitors of human placental aromatase. J. Med. Chem.
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- BHATNAGAR AS, HAUsLER A, SCHIEWECK K, LANG M, BOWMAN R: Highly selec-tive inhibition of oestrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J. Steroid Biochem. Molec. Biol. (1990) 37(6):1021–1027.
- LANG M: New aromatase inhibitors: synthe-sis, biological activity and molecular model-ing. XIIth International Symposium on Medic-inal Chemistry. Basel, Switzerland, September 13–17, 1992.
- WRIGHT JN, CALDER MR, AICHTAR M: Steroidal C-19 sulphur and nitrogen derivatives de-signed as aromatase inhibitors. J. Chem. Soc. Chem. Comm. (1985) 1733.
- CHILDERS WE, ROBINSON CH: Novel 10-n-thiiranyl steroids as aromatase inhibitors. J. Chem. Soc. Chem. Comm. (1987) 320.
- GEELEN JAA, DECKERS Gil, VAN DER WARDT JTH, LOOTEN HJJ, TAN LJW, KLOOSTERBOER HJ: Selection of 19-(ethyldithio)-androst-4-ene-3,17-dione (ORG 30958): a potent aro-matase inhibitor in vivo. J. Steroid Biochem. Molec. Biol 38(2):181–188.
- PEET NP, BURKHART JP, WRIGHT C-L, JOHNSTON JO: Time-dependent inhibition of human placental aromatase with a 2,19-methyleneoxy-bridged androstenedione. J. Med. Chem. (1992) 35:3303–3306.
- DELAISI C, DOUCET B, HARTMANN C, TRIC B, GOURVEST JF, LESUISSE D: RU 54115, a tight-binding aromatase inhibitor potentially use-ful for the treatment of breast cancer. J. Steroid Biochem. Molec. Biol. (1992) 41:773–777.
- LONNING PE, DOWSETT M, POWLES TJ: Post-menopausal oestrogen synthesis and meta-bolism: alterations caused by aromatase in-hibitors used for the treatment of breast can-cer. J. Steroid Biochem. (1990) 35:355–366.
- BRODIE A: Aromatase and its inhibitors - an overview. J. Steroid Biochem. Molec. Biol. (1991) 40:255-261. hibitors. Comparison with FCE 24304 and 4-hydroxy-androstene-dione. J. Steroid Biochem. Molec. Biol. (1990) 37(3):369–374.