14
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Overview: Recent Advances in Angiotensin II Receptor Antagonists

&
Pages 581-596 | Published online: 03 Mar 2008

References

  • DZAU VJ, PRATT RE: Renin-angiotensin sys-tem: biology, physiology and pharmacol-ogy. In: The Heart and Cardiovascular Sys-tem. (1986) Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (Eds), Raven Press, New York, pp1631–1662.
  • WONG PC, CHIU AT, PRICE WA JR, THOOLEN MJ, CARINI DJ, JOHNSON AL, TABER RI, TRVIMERMANS PB: Nonpeptide angiotensin II receptor antagonists. I. Pharmacological characterization of 2-n-butyl-4-chloro-l-(2-chlorobenzyffimidazole-5-acetic acid, sodium salt (S-8307). J. PharmacoL Exp. Then (1988) 247:1–7.
  • DUNCIA iv, CARINI DJ, CHIU AT, PIERCE ME, PRICE WA JR, SMITH RD, WELLS GJ, WONG PC, WEXLER RR, JOHNSON AL, TIMMERMANS PB: DuP-753, Losartan potassium, MK-954. Drugs of the Future (1992) 17:326–331.
  • DUNCIA iv, CARINI DJ, Cmu AT, JOHNSON AL, PRICE WA JR, WONG PC, WEXLER RR, TIMMERMANS PB: The discovery of DuP 753, a potent, orally active nonpeptide angio-tensin II receptor antagonist. Med. Res. Rev. (1992) 12:149–191.
  • SMITH RD, CHIU AT, WONG PC, HERBLIN WF, TTMMERMANS PB: Pharmacology of nonpep-tide angiotensin II receptor antagonists. Ann. Rev. PharmacoL ToxicoL (1992) 32:135–165.
  • TTMMERMANS PB, WONG PC, CHIU AT, HERB- LIN WF: Nonpeptide angiotensin II receptor antagonists. TIPS (1991) 12:55–62.
  • CHRISTEN Y, WAEBER B, NUSSBERGER J, PORCHET M, BORE RM, LEE RI, MAGGON K, SHRUM L, TIMMERMANS PB, BRUNNER HR: Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to nor-mal male volunteers-Inhibition of the pres-sor response to exogenous angiotensin I and H. Circulation (1991) 83:1333–1342.
  • NELSON E, MERRILL D, SWEET C, BRADSTREET T, PANEBIANCE R, BYYOY T, HERMAN K, LASSITER B, LEVY G, LEWIS FG, MCHAHON R, REEVES D, RUFF A, SHEPHERD D, WEIDLER J, IRVIN J: Efficacy and safety of oral MK- 954, DuP 753 and angiotensin receptor antagonists in essential hypertension. Fifth European Meeting on Hypertension, Eur. Soc. of Hypertension (1992) Milan, Italy, 512.
  • STEARNS RA, MILLER RR, DOSS GA, CHAKRA-VARTY PK, ROSEGAY R, GATTO GJ, LEE CS-H: The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey and human liver slices. Drug Metab. &Disp. (1992)20:281–287.
  • STEARNS RA, Doss GA, MILLER RR, LEE CS-H: Synthesis and identification of a novel te-trazole metabolite of the angiotensin II re-ceptor antagonist DuP 753. Drug Metab. & Disp. (1992) 19:1160–1162.
  • DOUGLAS JD: Angiotensin receptor subtypes of the kidney cortex. Am. J. PhysioL (1987) 253:Fl-F7.
  • REID LA: Actions of angiotensin II on the brain: mechanisms physiologic role. Am. J. Physiol. (1984) 246:F533–F543.
  • BLANKLEY CJ, HODGES JC, KLUTCHKO SR, HIMMELSBACH RI, CHUCHOLOWSKI A, CON-NOLLY CJ, NEERGAARD SJ, VAN NIEUWENHZE MS, SEBASTIAN A, QUTN J: Synthesis and structure-activity relationships of a novel se-ries of nonpeptide angiotensin II receptor binding inhibitors specific for the AT2 sub-type. J. Med. Chem. (1991) 34:3248–3260.
  • HODGES JC, HAMBY JM, BLANKLEY CJ: An- giotensin II receptor binding inhibitors. Drugs of the Future (1992) 17:575–593.
  • CHIU AT, HERBLIN WF, MCCALL DE, ARDECKY RI, CARINI DJ, DUNCIA JV, PEASE LJ, WONG PC, WEXLER RR, JOHNSON AL, TIMMERMANS PB: Identification of angiotensin II recep-tor subtypes. Biochem. Biophys. Res. Com-mun. (1989) 165:196–203.
  • DUDLEY DT, PANEK RL, MAJOR TC, LU GH, BRUNS RF, KLINKEFUS BA, HODGES JC, WEISHAAR RE: Subclasses of angiotensin II binding sites and their functional signifi-cance. Mol. Pharm. (1990) 38:370–377.
  • WHITEBREAD S, MELE M, KAMBER B, DE GASPARO M: Preliminary biochemical char- acterization of two angiotensin II receptor subtypes. Biochem. Biophys. Res. Commun. (1989) 163:284–291.
  • MURPHY TJ, ALEXANDER RW, GRIENDLING KK, RUNGE MS, BERSTEIN KE: Isolation of a cDNA encoding the vascular type-1 angio-tensin II receptor. Nature (1991) 351:233–236.
  • SASAKI K, YAMANO Y, BARDHAN S, IWAI N, MURRAY JJ, HASEGAWA M, MATSUDA Y, INAGAMI T: Cloning and expression of a com-plementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature (1991) 351:230–233.
  • YAMANO Y, OHYAMA K, CHAKI S, GUO D, INAGAMI T: Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagene-sis. Biochem. Biophys. Res. Commun. (1992) 187:1426–1431.
  • STRADER CD, SIGAL IS, DIXON RA: Struc-tural basis of beta-adrenergic receptor func-tion. FASEB J. (1989) 3:1825–1832.
  • STRADER CD AND DKON RA: Genetic analy-sis of the beta-adrenergic receptor. Adv. Exp. Med. Biol. (1991) 287:209–220.
  • STRADER CD, SIGAL IS, CANDELORE MR, RANDS E, HILL WS, DDCON RA: Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function. J. Biol. Chem. (1988) 263:10267–10271.
  • STRADER CD, CANDELORE MR, HILL WS, SIGAL IS, DIXON RA: Identification of two serine residues involved in agonist activation of the ^-adrenergic receptor. I. Biol. Chem. (1989) 264:13572–13578.
  • ELTON TS, STEPHAN CC, TAYLOR GR, KIMBALL MG, MARTIN MM, DURAND JN, OPARIL S: Isolation of two distinct type I angiotensin II receptor genes. Biochem. Biophys. Res. Com-mun. (1992) 184:1067–1073.
  • SANDBERG K, HONG J, CLARK AJ, SHAPIRA H, CATT KJ: Cloning and expression of a no-vel angiotensin II receptor subtype. J. Biol. Chem. (1992) 267:9455–9458.
  • KAKAR SS, SELLERS JC, DEVOR DC, MUSGROVE LC, NEILL ID: Angiotensin II type-1 receptor subtype cDNAs: Differential tissue expres-sion and hormonal regulation. Biochem. Bio-phys. Res. Commun. (1992) 183:1090–1096.
  • SASAMURA H, HEIN L, KRIEGER JE, PRATT RE, KOBILKA BK, DZAU VJ: Cloning, char-acterization, expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem. Biophys. Res. Commun. (1992) 185:252–259.
  • YOSHIDA H, KAKUCHI J, GUO D-F, FURUTA H, IWAI N, VAN DER MEER-DE JONG R, INAGAMI T, ICHIKAWA I: Analysis of the evolution of angiotensin II type I recep-tor gene in mammals (mouse, rat, bovine and human). Biochem. Biophys. Res. Corn-mun. (1992) 186:1042–1049.
  • TAKAYANAGI R, OHNAKA K, SAKAI Y, NAKAO R, YANASE T, HAJI M, INAGAMI T, FURUTA H, GUO D-F, NAKAMUTA M, NAWATA H: Molec-ular cloning, sequence analysis and expres-sion of a cDNA encoding human type-1 an-giotensin II receptor. Biochem. Biophys. Res. Commun. (1992) 183:910–916.
  • FURUTA H, GUO D-F, INAGAMI T: Molecu-lar cloning and sequencing of the gene en-coding human angiotensin II type 1 recep-tor. Biochem. Biophys. Res. Commun. (1992) 183:8–13.
  • BERGSMA DJ, ELLIS C, KUMAR C, NUTHULA-GANTI P, KERSTEN H, ELSHOURBAGY N, GRIFFTN E, STADEL JM, AIYAR N: Cloning and characterization of a human angiotensin Ii type 1 receptor. Biochem. Biophys. Res. Commun. (1992) 183:989–995.
  • CURNOW KM, PASCOE L, WHITE PC: Genetic analysis of the human type-1 angiotensin II receptor. Mol. Endo. (1992) 6:1113–1118.
  • TSUTSUMI K AND SAAVEDRA JM: Differential development of angiotensin II receptor sub-types in the rat brain. Endocrinology (1991) 128:630–632.
  • GRADY EF, SECHI LA, GRIFFIN CA, SCHAMB-ELAN M, KALINYAK JE: Expression of AT2 re-ceptors in the developing rat fetus. J. Clin. Invest. (1991) 88:921–933.
  • MILLAN MA, CARVALLO P, IZUMI S-I, ZEMEL S, CATT KJ, AGUILERA G: Novel sites of ex-pression of functional angiotensin II recep-tors in the late gestation fetus. Science (1989) 244:1340–1342.
  • VISWANATHAN M, TSUTSUMI K, CORREA FM, SAAVEDRA JM: Changes in expression of an-giotensin receptor subtypes in the rat aorta during development. Biochem. Biophys. Res. Commun. (1991) 179:1361–1367.
  • ZEMEL S, MILLAN MA, FEUILLANP, AGUILERA G: Characterization and distribution of angiotensin-II receptors in the primate fetus. J. Clin. Endo. Metab. (1990) 71:1003–1007.
  • DUDLEY DT, HUBBELL SE, SUMMERFELT RM: Characterization of angiotensin II (AT2) binding sites in R3T3 cells. MoL Pharm. (1991) 40:360–367.
  • PUCELL AG, HODGES JC, SEN I, BUMPUS FM, HUSAIN A: Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor. Endocrinology (1991) 128: 1947-1959.
  • WEBB ML, Liu EC-K, COHEN RB, HEDBERG A, BOGOSIAN EA, MONSHIZADEGAN H, MOLL-OY C, SERAFINO R, MORELAND S, MURPHY TJ, DICKINSON KE: Molecular characteriza-tion of angiotensin II type 2 receptors in rat pheochromocytoma cells. Peptides (1992) 13:499–508.
  • SUMNERS C, TANG W, ZELEZNA B, RAIZADA Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain. Proc. Natl. Acad. Sci. USA (1991) 88:7567–7571.
  • LEVENS NR, DE GASPARO M, WOOD TM, BOTTARI SP: Could the pharmacological dif-ferences observed between angiotensin II antagonists and inhibitors of angiotensin converting enzyme be clinically beneficial? Pharm. and ToxicoL (1992) 74:241–249.
  • BARNES NM, COSTALL B, KELLY ME, MURPHY DA, NAYLOR RJ: Cognitive enhancing action of DuP 753, a nonpeptide angiotensin II re-ceptor antagonist. 2nd International Sympo-sium on ACE Inhibitors (1992) London, UK, P–40.
  • HODSMAN GP, ZABLUDOWKSI JR, ZOCCALI C, FRASER R, MORTON JJ, MURRAY GD, ROBERTSON JI: Enalapril (MK421) and its lysine analogue (MK521): a comparison of acute and chronic effects on blood pressure, renin-angiotensin system and sodium excre-tion in normal man. Brit. J. Clin. PharmacoL (1984) 17:233–241.
  • SWEDBERD K, CONSENSUS TRIAL STUDY GROUP: Effect of enalapril on mortality in se-vere congestive heart failure. N. Engl. J. Med. (1987) 316:1429–1435.
  • YUSUF S, SOLVD INVESTIGATORS: Effect of enalapril on survival in patients with re-duced left ventricular ejection fractions and congestive heart failure. N. Engl. J. Med. (1991) 325:293–302.
  • BERNHART C, CLEMENT J, FERRARI B, MUN-EAUX Y, PERREAUT P, GOUGAT J, GUIRADOU P, LACOUR C, BRELIERE JC, CAZAUBON C, NISATO D: Spiro-dihydro-imidazolones; A new class of non-peptide angiotensin H re-ceptor antagonists. XHth International Sym- posium on Medicinal Chemistry (1992) Basel, Switzerland, P–084A.
  • WEXLER RR, CARTNI DJ, DUNCIA JV, JOHNSON AL, WELLS GJ, CHITTI AT, WONG PC, TJMMER- MANS PB: Rationale for the chemical devel-opment of angiotensin II receptor antago- nists. Am. J. Hyper. (1992) 5:209S–220S.
  • MEUNO K, NnMURA S, TANI M, SAITO I, SANADA H, TAKAHASHI M, OKAZAKI K, YAMAGUCHI M, FUKUCHI M: Hypotensive ac-tivity of TCV-116, a newly developed angio-tensin II receptor antagonist, in spontaneo-usly hypertensive rats. Life Sciences (1992) 51:183–187.
  • . BOHLMAYER P, OSTERMAYER F, C RI S C IONE L, DE GASPARO M, FURET P, FUHRER W, HEROLD P, LATTMAN R, SCHMIDLIN T, WHITE-BREAD S, WOOD J, ZBINDEN P: Nonpep-tidic angiotensin II antagonists: synthesis and structure-activity of a new series of alpha amino acid derivatives. XHth Inter-national Symposium on Medicinal Chemistry (1992) Basel, Switzerland, OC-04.3.
  • EDWARDS MP, ALLOTT CP, BRADBURY RH, MAJOR JS, MASEK BB, OLDHAM AA, PEARCE RJ, ROBERTS DA, RUSSELL ST: Potent, non- peptidic angiotensin II antagonists. 203rd ACS Meeting (1992) San Francisco, US, MEDI177.
  • BRADBURY RH, ALLOTT CP, DENNIS M, FISHER E, MAJOR JS, MASEK BB, OLDHAM AA, PEARCE RJ, RANKINE N, REVILE JM, ROBERTS DA, RUSSELL ST: New nonpeptide angiotensin II receptor antagonists. 2. Syn-thesis, biological properties and structure-activity relationships of 2-alky1-4-(bipheny-lylmethoxy)quinoline derivatives. J. Med. Chem. (1992) 35:4027–4038.
  • HODGES JC, SIRCAR I, EDMUNDS JJ, KOSTLAN CR, BUNCKER AM, CONNOLLY CJ, WINTERS TM, QUIN III J, KESTEN SJ, HAMBY JM, PANEK RJ, Lu GH, KEISER JA, RYAN MJ, OLSZEWSKI BJ, LEE P, HICKS G: 4-0H-Pyrrol-1-yDimidazoles with angiotensin II receptor (ATI) antagonist activity. 204th ACS Meeting (1992) Washington, DC, MEDI33.
  • OLINS GM, CORPUS VM, MCMAHON EG, PALOMO MA, SCHUH JR, BELHM DJ, HUANG H-C, REITZ DB, MANNING RE, BLAINE EH: In vitro pharmacology of a nonpeptidic angio-tensin II receptor antagonist, SC-51316. J. Pharm. Exp. Therap. (1992) 261:1037–1043.
  • REITZ DB, GARLAND DJ, NORTON MS, CHENG BK, OLINS GM, CORPUS VM, MCMAHON EG, PALOMO MA, KOEPKE JP, MOORE GK, SMITS GJ, MCGRAW DE, BLAINE EH, MANNING RE: 2H-Imidazol-2-ones as potent orally active angiotensin II receptor antagonists. 204th ACS Meeting (1992) Washington, DC, MEDI33.
  • DE B, WINN M, ZYDOWSKY M, KERKMAN DJ, DEBERNARDIS JF, LEE J, BUCKNER S, WARNER R, BRUNE M, HANCOCK A, OPGENORTH T, MARSH K: Discovery of a novel class of orally active, non-peptide angiotensin II antago-nists. I. Med. Chem. (1992) 35:3714–3717.
  • DE LASZIO SE, ALLEN EE, QUAGLIATO CS, GREENLEE WJ, SIGEL PK, CHANG RS, KIVLIGHI-SD, SCHORN TS, FAUST KA, CHEN T-B, ZINGARO GJ, LOTTI VI: Quinazolinones as angiotensin II (AT) receptor antagonists. Xllth International Symposium on Medicinal Chemistry (1992) Basel, Switzerland, P–218A.
  • MANTLO NB, CHAKRAVARTY PK, ONDEYKA DL, SIEGEL PK, CHANG RS, Lorn VI, FAUST KA, CHEN T-B, SCHRON TW, SWEET CS, EMMERT SE, PATCHETT AA, GREENLEE WJ: A potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonist. J. Med. Chem. (1991) 34:2919–2922.
  • MANTLO NB, ONDEYKA DL, CHANG RS, LOTTI VJ, KTVLIGHN SD, SIGEL PK, PATCHETT AA, GREENLEE WJ: Diacidic, non-peptide an-giotensin receptor antagonists. Fourth ACS Congress of North America (1991) New York, US, MEDI103.
  • CHIU AT, CARINI DJ, DUNCIA iv, LEUNG KB, MCCALL DE, PRICE WA JR, WONG PC, SMITH RD, WEXLER RR, TTMMERMANS PB: DuP532: A second generation of nonpeptide angio-tensin receptor antagonists. Biochem. Bio- phys. Res. Commun. (1991) 177:209–217.
  • ZHANG JS AND VAN ZWEITEN PA: Character-ization of two novel nonpeptide angiotensin n antagonists. Brit. J. Pharmacol. (1992) 105:AB85P.
  • ZHANG JS, ENTZEROTH M, WIENEN W, VAN MEEL JC: Characterization of BIBS 39 and BIBS 222: two new nonpeptide angiotensin H antagonists. Eur. J. Pharm. (1992) 218:35–41.
  • MIDDLEMISS D, DREW GM, ROSS BC, ROBER-SON MJ, SCOPES DI, DOWIE MD, AKERS J, CARDWELL K, CLARK KL, COOTE S, ELDRED CD, HAMBLETT J, HILDITCH A, HIRST GC, JACK T, MONTANA J, PANCHAL TA, PATON JM, SHAH P, STUART G, TRAVERS A: Bromoben-zofurans: a new class of potent, non-pep-tide antagonists of angiotensin II. Bio. Med. Chem. Lett. (1991) 1:711–716.
  • HILDITCH A, AKERS JS, TRAVERS A: Cardio-vascular effects of the angiotensin II antag-onist GR117289, in conscious renal hyper-tensive and normotensive rats. Br. J. Pharm. (1991) 104:423.
  • BUHLMAYER P, CRISCIONE L, FUHRER W, FURET P, DE GASPARO M, STUTZ S, WHITE- BREAD S: Nonpeptide angiotensin II antago-nists: Synthesis and in vitro activity of a se-ries of novel naphthalene and tetrahydron-aphthalene derivatives. J. Med. Chem. (1991) 34:3105–3114.
  • BOVY PR, COLLINS JT, OLINS GM, MCMAHON EG, HUTTON HC: Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptor antagonist proper-ties. J. Med. Chem. (1991) 34:2410–2414.
  • LIN H-S, RAMPERSAUD AA, ZIMMERMAN K, STEINBERG MI, BOYD DB: Nonpeptide an-giotensin II receptor antagonists: synthetic and computational chemistry of N-114-(2ff-tetrazole-5-0-l-cycloalken-l-yl]p henyl] m e-thylllmidazole derivatives and their in vitro activity. J. Med. Chem. (1992) 35:2658–2667.
  • BROOKS D, FREDRICKSON TA, WEINSTOCK J, RUFFOLO RR JR, EDWARDS RM, GELLAI M: Antihypertensive activity of the non-peptide angiotensin II antagonist, SK&F 108566, in rats and dogs. Arch. Pharmacol. (1992) 345:673–678.
  • EDWARDS RM, AIYAR N, OHLSTEIN EH, WEIDLEY EF, FRIFFIN E, EZEKIEL M, KEENAN M, RUFFOLO RR JR, WEINSTOCK J: Phar-macological characterization of the non-peptide angiotensin II receptor antagonist SK&F 108566. J. Pharm. Exp. Therap. (1992) 260:175–180.
  • WEINSTOCK J, KEENAN RM, SAMANEN J, HEMPLE J, FTNKELSTEIN JA, FRANZ RG, GAITANOPOULOS DE, GIRARD GR, GLEASON JG, HILL DT, MORGAN TM, PEISHOFF CE, AIYAR N, BROOKS DP, FREDRICKSON TA, OHLSTEIN EH, RUFFOLO RR JR, STACK EJ, SULPIZIO AC, WEIDLEY EF, EDWARDS RM: l-(Carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists. I Med. Chem. (1991) 34:1514–1517.
  • WHITESITT CA, STEINBERG MI, ZIMMERMAN KM, WIEST SA, LIFER SL, REEL JK, SIMON RL, MARSHALL WS: Evaluation of a novel se-ries of imidazole angiotensin II (All) recep-tor antagoniste. FASEB J. (1992) 6:A5412.
  • WONG PC, PRICE WA JR, CHIU AT, DUNCIA iv, CARINI DJ, WEXLER RR, JOHNSON AL, TIMMERMANS PB: Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP 3174: An active metabolite of Dup 753, an orally active antihypertensive agent I. Pharmacol. Exp. Ther. (1990) 255:211–217.
  • SK&F 108834 was found to be an insurmount-able antagonist in our laboratories.
  • BARNES NM, COSTALL B, KELLY ME, MURPHY DA, NAYLOR RJ: Anxiolytic-like action of DuP753, a non-peptide angiotensin II recep-tor antagonist. NeuroReport (1990) 1:15–16.
  • WILSON S, JIN Y, ELKO E, YORIO T: The oc-ular hypotensive effect of DuP753, a non-peptide angiotensin II antagonist. FASEB J. (1991) 5:A1218.
  • NAKASHIMA M, UEMATSU T, KOSUGE K, KANAMARU M: Pilot study of the uricosuric effect of DuP 753, a new angiotensin re-ceptor antagonist, in healthy subjects. Eur. J. Clin. Phamacol. (1992) 42:333–335.
  • LAPORTE S, ESCHER E: Neointima formation after vascular injury is angiotensin II medi-ated. Biochem. Biophys. Res. Commun. (1992) 187:1510–1516.
  • AZUMA H, NnMi Y, HAMASAKI H: Preven-tion of intimai thickening after endothelial removal by a nonpeptide angiotensin II re- ceptor antagonist, losartan. Br. J. Pharmacol. (1992) 106:665–671.
  • PRESCOTT MF, WEBB RL, REIDY MA: Angio- tensin-converting enzyme inhibitor versus angiotensin II, ATI receptor antagonist. Ef-fects on smooth muscle cell migration and proliferation after balloon catheter injury. Am. J. Path. (1992) 139:1291–1296.
  • KAUFFMAN RF, BEAN JS, ZIMMERMAN KM, BROWN RF, STEINBERG MI: Losartan, a non-peptide angiotensin II receptor antagonist, inhibits neointima formation following bal-loon injury to rat carotid arteries. Life Sci. (1992) 49:223–228.
  • AKERS JS, HJLDITCH A, ROBERTSON MJ, DREW GM: Does a relationship exist be-tween the antihypertensive action and the angiotensin receptor antagonist activity of DuP753 in conscious rats? Brit. J. Pharma-col. (1991) 104:126P.
  • OHLSTEIN EH, GELLAI M, BROOKS DP, VICKERY L, JUGUS J, SULPIZIO A, RUFFOLO RR JR, WEINSTOCK J, EDWARDS RM: The antihyper-tensive effect of the angiotensin II receptor antagonist DuP753 may not be due solely to angiotensin II receptor antagonism. J. Pharm. Exp. Therap. (1992) 262:595–601.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.