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Research Article

Patent Update Cardiovascular & Renal: Treatments for myocardial ischaemia

, PhD
Pages 531-542 | Published online: 03 Mar 2008

References to Primarv Literaturess

  • YANAGISAWA M, KURIHARA H, KIMLTRA 5, TOMOBE Y, KOBAYASHI M, MITSUI Y, YAZAKI Y, GOTO K, MASAIU T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (Land.) (1988), 332, 411–415.
  • HAYNES WG, DAVENPORT AP, WEBB DJ: Endothelin: progress in pharmacology and physiology. Trends Phar-macol. Sci. (1993) 14, 225–228. Meeting report from 3rd International Conference on Endothelin, Houston, Texas, USA, February 1993.
  • SCHOMISCH-MORAVEC C, REYNOLDS EE, S rEWART RW, BOND M: Endothelia is a positive inotropic agent in human and rat heart in MM. Biochem. Biophys. Res. Commun. (1989) 159: 14–18.
  • STEWART DJ, KUBAC G, COSTELLO KB, CERNACEK P:Increased plasma endothelia-1 in the early hours of acute myocardial infarction. J. Am. Coll. Cardiol. (1991) 18: 38–43.
  • TOMODA H: Plasma endothelin-1 in acute myocardial infarction with heart failure. Am. Heart]. (1993) 125: 667–672.
  • RAY SG, MCMURRAY JJ, MORTON JJ, DARGIE HJ: Circulat-hag endothelin in acute ischaemic syndromes. Br. Heart J. (1992) 67: 383–386.
  • TSUJI S, SAWAMURA A, WATANABE H, TAICIHARA K, PARK S-E, AZUMA J: Plasma endothelin levels during myocar-dial ischaemia and reperfusion. Life Sci. (1991) 48: 1745–1749.
  • LIU J, CASLEY DJ, NAYLER WG: Ischaemia causes exter-nalization of endothelin-1 binding sites in rat cardiac membranes. Biochem. Biophys. Res. Commun. (1989) 164: 1220–1225.
  • STAWSKI G, OLSEN UB, GRANDE P: Cytotoxk effect of endothelin-1 during simulated' ischaemia in cultured rat myocytes. Eur. J. Pharmacol. (1991) 201: 123–124.
  • SAITO T, FUSHIMI E, ABE T, KIMURA Y, TAKAHASHI K, KUDO Y, NAKAGOMI A, MIURA M: Augmented contrac- tile response to endothelin and blunted endothelium-dependent relaxation in post-ischaemic reperfused coronary arteries. Jpn. Circ. J. (1992) 56: 657–670.
  • MORROW JA, FORMAN MB, MURRAY JJ: Enhanced en- dothelin production during myocardial ischaemia stimulates adenosine release from neutrophils: a pos-sible protective mechanism against reperfusion. J. Am. Coll. Cardiot (1992) 19 (3, SuppL A): 131A. WATANABE T, SUZUKI N, SHIMAMOTO N, FUJINA M. IMADA, A: Endothelin in myocardial infarction. Nature (1990) 344: 114.
  • IHARA M, FUKURODA T, SAEKI T, NISHIKIBE M, KOJIRI K,SUDA H, YANO M: An endothelin receptor (ETA) antago-nist isolated from streptomyces tnisakiensis. Biochem. Biophys. Res. Commun. (1991) 178: 132–137.
  • ISHIKAWA K, FUICAMI T, NAGASE T, FUJITA K, HAYAMAT, NIYAMA K, MASE T, IHARA M, YANO M.: Cyclic pen-tapeptide endothelin antagonists with high ETA selec-tivity, potency and solubility-enhancing modifications. J. Med. Chem. (1992) 35: 2139–2142.
  • DOUGLAS SA, ELLIOTT JD, OHLSTEIN Eli: Regional vaso-dilation to endothelin-1 is mediated by a non-ETA re-ceptor subtype in the anaesthetized rat: effect of BQ-123 on systemic haemodynarnir responses. Eur. j Pharma-col. (1992) 221: 315–324
  • IHARA M, ISHIKAWA K, FUKURODA T, SAEKI T, FUNABASHI K, FUKAMI T, SUDA H, YANO M: In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor.]. Cardiovasc. Pharmacol. (1992) 20 (Suppl 12): S11–S14.
  • GROVER GJ, SLEPH PG, FOX M, TRIPPODO NC: Role ofendothelin-1 and big endothelin-1 in modulating coro-nary vascular tone, contractile function and severity of ischaemia in rat hearts. J. Pharmacol. Exp. 7ber. (1992) 263(3): 1074–1082.
  • MCMURDO L; THIEMERMANN C.; VANE JR: The en-dothelin ETA receptor antagonist, FR 139317, does not reduce infarct size in a rabbh model of acute myocardial ischaemia and reperfusion. Br. J. Pharmacol. (1993), Proceedings Supp. (July) 1301'.
  • SOGABE K, NIREI H, SHOUBO M, NOMOTO A, AO S,NOTSU Y, ONO T: Pharmacological profile of FR 139317, a novel, potent endothelin ETA receptor antagonist. J. Pharmacol. Exp. 7her. (1993) 264 (3): 1040–1046.
  • KIICUCHI T, ICUBO K, OHTAKI T, SUZUKI N, ASAMI T, SHIMAMOTO N, WAKIMASU M, FUJIN° M: Endothelin-1 analogues substituted at both position 18 and 19: highly potent endothelia antagonists with no selectivity for either receptor subytpe ETA or ETB. J. Med. Chem. (1993) 36: 4087–4093.
  • AKIYAMA H, INAGAIC.1 Y, KASHIWABARA T, OHTA H, FUKUSHIMA H, NISHIKORI K: Endothelin receptor bind-ing affinity and biological activity of a novel endothelin analog, 10ET-011. Jpn.J. Pharmacol. (1992) 58 (SuppL 1): 336P.
  • CODY WL, DOHERTY AM, HE pc, DEPUE PL, RAPUNDALOST, HINGORANI GA, MAJOR TC, PANEK RE, DUDLEY DT, HALEEN SJ, LADOUCEUR D, HILL KE, FLYNN MA, REYNOLDS EE: Design of a functional hexapeptide an-tagonist of endothelin. J. Med. Chem . (1992) 35:3301–3303.
  • CODY WL, DOHERTY AM, HE pc, DEPUE PL, WAITE LA,TOPLISS JG, HALEEN SJ, LADOUCEUR D, HILL KE, FLYNN MA, REYNOLDS EE: The rational design of a highly potent combined ETA and ET s receptor antagonist (PD 145065) and related analogs. Med. Chem. Res. (1993) 3:154–162.
  • DOHERTY AM, CODY WL, HE JX, DEPUE PL, CHENG X-M,WELCH KM, FLYNN MA, REYNOLDS EE, LADOUCEUR DM, DAVIS LS, KEISER JA, HALEEN SJ: In vitro and in vivo studies with a series of hexapepticle endothelin antago-nists. J. Cardiovasc. Pharmacol., (1993) 22\(SuppL 8):S98–S102.
  • FUJIMOTO M, MIHARA S-I, NAJAJIMA S, UEDA M, NAKA- MURA M, SAKURAI K: A novel non-peptide endothelin antagonist isolated from bayberry, Myrica cerifera. FEBS Lett. (1992) 305: 41–44.
  • MIHARA S, FUJIMOTO M: The endothelin ETA receptor- specific effect of 50-234, a non-peptide endothelin an-tagonist. Eur.J. Pharmacol. (1993) 246: 33–38.
  • OHASIII H, AKIYAMA H, NISHIKORI K, MOCHIZUKI J-I: Asterric add, a new endothelia binding inhibitor. J. Antibiot. (1992) 45(10):1684–1685.
  • CLOZEL M, BREU V, BURRI K, CASSAL J-M, FISCHLI W,GRAY GA, HIRTH G, LOFFLER B-M, MOLLER M, NEIDHARTW, RAMUZ H: Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature (1993) 365:759–761.
  • MUGRAGE B, MOLITERNI J, ROBINSON L, WEBB RE SHEITY SS, LIPSON ICE, CHIN MH, NEALE R, CIOFFI C: CGS 27830, A potent nonpeptide endothelin receptor an-tagonist. Biootg. Med. Chem. Lett. (1993) 3:2099–2104.
  • STEIN PD, HUNT JT, FLOYD DM, MORELAND S, DICKIN-SON KEJ, MITCHELL C, LIU EC-K, WEBB ML, MURUGESAN N, DICKEY J, MCMULLEN D, ZHANG R, LEE VG, SERAFINO R, DELANEY C, SCHAEFFER TR, KOZLOWSKI M: The dis-covery of sulfonamide endothelia antagonists and the development of the orally active ETA antagonist 5-(Di-methyl amino)-N-(3,4-dimethy1-5-isoxazoly0-1-naph-thalene sulfonamide J. Med. Chem. (1994) 37:329–331.
  • ROUX SP, CLOZEL M, SPRECHER U, GRAY G, CLOZEL JP:Ro 47203, a new endothelia receptor antagonist re- verses chronic vasospasm experimental subarachnoid hemorrhage. Circulation (1993) 4\(Part 2, Supplement)-.1–170.
  • DOCHERTY K, STEINER DF: Post-translational proteoly-sis in polypeptide hormone biosynthesis. Annu. Rev. Physiol. (1982) 44625–638.
  • HARRIS RB: Processing of pro-hormone precursor pro-teins. Arch. Biochem. Biophys. (1989) 275:315–333.
  • ICASHIWABARA T, INAGAKI Y, OHTA H, 1WAMATSU A, NOMIZU M, MORITA A, NISHIKORI K: Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo. FEM. Lett. (1989) 247:73–76.
  • KIMURA S, KAYSUYA Y, SAWAMURA T, SHINMI 0, SUGITAY, YANAGISAWA M, GOTO K, MASAKI T: Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: struc-ture-activity relationships of big endothelin-1. Cardiovasc. Pharmacol. (1989) 13:S5–S7.
  • OPGENORTH TJ, WU-WONG JR, SHIOSAKI K: Endothelin-converting enzymes. FASEB. J. (1992) 6:2653–2659.
  • POWERS JC, HARPER JW: Inhibitors of metalloproteases. In: Proteinase Inhibitors (1986). BARRETT AJ, SALVESEN G (Eds.) Elsevier, Amsterdam, Chapter 6.
  • VEMULAPALLI S, WATKINS RW, BROWN A, COOK J, BER-NARDINO V, CHIU PJ: Disparate effects of phosphorami-don on blood pressure in SHR and DOCA-salt hypertensive rats. Life. Sci. (1993) 53:783–793.
  • MCMAHON EG, PALOMO MA, BROWN MA, BERTENSHAW SR, CARTER JS: Effect of phosphoramidon (endothelia converting enzyme inhibitor) and BQ-123 (endothelia receptor subtype A antagonist) on blood pressure in hypertensive rats. Am. J. Hypertension. (1993) 6:667–673.
  • NIICAM SS, AHN K, PAN S, BENINGO K, HALEEN S, LADOUCEUR D, DOHERTY AM: Studies on the phospho-rus-containing inhibitors of endothelin converting en-zyme. MEDI 57, 206th ACS meeting, Chicago (August 1993).
  • BERTENSHAW SR, ROGERS RS, STERN MK, NORMAN BH, MOORE WM, JEROME GM, BRA_NSON LM, MCDONALD JF, MCMAHON EG, PALOMO MA: Phosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor po-tency. J. Med. Chem. (1993) 36:173–176.
  • BERTENSHAW SR, TALLEY JJ, ROGERS RS, CARTER JS, MOORE WM, BRANSON LM, KOBOLDT CM: Thiol and hydroxamic add containing inhibitors of endothelin converting enzyme. Biootg. Med. Chem. Len . (1993) 3:1953–1958.
  • SHIOSAICI K, TASKER AS, SULLIVAN GM, SORENSEN BK, VON GELDERN TW, WU-WONG JR, MARSELLE CA, OP-GENORTH TJ: Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme Identified Indic rat lung. j. Med. Chem. (1993) 36: 468–478.
  • OKADA K, ARMY, HATA M, MATSUYAMA K, YANO M: Big endothelin-1 structure important for specific process-ing by endothelin-converting enzyme of bovine endo-thelial cells. Eur. J. Biochem. (1993) 218: 493–498.
  • In: Potassium Channel Modulators (1992). WESTON AH,HAMILTON TC (Eds.), Blackwell Scientific Publications, Ox-ford. Extensive review of potassium channel modulation.
  • NOMA A: ATP-regulated K+ channels in cardiac muscle. Nature (1983) 305:147–148.
  • ATWAL KS: Modulation of potassium channels by or-ganic molecules. Med. Res. Rev. (1992) 12:569. Review of known potassium channel openers.
  • RICHER C, PRATZ J, MULDER P, MONDOT S, GIUDICELLI JF, CAVERO I: Cardiovascular and biological effects of K+ channel openers, a class of drugs with vasorelaxant and cardioprotective properties. Life Sci. (1990) 47: 1693–1705. Review.
  • TOSAIU A, SZERDAHELYI P, ENGELMAN RM, DAS DK:Potassium channel openers and blockers: do they pos-sess proarrhythrnic or antiarrhythm c activity in is-c.haemic and reperfused rat hearts? J. Pbarmacol. Exp. 7her. (1993) 267 (3): 1355–1362. Arrhythmic effects.
  • ATWAL KS, GROVER GJ, AHMED SZ, FERRARA FN, HARPERTW, KIM KS, SLEPH PG, DZWONCZYK S, RUSSELL AD, MORELAND S, MCCULLOUGH JR, NORMANDIN DE: Cardioselective anti-ischaemk ATP-sensitive potassium channel openers. J. Med. Chem. (1993) 36: 3971–3974. Novel class of potassium channel openers.
  • PIROI i B, TULLIO P, LEBRUN P, ANTOINE M-H, FON-TAINE JU, MASEREEL B, SCHYNTS M, DUPONT L, HER CHUELZ A, DELARGE J:3-(Alkylamino)-411-pyrido[4,3-4-1,2,4-thiadiazine 1,1-Dioxides as powerful inhibitors of Insulin release from rat pancreatic B-cells: A new class of potassium channel openers? J. Med. Chem. (1993) 36: 3211–3213.
  • GADWOOD RC, KAMDAR By, CIPKUS DUBRAY LA, WOLFEML, SMITH MP, WATT W, MIZSAK SA, GROPPI VE: Synthe-sis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers. J. Med. Chem. (1993)36: 1480–1487.
  • MANLEY PW, QUAST U, ANDRES H, BRAY K: Synthesis of and radioligand binding studies with a tritiated pi-nacidil analogue: receptor interactions of structurally different classes of potassium channel openers and blockers. J. Med. Chem. (1993) 36: 2004–2010.
  • THORNTON JD, THORNTON CS, STERLING DL, DOWNEYJM: Blockade of ATP-Sensitive potassium channels in-creases infarct size but does not prevent precondition-ing in rabbit hearts. Circulation Research (1993) 72:44–49.
  • GUBIN J, DE VOGELAER H, INION H, HOUBEN C, LUC- CHETTI J, MAHAUX J, ROSSEELS G, PEIREN M, CLINET M, POLSTER P, CHATELAIN P: Novel Heterocyclic analogues of the potent class of calcium channel blockers 1-[[4-aminoalkoxy)phenyl]sulfonyllindolizines. J. Med. Chem. (1993) 36: 1425–1433.
  • COLLIS MG, HOURANI SMO: Adenosine receptor sub-types. Trends Pharmacol. Sci. (1993) 14: 360–366.
  • SALVATORE CA, JACOBSON MA, TAYLOR HE, LINDEN J,JOHNSON RG: Molecular cloning and characterization of the human A3 adenosine receptor. Proc. Natl. Acad. Sci. USA (1993) 90: 10365–10369.
  • LINDEN J, TAYLOR HE, ROBEVA AS, TUCKER AL, STEHLEJH, RIVICEES SA, FINK JS, REPPERT SM: Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Mol. Phar-macol. (1993) 44: 524–532.
  • TUCKER AL, LINDEN J: Cloned receptors and cardiovas-cular responses to adenosine. Cardiovasc. Res. (1993) 27: 62–67.
  • VAN GALEN PJM, STILES GL, MICHAELS G, JACOBSON KA:Adenosine Al and A2 receptors: Structure function relationships. Med. Res. Rev. (1992) 12:423–471.
  • CONTI A, MONOPOLI A, GAMBA M, BOREA PA, ONGINI E: Effects of selective At and A2 Adenosine Receptor Agonists on Cardiovascular Tissues. Arch. Pharmacol. (1993) 348: 108–112.
  • LASLEY RD, MENTZER, JR. RM: Adenosine improves re-covery of postischaemic myocardial function via an adenosine At receptor mechanism. Am.J. Physiol. (1992) 263:H1460–H1465.
  • MULLANE K: Acadesine: the prototype adenosine regu-lating agent for reducing myocardial ischaemic injury.Cardiovascular Res. (1993) 27:43–47.
  • TSUCHIDA A, LIU GS, MULLANE K, DOWNEY JM: Acades-ine lowers temporal threshold for myocardial infarct size limiting effect of preconditioning. Cardiovascular Res. (1993) 27:116–120.
  • PAN W, MULLANE K, YOUNG M: Anti-ischaemic activity of the novel adenosine regulating agent, GP-1-468, in a canine model of stable angina. FASEB J. (1993) 7:A119.
  • SEIGFREID MR, ERHARDT J, RIDER T, MA X-L, LEFER AM:Cardioprotection and attenuation of endothelial dys-function by organic nitric oxide donors in myocardial ischamnia-reperfusion. J. Pharmacol. Exp. 7ber. (1992) 260(2):668–675.
  • LEPER AM, TSAO PS, LEPER DJ, MA X-L: Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischaemia. FASEB J. (1991) 5:2029–2034.
  • FLAHERTY JT, BECKER LC, BULICLEY BIT, WEISS JL, GER-STENBLITH G, KALLMAN M, SILVERMAN KJ, WEI JY, prrr B, WEISFELDT ML: A randomized prospective trial of Intravenous nitroglycerin in patients with acute myo-cardial infarction. Circulation (1983) 68:576–588.
  • BECKMAN JS, BECKMAN 1W, CHEN J, MARSHALL PA, FREEMAN BA: Apparent hydroxyl radical production by peroxynitrite:Itnplications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA (1990) 87:1620–1624.
  • SIMPSON PJ, TODD RF, FANTONE JC, MICKELSON JK, GRIFFIN, JD, LUCCHESI BR: Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (Anti-Mol, Anti-CD11b) that inhibits leuko-cyte adhesion.]. Clin. Invest. (1988) 81:624–629.

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