Overview Central & Peripheral Nervous Systems: Metabotropic glutamate receptors

References

• KNOPFEL T, GASPARINI F: Metabotropic glutamate re-ceptors: potential drug targets. Drug Discovery Today (1996) 1:103–108.
   Google Scholar
• KNOPFEL T, KUHN R, ALLGEIER H: Metabotropic gluta-mate receptors: novel targets for drug development.]. Med. Chem. (1995) 38:1417–1426.
   PubMedGoogle Scholar
• NICOLETTI F, BRUNO V, COPANI A, CASABONA G, KNOP-FEL T: Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. (1996) 19:267-271. Up to date review on the potential use of mGlu receptor ligands for the treatment of neurodegenerative diseases.
   Google Scholar
• HOLLMANN M, HEINEMANN S: Cloned glutamate recep-tors. Annu. Rev. Neurosci. (1994) 17:31–108.
   PubMed Web of Science ®Google Scholar
• PIN JP, DUVOISIN R: The metabotropic glutamate receptors: structure and functions. Neuropharmacology (1995)34:1-26. A thorough review.
   Google Scholar
• NAKANISHI S: Molecular diversity of glutamate recep-tors and implications for brain function. Science (1994 258:597–603.
   Google Scholar
• ABE T, SUGIHARA H, NAWA H et al.: Molecular charac-terization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. J. Biol. Chem. (1992) 267:13361–13368.
   PubMed Web of Science ®Google Scholar
• MASU M, TANABE Y, TSUCHIDA K, SHIGEMOTO R,
   Google Scholar
• •• NAKANISHI S: Sequence and expression of a metabot-ropic glutamate receptor. Nature (1991) 349:760-765. Cloning of first mGlu receptor.
   Google Scholar
• DUVOISIN RM, ZIIANG C, RAMONELL K: A novel metabot-ropic glutamate receptor expressed in the retina and olfactory bulb.]. Neurosci. (1995) 15:3075–3083.
   PubMed Web of Science ®Google Scholar
• NAKAJLMA Y, IWAKABE H, AKAZAWA C et at: Molecular characterization of a novel retinal metabotropic gluta-mate receptor mGluR6 with a high agonist selectivity for L-2-atzdno-4-phosphonobutyrate. J. Biol. Chem. (1993) 268:11868–11873.
   PubMedGoogle Scholar
• OKAMOTO N, HORI S, AKAZAWA C et al.: Molecular characterization of a new metabotropic glutamate re-ceptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J. Biol. Chem. (1994) 269:1231–1236.
   PubMedGoogle Scholar
• SAUGSTAD JA, KINZIE JIVI, MULVIHILL ER, SEGERSON TP, WESTBROOK GL: Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Mol. Pharmacol. (1994) 45:367–372.
   PubMedGoogle Scholar
• TANABE Y, MASU M, ISHII R, SHIGEMOTO R, NAKANISHIS: A family of metabotropic glutamate receptors. Neuron (1992) 8:169–179.
   PubMed Web of Science ®Google Scholar
• TANABE Y, NOMURA A, MASU M et al.: Signal transduc-tion, pharmacological properties and expression pat-terns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J. Neurosci. (1993) 13:1372–1378.
   PubMed Web of Science ®Google Scholar
• MARTIN LJ, BLACKSTONE CD, HUGANIR RL, PRICE DL:
   Google Scholar
• • Cellular localization of a metabotropic glutamate recep-tor in rat brain_ Neuron (1992) 9:259-270. First report on immunohistochemical localisation of a mGlu receptor protein.
   Google Scholar
• IKEDA SR, LOVINGER DM, MCCOOL BA, LEWIS DL: Heterologous expression of metabotropic glutamamte receptors in rat sympathetic neurons: subtypes-specific coupling to ion channels. Neuron (1995) 14:1029-1038. First report on signal transduction of cloned mGlu receptor subtypes in neurones.
   Google Scholar
• ANIKSZTEJN L, BREGESTOVSKI P, BEN-ARI Y: Selective activation of quisqualate metabotropic receptors poten-tiates NMDA but not AMPA responses. Eur.J. Pharmacol. (1991) 205:327–328.
   PubMedGoogle Scholar
• TROMBLEY PQ, WESTBROOK GL: L-AP4 inhibits caMum currents and synaptic transmission via G-protein-cou-pled glutamate receptors. J. Neurosci. (1992) 12:2043–2050.
   PubMed Web of Science ®Google Scholar
• VAZQUEZ E, BUDD DC, HERRERO I, NICHOLLS DG, SANCHEZ-PRIETO J: Co-existence and interaction be-tween facilitatory and inhibitory metabotropic gluta-mate receptors and the inhibitory adenosine Al receptor in cerebrocortical nerve terminals. Neurophar-macology (1995) 34:919–927.
   PubMedGoogle Scholar
• PONCER JC, SHINOZAKI H, MILES R: Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in the rat hippocampus. J. Physiol. (1995) 485:121–134.
   PubMedGoogle Scholar
• DALBY NO, THOMSEN C: Modulation of seizure activity In mice by metabotropic glutamate receptor ligands. J. Pharmacol. Exp. Ther. (1996) 276:516–522,
   PubMed Web of Science ®Google Scholar
• BRUNO V, BATTAGLIA G, COPANI A et al: Activation of class formmetabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degenera-tion. Eur.J. Neurosci. (1995) 7:1906–1913.
   PubMedGoogle Scholar
• GONG QZ, DELAHUNTY TM, HAMM RJ, LYETH BG: Metabotropic glutamate antagonist, MCPG, treatment of traumatic brain injury in rats. Brain Res. (1995) 700:299–302.
   PubMedGoogle Scholar
• LEE RICK, WURTMAN RJ, COX AJ, NITSCH RM: Amyloidprecursor protein processing is stimulated by metabot-ropic glutamate receptors. Proc. Natl. Acad. Sci. USA (1995) 92:8083–8087.
   PubMedGoogle Scholar
• COPANI A, BRUNO V, BATTAGLIA G et al.: Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by P-amyloid pep-tide. Mol. Pharmacol. (1995) 47:890–897.
   PubMedGoogle Scholar
• NEUGEBAUER V, LUCKE T, SCHAIBLE HG: Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons. Eur.J. Neurosci. (1994) 6:1179–1186.
   PubMedGoogle Scholar
• SALT TE, EATON SA: The function of metabotropic glutamate exdtatory amino add receptors in synaptic transmission in the thalamus: studies with novel phenylglycine antagonists. Neurochem. Mt. (1994) 24:451458.
   Google Scholar
• ROBERTS PJ: Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs): phenyl-glycine derivatives and other selective antagonists - an update. Neuropharrnacology (1995) 34:813-819. A recent review on the development of compounds by the Bristol group.
   Google Scholar
• WATKINS J, COLLINGRIDGE G: Phenylglycine derivatives as antagonists of metabotropk glutamate receptors. Trends Pharmacol. Sci. (1994) 15:333–342.
   PubMedGoogle Scholar
• SCHOEPP DD, JOHNSON BG; SALHOFF CR et al.: Selective Inhibition of forskolin-stimulated cyclic AMP forma-tion in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarlboxylate. Neuro-pharmacology (1995) 34:843–850.
   Google Scholar
• SHIMAMOTO K, OHFUNE Y: Syntheses and conforma-tional analyses of glutamate analogs: 2-(2-carboxy-3-substituted-cyclopropyl)glycines as useful probes for excitatory amino acid receptors. J. Med. Chem. (1996) 39:407–423.
   PubMed Web of Science ®Google Scholar