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Expert Opinion on Therapeutic Patents Volume 6, 1996 - Issue 2
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Research

Patent Update Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Neurokinin receptor antagonists for the treatment of inflammation

Nicholas I Carruthers Schering-Plough Research Institute, Kenilworth, New Jersey, 07033, USA
&
James J Kaminski Schering-Plough Research Institute, Kenilworth, New Jersey, 07033, USA
Pages 169-174 | Published online: 29 Feb 2008

References to Primary Literature

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  • LADDUWAHETTY T, KEOWN L, CASCIERI MA, SADOWSKIS: Morpholine-based substance P antagonists: assess-ment of the 3-point binding modeL Bioorg. Med. Chem. Lett. (1994) 4(16)19174920.
  • SEWARD EM, SWAIN CJ, MERCHANT KJ, OWEN SN, SABIN V, CASCIERI MA, SADOWSKI S, STRADER C, BAKER R: Quinuclidine-based NICi antagonists 1. 3-Benzyloxy- 1-azabicyclof2.2.2.]octanes. Btoorg. Med. Chem. Lett. (1993) 3(6):1361–1366.
  • SWAIN CJ, SEWARD EM, SABIN V, OWEN S, CASCIERI MA, SADOWSKI S, STRADER C, BAKER R, BALL RG: Quinuclidine-based NICI antagonists 2. Determination of the ab-solute stereochemical requirements. Bloom. Med. Chem. Lett. (1993) 3(8):1703–1706.
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  • MACLEOD AM, MERCHANT KJ, BROOKFIELD F, KELLEHER F, STEVENSON GI, OWENS AP, SWAIN CJ, CASCIERI MA, SADOWSKI S, BER E, STRADER CD, MACINTYRE DE, METZGER JM, BALL RG, BAKER R: Identification of L-tryp-tophan derivatives with potent and selective antagonist activity at the NICI. receptor. J. Med. Chem. (1994) 37:1269–1274.
  • LEWIS RT, MACLEOD AM, MERCHANT KJ, KELLEHER F,SANDERSON I, HERBERT RH, CASCIERI MA, SADOWSKI S, BALL RG, HOOGSTEEN K: Tryptophan-derived NICir an-tagonists: conformationally constrained heterocyclic biosteres of the ester linkage. J. Med. Chem. (1995) 38:923–933.
  • MACLEOD AM, CASCIERI MA, MERCHANT KJ, SADOWSKIS, HARDWICKE S, LEWIS RT, MACINTYRE DE, METZGER JM, FONG TM, SHEPHEARD S, TATTERSALL FD, HAR-GREAVES R, BAKER R: Synthesis and biological evalu-ation of NIQ antagonists derived from L-tryptophan. J. Med. Chem. (1995) 38:934–941.
  • Scrip (1994) 24:1984.

References to Patent Literature

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