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Expert Opinion on Therapeutic Patents Volume 6, 1996 - Issue 8
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Research

Patent Evaluation Cardiovascular & Renal: Novel aminoheterocyclic derivatives as inhibitors of factor Xa

Pages 795-799 | Published online: 29 Feb 2008

References to Primary Literature

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  • VLASUK GP: Structural and functional characterizationof tick anticoagulant peptide (TAP): a potent and selec-tive inhibitor of blood coagulation factor Xa. Thromb. Haemostas. (1993) 70:212.
  • DUNW1DDIE CT, WAXMAN L, VLASUK GP et al.: Purifica-tion and characterization of inhibitors of blood coagu-lation factor Xa from hematophageous organisms. Methods Enzymol. (1993) 223:291.
  • CHOAY J, PET1TOU M, LORMEAU JC et al.: Structure-activ-ity relationships in heparin: a synthetic pentastiecha-ride with high affinity for antithrombotin M and eliciting high anti-factor Xa activity. Biochem. Biophys. Rev. Commun. (1983) 116:492.
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  • AL-OBEIDI FAD, WILDGOOSE P, STRINGER SK et al.: Discovery and optimization of a specific, orally avail-able, active site inhibitor of factor Xa discovered using synthetic combinatorial chemistry. J. Invest. Med. (1995) 43\(Suppl. 2):232A.
  • NAGAHARA T, YOKOYAMA Y, INAMURA K et al.: Dibasic(amidinoaryfipropartok acid derivatives as novel blood coagulation factor Xa inhibitors. J. Med. Chem, (1994) 37:1200.
  • NAGAHARA T, KATAKURA SI, YOKOYAMA Y et al.: Design,synthesis and biological activities of orally active coagu-lation factor /Ca inhibitors. Eur. J. Med. Chem, (1995) 30:139s.
  • HARA T, YOKOYAMA A, MORISHIMA Y et al.: Species differences in anticoagulant and anti-Xa activity of DX-9065a, a highly selective factor Xa inhibitor. Thromb. Res. (1995) 80:99.
  • HARA T, YOKOYAMA A, ISHIHARA H et al.: DX-9065a, anew synthetic, potent anticoagulant and selective in-hibitor for factor Xa. Thromb. Haemostas. (1994) 71:314.

References to Patent Literature

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