Involvement of the Na+,K+-ATPase and its inhibitors in cardiovascular diseases

Bibliography

• JORGENSEN PL: Na±,K+-ATPase, structure and transportmechanism. In: Molecular Aspects of Transport Proteins. De Pont JM (Ed.), Elsevier Science Publishers Amsterdam, The Netherlands/New York, NY (1992):1–26.
   Google Scholar
• BOVA S, GOLDMAN W, YUAN XJ, BLAUSTEIN M: Influ-ence of Na + gradient on Ca ±± transients and contraction in vascular smooth muscle. Am. J. PhysioL (1990) 259:H409–H423.
   Google Scholar
• GOLOVINA V, BLAUSTEIN M: Spatially and functionally distinct Ca ++ stores in sarcoplasmic and endoplasmic reticulum. Science (1997) 275:1643–1648.
   PubMed Web of Science ®Google Scholar
• AKERA T, BRODY TM: The role of the Na+,K+-ATPase in the inotropic action of digitalis. PharmacoL Rev. (1978) 29:187–220.
   Google Scholar
• GEERING K: Subunit assembly and functional matura-tion of Na+,K+-ATPase. J. Membr, Biol. (1990) 115:109–121.
   PubMed Web of Science ®Google Scholar
• MERCER R, BIEMESDERFER D, BLISS D et al.: Molecular cloning and immunological characterization of the y-subunit of the Na+,K+-ATPase. In: The Sodium Pump: Recent Developments. Kaplan J, De Weer P (Eds.), (1990:37–42.
   Google Scholar
• SACHS JR: The role of (c43) protomer interaction in de-termining functional characteristics of Na+,K+-ATPase. Biochim, Biophys, Acta (1994) 1193:199–211.
   Google Scholar
• SWEADNER K: Isoenzymes of the Na+,K+-ATPase. Bio-chim, Biophys, Acta (1989) 988:185–220.
   PubMed Web of Science ®Google Scholar
• TAKEYASU K, MIZUSHIMA A, BARSTEIN A et al.: Evolu-tionary conservation of the Na+,K+-ATPase genes. In: The Sodium Pump: Recent Developments. Kaplan J, De Weer P (Eds.), (1990:11–18.
   Google Scholar
• SWEADNER K, FARSHI SK: Rat cardiac ventricle has twoNa+,K+-ATPases with different affinities for ouabain: developmental changes in immunologically different catalytic subunits. Proc. NatL Acad. Sci, USA (1987) 84:8404–8407.
   Google Scholar
• UROYAMA 0, SWEADNER K: Ouabain sensitivity of thea3 isoenzyme of rat Na+,K+-ATPase. Biochem, Biophys, Res. Commun. (1988) 156:796–800.
   Google Scholar
• DE POVER A, GODFRAIND T: Interaction of ouabainwith Na+,K+-ATPase from human heart and from guinea-pig heart. Biochem, PharmacoL (1979) 28:3051–3056.
   PubMedGoogle Scholar
• BROWN L, ERDMANN E: Binding of digitalis derivativesto beef, cat and human cardiac Na+,K+-ATPase. Affinity and kinetic constants. Arch. Int. Pharmacodyn, (1984) 271:229–240.
   Google Scholar
• MCDONOUGH A, AZUMA K, LESCALE-MATYS L et al.:Physiological rationale for multiple Na+-K+ isoforms: differential regulation of ai vs. a2 by ionic stimuli. Ion-motive ATPases: structure, function and regula-tion. Ann. NY Acad. Sci, (1992) 671:156–169.
   Google Scholar
• SELDIN SW, GIEBISCH G: In: The Regulation of Potassiumbalance. Raven press, New York (1989):15–22.
   Google Scholar
• ZAHLER R, GILMORE-HEBERT M, BALDWIN J et al.: Ex-pression of a isoforms of the Na+,K+-ATPase in human heart. Biochim, Biophys, Acta (1993) 1149:189–194.
   PubMedGoogle Scholar
• WANG J, SCHWINGER R, FRANK K etal.: Regional expres-sion of the Na + pump subunit isoforms and Na-Ca++ exchanger in the human heart. J. Din. Invest. (1996) 98:1650–1658.
   Google Scholar
• ZAHLER R, SUN W, ARDITO T, KASHGARIAN M: Na+,K+-ATPase a-isoform expression in heart and vascular endothelia: cellular and developmental regulation. Am. J. PhysioL (1996) 270:C361–C371.
   Google Scholar
• MCDONOUGH A, ZHANG Y, SHIN V, FRANK JS: Subcellu-lar distribution of sodium pump isoform subunits in mammalian cardiac myocytes. Am. J. PhysioL (1996) 270:C1221–C1227.
   Google Scholar
• LELIEVRE L, CHARLEMAGNE D, MOUAS C, SWYNGHE-DAW B: Respective involvements of high and low affin-ity digitalis receptors in the inotropic response of isolated rat hearts to ouabain. Biochem, PharmacoL (1986) 35:3449–3455.
   Google Scholar
• Demonstration of the dual mechanisms underlying the ino-tropic, and toxic digitalis actions of al and a3 isoforms of Na+,KtATPase in rats.
   Google Scholar
• REPKE K, SWEADNER K, WEILAND J et al.: In search of ideal inotropic steroids: recent progress. Progress Drug Res. (1996) 47:11–53.
   Google Scholar
• Overview of recent progress in cardiac drug research.
   Google Scholar
• LUCCHESI PA, SWEADNER K: Postnatal changes in Na+,K+-ATPase isoform expression in rat cardiac ven-tricle. J. Biol. Chem. (1991) 266:9327–9331.
   PubMed Web of Science ®Google Scholar
• ORLOWSKI J, LINGREL JB: Thyroid and glucocorticoid hormones regulate the expression of multiple Na+,K+-ATPase genes in cultured neonatal rat cardiac myocytes. J. Biol. Chem. (1990) 265:3462–3470.
   Google Scholar
• MIDDLETON J: Direct regulation of the Na+-K+ pump by signal trasduction mechanisms. Miner. Electrolyte Me-tab. (1996) 22:293–302.
   Google Scholar
• MAGYAR C, WANG J, AZUMA K, MCDONOUGH A: Recip-rocal regulation of cardiac Na+,K+-ATPase and Na/Ca++ exchanger: hypertension, thyroid hormone, development. Am. J. PhysioL (1995) 269:C675–C682.
   Google Scholar
• SHAMRAJ OL, GRUP IL, GRUP G et al.: Characterization of Na+,K+-ATPase, its isoforms and the inotropic re-sponse to ouabain in isolated failing human hearts. Cardiovasc, Res. (1993) 23:2229–2237.
   Google Scholar
• ELLINGSEN 0, HOLTHE MR, SVINDLAND A et al.: Na+-K+ pump concentration in hypertrophied human hearts. Eur, Heart]. (1994) 15:1184–1190.
   Google Scholar
• BUNDGAARD H, KJELDSEN K: Human myocardial Na+,K+-ATPase concentration in heart failure. Molec, Cell. Biochem, (1996) 163/164:277–283.
   Google Scholar
• BOOK CB, MOORE RS, SEMANCHIK A, NG YC: Cardiachypertrophy alters expression of Na+,K+-ATPase subunit isoforms at mRNA and protein levels in rat myocardium. Mol, Cell. Cardiol, (1994) 26:591–600.
   Google Scholar
• HERRERA VLM, CHOBANIAN A, RUIZ-OPAZO N: Isoform-specific modulation of Na+,K+-ATPase a-subunit gene expression in hypertension. Science (1988) 241:221–223.
   Google Scholar
• SAHIN-ERDEMLI I, MEDFORD R, SONGU-MIZE E: Regula-tion of Na+,K+-ATPase a subunit isoforms in rat tissues during hypertension. Eur, PharmacoL (1995) 292:163–171.
   Google Scholar
• LIU X, SONGU-MIZE E: Alterations in a subunit expres-sion of cardiac Na±,K+-ATPase in spontaneously hyper-tensive rats: effect of anti-hypertensive therapy. Eur. J. Pharmacol. (1997) 327:151–156.
   PubMed Web of Science ®Google Scholar
• WOOLFSON R, POSTON L, DE WARDENER H: Digoxin-like inhibitors of active sodium transport and blood pressure: the current status. Kidney Int. (1994) 46:297–309.
   PubMed Web of Science ®Google Scholar
• TYMIAK AA, NORMAN JA, BOLGAR M et al.: Physico-chemical characterization of an ouabain isomer from bovine hypothalamus. Proc. Natl. Acad. Sci. USA (1993) 90:8189–8193.
   PubMed Web of Science ®Google Scholar
• ZHAO N, LO LC, BEROVA N et al.: Na±,K+-ATPase inhibi-tors from bovine hypothalamus and human plasma are different from ouabain: nanogram scale CD struc-tural analysis. Biochemistry (1995) 34:9893–9896.
   PubMed Web of Science ®Google Scholar
• Chemical analysis proving that the endogenous ouabain-like compound is a closely related isomer, distinguishable from ouabain.
   Google Scholar
• BAGROV A, FEDOROVA 0, MASLOVA M et al.: Endoge-nous plasma Na±,K+-ATPase inhibitory activity and digoxin-like immunoreactivity after acute myocardial infarction. Cardiovasc. Res. (1991) 25:371–377.
   Google Scholar
• DELVA P, DEVYNCK MA, DEGAN M et al.: Plasma levels ofan endogenous Na+-K+ pump inhibitor in relation to haemodynamic data in cardiopathic patients. Din. Sci. (1991) 81:23–29.
   Google Scholar
• GOTTLIEB SS, ROGOWSKI A, WEINBERG M et al.: Ele-vated concentrations of endogenous ouabain in pa-tients with congestive heart failure. Circulation (1992) 86:420–425.
   PubMed Web of Science ®Google Scholar
• HAMLYN J, RINGEL R, SCHAFFER J et al.: A circulating in-hibitor of the Na±,K+- ATPase associated with essential hypertension. Nature (1982) 300:650–652.
   PubMed Web of Science ®Google Scholar
• ROSSI GP, MANUNTA P, HAMLYN J et al.: Immunoreac-five endogenous ouabain in primary aldosteronism and essential hypertension: relationship with plasma renin, aldosterone and blood pressure levels. J. Hyper-tens. (1995)13:1181–1191.
   Google Scholar
• High plasma concentrations of the endogenous ouabain-like factor correlate with high blood pressure levels in hy-pertensive patients.
   Google Scholar
• FERRANDI M, MINOTTI E, SALARDI S et al.: Ouabain-like factor in Milan hypertensive rats. Am. J. PhysioL (1992) 263:F739–F748.
   Google Scholar
• DORIS PA: Ouabain in plasma from spontaneously hy-pertensive rats. Am. J. PhysioL (1994) 266:H360–H364.
   Google Scholar
• LEENEN FHH, HARMSEN E, YU H: Dietary sodium and central vs. peripheral ouabain-like activity in Dahl salt-sensitive rats. Am. J. Physiol. (1994) 267 (36):H1916–H1920.
   Google Scholar
• YUAN CM, MANUNTA P, HAMLYN J et al.: Long-term oua-bain administration produces hypertension in rats. Hypertension (1993) 22:178–187.
   PubMed Web of Science ®Google Scholar
• Evidence for the hypertensive action of low doses of oua-bain in chronically treated rats.
   Google Scholar
• YUAN CM, MANUNTA P, CHEN S et al.: Role of ouabain- like factors in hypertension: effects of ouabain and certain endogenous ouabain-like factors in hyperten-sion. J. Cardiovasc. Pharmacol. (1993) 22 (Suppl. 2):S10–S12.
   Google Scholar
• SEKIHARA H, YAZAKI Y, KOJIMA T: Ouabain as an ampli-fier of mineralcorticoid- induced hypertension. Endo-crinology (1992) 131:3077–3082.
   Google Scholar
• MELVILLE KI, SHISTER HE, KLINGNER B: Comparative blood pressure and electrocardiographic changes in-duced by proscillaridin and ouabain. Can. J. PhysioL Pharmacol. (1966) 44:887–892.
   Google Scholar
• FERRARI P, TORIELLI L, FERRANDI M et at.: PST 2238, a new antihypertensive compound antagonist of the long-term pressor effect of oubain. I Pharm. Exp. Then (1997). (In Press).
   Google Scholar
• PERRY G, BROWN E, THORNTON R et al.: The effect of di-goxin on mortality and morbidity in patients with heart failure. New Engl. J. Med. (1997) 336:525–533.
   Google Scholar
• R&D Focus Drug News (22 May 1995).
   Google Scholar
• GHEORGHIADE M, PITT B, et al.: Digitalis investigation group (DIG) trial: a stimulus for further research. Am. Heart]. (1997) 134(0:3–12.
   Google Scholar
• Experimental Biology Meeting. New Orleans, USA (1993):Abstract 697.
   Google Scholar
• NOEL F, FAGOO M, GODFRAIND T: A comparison of the affinities of rat (Nat + IC)-ATPase isozymes for cardio-active steroids, role of lactone ring, sugar moiety and KC1 concentration. Biochem. Pharmacol. (1990) 40(12):2611–2616.
   Google Scholar
• TEMPLETON JF, LING Y, ZEGLAM TH, LABELLA FS: Syn-thesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-513,1413-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor. J. Med. Chem. (1993) 36(1):42–45.
   Google Scholar
• TEMPLETON JF, LING Y, MARAT K, LABELLA FS: Synthesis and structure- activity relationships of 1713-substituted-1413-hydroxysteroid 3-(a-L-rhamnopyranosides): steroids that bind to the digi-talis receptor. .1 Med. Chem. (1997) 40(101439–1446.
   Google Scholar
• TEMPLETON JF, LING Y, ZEGLAM TH et al.: Pregnane and 21-norpregnane derivatives of ouabain that bind to the digitalis receptor. Eur. J. Med. Chem. (1994) 29:799–804.
   Google Scholar
• TEMPLETON JF, LING Y, KUMAR VPS, LABELLA FS: Syn-thesis and structure-activity relationships of 1413-hydroxy-5a pregnanes: pregnanes that bind to the cardiac glycoside receptor. Steroids (1993) 58(10:518–523.
   Google Scholar
• BROWN L, ERDMANN E: Comparison of the affinity of human, beef and cat heart Na±,K+-ATPase for different digitalis derivatives. Arzneim. Forsh. (1984) 34:1314–1318.
   Google Scholar
• JORGHENSEN PL: Purification and characterization ofNa±,K+-ATPase. III. Purification from the outer medulla of mammalian kidney after selective removal of rembrane components by sodium dodecylsulphate. Biochim. Biophys. Acta (1974) 356:36–52.
   Google Scholar
• NOEL F, GODFRAIND T: Heterogeneity of ouabain spe- cific binding sites and sodium-potassium ATP-ase inhi-bition in microsomes from rat heart. Biochem. Pharmacol. (1984) 33:47–53.
   PubMedGoogle Scholar
• CERRI A, SERRA F, FERRARI P et al.: Synthesis, cardio-tonic activity and structure-activity relationships of 1713-guanylhydrazone derivatives of 513-androstane-313,1413-diol acting on Na±,K+-ATPase re-ceptor. J. Med. Chem. (1997) 40(20:3484–3488.
   Google Scholar
• QUADRI L, CERRI A, FERRARI P et al.: Synthesis and quan-titative structure- activity relationships of 1713-hydrazonomethy1-513-androstane-313,1413-diol de-rivatives that bind to Na±,K+-ATPase receptor. J. Med. Chem. (1996) 39(17):3385–3393.
   Google Scholar
• GOBBINI M, BENICCHIO A, PADOANI G et al.: Digitalis-like compounds: synthesis and biological evaluation of 33-(aminoalkylthio) derivatives. Bloorg. Med. Chem. Letts (1997) 7(4):469–472.
   Google Scholar
• GOBBINI M, BENICCHIO A, MARAZZI G et al.: Digitalis-like compounds: synthesis and biological evaluation of seco-D and D-homo derivatives. Steroids (1996) 61:572–582.
   Google Scholar
• QUADRI L, BIANCHI G, CERRI A et al.: 171343-Fury1)-513-androstane-313,1413,17a- triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action. J. Med. Chem. (1997) 40 (11):1561–1564.
   Google Scholar
• Novel antihypertensive mechanism of action of a syntheticandrostane derivative.
   Google Scholar
• BOUTAGY JS, THOMAS RE: Cardenolide analogues. I.Route for preparing semi- synthetic analogues of digi-toxigenin. Aust. J. Chem. (1971) 24:2723–2728.
   Google Scholar
• BOUTAGY J, GELBART A, THOMAS R: Cardenolide ana-logues. IV. Inhibition of Na±,K+-ATPase. Aust. J. Pharm. Sci. (1973) 2:41–46.
   Google Scholar
• REPKE K, WEILAND J, MEGGES R, SCHON R: Approach tothe chemotopography of the digitalis recognition ma-trix in Na+-K+ transporting ATPase as a step in the ra-tional design of new inotropic steroids. In: Progress in Medicinal Chemistry. Ellis GP, Luscombe DK (1993) 30:135–202.
   Google Scholar
• SCHON R, WEILAND J, MEGGES R, REPKE K: Differentia-tion between isoforms of Na+-K+ transporting ATPase from human and guinea-pig cardiac muscle through use of digitalis derivatives as analytical probes. Naunyn-Schmiedeberg's Arch. Pharmacol. (1995) 351:282–292.
   Google Scholar
• REPKE K, MEGGES R, WEILAND J: Differentiation be-tween various types of inotropes through discovery of differences in their ability to detect isoforms of Na±,K+-ATPase. J. Enz. Inhib. (1997)12:53–58.
   Google Scholar
• FERRANDI M, TRIPODI G, SALARDI S et al.: RenalNa±,K+-ATPase in genetic hypertension. Hypertension (1996) 28:1018–1025.
   PubMed Web of Science ®Google Scholar