16
Views
13
CrossRef citations to date
0
Altmetric
Review

The 5-hydroxytryptamine 6 receptor: localisation and function

, , , &
Pages 1217-1224 | Published online: 25 Feb 2005

Bibliography

  • BOESS FG, MARTIN IL: Molecular biology of 5-HT receptors. Neuropharmacology (1994) 133:275–317.
  • •Excellent review of 5-HT receptor pharmacology.
  • MONSMA FJ, SHEN Y, WARD RP et al.: Cloning and expression of a novel serotonin receptor with high affin-ity for tricyclic psychotropic drugs. Mol. Pharmacol (1993) 43:320–327.
  • •Details the cloning of the rat and human 5-HT6 receptors.
  • RUAT M, TRAIFFORT E, ARRANG J-M et al: A novel serotonin (5-111‘6) receptor: molecular cloning, localisa-tion and stimulation of cAMP accumulation. Biochem. Biophys. Res. Corn. (1993) 193:269–276.
  • •Details the cloning of the rat and human 5-HT6 receptors.
  • KOHEN R, METCALF MA, KHAN N et al.: Cloning, characterization of chromosomal localization of a human 5-11T6 serotonin receptor. J. Neurochem. (1996) 66:47–56.
  • •Details the cloning of the rat and human 5-HT6 receptors.
  • WARD RP, HAMBLIN MW, LACHOWICZ JE et al.: Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry. Neuroscience (1995) 64:1105–1111.
  • GERARD C, EL MESTIKAWY S, LEBRAND C et al: Quantita-tive RT-PCR distribution of serotonin 5-11T6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse (1996) 23:164–173.
  • GERARD C, MARTRES M-P, LEFEVRE K et al: Immuno-localization of serotonin 5-11T6 receptor-like material in the rat central nervous system. Brain Res. (1997) 746:207–219.
  • YAU JLW, NOBLE J, WIDDOWSON J et al.: Impact of adre-nolectomy on 5-11T6 and 5-11T7 receptor gene expres-sion in the rat hippocampus. Mol. Brain. Res. (1997) 45:182–186.
  • BOESS FG, MONSMA FJ, CAROLO C et al.: Functional and radioligand binding characterization of rat 5-11T6 re-ceptors stably expressed in 11EK293 cells. Neurophar-macology (1997) 36:713–720.
  • GLATT CE, SNOWMAN AM, SIBLEY DR et al.: Clozapine: selective labeling of sites resembling 5-11T6 serotonin receptors may reflect psychoactive profile. Mol. Med. (1995) 1:398–406.
  • ROTH BL, CRAIGO SC, CHOUDHARY MS et al.: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 re-ceptor. J. Pharmacol Exp. Ther. (1994) 268:1403–1410.
  • BOESS FG, MONSMA FJ, MEYER V et al.: Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-HT6 receptor. Mol. Pharmacol. (1997) 52:515–523.
  • BOESS FG, MONSMA FJ, ZWINGELSTEIN C et al.: Identifi-cation of residues in transmembrane regions III and VI that contribute to the ligand binding site of the 5-11T6 receptor. J. Neurochem. (1998). (In Press).
  • SLEIGHT AJ, BOESS FG, BOS M et al.: Characterization of Ro 04-6790 and Ro 63-0563: potent and selective an-tagonists at human and rat 5-11T6 receptors. Br. J. Phar-macol. (1998) 124:556–562.
  • ••Provides the first report of potent and selective 5-HT6 recep-tor antagonists.
  • BOESS FG, RIEMER C, BOS M et al.: The selective 5-11T6 receptor radioligand [311]Ro 63–0563 labels 5-11T6 re-ceptor binding site in rat and porcine striatum. Mol. Pharmacol. (1998). (In Press).
  • ••Provides the first report of the identification of 5-HT6 recep-tor binding sites in the brain.
  • UNS WORTH CD, MOLINOFF PB: Characterization of a 5-hydroxytryptamine receptor in mouse neuroblas-tomo N18TG2 cells. J. Pharmacol Exp. Ther. (1994) 269:246–255.
  • MACDERMOT J, HIGASHIDA H, WILSON SP et al: Adeny-late cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids. Proc. Nati Acad. Sci. USA (1979) 76:1135–1139.
  • BERRY-KRAVIS E, DAWSON G: Characterization of anadenylate cyclase-linked serotonin (5-HT1) receptor in a neuroblastoma X brain explant hybrid cell line (NCB-20). J. Neurochem. (1983) 40:977–985.
  • CONNER DA, MANSOUR TE: Serotonin receptor-mediated activation of adenylate cyclase in the neuro-blastoma NCB.20: a novel 5-hydroxytryptamine recep-tor. Mol. Pharmacol. (1990) 37:742–751.
  • SCHOEFFTER P, WAEBER C: 5-Hydroxytryptamine re-ceptors with a 5-11T6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. (1994) 350:356–360.
  • SEBBEN M, ANSANAY H, BOCKAERT J et al.: 5-11T6 recep-tors positively coupled to adenylyl cyclase in striatal neurones in culture. Neuroreport (1994) 5:2553–2557.
  • BOURSON A, BORRONI E, AUSTIN RH et al.: Determina-tion of the role of the 5-11T6 receptor in the rat brain: a study using antisense oligonucleotides. J. Pharmacol Exp. Ther. (1995) 274:173–180.
  • ••References 22 and 23 were the first studies to demonstratefunctional effects of 5-HT6 receptors using antisense oligonucleotides.
  • SLEIGHT AJ, MONSMA FJ, BORRONI E et al.: Effects of altered 5-11T6 expression in the rat: functional studies using antisense oligonucleotides. Behav. Brain Res. (1996) 73: 245–248.
  • ••References 22 and 23 were the first studies to demonstratefunctional effects of 5-HT6 receptors using antisense oligonucleotides.
  • BENTLEY JC, FONE KCF, MARSDEN CA et al.: Stretchingbehaviour induced by the potent and selective 5-11T6 antagonist Ro 04–6790 in rats. IUPHAR (1998) (Munich).
  • MARTIN GR, EGLEN RM, HAMBLIN MW et al.: The struc-ture and signalling properties of 5-HT receptors: an endless diversity. Trends Pharmacol. Sci. (1998) 19:2–4.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.