474
Views
69
CrossRef citations to date
0
Altmetric
Reviews

A new target for proteasome inhibitors: FoxM1

Pages 235-242 | Published online: 15 Jan 2010

Bibliography

  • Rubin DM, Finley D. Proteolysis. The proteasome: a protein-degrading organelle? Curr Biol 1995;5(8):854-8
  • Mitsiades N, Mitsiades CS, Richardson PG, The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003;101(6):2377-80
  • Chan DW, Yu SY, Chiu PM, Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis. J Pathol 2008;215(3):245-52
  • Fernandez Y, Verhaegen M, Miller TP, Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res 2005;65(14):6294-304
  • Mitsiades N, Mitsiades CS, Poulaki V, Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA 2002;99(22):14374-9
  • Podar K, Gouill SL, Zhang J, A pivotal role for Mcl-1 in Bortezomib-induced apoptosis. Oncogene 2008;27(6):721-31
  • Pei XY, Dai Y, Grant S. The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells. Leukemia 2003;17(10):2036-45
  • Nickeleit I, Zender S, Sasse F, Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell 2008;14(1):23-35
  • Fennell DA, Chacko A, Mutti L. BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 2008;27(9):1189-97
  • Lingbeek ME, Jacobs JJ, van Lohuizen M. The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. J Biol Chem 2002;277(29):26120-7
  • Nencioni A, Grunebach F, Patrone F, Proteasome inhibitors: antitumor effects and beyond. Leukemia 2007;21(1):30-6
  • Shah JJ, Orlowski RZ. Proteasome inhibitors in the treatment of multiple myeloma. Leukemia 2009;11:1965-79
  • Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009;8(1):33-40
  • Nakanishi C, Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 2005;5(4):297-309
  • Mulligan G, Mitsiades C, Bryant B, Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib. Blood 2007;109(8):3177-88
  • Bhat UG, Halasi M, Gartel AL. FoxM1 is a general target for proteasome inhibitors. PLoS ONE 2009;4(8):e6593
  • Laoukili J, Stahl M, Medema RH. FoxM1: at the crossroads of ageing and cancer. Biochim Biophys Acta 2007;1775(1):92-102
  • Ueno H, Nakajo N, Watanabe M, FoxM1-driven cell division is required for neuronal differentiation in early Xenopus embryos. Development 2008;135(11):2023-30
  • Krupczak-Hollis K, Wang X, Kalinichenko VV, The mouse forkhead box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol 2004;276(1):74-88
  • Kalinichenko VV, Gusarova GA, Tan Y, Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury. J Biol Chem 2003;278(39):37888-94
  • Wang X, Hung NJ, Costa RH. Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury. Hepatology 2001;33(6):1404-14
  • Zhao YY, Gao XP, Zhao YD, Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury. J Clin Invest 2006;116(9):2333-43
  • Major ML, Lepe R, Costa RH. Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators. Mol Cell Biol 2004;24(7):2649-61
  • Teh MT, Wong ST, Neill GW, FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res 2002;62(16):4773-80
  • Penzo M, Massa PE, Olivotto E, Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1. J Cell Physiol 2009;218(1):215-27
  • Bektas N, Haaf A, Veeck J, Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer. BMC Cancer 2008;8(1):42
  • Pandit B, Halasi M, Gartel AL. p53 negatively regulates expression of FoxM1. Cell Cycle 2009;8(20):3425-7
  • Wang IC, Chen YJ, Hughes D, Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol 2005;25(24):10875-94
  • Myatt SS, Lam EW. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 2007;7(11):847-59
  • Romagnoli S, Fasoli E, Vaira V, Identification of potential therapeutic targets in malignant mesothelioma using cell-cycle gene expression analysis. Am J Pathol 2009;174(3):762-70
  • Wonsey DR, Follettie MT. Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe. Cancer Res 2005;65(12):5181-9
  • Garber ME, Troyanskaya OG, Schluens K, Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA 2001;98(24):13784-9
  • van den Boom J, Wolter M, Kuick R, Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Pathol 2003;163(3):1033-43
  • Liu M, Dai B, Kang SH, FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 2006;66(7):3593-602
  • Gemenetzidis E, Bose A, Riaz AM, FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS ONE 2009;4(3):e4849
  • Li Q, Zhang N, Jia Z, Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res 2009;69(8):3501-9
  • Douard R, Moutereau S, Pernet P, Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. Surgery 2006;139(5):665-70
  • Okabe H, Satoh S, Kato T, Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res 2001;61(5):2129-37
  • Nakamura T, Furukawa Y, Nakagawa H, Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene 2004;23(13):2385-400
  • Obama K, Ura K, Li M, Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma. Hepatology 2005;41(6):1339-48
  • Chandran UR, Ma C, Dhir R, Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process. BMC Cancer 2007;7:64
  • Kalin TV, Wang IC, Ackerson TJ, Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice. Cancer Res 2006;66(3):1712-20
  • Kim IM, Ackerson T, Ramakrishna S, The forkhead box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res 2006;66(4):2153-61
  • Wang Z, Banerjee S, Kong D, Down-regulation of forkhead box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells. Cancer Res 2007;67(17):8293-300
  • Ahmad kiA, Wang Z, Kong D, FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors. Breast Cancer Res Treat 2009 Oct 8 [E-pub ahead of print]
  • Radhakrishnan SK, Gartel AL. FOXM1: the Achilles' heel of cancer? Nat Rev Cancer 2008;8(3): c1; author reply c2
  • Adami GR, Ye H. Future roles for FoxM1 inhibitors in cancer treatments. Future Oncol 2007;3(1):1-3
  • Gartel AL. FoxM1 inhibitors as potential anticancer drugs. Expert Opin Ther Targets 2008;12(6):663-5
  • Radhakrishnan SK, Bhat UG, Hughes DE, Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1. Cancer Res 2006;66(19):9731-35
  • Bhat UG, Zipfel PA, Tyler DS, Gartel AL. Novel anticancer compounds induce apoptosis in melanoma cells. Cell Cycle 2008;7(12):1851-5
  • Kwok JM, Myatt SS, Marson CM, Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Molecular Cancer Ther 2008;7(7):2022-32
  • Bhat UG, Halasi M, Gartel AL. Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. PLoS ONE 2009;4(5):e5592
  • Lentzen G, Klinck R, Matassova N, Structural basis for contrasting activities of ribosome binding thiazole antibiotics. Chem Biol 2003;10(8):769-78
  • Hagg M, Biven K, Ueno T, A novel high-through-put assay for screening of pro-apoptotic drugs. Invest New Drugs 2002;20(3):253-9
  • Erdal H, Berndtsson M, Castro J, Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci USA 2005;102(1):192-7
  • Nicolaou KC, Zak M, Rahimipour S, Discovery of a biologically active thiostrepton fragment. J Am Chem Soc 2005;127(43):15042-4
  • Halasi M, Gartel AL. A novel mode of FoxM1 regulation: positive auto-regulatory loop. Cell Cycle 2009;8(12):1966-7
  • Matta H, Chaudhary PM. The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther 2005;4(1):77-82
  • Wierstra I, Alves J. FOXM1, a typical proliferation-associated transcription factor. Biol Chem 2007;388(12):1257-74

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.