54
Views
1
CrossRef citations to date
0
Altmetric
Miscellaneous

Farnesoid X receptor agonism – a new approach to the treatment of cholesterol gallstone disease

Pages 535-538 | Published online: 22 Apr 2005

Bibliography

  • MAKISHIMA M, OKAMOTO AY,REPA JJ et al.: Identification of a nuclear receptor for bile acid. Science (1999) 284:1362–1365.
  • PARKS DJ, BLANCHARD SG, BLEDSOE RK et al.: Bile acids: natural ligands for an orphan nuclear receptor. Science (1999) 284:1365–1368.
  • MALONEY PR, PARKS DJ, HAFFNER CD et al.: Identification of a chemical tool for the orphan nuclear receptor FXR. ./. Med. Chem. (2000) 43:2971–2974.
  • MOSCHETTA A, BROOKOUT AL, MANGELDORF D: Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat. Med. (2004) 12:1352–1358.
  • SINAL CJ, TOHKIN M, MIYATA M et al.: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell (2000) 102:731–744.
  • LIU Y, BINZ J, NUMERICK MJ et al.:Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. I Chu. Invest. (2003) 112:1678–1687.
  • PALLICCARI R, FIORUCCI S, CAMAIONI E et al.: 6a-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. Med. Chem. (2002) 45:3569–3572.
  • PILLICCIARI R, CONSTANTINO G, CAMAIONI E et al.: Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. I Med. Chem. (2004) 47:4559-4569. Expert Op/n. lnvestig. Drugs (2005) 14(4)537
  • FIORUCCI S, CLERICI C, ANTONELLI E et al: Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X (FXR) ligand, in estrogen induced cholestasis. ./. Pharmacol. Exp. Ther. (2005) (In Press).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.