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Expert Opinion on Investigational Drugs Volume 15, 2006 - Issue 2

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Editorial

What are we looking for in new antibacterials and how do we design it?

John F Barrett Merck Research Laboratories, Department of Infectious Diseases, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA. [email protected]

Mary Motyl Merck Research Laboratories, Department of Infectious Diseases, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA. [email protected]

Pages 85-88 | Published online: 24 Jan 2006

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https://doi.org/10.1517/13543784.15.2.85

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BARRETT JF: Can biotech deliver new antibiotics? Curr. Opin. Microbiol. (2005) 8:498-503.
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WALSH CT: Where will new antibiotics come from? Nat. Rev. Microbiol. (2003) 1:65-70.
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RATTI E, TRIST D: Continuing evolution of the drug discovery process in pharmaceutical industry. Pure Appl. Chem. (2001) 73(1):67-75.
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WILLIAMS JA, BAUMAN J, CAI H et al.: In vitro ADME phenotyping in drug discovery: current challenges and future solutions. Curr. Opin. Drug Discov. Devel. (2005) 8:78-88.
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SCHUSTER D, LAGGNER C, LANGER T: Why drugs fail – a study on side effects in new chemical entities. Curr. Pharm. Design (2005) 11(27):3545-4559.
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NATHAN C, GOLDBERG FM: The profit problem in antibiotic R&D. Nat. Rev. Drug Disc. (2005) 4:887-891.
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Websites

http://www.idsociety.org/pa/IDSA_Paper4_final_web.pdf Bad bugs, no drugs: as antibiotic discovery stagnates: a public health crisis brews (2004).
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http://www.intl.elsevierhealth.com/e-books/pdf/1175.pdf The drug discovery process: general principles and some case histories (2004).
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