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Drug Evaluations

Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market?

, MD, , PharmD &
Pages 61-75 | Published online: 20 Dec 2007

Bibliography

  • Akhondzadeh S. Pharmacotherapy of schizophrenia: the past, present and future. Curr Drug Ther 2006;1:1-7
  • McGrath JJ. Variations in the incidence of schizophrenia: data versus dogma. Schizophr Bull 2006;32:195-7
  • Bernardo M, Azanza JR, Rubio-Terres C, Rejas J. Cost-effectiveness analysis of schizophrenia relapse prevention. An economic evaluation of the ZEUS (Ziprasidone-Extended-Use-In-Schizophrenia) study in Spain. Clin Drug Invest 2006;26:447-57
  • Stahl SM. Psychopharmacology of antipsychotics. London: Martin Dunitz; 1999
  • Freedman R. Schizophrenia. N Engl J Med 2003;349:1738-49
  • Rosenheck R, Cramer J, Xu W, et al. A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. N Engl J Med 1997;337:809-15
  • Di Forti M, Lappin JM, Murray RM. Risk factors for schizophrenia – all roads lead to dopamine. Eur Neuropsychopharm 2007;17:S101-S107
  • Raggi MA. Pharmacological treatment of schizophrenia: recent antipsychotic drugs and new therapeutic strategies. Current Medicinal Chemistry. Raggi MA, editor. Chicago: Bentham Publisher; 2004; p. 1-396
  • Meltzer HY. Role of serotonin in the action of atypical antipsychotic drugs. Clin Neurosci 1995;3:64-75
  • Singh AN. Trend of new antipsychotics in development for schizophrenia. Int Med J 2005;12:175-80
  • Raggi MA, Mandrioli R, Sabbioni C, Pucci V. Atypical antipsychotics: pharmacokinetics, therapeutic drug monitoring and pharmacological interactions. Curr Med Chem 2004;11:279-96
  • Emsley RA. Partial response to antipsychotic treatment: the patient with enduring symptoms. J Clin Psych 1999;60(Suppl 23):10-3
  • Martindale – The Complete Drug Reference. Sweetman SC, editor. London: Pharmaceutical Press; 2004; p. 675-8
  • Meltzer HY, Matsubara S, Lee JC. The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacol Bull 1989;25:390-2
  • Raggi MA. Therapeutic drug monitoring: chemical-clinical correlations of atypical antipsychotic drugs. Curr Med Chem 2002;9:1397-409
  • Conley RR, Kelly DL. A review of current drug targets and pharmacology of antipsychotic treatment. Med Chem Rev 2005;2:177-82
  • Friedman JI, Temporini H, Davis KL. Pharmacologic strategies for augmenting cognitive performance in schizophrenia. Biol Psychiatry 1999;45:1-16
  • Richelson E, Souder T. Binding of antipsychotic drugs to human brain receptors-focus on newer generation compounds. Life Sci 2000;68:29-39
  • Bymaster FP, Felder CC, Tzavara E, et al. Muscarinic mechanisms of antipsychotic atypicality. Progr Neuro-Psychoph 2003;27:1125-43
  • Ananth J, Parameswaran S, Gunatilake S. Side effects of atypical antipsychotic drugs. Curr Pharm Design 2004;10:2219-29
  • Dorado P, Berecz R, Penas-Lledo EM, Llerena A. Antipsychotic drugs and QTc prolongation: the potential role of CYP2D6 genetic polymorphism. Expert Opin Drug Metab Toxicol 2007;3:9-19
  • Martindale – The Complete Drug Reference. Sweetman SC, editor. London: Pharmaceutical Press; 2004. p. 685-9
  • Yoshimura R, Ueda N, Nakamura J. Possible relationship between combined plasma concentrations of risperidone plus 9-hydroxyrisperidone and extrapyramidal symptoms. Neuropsychobiology 2001;44:129-33
  • Pajonk FG. Risperidone in acute and long-term therapy of schizophrenia – a clinical profile. Progr Neuro-Psychoph 2004;28:15-23
  • Love RC, Nelson MW. Pharmacology and clinical experience with risperidone. Expert Opin Pharmacother 2000;1:1441-53
  • Tarsy D, Baldessarini RJ, Tarazi FI. Effects of newer antipsychotics on extrapyramidal function. CNS Drugs 2002;16:23-45
  • Gaszner P, Makkos Z. Clozapine maintenance therapy in schizophrenia. Progr Neuro-Psychoph 2004;28:465-9
  • Raggi MA, Mandrioli R, Pucci V, Sabbioni C. Advances in therapeutic drug monitoring of atypical antipsychotic drugs. Med Chem Rev 2004;1:299-316
  • Stahl SM. Dopamine system stabilizers, Aripiprazole, and the next generation of antipsychotics, part 1, “Goldilocks” actions at dopamine receptors. J Clin Psychiat 2001;62:841-2
  • Davies MA, Sheffler DJ, Roth BL. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev 2004;10:317-36
  • Swainston HT, Perry CM. Aripiprazole. A review of its use in schizophrenia and schizoaffective disorder. Drugs 2004;64:1715-36
  • Stahl SM, Shayegan DK. The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. J Clin Psychiat 2003;64(Suppl 19):6-12
  • Taylor D. Ziprasidone in the management of schizophrenia: the QT interval issue in context. CNS Drugs 2003;17:423-30
  • Racagni G, Canonico PL, Ravizza L, et al. Consensus on the use of substituted benzamides in psychiatric patients. Neuropsychobiology 2004;50:134-43
  • Pani L, Gessa GL. The substituted benzamides and their clinical potential on dysthymia and on the negative symptoms of schizophrenia. Mol Psychiatr 2002;7:247-53
  • Thomson Centerwatch website, 2007. Available from: URL: http://www.centerwatch.com/patient/drugs/area17.html
  • Lindstroem E, Levander S. Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother 2006;7:1825-34
  • Serdolect website, 2006. Available from: http://www.serdolect.com/content/downloadarea/pdf/serdolect_monograph.pdf
  • Revill P, Serradell N, Bolos J. Paliperidone. Antipsychotic agent, treatment of bipolar disorder, dual dopamine D2/5-HT2A receptor antagonist. Drug Future 2006;31:579-84
  • Owen RT. Extended-release paliperidone: efficacy, safety and tolerability profile of a new atypical antipsychotic. Drugs Today 2007;43:249-58
  • Yang LPH, Plosker GL. Paliperidone extended release. CNS Drugs 2007;21:417-25
  • FDA website, 2007. Available from: URL: http://www.fda.gov/cder/foi/label/2006/021999lbl.pdf
  • Auclair AL, Galinier A, Besnard J, et al. Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats. Psychopharmacology 2007;193:45-54
  • Wadenberg M-LG. Bifeprunox: a novel antipsychotic agent with partial agonist properties at dopamine D2 and serotonin 5-HT1A receptors. Future Neurol 2007;2:153-65
  • Wyeth Pharmaceuticals, Inc. website press release. Available from: URL: http://www.wyeth.com/news?nav=display&pnavTo=/wyeth_html/home/news/pressreleases/2007/1186749065400.html
  • Fleming K, Potkin SG, Binneman B, et al. Asenapine cognitive function effects in acute schizophrenia: a placebo- and risperidone-controlled trial. NCDEU, Boca Raton, USA: 47th Annual Meeting, 2007; Session I-72
  • Potkin SG. Asenapine safety and tolerability during acute schizophrenia: a placebo- and risperidone-controlled trial. American Psychiatric Association, Toronto, Canada: 159th Annual Meeting, 2006; NR420
  • Hirschfeld RM. Asenapine in acute mania: a randomized, double blind, placebo- and olanzapine-controlled trial (ARES 7501005). San Diego, USA: American Psychiatric Association, 160th Annual Meeting, 2007; NR333
  • Andree B, Halldin C, Vrijmoed-De Vries M, Farde L. Central 5-HT2A and D2 dopamine receptor occupancy after sublingual administration of ORG 5222 in healthy men. Psychopharmacology 1997;131:339-45
  • Dainippon Sumitomo Pharma Co. website, 2007. Available from: URL: http://www.ds-pharma.co.jp/english/rd/pdf/prof_20070730e.pdf
  • Keppel Hesselink JM. Iloperidone. IDrugs 2002;5:84-90
  • Titan Pharmaceuticals, Inc. website press release, 2001. Available from: URL: http://www.titanpharm.com/press/Zomaril_Japan.html
  • Titan Pharmaceuticals, Inc. website press release, 2004. Available from: URL: http://www.titanpharm.com/press/IloperidoneLicense.htm
  • Vanda Pharmaceuticals, Inc. website, 2007. Available from: URL: http://www.vandapharmaceuticals.com/development.html
  • Caccia S. Biotransformation of post-clozapine antipsychotics. Clin Pharmacokinet 2000;38:393-414
  • Mucke HA, Castaner J. Iloperidone. Drug Future 2000;25:29-40
  • Strupczewski JT, Bordeau KJ, Chiang Y, et al. 3-(Aryloxy)alkyllpiperidinyl-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873). J Med Chem 1995;38:1119-31
  • Szewczak MR, Corbett R, Rush DK, et al. The pharmacological profile of iloperidone, a novel atypical antipsychotic agent. J Pharmacol Exp Ther 1995;274:1404-13
  • Kongsamut S, Roehr JE, Cai J, et al. Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol 1996;317:417-23
  • Kalkman HO, Subramanian N, Hoyer D. Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology 2001;25:904-14
  • Kalkman HO, Feuerbach D, Loetscher E, Schoeffter P. Functional characterization of the novel antipsychotic iloperidone at human D2, D3, α2C, 5-HT6 and 5-HT1A receptors. Life Sci 2003;73:1151-9
  • Kalkman HO, Loetscher E. α2C-adrenoceptor blockade by clozapine and other antipsychotic drugs. Eur J Pharmacol 2003;462:33-40
  • Szczepanik AM, Brougham LR, Roehr JE, et al. Ex vivo studies with iloperidone (HP 873), a potential atypical antipsychotic with dopamine D2/5-hydroxytryptamine2 receptor antagonist activity. J Pharmacol Exp Ther 1996;278:913-20
  • Barr AM, Powell SB, Markou A, Geyer MA. Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology 2006;51:457-65
  • Corbett R, Griffiths L, Shipley JE, et al. Iloperidone: preclinical profile and early clinical evaluation. CNS Drug Rev 1997;3:120-47
  • Corbett R, Hartman H, Kerman LL, et al. Effects of atypical antipsychotic agents on social behavior in rodents. Pharmacol Biochem 1993;459-17
  • Gemperle AY, McAllisteR KH, Olpe HR. Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm. Psychopharmacology 2003;169:354-64
  • Jain KK. An assessment of iloperidone for the treatment of schizophrenia. Expert Opin Investig Drugs 2000;9:2935-43
  • Sainati M, Hubbard JW, Chi E, et al. Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. J. Clin Pharmacol 1995;35:713-20
  • Fairweather DB, Young E, Zaninelli R. Iloperidone is effective and well tolerated in the long term treatment of schizophrenia and schizoaffective disorder. Eur Neuropsychopharm 2001;12(Suppl 3 P.2.054)
  • Vanda Pharmaceuticals Inc. website press release, 2006. Available from: URL: http://phx.corporate-ir.net/phoenix.zhtml?c=196233&p=irol-newsArticle_Print&ID=939941&highlight=
  • El-Bizri H, Fairweather DB, Guven A, Zaninelli R. Efficacy and tolerability of iloperidone in elderly patients with psychotic and behavioral symptoms associated with dementia. Eur Neuropsychopharm 2001;12(Suppl 3 P.2.055)
  • Baroldi P, Wolfgang C. A Pharmacokinetic (PK)-Pharmacodynamic (PD) relationship exist for efficacy of iloperidone: a novel investigation atypical antipsychotic agent. San Diego, USA: American Psychiatric Association, 160th Annual Meeting, 2007; NR507
  • Mutlib AE, Strupczewski JT, Chesson SM. Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone. Drug Metab Dispos 1995;23:951-64
  • Caccia S. New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update. Curr Opin Invest Drugs 2002;3:1073-80
  • Mutlib AE, Klein JT. Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone. J Pharmacol Exp Ther 1998;286:1285-93
  • Chesson SM, Hsu RS, Dileo EM, Strupczewski JT. Pharmacokinetics of HP 873, a potential atypical antipsychotic, in rats and dogs abstract. Pharmacologist 1991;33:177-82
  • Subramanian N, Kalkman HO. Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone. Progr Neuro-Psychoph 2002;26:553-60
  • Wolfgang C. Genotyping facilitates individualized prediction of pharmacokinetic response to iloperidone in extensive and Poor CYP2D6 metabolizers. San Diego, USA: American Psychiatric Association, 160th Annual Meeting, 2007; NR508
  • Sedek G, Wolfgang C. Iloperidone is well tolerated by subjects with renal or hepatic impairment in single-dose clinical pharmacokinetic studies. San Diego, USA: American Psychiatric Association, 160th Annual Meeting, 2007; NR476
  • McCollough K, Wolfgang C. Iloperidone, a novel atypical antipsychotic, is associated with improvement, or no change, in akathisia symptoms. San Diego, USA: American Psychiatric Association, 160th Annual Meeting, 2007; NR475
  • Titan Pharmaceuticals, Inc. website press release, 2002. Available from: URL: http://www.titanpharm.com/press/Iloperidone_EKG.html
  • Yerrabolu M, Prabhudesai S, Tawam M, et al. Effect of risperidone on QT interval and QT dispersion in the elderly. Heart Dis 2000;2:10-2
  • Albers LJ, Ozdemir V. Pharmacogenomic-guided rational therapeutic drug monitoring: conceptual framework and application platforms for atypical antipsychotics. Curr Med Chem 2004;11:297-312
  • Mutlib AE, Strupczewski JT. Picogram determination of iloperidone in human plasma by solid-phase extraction and by high-performance liquid chromatography-selected-ion monitoring electrospray mass spectrometry. J Chromatogr B 1995;669:237-46
  • Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiat 1988;45:798-6
  • Titan Pharmaceuticals, Inc. website, 2006. Available from: URL: http://www.titanpharm.com/pdf/VANDA-Iloperidone-Prospectus.pdf
  • Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353:1209-23

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