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Expert Opinion on Investigational Drugs Volume 17, 2008 - Issue 8
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Review

New drugs in development for the treatment of endometriosis

Luigi Fedele Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]; Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, MD,
Edgardo Somigliana Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]
, MD PhD,
Giada Frontino Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]; Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, MD,
Laura Benaglia Fondazione IRCCS Ospedale Maggiore Policlinico, Obstetrics and Gynecology, Mangiagalli e Regina Elena, Via Commenda 12, 20122 Milano, Italy +39 02 55032318; +39 02 50320252; [email protected]; Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, MD &
Paola Vigano Università degli Studi di Milano, Via Commenda 12, 20122 Milan, Italy
, PhD
Pages 1187-1202 | Published online: 10 Jul 2008

Bibliography

  • Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am 1997;24:235-58
  • Farquhar C. Endometriosis. BMJ 2007;334:249-53
  • Simoens S, Hummelshoj L, D'Hooghe T. Endometriosis: cost estimates and methodological perspective. Hum Reprod Update 2007;13:395-404
  • Bianconi L, Hummelshoj L, Coccia ME, et al. Recognizing endometriosis as a social disease: the European Union-encouraged Italian Senate approach. Fertil Steril 2007;88:1285-7
  • Nisolle M, Donnez J. Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil Steril 1997;68:585-96
  • Vignali M, Infantino M, Matrone R, et al. Endometriosis: novel etiopathogenetic concepts and clinical perspectives. Fertil Steril 2002;78:665-78
  • Rodgers AK, Falcone T. Treatment strategies for endometriosis. Expert Opin Pharmacother 2008;9:243-55
  • American Society for Reproductive Medicine (ASRM). Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67:817-21
  • Somigliana E, Vercellini P, Viganó P, et al. Should endometriomas be treated before IVF-ICSI cycles? Hum Reprod Update 2006;12:57-64
  • Bazot M, Darai E, Hourani R, et al. Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease. Radiology 2004;232:379-89
  • Del Frate C, Girometti R, Pittino M, et al. Deep retroperitoneal pelvic endometriosis: MR imaging appearance with laparoscopic correlation. Radiographics 2006;26:1705-18
  • Chapron C, Fauconnier A, Goffinet F, et al. Laparoscopic surgery is not inherently dangerous for patients presenting with benign gynaecologic pathology. Results of a meta-analysis. Hum Reprod 2002;17:1334-42
  • Hadfield R, Mardon H, Barlow D, Kennedy S. Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK. Hum Reprod 1996;11:878-80
  • Chapron C, Vercellini P, Barakat H, et al. Management of ovarian endometriomas. Hum Reprod Update 2002;8:591-7
  • Garry R. The effectiveness of laparoscopic excision of endometriosis. Curr Opin Obstet Gynecol 2004;16:299-303
  • Donnez J, Pirard C, Smets M, et al. Surgical management of endometriosis. Best Pract Res Clin Obstet Gynaecol 2004;18:329-48
  • Jones KD, Sutton CJ. Pregnancy rates following ablative laparoscopic surgery for endometriomas. Hum Reprod 2002;17:782-5
  • Vercellini P, Fedele L, Aimi G, et al. Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system. Hum Reprod 2006;21:2679-85
  • Somigliana E, Daguati R, Vercellini P, et al. The use and effectiveness of in vitro fertilization in women with endometriosis: the surgeon's perspective. Fertil Steril 2008: published online 2 April 2008, PMID: 18394620
  • Jacobson TZ, Barlow DH, Garry R, Koninckx P. Laparoscopic surgery for pelvic pain associated with endometriosis. Cochrane Database Syst Rev 2001;4:CD001300
  • Fedele L, Bianchi S, Zanconato G, et al. Laparoscopic excision of recurrent endometriomas: long-term outcome and comparison with primary surgery. Fertil Steril 2006;85:694-9
  • Vercellini P, Somigliana E, Viganò P, et al. Endometriosis: current and future medical therapies. Best Pract Res Clin Obstet Gynaecol 2008;22:275-306
  • Allen C, Hopewell S, Prentice A. Non-steroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev 2005;4:CD004753
  • Crosignani P, Olive D, Bergqvist A, Luciano A. Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update 2006;12:179-89
  • D'Hooghe TM, Debrock S, Meuleman C, et al. Future directions in endometriosis research. Obstet Gynecol Clin North Am 2003;30:221-44
  • Vercellini P, Somigliana E, Daguati R, et al. Postoperative oral contraceptive exposure and risk of endometrioma recurrence. Am J Obstet Gynecol 2008;198(5):504.e1-5
  • Yap C, Furness S, Farquhar C. Pre and post operative medical therapy for endometriosis surgery. Cochrane Database Syst Rev 2004;3:CD003678
  • Jun SH, Hornstein MD. Is there a role for preparatory cycle in ovum donation recipients? Curr Opin Obstet Gynecol 2006;18:333-7
  • Sauer MV, Kavic SM. Oocyte and embryo donation 2006: reviewing two decades of innovation and controversy. Reprod Biomed Online 2006;12:153-62
  • Chlouber RO, Olive DL, Pritts EA. Investigational drugs for endometriosis. Expert Opin Investig Drugs 2006;15:399-407
  • Mihalyi A, Simsa P, Mutinda KC, et al. Emerging drugs in endometriosis. Expert Opin Emerging Drugs 2006;11:503-24
  • Möller C, Hoffmann J, Kirkland TA, Schwede W. Investigational developments for the treatment of progesterone-dependent diseases. Expert Opin Investig Drugs 2008;17:469-79
  • Kyama CM, Mihalyi A, Simsa P, et al. Non-steroidal targets in the diagnosis and treatment of endometriosis. Curr Med Chem 2008;15:1006-17
  • Brodie A, Long B. Aromatase inhibition and inactivation. Clin Cancer Res 2001;7(Suppl):4343s-4349s
  • McGee EA, Hsueh AJ. Initial and cyclic recruitment of ovarian follicles. Endocr Rev 2000;21:200-14
  • Simpson ER, Mahendroo MS, Means GD, et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 1994;15:342-55
  • Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis? Fertil Steril 2006;85:1307-18
  • Takayama K, Zeitoun K, Gunby RT, et al. Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertil Steril 1998;69:709-13
  • Razzi S, Fava A, Sartini A, et al. Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman. BJOG 2004;111:182-4
  • Shippen ER, West WJ Jr. Successful treatment of severe endometriosis in two premenopausal women with an aromatase inhibitor. Fertil Steril 2004;81:1395-8
  • Fatemi HM, Al-Turki HA, Papanikolaou EG, et al. Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor. Reprod Biomed Online 2005;11:455-7
  • Mousa NA, Bedaiwy MA, Casper RF. Aromatase inhibitors in the treatment of severe endometriosis. Obstet Gynecol 2007;109:1421-3
  • Ailawadi RK, Jobanputra S, Kataria M, et al. Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. Fertil Steril 2004;81:290-6
  • Amsterdam LL, Gentry W, Jobanputra S, et al. Anastrazole and oral contraceptives: a novel treatment for endometriosis. Fertil Steril 2005;84:300-4
  • Hefler LA, Grimm C, van Trotsenburg M, Nagele F. Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study. Fertil Steril 2005;84:1033-6
  • Remorgida V, Abbamonte LH, Ragni N, et al. Letrozole and norethisterone acetate in rectovaginal endometriosis. Fertil Steril 2007;88:724-6
  • Remorgida V, Abbamonte LH, Ragni N, et al. Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis. Aust N Z J Obstet Gynaecol 2007;47:222-5
  • Soysal S, Soysal ME, Ozer S, et al. The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial. Hum Reprod 2004;19:160-7
  • Huirne JA, Lambalk CB. Gonadotropin-releasing-hormone-receptor antagonists. Lancet 2001;358:1793-803
  • Batzer FR. GnRH analogs: options for endometriosis-associated pain treatment. J Minim Invasive Gynecol 2006;13:539-45
  • Hornstein MD, Surrey ES, Weisberg GW, Casino LA. Leuprolide acetate depot and hormonal add-back in endometriosis: a 12-month study. Lupron Add-Back Study Group. Obstet Gynecol 1998;91:16-24
  • Küpker W, Felberbaum RE, Krapp M, et al. Use of GnRH antagonists in the treatment of endometriosis. Reprod Biomed Online 2002;5:12-6
  • Winneker RC, Fensome A, Wrobel JE, et al. Nonsteroidal progesterone receptor modulators: structure activity relationships. Semin Reprod Med 2005;23:46-57
  • Zhang Z, Olland AM, Zhu Y, et al. Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. J Biol Chem 2005;280:28468-75
  • Bruner-Tran KL, Zhang Z, Eisenberg E, et al. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J Clin Endocrinol Metab 2006;91:1554-60
  • Spitz IM. Progesterone receptor antagonists. Curr Opin Investig Drugs 2006;7:882-90
  • Kettel LM, Murphy AA, Mortola JF, et al. Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis. Fertil Steril 1991;56:402-7
  • Kettel LM, Murphy AA, Morales AJ, Yen SS. Clinical efficacy of the antiprogesterone RU486 in the treatment of endometriosis and uterine fibroids. Hum Reprod 1994;9(Suppl 1):116-20
  • Kettel LM, Murphy AA, Morales AJ, et al. Treatment of endometriosis with the antiprogesterone mifepristone (RU486). Fertil Steril 1996;65:23-8
  • Kettel LM, Murphy AA, Morales AJ, Yen SS. Preliminary report on the treatment of endometriosis with low-dose mifepristone (RU 486). Am J Obstet Gynecol 1998;178:1151-6
  • Chwalisz K, Perez MC, Demanno D, et al. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Endocr Rev 2005;26:423-38
  • Dhingra K. Antiestrogens – tamoxifen, SERMs and beyond. Invest New Drugs 1999;17:285-311
  • Buelke-Sam J, Bryant HU, Francis PC. The selective estrogen receptor modulator, raloxifene: an overview of nonclinical pharmacology and reproductive and developmental testing. Reprod Toxicol 1998;12:217-21
  • Yao Z, Shen X, Capodanno I, et al. Validation of rat endometriosis model by using raloxifene as a positive control for the evaluation of novel SERM compounds. J Invest Surg 2005;18:177-83
  • Yavuz E, Oktem M, Esinler I, et al. Genistein causes regression of endometriotic implants in the rat model. Fertil Steril 2007;88(4 Suppl):1129-34
  • Stratton P, Sinaii N, Segars J, et al. Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial. Obstet Gynecol 2008;111:88-96
  • Lecce G, Meduri G, Ancelin M, et al. Presence of estrogen receptor beta in the human endometrium through the cycle: expression in glandular, stromal, and vascular cells. J Clin Endocrinol Metab 2001;86:1379-86
  • Leventhal L, Brandt MR, Cummons TA, et al. An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain. Eur J Pharmacol 2006;553:146-8
  • Harris HA, Bruner-Tran KL, Zhang X, et al. A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis. Hum Reprod 2005;20:936-41
  • Groothuis PG, Nap AW, Winterhager E, Grümmer R. Vascular development in endometriosis. Angiogenesis 2005;8:147-56
  • Becker CM, D'Amato RJ. Angiogenesis and antiangiogenic therapy in endometriosis. Microvasc Res 2007;74:121-30
  • Laschke MW, Menger MD. In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis. Hum Reprod Update 2007;13:331-42
  • Hull ML, Charnock-Jones DS, Chan CL, et al. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab 2003;88:2889-99
  • Nap AW, Griffioen AW, Dunselman GA, et al. Antiangiogenesis therapy for endometriosis. J Clin Endocrinol Metab 2004;89:1089-95
  • Becker CM, Sampson DA, Rupnick MA, et al. Endostatin inhibits the growth of endometriotic lesions but does not affect fertility. Fertil Steril 2005;84(Suppl 2):1144-55
  • Laschke MW, Elitzsch A, Vollmar B, et al. Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions. Hum Reprod 2006;21:262-8
  • Becker CM, Sampson DA, Short SM, et al. Short synthetic endostatin peptides inhibit endothelial migration in vitro and endometriosis in a mouse model. Fertil Steril 2006;85:71-7
  • Oktem M, Esinler I, Eroglu D, et al. High-dose atorvastatin causes regression of endometriotic implants: a rat model. Hum Reprod 2007;22:1474-80
  • Jiang HQ, Li YL, Zou J. Effect of recombinant human endostatin on endometriosis in mice. Chin Med J (Engl) 2007;120:1241-6
  • Becker CM, Rohwer N, Funakoshi T, et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1α and suppresses growth of lesions in a mouse model of endometriosis. Am J Pathol 2008;172:534-44
  • Klauber N, Rohan RM, Flynn E, D'Amato RJ. Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470. Nat Med 1997;3:443-6
  • Ingelmo JM, Quereda F, Acién P. Intraperitoneal and subcutaneous treatment of experimental endometriosis with recombinant human interferon-alpha-2β in a murine model. Fertil Steril 1999;71:907-11
  • Somigliana E, Viganò P, Rossi G, et al. Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis. Hum Reprod 1999;14:2944-50
  • Keenan JA, Williams-Boyce PK, Massey PJ, et al. Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole. Fertil Steril 1999;72:135-41
  • Uygur D, Aytan H, Zergeroglu S, Batioglu S. Leflunomide – an immunomodulator – induces regression of endometrial explants in a rat model of endometriosis. J Soc Gynecol Investig 2006;13:378-83
  • Selkov SA, Pavlov RV. Comparative efficiency of intraperitoneal interleukine-2 and interferon-α in rats with experimental endometriosis. Bull Exp Biol Med 2007;143:363-7
  • Ocal G, Kokcu A, Cetinkaya MB, et al. Efficacy of levamisole on experimental endometriosis. Int J Gynaecol Obstet 2007;99:38-42
  • Aytan H, Caglar P, Uygur D, et al. Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model. Fertil Steril 2007;87:698-701
  • Quereda F, Bermejo R, Velasco I, et al. The effect of intraperitoneal interleukin-2 on surgically induced endometriosis in rats. Eur J Obstet Gynecol Reprod Biol 2008;136:243-8
  • Altintas D, Kokcu A, Tosun M, et al. Efficacy of recombinant human interferon alpha-2b on experimental endometriosis. Eur J Obstet Gynecol Reprod Biol 2007: published online 23 October 2007, PMID: 17961906
  • Altintas D, Kokcu A, Kandemir B, et al. Efficacy of imiquimod, an immunomodulatory agent, on experimental endometriosis. Fertil Steril 2007: published online 5 November, PMID: 17980874
  • Itil IM, Cirpan T, Akercan F, et al. Effect of BCG vaccine on peritoneal endometriotic implants in a rat model of endometriosis. Aust N Z J Obstet Gynaecol 2006;46:38-41
  • Acién P, Quereda FJ, Gómez-Torres MJ, et al. GnRH analogues, transvaginal ultrasound-guided drainage and intracystic injection of recombinant interleukin-2 in the treatment of endometriosis. Gynecol Obstet Invest 2003;55:96-104
  • Acién P, Pérez-Albert G, Quereda FJ, et al. Treatment of endometriosis with transvaginal ultrasound-guided drainage under GnRH analogues and recombinant interleukin-2 left in the cysts. Gynecol Obstet Invest 2005;60:224-31
  • Acién P, Quereda F, Campos A, et al. Use of intraperitoneal interferon alpha-2b therapy after conservative surgery for endometriosis and postoperative medical treatment with depot gonadotropin-releasing hormone analog: a randomized clinical trial. Fertil Steril 2002;78:705-11
  • Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril 2001;75:1-10
  • Hull ML, Prentice A, Wang DY, et al. Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis. Hum Reprod 2005;20:350-8
  • Dogan E, Saygili U, Posaci C, et al. Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib. Fertil Steril 2004;82(Suppl 3):1115-20
  • Matsuzaki S, Canis M, Darcha C, et al. Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats. Fertil Steril 2004;82:1609-15
  • Efstathiou JA, Sampson DA, Levine Z, et al. Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model. Fertil Steril 2005;83:171-81
  • Ozawa Y, Murakami T, Tamura M, et al. A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice. Fertil Steril 2006;86(Suppl 4):1146-51
  • Laschke MW, Elitzsch A, Scheuer C, et al. Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis. Fertil Steril 2007;87:163-71
  • Cobellis L, Razzi S, De Simone S, et al. The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis. Eur J Obstet Gynecol Reprod Biol 2004;116:100-2
  • Brophy JM. Cardiovascular effects of cyclooxygenase-2 inhibitors. Curr Opin Gastroenterol 2007;23:617-24
  • Olive DL, Lindheim SR, Pritts EA. New medical treatments for endometriosis. Best Pract Res Clin Obstet Gynaecol 2004;18:319-28
  • Balasch J, Creus M, Fábregues F, et al. Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: a pilot randomized clinical trial. Hum Reprod 1997;12:2046-50
  • Creus M, Fábregues F, Carmona F, et al. Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial. Hum Reprod 2008: published online 16 May, PMID: 18487215
  • Alborzi S, Ghotbi S, Parsanezhad ME, et al. Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: a prospective, double-blind, randomized, placebo-controlled study. J Minim Invasive Gynecol 2007;14:54-8
  • Kamencic H, Thiel JA. Pentoxifylline after conservative surgery for endometriosis: a randomized, controlled trial. J Minim Invasive Gynecol 2008;15:62-6
  • Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996;1302:93-109
  • Ricote M, Li AC, Willson TM, et al. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998;391:79-82
  • Cunard R, Ricote M, DiCampli D, et al. Regulation of cytokine expression by ligands of peroxisome proliferators activated receptors. J Immunol 2002;168:2795-802
  • Hornung D, Waite LL, Ricke EA, et al. Nuclear peroxisome proliferator-activated receptors alpha and gamma have opposing effects on monocyte chemotaxis in endometriosis. J Clin Endocrinol Metab 2001;86:3108-14
  • Pritts EA, Zhao D, Ricke E, et al. PPAR-gamma decreases endometrial stromal cell transcription and translation of RANTES in vitro. J Clin Endocrinol Metab 2002;87:1841-4
  • Pritts EA, Zhao D, Sohn SH, et al. Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. Fertil Steril 2003;80:415-20
  • Lebovic DI, Kir M, Casey CL. Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis. Fertil Steril 2004;82(Suppl 3):1008-13
  • Demirturk F, Aytan H, Caliskan AC, et al. Effect of peroxisome proliferator-activated receptor-gamma agonist rosiglitazone on the induction of endometriosis in an experimental rat model. J Soc Gynecol Investig 2006;13:58-62
  • Aytan H, Caliskan AC, Demirturk F, et al. Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reduces the size of experimental endometriosis in the rat model. Aust N Z J Obstet Gynaecol 2007;47:321-5
  • Lebovic DI, Mwenda JM, Chai DC, et al. PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo- and drug-controlled study. Fertil Steril 2007;88(4 Suppl):1108-19
  • D'Antonio M, Martelli F, Peano S, et al. Ability of recombinant human TNF binding protein-1 (r-hTBP-1) to inhibit the development of experimentally-induced endometriosis in rats. J Reprod Immunol 2000;48:81-98
  • D'Hooghe TM, Nugent NP, Cuneo S, et al. Recombinant human TNFRSF1A (r-hTBP1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study. Biol Reprod 2006;74:131-6
  • Falconer H, Mwenda JM, Chai DC, et al. Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon. Hum Reprod 2006;21:1856-62
  • Barrier BF, Bates GW, Leland MM, et al. Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons. Fertil Steril 2004;81(Suppl 1):775-9
  • Carmona L, Gómez-Reino JJ, Rodríguez-Valverde V, et al. Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists. Arthritis Rheum 2005;52:1766-72
  • Askling J, Fored CM, Brandt L, et al. Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden. Arthritis Rheum 2005;52:1986-92
  • Askling J, Fored CM, Geborek P, et al. Swedish registers to examine drug safety and clinical issues in RA. Ann Rheum Dis 2006;65:707-12
  • Bongartz T, Sutton AJ, Sweeting MJ, et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006;295:2275-85
  • Schiff MH, Burmester GR, Kent JD, et al. Safety analyses of adalimumab (HUMIRA) in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis. Ann Rheum Dis 2006;65:889-94
  • Kayisli UA, Berkkanoglu M, Zhang L, et al. The broad-spectrum chemokine inhibitor NR58-3.14.3 suppresses the implantation and survival of human endometrial implants in the nude mice endometriosis model. Reprod Sci 2007;14:825-35
  • González-Ramos R, Van Langendonckt A, Defrère S, et al. Agents blocking the nuclear factor-kappaB pathway are effective inhibitors of endometriosis in an in vivo experimental model. Gynecol Obstet Invest 2007;65:174-86
  • Güney M, Nasir S, Oral B, et al. Effect of caffeic acid phenethyl ester on the regression of endometrial explants in an experimental rat model. Reprod Sci 2007;14:270-9
  • Güney M, Oral B, Karahan N, Mungan T. Regression of endometrial explants in a rat model of endometriosis treated with melatonin. Fertil Steril 2007: published online 18 June 2007, Fertil Steril 2008;89(4):934-42
  • Muzii L, Marana R, Caruana P, et al. Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: a prospective, randomized trial. Am J Obstet Gynecol 2000;183:588-92
  • Fedele L, Bianchi S, Zanconato G, et al. Bipolar electrocoagulation versus suture of solitary ovary after laparoscopic excision of ovarian endometriomas. J Am Assoc Gynecol Laparosc 2004;11:344-7
  • Tulandi T, Al-Shahrani A. Adhesion prevention in gynecologic surgery. Curr Opin Obstet Gynecol 2005;17:395-8

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