Hepatocyte growth factor is an attractive target for the treatment of pulmonary fibrosis

Bibliography

• Vaux DL, Korsmeyer SJ. Cell death in development. Cell 1999;96:245-54
   PubMed Web of Science ®Google Scholar
• Antoniou KM, Pataka A, Bouros D, Siafakas NM. Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis. Pulm Pharmacol Ther 2007;20:453-61
   PubMed Web of Science ®Google Scholar
• Powell RJ, Goodney P, Mendelsohn FO, HGF-0205 Trial Investigators. Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: results of the HGF-0205 trial. J Vasc Surg 2010;52:1525-30
   PubMed Web of Science ®Google Scholar
• Powell RJ, Simons M, Mendelsohn FO, Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation 2008;118:58-65
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Toews GB, White ES, Mechanisms of pulmonary fibrosis. Annu Rev Med 2004;55:395-417
   PubMed Web of Science ®Google Scholar
• Rennard SI, Bitterman PB, Crystal RG. Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall. Chest 1983;84:735-9
   PubMed Web of Science ®Google Scholar
• Raghu G, Weycker D, Edelsberg J, Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174:810-16
   PubMed Web of Science ®Google Scholar
• Hogan BL, Yingling JM. Epithelial/mesenchymal interactions and branching morphogenesis of the lung. Curr Opin Genet Dev 1998;8:481-6
   PubMed Web of Science ®Google Scholar
• Bostrom H, Willetts K, Pekny M, PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996;85:863-73
   PubMed Web of Science ®Google Scholar
• Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341:738-46
   PubMed Web of Science ®Google Scholar
• Tomasek JJ, Gabbiani G, Hinz B, Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002;3:349-63
   PubMed Web of Science ®Google Scholar
• Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001;134:136-51
   PubMed Web of Science ®Google Scholar
• Adamson IY, Young L, Bowden DH. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 1988;130:377-83
   PubMed Web of Science ®Google Scholar
• Evans MJ, Cabral LJ, Stephens RJ, Freeman G. Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2. Exp Mol Pathol 1975;22(1):142-50
   PubMed Web of Science ®Google Scholar
• Lawson WE, Crossno PF, Polosukhin VV, Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol 2008;294(6):L1119-26
   PubMed Web of Science ®Google Scholar
• Korfei M, Ruppert C, Mahavadi P, Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008;178(8):838-46
   PubMed Web of Science ®Google Scholar
• Kuwano K, Kunitake R, Kawasaki M, P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1996;154(2 Pt 1):477-83
   PubMed Web of Science ®Google Scholar
• Plataki M, Koutsopoulos AV, Darivianaki K, Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis. Chest 2005;127:266-74
   PubMed Web of Science ®Google Scholar
• Hagimoto N, Kuwano K, Nomoto Y, Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol 1997;16:91-101
   PubMed Web of Science ®Google Scholar
• Uhal BD. Apoptosis in lung fibrosis and repair. Chest 2002;122(6 Suppl):293S-8S
   PubMed Web of Science ®Google Scholar
• Kuwano K, Kunitake R, Maeyama T, Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 2001;280:L316-25
   PubMed Web of Science ®Google Scholar
• Lee CG, Cho SJ, Kang MJ, Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004;200:377-89
   PubMed Web of Science ®Google Scholar
• Kuwano K, Hagimoto N, Kawasaki M, Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest 1999;104:13-19
   PubMed Web of Science ®Google Scholar
• Hagimoto N, Kuwano K, Miyazaki H, Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen. Am J Respir Cell Mol Biol 1997;17:272-8
   PubMed Web of Science ®Google Scholar
• Golan-Gerstl R, Wallach-Dayan SB, Amir G, Breuer R. Epithelial cell apoptosis by fas ligand-positive myofibroblasts in lung fibrosis. Am J Respir Cell Mol Biol 2007;36:270-5
   PubMed Web of Science ®Google Scholar
• Waghray M, Cui Z, Horowitz JC, Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts. FASEB J 2005;19:854-6
   PubMed Web of Science ®Google Scholar
• Crestani B, Marchand-Adam S, Quesnel C, Hepatocyte growth factor and lung fibrosis. Proc Am Thorac Soc 2012;9(3):158-63
   PubMedGoogle Scholar
• Christensen PJ, Bailie MB, Goodman RE, Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2000;279(3):L487-95
   PubMed Web of Science ®Google Scholar
• Eitzman DT, McCoy RD, Zheng X, Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996;97(1):232-7
   PubMed Web of Science ®Google Scholar
• Sisson TH, Hattori N, Xu Y, Treatment of bleomycin-induced pulmonary fibrosis by transfer of urokinase-type plasminogen activator genes. Hum Gene Ther 1999;10(14):2315-23
   PubMed Web of Science ®Google Scholar
• Chan JCY, Duszczyszyn DA, Castellino FJ, Accelerated skin wound healing in plasminogen activator inhibitor–1–deficient mice. Am J Pathol 2001;159:1681-8
   PubMed Web of Science ®Google Scholar
• Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012;49(1):35-43
   PubMed Web of Science ®Google Scholar
• Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 2003;200:500-3
   PubMed Web of Science ®Google Scholar
• Phan SH. The myofibroblast in pulmonary fibrosis. Chest 2002;122(Suppl 6):286S-9S
   PubMed Web of Science ®Google Scholar
• Phillips RJ, Burdick MD, Hong K, Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004;114:438-46
   PubMed Web of Science ®Google Scholar
• Hashimoto N, Jin H, Liu T, Bone marrow–derived progenitor cells in pulmonary fibrosis. J Clin Invest 2004;113:243-52
   PubMed Web of Science ®Google Scholar
• Willis BC, Liebler JM, Luby-Phelps K, Induction of epithelial–mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005;166:1321-32
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Lee DY, White ES, Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem 2003;278:12384-9
   PubMed Web of Science ®Google Scholar
• Kasai H, Allen JT, Mason RM, TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005;6:56
   PubMed Web of Science ®Google Scholar
• Daniels CE, Wilkes MC, Edens M, Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest 2004;114:1308-16
   PubMed Web of Science ®Google Scholar
• Desmouliere A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1995;146:56-66
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Horowitz JC. Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006;3(4):350-6
   PubMedGoogle Scholar
• Horowitz JC, Ajayi IO, Kulasekaran P, Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis. Int J Biochem Cell Biol 2012;44(1):158-69
   PubMed Web of Science ®Google Scholar
• Tanaka T, Yoshimi M, Maeyama T, Resistance to Fas-mediated apoptosis in human lung fibroblast. Eur Respir J 2002;20:359-68
   PubMed Web of Science ®Google Scholar
• Zhang HY, Phan SH. Inhibition of myofibroblast apoptosis by transforming growth factor beta(1). Am J Respir Cell Mol Biol 1999;21:658-65
   PubMed Web of Science ®Google Scholar
• Matsuyama W, Watanabe M, Shirahama Y, Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis. Am J Pathol 2006;168:866-77
   PubMed Web of Science ®Google Scholar
• Jordana M, Schulman J, McSharry C, Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue. Am Rev Respir Dis 1988;137:579-84
   Google Scholar
• Raghu G, Chen YY, Rusch V, Rabinovitch PS. Differential proliferation of fibroblasts cultured from normal and fibrotic human lungs. Am Rev Respir Dis 1988;138:703-8
   PubMed Web of Science ®Google Scholar
• Hauber HP, Blaukovitsch M. Current and future treatment options in idiopathic pulmonary fibrosis. Inflamm Allergy Drug Targets 2010;9(3):158-72
   PubMedGoogle Scholar
• Hunninghake GW, Kalica AR. Workshop summary: approaches to the treatment of pulmonary fibrosis. Am J Respir Crit Care Med 1995;151:915-18
   PubMed Web of Science ®Google Scholar
• Mapel DW, Samet JM, Coultas DB. Corticosteroids and the treatment of idiopathic pulmonary fibrosis: past, present, and future. Chest 1996;110:1058-67
   PubMed Web of Science ®Google Scholar
• Raghu G, Brown KK, Costabel U, Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial. Am J Respir Crit Care Med 2008;178(9):948-55
   PubMed Web of Science ®Google Scholar
• Fulmer J, Elson N, Von Gal E, Treatment of idiopathic pulmonary fibrosis. Clin Res 1978;26:538A
   Google Scholar
• Douglas WW, Ryu JH, Swensen SJ, Colchicine versus prednisone in the treatment of idiopathic pulmonary fibrosis: a randomized prospective study. Members of the Lung Study Group. Am J Respir Crit Care Med 1998;158:220-5
   PubMed Web of Science ®Google Scholar
• Chapela R, Zuniga G, Selman M. D-penicillamine in the therapy of fibrotic lung diseases. Int J Clin Pharmacol Ther Toxicol 1986;24:16
   PubMedGoogle Scholar
• Mutsaers SE, Marshall RP, Goldsack NR, Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats. Pulm pharmacol Ther 1998;11(2-3):221-5
   PubMed Web of Science ®Google Scholar
• Azuma A. Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis. Expert Rev Resp Med 2010;4:301-10
   PubMedGoogle Scholar
• Taniguchi H, Ebina M, Kondoh Y, Pirfenidone Clinical Study Group in Japan. Pirfenidone in Idiopathic Pulmonary Fibrosis: A phase III clinical trial in Japan. Eur Respir J 2010;35:821-821
   PubMed Web of Science ®Google Scholar
• Azuma A, Taguchi Y, Ogura T, Pirfenidone Clinical Study Group in Japan. Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment. Respir Res 2011;12:143
   PubMed Web of Science ®Google Scholar
• Behr J, Maier K, Degenkolb B, Antioxidative and clinical effects of high-dose n-acetylcysteine in fibrosing alveolitis: adjunctive therapy to maintenance immunosuppression. Am J Respir Crit Care Med 1997;156:1897-901
   PubMed Web of Science ®Google Scholar
• Idiopathic Pulmonary Fibrosis Clinical Research Network. Raghu G, Anstrom KJ, King TE Jr, Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med 2012;366:1968-77
   PubMed Web of Science ®Google Scholar
• Thabut G, Mal H, Castier Y, Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis. J Thorac Cardiovasc Surg 2003;126:469-75
   PubMed Web of Science ®Google Scholar
• Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 1984;122:1450-9
   PubMed Web of Science ®Google Scholar
• Nakamura T, Nishizawa T, Hagiya M, Molecular cloning and expression of human hepatocyte growth factor. Nature 1989;342:440-3
   PubMed Web of Science ®Google Scholar
• Matsumoto K, Nakamura T. Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem Biophys Res Commun 1997;239:639-44
   PubMed Web of Science ®Google Scholar
• Bottaro DP, Rubin JS, Faletto DL, A Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991;251:802-4
   PubMed Web of Science ®Google Scholar
• Stamos J, Lazarus RA, Yao XY, Crystal structure of the HGF β-chain in complex with the sema domain of the Met receptor. EMBO J 2004;23:2325-35
   PubMed Web of Science ®Google Scholar
• Kataoka H, Miyata S, Uchinokura S, Itoh H. Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor. Cancer Metastasis Rev 2003;22(2-3):223-36
   PubMed Web of Science ®Google Scholar
• Kataoka H, Kawaguchi M. Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo. FEBS J 2010;277:2230-7
   PubMed Web of Science ®Google Scholar
• Ronsin C, Muscatelli F, Mattei MG, Breathnach R. A novel putative receptor protein tyrosine kinase of the met family. Oncogene 1993;8:1195-202
   PubMed Web of Science ®Google Scholar
• Naldini L, Weidner KM, Vigna E, Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J 1991;10:2867-78
   PubMed Web of Science ®Google Scholar
• Gandino L, Longati P, Medico E, Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J Biol Chem 1994;269:1815-20
   PubMed Web of Science ®Google Scholar
• Peschard P, Ishiyama N, Lin T, A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. J BiolChem 2004;279:29565-71
   PubMed Web of Science ®Google Scholar
• Longati P, Bardelli A, Ponzetto C, Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene 1994;9:49-57
   PubMed Web of Science ®Google Scholar
• Vigna E, Naldini L, Tamagnone L, Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cell Mol Biol (Noisy-le-grand) 1994;40(5):597-604
   PubMed Web of Science ®Google Scholar
• Rodrigues GA, Park M, Schlessinger J. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J 1997;16:2634-45
   PubMedGoogle Scholar
• Organ SL, Tsao MS. An overview of the c-MET signaling pathway. Ther Adv Med Oncol 2011;3(1 Suppl):S7-S19
   PubMedGoogle Scholar
• Maulik G, Madhiwala P, Brooks S, Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. J Cell Mol Med 2002;6:539-53
   PubMed Web of Science ®Google Scholar
• Graziani A, Gramaglia D, dalla Zonca P, Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J Biol Chem 1993;268:9165-8
   PubMed Web of Science ®Google Scholar
• Paumelle R, Tulasne D, Kherrouche Z, Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 2002;21:2309-19
   PubMed Web of Science ®Google Scholar
• Fixman ED, Fournier TM, Kamikura DM, Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein. J Biol Chem 1996;271:13116-22
   PubMed Web of Science ®Google Scholar
• Xiao GH, Jeffers M, Bellacosa A, Antiapoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen activated protein kinase pathways. Proc Natl Acad Sci USA 2001;98:247-52
   PubMed Web of Science ®Google Scholar
• Garcia-Guzman M, Dolfi F, Zeh K, Vuori K. Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 – Crk signaling complex formation. Oncogene 1999;18:7775-86
   PubMed Web of Science ®Google Scholar
• Rodrigues GA, Park M. Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase. Oncogene 1994;9:2019-27
   PubMed Web of Science ®Google Scholar
• Boccaccio C, Ando M, Tamagnone L, Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 1998;391:285-8
   PubMed Web of Science ®Google Scholar
• Syed ZA, Yin W, Hughes K, HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop. BMC Cancer 2011;11:180
   PubMed Web of Science ®Google Scholar
• Zhang YW, Wang LM, Jove R, Vande Woude GF. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene 2002;21:217-26
   PubMed Web of Science ®Google Scholar
• Ponzetto C, Bardelli A, Zhen Z, A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994;77:261-71
   PubMed Web of Science ®Google Scholar
• Rahimi N, Hung W, Tremblay E, c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells. J Biol Chem 1998;273:33714-21
   PubMed Web of Science ®Google Scholar
• Ohmichi H, Koshimizu U, Matsumoto K, Nakamura T. Hepatocyte growth factor (HGF) acts as a mesenchyme-derived morphogenic factor during fetal lung development. Development 1998;125:1315-24
   PubMed Web of Science ®Google Scholar
• Yanagita K, Matsumoto K, Sekiguchi K, Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury. J Biol Chem 1997;268:21212-17
   Google Scholar
• Phin S, Marchand-Adam S, Fabre A, Imbalance in the prohepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice. Am J Respir Cell Mol Biol 2010;42:286-93
   PubMed Web of Science ®Google Scholar
• Marchand-Adam S, Marchal J, Cohen M, Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003;168:1156-61
   PubMed Web of Science ®Google Scholar
• Marchand-Adam S, Fabre A, Mailleux AA, Defect of prohepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006;174:58-66
   PubMed Web of Science ®Google Scholar
• Dohi M, Hasegawa T, Yamamoto K, Marshall BC. Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 2000;162(6):2302-7
   PubMed Web of Science ®Google Scholar
• Watanabe M, Ebina M, Orson FM, Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis. Mol Ther 2005;12(1):58-67
   PubMed Web of Science ®Google Scholar
• Umeda Y, Marui T, Matsuno Y, Skeletal muscle targeting in vivo electroporation-mediated HGF gene therapy of bleomycin-induced pulmonary fibrosis in mice. Lab Invest 2004;84(7):836-44
   PubMed Web of Science ®Google Scholar
• Leuenberger A, Gazdhar A, Herrmann G, Cell-specific expression of human HGF by alveolar type II cells induces remodeling of septal wall tissue in the lung: a morphometric study. J Appl Physiol 2012;113(5):799-807
   PubMed Web of Science ®Google Scholar
• Yaekashiwa M, Nakayama S, Ohnuma K, Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care Med 1997;156:1937-44
   PubMed Web of Science ®Google Scholar
• Gazdhar A, Temuri A, Knudsen L, Targeted gene transfer of hepatocyte growth factor to alveolar type II epithelial cells reduces lung fibrosis in rats. Hum Gene Ther 2013;24:105-16
   PubMed Web of Science ®Google Scholar
• Bussolino F, Di Renzo MF, Ziche M, Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992;119:629-41
   PubMed Web of Science ®Google Scholar
• Nakagami H, Morishita R, Yamamoto K, Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells. Hypertension 2001;37(2 Pt 2):581-6
   PubMed Web of Science ®Google Scholar
• Wang X, Zhou Y, Kim HP, Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. J Biol Chem 2004;279(7):5237-43
   PubMed Web of Science ®Google Scholar
• Mason RJ, McCormick-Shannon K, Rubin JS, Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid. Am J Physiol 1996;271(1 Pt 1):L46-53
   PubMed Web of Science ®Google Scholar
• Bardelli A, Longati P, Albero D, HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J 1996;15:6205-12
   PubMed Web of Science ®Google Scholar
• Kim HJ, Sammak PJ, Ingbar DH. Hepatocyte growth factor stimulates migration of type II alveolar epithelial cells on the provisional matrix proteins fibronectin and fibrinogen. Chest 1999;116:94S-5S
   PubMed Web of Science ®Google Scholar
• Shiratori M, Michalopoulos G, Shinozuka H, Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro. Am J Respir Cell Mol Biol 1995;12(2):171-80
   PubMed Web of Science ®Google Scholar
• Okada M, Sugita K, Inukai T, Hepatocyte growth factor protects small airway epithelial cells from apoptosis induced by tumor necrosis factor-alpha or oxidative stress. Pediatr Res 2004;56(3):336-44
   PubMed Web of Science ®Google Scholar
• Gazdhar A, Fachinger P, van Leer C, Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2007;292(2):L529-36
   PubMed Web of Science ®Google Scholar
• Liu Y. Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms. Am J Physiol 1999;277(4 Pt 2):F624-33
   PubMed Web of Science ®Google Scholar
• Togo S, Sugiura H, Nelson A, Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells. Exp Cell Res 2010;316(20):3501-11
   PubMed Web of Science ®Google Scholar
• Wang R, Alam G, Zagariya A, Apoptosis of lung epithelial cells in response to TNF-alpha requires angiotensin II generation de novo. J Cell Physiol 2000;185:253-9
   PubMed Web of Science ®Google Scholar
• Wang R, Zagariya A, Ang E, Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction. Am J Physiol 1999;277:L1245-50
   PubMed Web of Science ®Google Scholar
• Wang R, Ibarra-Sunga O, Verlinski L, Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 2000;279:L143-51
   PubMed Web of Science ®Google Scholar
• Day RM, Thiel G, Lum J, Hepatocyte growth factor regulates angiotensin converting enzyme expression. J Biol Chem 2004;279:8792-801
   PubMed Web of Science ®Google Scholar
• Shukla MN, Rose JL, Ray R, Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol 2009;40:643-53
   PubMed Web of Science ®Google Scholar
• Makondo K, Kimura K, Kitamura N, Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca(2+)- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells. Biochem J 2003;374:63-9
   PubMed Web of Science ®Google Scholar
• Vyas-Read S, Shaul PW, Yuhanna IS, Willis BC. Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2007;293:L212-21
   PubMed Web of Science ®Google Scholar
• Moore AE, Greenhough A, Roberts HR, HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. Carcinogenesis 2009;30:1796-804
   PubMed Web of Science ®Google Scholar
• Lee YH, Suzuki YJ, Griffin AJ, Day RM. Hepatocyte growth factor regulates cyclooxygenase-2 expression via beta-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008;294:L778-86
   PubMed Web of Science ®Google Scholar
• Thomas PE, Peters-Golden M, White ES, PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling. Am J Physiol Lung Cell Mol Physiol 2007;293:L417-28
   PubMed Web of Science ®Google Scholar
• Mizuno S, Matsumoto K, Li MY, Nakamura T. HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. FASEB J 2005;19:580-2
   PubMed Web of Science ®Google Scholar
• Nagai A, Chiyotani A, Nakadate T, Konno K. Lung cancer in patients with idiopathic pulmonary fibrosis. Tohoku J Exp Med 1992;167:231-7
   PubMed Web of Science ®Google Scholar