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Expert Opinion on Investigational Drugs Volume 25, 2016 - Issue 1
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Reviews

Investigational drugs to treat methicillin-resistant Staphylococcus aureus

Cuong VuongPrincipal Scientist/Laboratory Head, Bacteriology, AiCuris GmbH & Co. KG, Friedrich-Ebert-Str. 475/Geb. 302, 42117Wuppertal, Germany
,
Anthony J. YehPost-baccalaureate IRTA, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 33, 1W10, 9000 Rockville Pike, Bethesda, MD20892, USA
,
Gordon YC CheungStaff Scientist, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Bacteriology, Bldg. 33, 1W10, 9000 Rockville Pike, Bethesda, MD20892, USA
&
Michael OttoSenior Investigator, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Bacteriology, Bldg. 33, 1W10, 9000 Rockville Pike, Bethesda, MD20892, USACorrespondence[email protected]
Pages 73-93 | Published online: 04 Nov 2015

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•• Describes the protective efficacy of a vaccine comprised of four staphylococcal antigens. Antibodies from vaccinated animals provided protection against S. aureus infection

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• Discusses the dual mechanism of α-hemolysin interference by mAb MEDI4893

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• Isotype switching of mAbs directed towards staphylococcal enterotoxin B can alter protective potency

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• Describes the unique mechanism of action of a mAb that is directed to iron regulated surface determinant B

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