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Research

Fertilization promoting peptide (FPP): a new peptide of importance in male fertility?

Pages 571-575 | Published online: 03 Mar 2008

References

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  • The first full structural characterisation of FPP, by fast atom bom-bardment (FAB) mass spectrometry.
  • GREEN CM, COCKLE SM, WATSON PF, FRASER LR: Stimu-lating effect of pyroglutamylglutamylprolineamide, a prostatic TRH-related tripeptide, on mouse sperm ca-pacitation and fertilizing ability in vitro. MoL Reprod. Devel. (1994) 38(2): 215–221.
  • The first definitive evidence for an important physiological role for FPP in activation of spermatozoa.
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  • HOKFELT T, TSURUO Y, ULFHAKE B, CULLHEIM S, ARVIDSSON U, FOSTER GA, SCHULZBERG M, SCHALLING M, ARBORELIUS L, FREEDMAN J, POST C, VISSER T: Distri-bution of TRH-like iffununoreactivity with special ref-erence to co-existence with other neuroactive compounds. Ann. NY Acad. Sci. (1989) 553:76–105.
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  • The first report of a TRH-like peptide with different chromatographic properties from authentic TRH in male reproductive tissues.
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  • First report of FPP in human semen, with full structural charac-terisation of the peptide.
  • BILEK R, GKONOS PJ, TAVIAN1NI MA, SMYTH DG, ROOS BA: The thyrotrophin-releasing (IR11)-like peptides in rat prostate are not formed by the expression of the TRH gene but are suppressed by thyroid hormones. Endocrinot (1992) 132:177–184.
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  • First preliminary evidence that FPP may affect sperm function, in particular causing a slight stimulation of sperm motility.
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  • This investigation validates the use of the CTC assay for following capacitation in mouse epididymal sperm.
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