References
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- The first full structural characterisation of FPP, by fast atom bom-bardment (FAB) mass spectrometry.
- GREEN CM, COCKLE SM, WATSON PF, FRASER LR: Stimu-lating effect of pyroglutamylglutamylprolineamide, a prostatic TRH-related tripeptide, on mouse sperm ca-pacitation and fertilizing ability in vitro. MoL Reprod. Devel. (1994) 38(2): 215–221.
- The first definitive evidence for an important physiological role for FPP in activation of spermatozoa.
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- The first report of a TRH-like peptide with different chromatographic properties from authentic TRH in male reproductive tissues.
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- First report of FPP in human semen, with full structural charac-terisation of the peptide.
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- First preliminary evidence that FPP may affect sperm function, in particular causing a slight stimulation of sperm motility.
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- This investigation validates the use of the CTC assay for following capacitation in mouse epididymal sperm.
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- This paper has attracted much publicity in the media recently (e.g. BBC Horizon: male infertility, 11th April 1994), and suggests that the observed decrease in sperm count since 1940 may be due to environmental factors.
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