Inhibitors of intracellular phosphatidic acid production: novel therapeutics with broad clinical applications

References

• MOOLENAAR WH, KRUIJER W, TILLEY BC, VERLAAN I, BIERMAN A, DELAAT SW: Growth factor-like action ofphosphatidic acid. Nature (1986) 323:171–173.
   PubMed Web of Science ®Google Scholar
• ALTIN JG, BYGRAVE FL: Phosphatidic add and arachi-donic add each interact synergistically with glucagon to stimulate Ca2+ influx in the perfused rat liver. Bio-chemical Journal (1987) 247:613–619.
   PubMed Web of Science ®Google Scholar
• KNAUSS TC, JAFFER FE, ABBOUD HE: Phosphatidic add modulates DNA synthesis, phospholipase C, and plate-let-derived growth factor mRNAs in cultured mesangLal cells. Role of protein kinase C. "Biol.Chem. (1990) 265: 14457–14463.
   Google Scholar
• NIARCOZ P, NEMOZ G, PRIGENT AF, LAGARDE M: Phos-phatidic add stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes. Biochirn.Biophys.Acta (1993) 1176: 129–136.
   PubMed Web of Science ®Google Scholar
• KURZ T, WOLF RA, CORR PB: Phosphatidic add stimu-lates inoshol 1,4,5-trisphosphate production in adult cardiac myocytes. Circulation Res. (1993) 72: 701–706.
   PubMed Web of Science ®Google Scholar
• MURAYAMA T, UI M: Phosphatidic add may stimulate membrane receptors mediating adenylate cyclase inhi-bition and phospholipid breakdown in 3T3 fibroblasts. J.BioLChem. (1987) 262: 5522–5529.
   PubMed Web of Science ®Google Scholar
• HAINES NA, REIBMAN J, TANG X, BLAKE M, WEISSMAN G:Effects of protein I of Neisseria gonorrhoeae on neu-trophil activation: generation of diacylglycerol from phosphatidylcholine via a specific phospholipase C is associated with exocytosis. Journal of Clinical Investiga-tion (1991) 114:433–442.
   Google Scholar
• BAULDRY SA, BASS DA, COUSART SL MCCALL CE: Tumornecrosis factor alpha priming of phospholipase D in human neutrophils. Correlation between phosphatidic add production and superoxide generation. Journal of Biological Chemistry (1991) 266: 4173–4179.
   Google Scholar
• BELLAVITE P, CORSO F, DUSI S, GRZESKOWIAK M, DELLABIANCA V, ROSSI F: Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic add. J.Biol.Chem. (1988) 263: 8210–8214.
   PubMed Web of Science ®Google Scholar
• AGWU DE, MCPHAIL LC, SOZZANI S, BASS DA, MCALL CE:Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase. Journal of Clinical Investigation (1991) 88:531–539.
   PubMed Web of Science ®Google Scholar
• BURSTEN SL, HARRIS WE, RESCH K, LOVETT DH: Lipidactivation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid. American Journal of Physiology (1992) 262:C328–C338.
   PubMed Web of Science ®Google Scholar
• ABRAHAM E, BURSTEN SL, SHENKAR R, ALLBEE J, SCHWARTZ M, WOODSON P, SINGER JW, REPINE jE: Inhibition of phosphatidic acid generation by CT-1501R inhibits cytokine expression and prevents acute lung Injury in mice subjected to hemorrhagic shock. Clin.Res. (1994) 42: 146A. (Abstract).
   Google Scholar
• GUIDOT DM, RICE GC, SINGER JW, BURS-1EN SL, BIANCO JA, REPINE JE: Inhibition of lyso-phosphatidic add acyl transferase (LPAAT) activity by CT1501R suppresses neutrophil adherence and chemotaxis in vitro and decreases interleukin-8 (IL-8)-induced injury in isolated rat lungs perfused with human neutrophils. (1994) 42: 145A. (Abstr.).
   Google Scholar
• BURSTEN SL, HARRIS WE, BOMSZTYK K, LOVETT D: Interleukin-1 rapidly stimulates lysophosphatidateacyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells. Journal of Biological Chemistry (1991) 266: 20732–20743.
   PubMed Web of Science ®Google Scholar
• BURSTEN SL, HARRIS WE, BIANCO JA, SINGER JW: CT-1501R inhibits rapid synthesis of specific phosphatidic add (PA) species following stimulation of tumor tie-crosis factor alpha (TNFa) type 1 but not type 2 recep-tors. Blood (1994) 82: 363A. (Abstr.)
   Google Scholar
• RICE GC, BROWN PA, KAZLAUSICAS A, SINGER JW, BIANCO JA, BURSTEN SL: Generation of the lipid second messen-ger molecule phosphatic acid is involved in signal transduction for PDGF, VEGF and EGF-induced mito-genesis. J.Cell Biochem (1994) 18A(Suppl.):272 (Abstr.).
   Google Scholar
• KISS Z: Differential effects of PDGF, serum, and bombe-sin on phospholipase D-mediated hydrolysis of phos-phatidylethanolamine in NIH-3T3 fibroblasts. BiochemJ. (1992) 285: 229–233.
   PubMed Web of Science ®Google Scholar
• BURSTEN SL, RICE GC, CHANEY R, HARRIS WE: Inter-leukin-113 (11–113) and tumor necrosis factor a (TNFa) signal through structurally distinct phosphatidic acid (PA) molecules in human umbilical vein endothelial cells (HUVEC). Clin Res. (1994) Submitted:
   Google Scholar
• EARDLEY DD, KOSHLAND ME: Glycosylphosphatidyli-nositol A candidate system for interleukin-2 signal transduction. Science (1991) 251: 78–81.
   PubMed Web of Science ®Google Scholar
• RICE GC, TINO W, BURSTEN SL, VALENTINE M, BIANCOJA, SINGER JW: Development of novel specific pharma-cologic inhibitors of intereukin-2 (IL-2) signal transduc-tion. Blood (1993) 82: 189a.
   Web of Science ®Google Scholar
• SUNKARA PS, FINNEY R, STRINGER C, UNDEREINER G,RICE G, BURSTEN S, BIANCO JA, SINGER JW: A novel class of low molecular weight phospholipid sign ling inhibi-tors are selectively cytotoxic for tumor cells. Proc.AACR (1994) 35: 409. (Abstr.)
   Google Scholar
• RICE GC, BROWN PA, NELSON R, BIANCO JA, SINGER JW,BURSTEN SE: Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc.Natl.Acad.Sci.USA (1994) 91:3857–3861.
   PubMed Web of Science ®Google Scholar
• RICE GC, ROSEN JW, WEEKS R, MICHNICK J, BURSTEN SL,BIANCO JA, SINGER JW: CT-1501R selectively inhibits Induced inflammatory monokines in human whole blood ex vivo. Shock (1994) 1: 1–13.
   PubMedGoogle Scholar
• BEUTLER B: Tumor necrosis, cachexia, shock and in-flammation: a common mediator. Ann.Rev.Biochem. (1988) 57: 505–518.
   PubMed Web of Science ®Google Scholar
• BEUTLER B, MILSARK 1W, CERAMI A: Passive immuniza-tion against cachectin/tumour necrosis factor protects mice from the lethal effect of endotoxin. Science (1985) 229: 869–871.
   PubMed Web of Science ®Google Scholar
• TRACEY KJ, FONG Y, HESSE DG, MANOGUE KR, I FF AT, KUO GC, LOWRY SF, CERAMI A: Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature (1987) 330: 662–664.
   PubMed Web of Science ®Google Scholar
• ALEXANDER HR, DOHERTY GM, BURESH CM, VENZON DJ,NORTON JA: A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endo-toxin in mice. J.Exp Med. (1991) 173: 1029–1032.
   PubMed Web of Science ®Google Scholar
• OKUSAWA S, GELFAND JA, IKEJIMA T, CONNOLLY RJ, DINARELLO CA: Interleukin 1 induces a shock like state in rabbits. J. C/in./nvest. (1988) 81: 1162–1172.
   PubMed Web of Science ®Google Scholar
• WAKABAYASHI G, GELFAND JA, BURKE JF, THOMPSON RC, DINARELLO CA: A specific receptor antagonist for interleukin 1 prevents Escberichia coil-induced shock in rabbits. FASEBJ. (1991) 5: 338–343.
   PubMed Web of Science ®Google Scholar
• LIBERT C, VINK A, COUL1E P, BROUCKAERT P, EVERAERDT B, VAN SNICK J, HERS W: Limited involvement of inter-leukin 6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin 6 or its receptor in various murine models. Eurflmmunol. (1992) 22: 2625–2630.
   Web of Science ®Google Scholar
• DOHERTY GM, LANGE JR, LANGSTEIN HN, ALEXANDER FIR, BURESH CM, NORTON JA: Evidence for IFN-y as a mediator of the lethality of endotoxin and tumour necrosis factor alpha. J.Immunol. (1992) 149: 1666–1670.
   PubMed Web of Science ®Google Scholar
• TOTH, PD: The biological effects of PAP antagonists on endotoxemia. In: Platelet Activating Factor in Endotoxin and Immune Diseases, New York: Dekker, Inc., 1990, p589–608.
   Google Scholar
• GIMBRONE MAJ, OBIN MS, BROCK AF, LUIS EA, HASS PE,HEBERT CA, YIP YK, LEUNG DW, LOWE DG, KOHR WJ, DARBONNE WC, BECHTOL KB BAKER JB: Endothelial interleukin-8: a novel inhibitor of leukocyte-endothe-lial interactions. Science (1989) 246: 1601-1603.
   Google Scholar
• CREASEY AA, CHANG CK, FEIGEN L, WUN TC, TAYLOR FBHINSHAW LB: Tissue factor pathway inhibitor reduces mortality from Escbertcbia coil septic shock. J.Clinin-vest. (1993) 91: 2850–2860.
   PubMed Web of Science ®Google Scholar
• SCHALL TS: Biology of the RANTES/SIS cytokine family. Cytokine (1991) 3: 165–183.
   PubMed Web of Science ®Google Scholar
• SHUKLA SD: Inositol phospholipid turnover in PAP transmembrane signalling. Lipids (1991) 26: 1028–1033.
   PubMed Web of Science ®Google Scholar
• MOORE MAS: Clinical implications of positive and nega-tive hematopoietic stem cell regulators. Blood (1991) 78: 1–19.
   PubMed Web of Science ®Google Scholar
• METCALF D: Control of granulocytes and macrophages:molecular, cellular, and clinical aspects. Science (1991) 254: 529–533.
   PubMed Web of Science ®Google Scholar
• DAN1AK N, GUIGON M, BROXMEYER HE, LEMOINE F, NAJMAN A: Meeting on negative regulation of he-matopoietic cell growth and differentiation. Exp.Hema-tol. (1994) 22: 399–405.
   PubMed Web of Science ®Google Scholar
• HAN ZC, LEBEURIER, I, CAEN, JP: Negative regulation of megakaryocytopoiesis. In: The negative regulation of he-matopoiesis from fundamental aspects to clinical applica-tions. Guidon M, Lemoine FM, Dainiak N, Schechter A, Naiman A (Eds) John Libbey Eurotext, 1993,
   Google Scholar
• ICELLFR JR, SING GK, ELLINGSWORTH LR RUSCEI th FW: Transforming growth factor B: Possible roles in the regulation of normal and leukemic hematopoictic cell growth. J.Cell Biachem. (1989) 39: 175.
   PubMed Web of Science ®Google Scholar
• HALLAHAN DE, SPRIGGS DR, BECKETT MA, KUFE DW, WEICHSELBAUM RR: Increased tumour necrosis factor-a mNRA after celhilar exposure to ionizing radiation. Proc.NatlAcad.Sci.(USA) (1989) 86: 10104–10109.
   PubMed Web of Science ®Google Scholar
• NEMUNAMS J, ROSENFELD C, ASH R, FLOMENBERG N,FRIEDMAN M, DEEG J, APPELBAUM F, SINGER JW, DALTON W, ELFENBEIN G, RIFICIN R, RUBIN A, AGOSTI J, HAYES EA, SHADDUCK RK: Phase HI double-bind trial of rhGM-CSF (Sargramostin) following allogeneic bone marrow transplant (BmT). Blood (1994) 82: 286A. (Abstr.)
   Google Scholar
• RICE G, GALLIS B, SUNKARA P, SINGER JW, BURSTEN S:Inhibition of FGF, VEGF, and PDGF endothelial cell mitogenes is by inhibition of phosphatidic acid. Proc.AACR (1994) 35: 67. (Abstr.)
   Google Scholar
• RICE G, CHANEY R, WEST J, BURSTEN 5, TOMPICINS C,SUNKARA P, SINGER JW: Inhibition of tumour cell adhe-sion to activated human umbilical vein endothelial cells (HUVEC) by novel compounds that inhibit phos-pholipk1 signaling. Proc .AACR (1994) 35: 21. (Abstr.)
   Google Scholar