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Research Article

Section Review: Biologicals & Immunologicals: Intracellular antibodies for HIV-1 gene therapy

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Pages 823-831 | Published online: 03 Mar 2008

References

  • NECKERS L, WHITESELL L: Antisense technology: Biologi- cal utility and practical considerations. Am. J. Physiol. (1993) 245:L1–L12.
  • BRATTY J, CHARTRAND P, FERBEYRE G, CEDERGREN R: The hammerhead RNA domain, a model ribozyme. Biochtm. Biophys. Acta (1993) 1215:345–359.
  • SCHAAP D, VAN DER WAL.1, HO'37E LR, MARSHALL CJ, VAN B111IERSWIJK 'OCT A dominant-negative mutant of rasblocks mitogen-activated protein kinase activation by growth factors and oncogenic p2lras. J. Biol. Chem. (1993) 268:20232–20236.
  • CAPECCHI MR: Targeted gene replacement Sci. Am. (1994) 270:52–58.
  • MARASCO WA, HASELTINE WA, CHEN SY: Design, intra- cellular expression, and activity of a human anti-HIV-1gp120 single chain antibody. Proc. Natl. Acad. Sci. USA (1993) 90:7889–7893.
  • WINTER G, MILSTEIN C: Man-made antibodies. Nature (1991) 349:293–299.
  • CARLSON JR: A new use for intracellular antibody ex- pression. Inactivation of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA (1993) 90:7427–7428.
  • CHEN SY, BAGLEY J, MARASCO WA: Intracellular anti- bodies as a new class of therapeutic molecules for gene therapy. Hum. Gene 713er. (1994) 5:595–601.
  • MHASHIKAR AM, BAGLEY J, CHEN SY, SZELVAY AM, HEL- LAND DG, MARASCO WA: Inhibition of HIV-1 infection using cytoplasmic anti-Tat antibodies. EMBO J. (1995) 14:1542–1551.
  • MERCER WE, AVIGNOLO C, BASERGA R: Role of the p53 protein in cell proliferation as studied by microinjec-don of monoclonal antibodies. Mol. Cell Biol. (1984) 4:276–281.
  • FERAMISCO JR, CLARK R, WONG G, ARNHEIM N, MILLE' Y R, MCCORMICK F: Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein. Nature (1985) 314:639–642.
  • DUBIN JA, LINK VC, STERN DF, WEINBERG RA, GREENE MI: Down-modulation of an oncogene protein product and reversion of the transformed phenotype by mono-clonal antibodies. Cell (1985) 41:697–706.
  • BRAKE DA, GOUDSMIT J, KRONE WJ, SCHAMEL P, AP-PLEBY N, MELOEN RH, DEBOUCK C: Characterisation of murine monoclonal antibodies to the Tat protein from human immunodeficiency virus type 1.1 Virol. (1990) 64:962–965.
  • MAZANEC MB, KAETZEL CS, IAMM ME, FLETCHER D, NEDRLTD JG: Intracellular neutralization of virus by immtmoglobulin A antibodies. Proc. Natl. Acad. Sci. USA (1992) 89:6901–6905.
  • PARDRIDGE WM, BICKEL U, BUCIAK J, YANG J, DIAGNE A: Enhanced endocytosis and anti-human immunode-ficiency virus type 1 activity of anti-Rev antibodies after cationization. J. Infect. Dis. (1994) 169:55–61.
  • CARLSON JR: A new means of inducibly inactivating a cellular protein. Mol. Cell Biol. (1988) 8:2638–2646.
  • TANG Y, HICKS JB, HILVERT D: In vivo catalysis of a metabolically essential reaction by an antibody. Proc. Natl. Acad. Sci. USA (1991) 88:8784–8786.
  • BIOCCA S, NEUBERGER MS, CATTANEO A: Expression and targeting of intraccliniar antibodies in mammalian cells. EMBOJ. (1990) 9:101–108.
  • \VERGE TM, BIOCCA S, CATTANEO A: Intracellular im-munization: Cloning and intracellular expression of a monoclonal antibody to the p2lras protein. FESS Lett. (1990) 274:193–198.
  • PICCIOLI P, RUBERTI F, BIOCCA 5, DILUZIO A, WERGE TM,BRADBURY A, CATTANEO A: Neuroantlbodies: Molecu-lar cloning of a monoclonal antibody against substance P for expression in the central nervous system. Proc. Natl. Acad. Sci. USA (1991) 88:5611–5615.
  • EARL PL, DOMS RW, MOSS B: Oligomeric structure of the human immunodeficiency virus type 1 envelope glyco-protein. Proc. Natl. Acad. Sci. USA (1990) 87:648–652.
  • MUNRO S, PELHAM HE: A C-terminal signal prevents secretion of lumina' ER proteins. Cell (1987) 48:899–907.
  • MELNICK J, DUL JL, ARGON Y: Sequential interaction of the chaperones HIP and GRP94 with inuntmogkrbulin chains in the endoplasmic reticulum. Nature (London) (1994) 370:373–375.
  • POSNER MR, HIDESHIMA T, CANNON T, MUKHERJEE M, MAYER KH, BYRN RA: An IgG monoclonal antibody that reacts with 111V-1/gp120, inhibits virus binding to cells, and neutralises infection. J. Immunol. (1991) 146:4325–4332.
  • MARASCO WA, BAGLEY J, ZANI C, POSNER M, CAVACINI L, HASELTINE WA, SODROSKI J: Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody. J. Clin. Invest. (1992) 90:1467–1478.
  • KOGA Y, SASAKI M, YOSHIDA H, WIGZELL H, KIMURA G, NOMOTO K: Cytopathic effects determined by the amount of C04 molecules in human cell lines express-ing envelope glycoprotein of 111V. J. Immunol. (1990) 144:94–102.
  • HOXIE JA, ALPERS JD, RACKOWSKI JL, HEUBNER K, HAG-GARTY BS, CEDARBAUM AJ, REED JC: Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV. Science (1986) 234:1123–1127.
  • BUONOCORE L, ROSE JK: Prevention of HIV-1 glycopro-tein transport by soluble CD4 retained in the endoplas-mic reticulum. Nature (London) (1990) 345:625–628.
  • CRISE B, ROSE JK: HIV-1 glycoprotein precursor retainsa CD4-p561ck complex in the endoplasmic reticulum. J. Virol. (1992) 66:2296–2301.
  • DUAN L, BAGASRA 0, LAUGHLIN MA, OAKES JW, POMER- ANTZ RJ: Potent inhibition of human immunodefi-ciency virus type-1 replication by an intracellular anti-Rev single-chain antibody. Proc. Natl. Acad. Sci. USA (1994) 91:5057–5079.
  • DUAN L, ZHANG H, OAKESJW, BAGASRA 0, POMERANTZRJ: Molecular and virological effects of intracellar anti-Rev single chain variable fragments on the expression of various human immunodeficiency virus-1 strains. Hum. Gene Ther. (1994) 5:315–1324.
  • ROSEN CA, SODROSKI JG, HASELTINE WA: The locationof cis-acting regulator sequences in the human T-cell lymphotropic virus type m (Ininr-mtiAv) long termi-nal repeat. Cell (1985) 41:813–823.
  • ROY S, DELLING U, CHEN CH, ROSEN CA, SONENBERG N:A bulge structure on HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev. (1990) 4:1365–1376.
  • BERKHOUT B, SILVERMAN RH, JEANG KT: Tat trans-acti-vates the human immunodeficiency virus through a nascent RNA target. Cell (1989) 59:273–282.
  • LASPIA MF, RICE AP, MATHEWS MB: HIV-1 Tat protein Increases transcriptional initiation and stabilizes elon-gation. Cell (1989) 59:283–292.
  • MARCINIAK RA, SHARP PA: HIV-1 Tat protein promotes formation of more processive elongation complexes. EMBO J. (1991) 10:4189–4196.
  • KATO H, SUMIMOTO H, POGNONEC P, CHEN CH, ROSENCA, ROEDER RG: HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. Genes Dev. (1992) 6:655–666.
  • SHIBUYA H, NINOMIYA-TSUJI J, GOEBL M, TANIGUCHI T,MATSUMOTO K: New human gene encoding a positive modulator of HIV Tat-mediated transactivation. Nature (1992) 357:700–702.
  • OHANA B, MOORE OPA, RUBEN SM, SOUTHGATE CD, GREEN MR, ROSEN CA: The type 1 human immunodefi-ciency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolution-arily conserved genes. Proc. Natl. Acad. Sci. USA (1993) 90:138–142.
  • KASHANCHI F, PIRAS G, RADONOVICH MF, DUVALL JF,FATTAEY A, CLIANG CM, ROEDER RG, BRADY JN: Direct Interaction of human 'Mid with the HIV-1 transactiva-tor Tat. Nature (1994) 367:295–299.
  • MARCINIAK RA, BARCIA-BLANCO MA, SHARP PA: Identi-fication and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA (1990) 87:3624–3628.
  • GAYNOR R, SOULTANAKIS E, KUWABARA M, GARCIA J,SIGMAN DS: Specific binding of a HeLa nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region. Proc. Natl. Acad. Sci. USA (1989) 86:4858–4862.
  • SHELINE CT, MILOCCA LT, JONES KA: Two distinct nu-clear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin. Genes Dev, (1991) 8:2508–2520.
  • GATIGNOL A, BUCKLER-WHITE A, BERKHOUT B, JEANGKT: Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. Science (1991) 251:597–600.
  • BERKHOUT B, JEANG KT: Functional roles for the TATA promoter and enhancers in basal and Tat-induced ex-pression of the HIV-1 LT11. j Virol. (1992) 66:139–149.
  • YONEDA Y, SEMBA T, KANEDA Y, NOBLE RI., MATSUOKA Y, KURIHARA T, OKADA Y, IMAMOTO N: Along synthetic peptide containing a nuclear localization signal and its flanking sequences of SV40 T-antigen directs the trans-port of 1gM into the nucleus efficiently. Exp. Cell Res. (1992) 201:312–320.
  • HASELTTNE WA: Molecular biology of the human immu-nodeficiency virus type 1. FASEBJ. (1991) 5(10):2349–2360.
  • OLSEN HS, COCHRANE AW, DILLON PJ, NALIN CM, ROSE CA: Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA Is dependent on multimer formation mediated through a basic stretch of amino acids. Genes Dev. (1990) 4:1357–1364.
  • MALIM ME, CULLEN BR: HIV-1 structural gene expres-sion requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. Cell (1991) 65:241–248.
  • MARASCO WA, SZLLVAY AM, KALLAND KH, HELLAND DG,REYES HM, WALTER RJ: Spatial association of HIV-1 Tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells. Arch. Virol. (1994) 139:133–154.
  • FANKHAUSER C, IZAURRALDE E, ADACHI Y, WINGFIELDP, LAEMMLI UK: Specific complex of human immunode-ficiency virus type 1 Rev and nucleolar B23 proteins: dissociation by the Rev response element Mol. Cell Biol. (1991) 11:2567–2575.
  • KALLAND KH, SZILVAY AM, LAGHOFF E, HAUKENES G: Subcellular distribution of human immunodeficiency virus type 1 Rev and colocalization of Rev with RNA splicing factors in a speckled pattern in the nucleo-plasm. J. Virol. (1994) 68:475–485.
  • KELLAND KH, SZILVAY AM, BROKSTAD KA, SAETREVIK W, HAUKENES G: The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments. Mol. Cell Biol. (1994) 14:7436–7444.
  • MEYER BE, MALIM MH: The HIV-1 Rev trans-activatorshuttles between the nucleus and the cytoplasm. Genes Dev. (1994) 8:535–547.
  • RUHL M, HIMELSPACH M, BAHR GM, HAMMERSCHMID F, JAKSCHE H, WOLFF B, ASCHAUER H, FARRINGTON GK, PROBST H, BEVEC D, HAUBER J: Eckaryotic initiation factor 5A is a cellular target of the human immunode-ficiency virus type 1 Rev activation domain mediating trans-activation. J. Cell Biol. (1993) 123:1309–1320.
  • LUO Y, YU H. PETERLIN BM: Cellular protein modulates effects of human immunodeficiency virus type 1 Rev. J. Virol. (1994) 68:850–856.
  • SHUKLA RR, IUMMEL PL, KUMAR A: Human immunode-ficiency virus type 1 Rev-responsive element RNA binds to host cell-specific proteins. J. Virol. (1994) 68:2224–2229.
  • PARK H, DAVIES MV, LANGLAND JO, CHANG HW, NAM YS, TARTAGLIA J, PAOLETTI E, JACOBS BL, KAUFMAN RJ, VENKATESAN S: TAR RNA-binding protein is an inhibi-tor of the interferon-induced protein kinase PICR. Proc. Natl. Acad. Sci. USA (1994) 91:4713–4717.
  • LEDERMAN MM: Host-directed and immune-based thera-pies for human immunodeficiency virus infection. Ann. Intern. Med. (1995) 122:218–222.
  • ELROY-STEIN 0, FUERST TR, MOSS B: Cap-independenttranslation of mRNA conferred by encephalomyocardi-tis virus 5' sequence improves the performance of the vaccina virus/bacteriophage T7 hybrid expression sys-tem. Proc. Natl. Acad. Sci, USA (1989) 86:6126–6130.
  • PARKS GD, DUKE GM, PALMENBERG AC: Encephalomyo-carditis virus 3C protease: Efficient cell-free expression from clones which link viral 5' noncoding sequences to the P3 region. J. Vim!. (1986) 60:376–384.
  • SARNOW P: Role of 3'-end sequences in infectivity ofpoliovirus transcripts made in vitro. J. Vim!. (1989) 63:467–470.
  • MACEJAK DG, SARNOW P: Internal initiation of transla-tion mediated by the 5' leader of a cellular mRNA. Nature (1991) 353:90–94.
  • KOO 11M, BROWN AM, KAUFMAN RJ, PROROCK CM, RON Y, DOUGHERTY JP: A spleen necrosis virus-based retroviral vector which expresses two genes from a dicistronic mRNA. Virology (1992) 186:669–675.
  • DIRKS W, WIRTH M, HAUSER H: Dicistronic transcription units for gene expression in mammalian cells. Genes (1993) 12:247–249.
  • SUGIMOTO Y, AKSEN 1VEVICH I, GOTTRESMAN M, PAS-TAN I: Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribo-some entry site. Bio/Technology (1994) 12:694–698.
  • BEX F, HERMANS P, SPRECHER S, ACHOUR A, BADJOU R, DESGRANGES C, COGNIAUX J, FRANCHIOLI P, VANHULLE C, LACHGAR A, STRYCKMANS P, ZAGURY D, BURNY A, CLUMECK N: Syngeneic adoptive transfer of anti-human Immunodeficiency virus (HIV-1)-primed lymphocytes from a vaccinated HIV-seronegative individual to his HIV-1-infected identical twin. Blood (1994) 84:3317–3326.
  • WEI X, GHOSH SK, TAYLOR ME, JOHNSON VA, EMINI EA,DEUTSCH P, LIFSON JD, BONHOEFFER S, NOWAK MA, HAHN BH, SAAG MS, SHAW GM: Viral dynamics in human HIV-1 infection. Nature (1995) 373:117–122.
  • HO DD, NEUMANN AU, PERELSON AS, CHEN W, LEONARDJM, MARKOWITZ M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 373:123–126.
  • GELDERBLOM FIR, HAUSMANN EH, OZEL M, PAULI G, KOCH MA: Fine structure of human immunodeficiency virus (HIV) and immunolocalisation of structural pro-teins. Virology (1987) 156:171–176.
  • HOGLUND S, OFVERSTEDT LG, NILSSON A, LUNDQUISTP, GELDERBLOM H, OZEL M, SKOGLUND U: Spatial visu-alisation of the maturing HIV-1 core and its linkage to the envelope. AIDS Res. Hum. Retroviruses (1992) 8:1–7.
  • NI:EDAM M, HINKULA J, WEIGELT W, L'AGE-STEHR J,PAULI G, ROSEN J, WAHREN B: Epitope mapping of monoclonal antibodies against human immunodefi-ciency virus type 1 structural proteins by using pep-tides. J. Virol. (1989) 63:3525–3528.
  • HINKULA J, ROSEN J, SUNDQVIST VA, STIGBRAND T, WAHREN B: Epitope mapping of the HIV-1 gag region with monoclonal antibodies. Mol. Immunol. (1990) 27:395–403.
  • NIEDRIG M, HARTUS HP, HINKULA J, BROKER M, BICK-HARD H, FAULT G, GELDERBLOM HR, WAHREN B: Inhibi-tion of viral replication by monoclonal antibodies directed against human immunodeficiency virus gp120. Proc. Natl. Acad. Sci. USA (1991) 65:4529–4533.
  • DORFMAN T, MAMMANO F, HASELTINE WA, GOTTLINGERHG: Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein. Vim/. (1994) 68: 1689–1696.
  • MAMMANO F, OHAGEN A, HOGLLTND S, GOTTLINGER HG:Role of the major homology region of human immu-nodeficiency virus type 1 in virion morphogensis. J. Vim!. (1994) 68:4927–4936.
  • FRANKE EK, YUAN FIE, LUBAN J: Specific incorporationof cyclophilin A into IIIV-1 virions. Nature (1994) 372:359–362.
  • THALI M, BUKOVSKY A, KONDO E, ROSENWIRTH B, WALSH CT, SODROSKI J, GOTTLINGER HG: Functional association of cyclophilin A with HIV-1 virions. Nature (1994) 372:363–365.
  • BUKRINSKAYA AG, VORKUNOVA GK, TENTSOV YYU: HIV-1 matrix protein p17 resides in cell nudei in association with genomic RNA. AIDS Res. Hum. Retroviruses (1992) 8:1795–1801.
  • BUKRINSKY MI, SHAROVA N, DEMPSEY MP, STANWICKTL, BUICRINSKAYA AG, HAGGERTY S, STEVENSON M: Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc. Natl. Acad. Sci. USA (1992) 80:6580–6584.
  • BUKRINSICY MI, SHAROVA N, MCDONALD TL, PUSHKAR-SICAYA T, TARPLEY WG, STEVENSON M: Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nu-cleic adds following acute infection. Proc. Natl. Acad. Sci. USA (1993) 90:6125–6129.
  • BUKRINSICY MI, HAGGERTY S, DEMPSEY MP, SHAROVAN, ADZHUBEL A, SPITZ L, LEWIS P, GOLDFARB D, EMER-MAN M, STEVENSON M: A nuclear loc•B•ation signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature (1993) 365:666–669.
  • VON SCHWEDLER U, KORBLUTH RS, TRONO D: The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the es-tablishment of infection in macrophages and quiescent T-lymphocytes. Proc. Natl. Acad. Sci. USA (1994) 91:6992–6996.
  • HEINZINGER NK, BUKINSKY MI, HAGGERTY SA, RAGLAND AM, KEWALRAMANI V, LEE MA, GENDELMAN HE, RATHER L, STEVENSON M, EMERMAN M: The Vpr protein of human immunodeficiency virus type 1 influ-ences nuclear localization of viral nucleic acids in nondividing host cells. Proc. Natl. Acad. Sci. USA (1994) 91:7311–7315.
  • CHEN SY, KHOURI Y, BAGLEY J, MARASCO WA: Com- bitted intra- and extracelluLar immunization against WV-1 infection using a human anti-gp120 antibody. Proc. Natl. Acad. Sci. USA (1994) 91:5934–5936.
  • BUONOCORE L, ROSE JK: Blockade of human immu- nodeficiency virus type 1 production in CD4 + T-cells by an intracPlhilar CD4 expressed under control of the viral long terminal repeat. Proc. Natl. Acad. Sci. USA (1993) 90:2695–2699.
  • JIANG W, VENUGOPAL K, GOULD E: Intracellular inter-ference of tick-borne Flavivints infection by using a single-chain antibody fragment delivered by recombi-nant Sindbis virus. J. Vim!. (1995) 69:1044–1049.
  • BEERLI RR, WETS W, HYNES NE: Intracellular expression of single chain antibodies reverts etisB-2 transforma-tion. J. Biol. Chem. (1994) 289:23931–23936
  • DESHANE J, LOECHEL F, CONRY RM, SIEGAL GP, KING CR, CURIEL DT: Intracellular sFv directed against erb B-2 down-regulates surface erb B-2 and exhibits a selective active proliferative effect in erb B-2 over-expression cancer cell lines. Gene Therapy (1994) 1:332–337.
  • RICHARDSON JH, SODROSKI JG, WALDMANN TA, MARASCO W: Phenotypic knockout of the high-affinity human 11.2 receptor by intracellular single-chain anti-bodies against the a subunit of the receptor. Proc. Natl. Acad. Sci. USA (1995) 92:3137–3141.

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