Section Review Biologicals & Immunologicals: Matrix metalloproteinases and malignant disease: Recent developments

References

• FIDLER IJ, NAITO S, PATHAK S: Orthotopic implantation is essential for the selection, growth and metastasis of human renal cell cancer in nude mice. Cancer Metastasis Rev. (1990) 9:149–165.
   PubMed Web of Science ®Google Scholar
• EcyrrA LA, STEEG PS, STETLER-STEVENSON WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell (1991) 64:327–336.
   PubMed Web of Science ®Google Scholar
• MIGNATTI P, RIFKIN DB: Biology and biochemistry of proteirtases in tumor invasion. Physiol. Rev. (1993) 73:161–195.
   PubMed Web of Science ®Google Scholar
• RAY JM, STETLER-STEVENSON WG: The role of matrix metalloproteases and their inhibitors in tumor inva-sion, metastasis and angiogenesis. Fur. Resp. J. (1994) 7:2062–2072.
   PubMed Web of Science ®Google Scholar
• BIRKEDAL-HANSEN H, MOORE WGI, BODDEN MK, WIND- ?SOR LJ, BIRKEDAL-HANSEN B, DECARLO A, ENGLER JA: Matrix metalloproteinases: a review Crit. Rev. Oral Biol. Med. (1993) 4:197–250.
   Google Scholar
• MATRISIAN LM, MCDONNELL S, MILLER DB, NAVRE M, SEFTOR EA, HENDRIX MJ: The role of the matrix metal-loproteinase stromelysin in the progression of squamous cell carcinomas. Am. J. Med. Sci. (1991) 302:157–162.
   PubMed Web of Science ®Google Scholar
• MATRISIAN LM: The matrix-degrading metalloprotei-nases. BioEssays (1992) 14:455–463.
   PubMed Web of Science ®Google Scholar
• SATO J, TAKINO T, OKADA Y, CAO J, SHINAGAWA A, YAMAMOTO E, SEIKI M: A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature (1994) 370:61–65.
   PubMed Web of Science ®Google Scholar
• PEI D, WEISS SJ: Furin-dependent intracellular activa-tion of the human stromelys in-3 zymogen. Nature (1995) 375:244–247.
   PubMed Web of Science ®Google Scholar
• URBANSKI S.J, EDWARDS DR, MAITLAND A, LECO KJ, WATSON A, KOSSAKOWSKA AE: Expression of metallo-proteinases and their inhibitors in primary pulmonary carcinomas. Br. J. Cancer (1992) 66:1188–1194.
   PubMed Web of Science ®Google Scholar
• STETLER-STEVENSON WG, AZNAVOORIAN S, uarrA LA: •Tumor cell interactions with the extracelluLlr matrixduring invasion and metastasis. Ann. Rev. Cell Biol. (1993) 9:541–573.
   PubMed Web of Science ®Google Scholar
• STETLER-STEVENSON WG, LIOTTA LA, KLEINER DE, Jr.:Extracellular matrix 6: role of matrix metalloprotei-nases in tumor invasion and metastasis. FASEB J. (1993) 7:1434–1441.
   Google Scholar
• BAYLIN M, GOMEZ E, SINHA CC, THORGEIRSSON UP: Ras oncogene mediated induction of a 92-1tDa metallopro-teinase: strong correlation with the rualign2nt pheno-type. Biochem. Biophys. Res. Commun. (1988) 154:832–838.
   PubMedGoogle Scholar
• GARBISA S, POZZATTI R, MUSCHEL R, SAFFIOTI V, BAUIN M, GOLDFARB R, KHOURY G, LIOTTA L: Secretion of type IV collagenolytic protease and metastatic phenotype: 38. induction by transfection with c-Ha-ras but not c-Ha- ras plus Ad2-Ela. Cancer Res. (1987) 47:1523–1528.
   Google Scholar
• MATRISIAN LM, HOGAN BLM: Growth factor-regulatedprotease and extrareltular matrix remodeling during mammalian development. Curr. Top. Dev. Biol. (1990) 24:219–259.
   PubMedGoogle Scholar
• WILHELM SM, COLLIER IE, MARMER BL, EISEN AZ, GRANTGA, GOLDBERG GI: SV40-transformed human lung fi-broblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macro-phages. J. Biol. Chem. (1989) 264:17213–17221.
   PubMed Web of Science ®Google Scholar
• YAMAGATA S, TANAKA R, YOSHIDA I, SHIMIZU S: Gelat-inase of murine metastatic tumor cells. Biochem.Biophys. Res. Commun. (1989) 158:228–234.
   PubMed Web of Science ®Google Scholar
• URA H, BONFIL RD, REICH R, REDDEL R, PFIEFER A,HARRIS CC, KLEIN-SZANTO AJP: Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res. (1989) 49:4615–4621.
   PubMed Web of Science ®Google Scholar
• RAY JM, STETLER-STEVENSON WG: Gelatinase A activitydirectly modulates melanoma cell adhesion and spread-ing. EMBO J. (1995) 14:908–917.
   PubMed Web of Science ®Google Scholar
• MCCARTHY JB, SKUBITZ APN, RDA J, MOORADIAN DL,WILKE MS, FURCHT LT: Tumor cell adhesive mechanisms and their relationship to metastasis. Semin. Cancer Biol. (1991) 2:155–167.
   PubMedGoogle Scholar
• SATO H, KIDA Y, MAT M, ENDO Y, SASAKI T, TANAKA J,SEIKI M: Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells. On-cogene (1992) 7:77–83.
   Google Scholar
• LYONS JG, BIRICEDAL-HANSEN B, MOORE WG, O'GRADYRE, BIRKEDAL-HANSEN H: Characteristics of a 95-kDa matrix metalloproteinase produced by mammary car-cinoma cells. Biochemistry (1991) 30:1449–1456.
   PubMed Web of Science ®Google Scholar
• LEVY AT, CIOCE V, SOBEL ME, GARBISA S, GRIGIONI WF,LIOTTA LA, STETLER-STEVENSON WG: Increased expres-sion of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma. Cancer Res. (1991) 51:439–444.
   PubMed Web of Science ®Google Scholar
• VAN DER STAPPENJWJ, HENDRIKS T, WOBBES T: Corre-lation between collagenolytic activity and grade of histological differentiation in colorectal tumors. Int. J. Cancer (1990) 45:1071–1078.
   PubMed Web of Science ®Google Scholar
• HEWITT RE, LEACH IH, POWE DG, CLARK IM, CAWSTON TE, TURNER DR: Distribution of collagenase and tissue Inhibitor of metalloproteinases (TIMP) in colorectal tumours. Intl. Cancer (1991) 49:666–672.
   PubMed Web of Science ®Google Scholar
• GRAY ST, 'WILKINS RJ, YUN K: Interstitial collagenase gene expression in oral squamous cell carcinoma. Am. Pathol. (1992) 141:301–306.
   PubMed Web of Science ®Google Scholar
• MULLER D, BREATHNACH R, ENGELMANN A, MILLON R,BRONNER G, FLESCH H, DUMONT P, EBER M, ABECASSIS J: Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours. Int. J. Cancer (1991) 48:550–556.
   PubMed Web of Science ®Google Scholar
• POLETTE M, CLAVEL C, MULLER D, ABECASSIS J, BINNIN-GER I, BIREMBAUT P: Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization. Invasion Metas-tasis (1991) 11:76–83.
   PubMedGoogle Scholar
• PEI D, MAJMUDAR G, WEISS SJ: Hydrolytic inactivationof a breast carcinoma cell-derived serpin by human stromelysin-3. J. Biol. Chem. (1994) 269:25849–25855.
   PubMed Web of Science ®Google Scholar
• MCDONNELL S, NAVRE M, COFFEY RJ, MATRISIAN LM: Expression and loc2117ation of the matrix metallopro-teinase pump-1 (MMP-7) in human gastric and colon carcinomas. Mol. Carrinog. (1991) 4:527–33.
   PubMedGoogle Scholar
• PAJOUH MS, NAGLE RB, BREATHNACH R, FINCH JS, BRA WER MK, BOWDEN GT: Expression of metalloprote-inase genes in human prostate cancer. J. CancerRes. Clin. Oncol. (1991) 117:144–50.
   PubMed Web of Science ®Google Scholar
• POWELL WC, KNOX JD, NAVRE M, GROGAN TM, KIT ILL-SON J, NAGLE RB, BONVDEN T: Expression of the metal-loproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodefi-dent mice. Cancer Res. (1993) 53:417–422.
   PubMed Web of Science ®Google Scholar
• PYRE C, RALFKLAER E, TRGGVASON K, DANO K: Messen-ger RNA for two type IV collagenases is located in stromal cells in human colon cancer. Am.J.Pathol. (1993) 142:359–365.
   PubMed Web of Science ®Google Scholar
• YAMAMOTO H, ITOH F, HINODA Y, IMAI K: Suppression of matrilysin inhibits colon cancer cell invasion in vitro. Intl. Cancer (1995) 61:218–222.
   PubMed Web of Science ®Google Scholar
• BASSET P et al.: A novel metalloproteinase gene specifi-cally expressed in stromal cells of breast carcinoma. Nature (1990) 348:699–704.
   PubMed Web of Science ®Google Scholar
• MULLER D et al.: Increased stromelysin 3 gene expres-sion is associated with increased local invasiveness in head and neck squamous cell carcinomas. Cancer Res. (1993) 53:165–169.
   PubMed Web of Science ®Google Scholar
• WOLF C, CHENARD M-P, DE GROSSOUVRE PD, BELLOCQJ-P, CHAMBON P, BASSET P: Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing. J. Invest. Dermatol. (1992) 99:870–872.
   PubMed Web of Science ®Google Scholar
• BERNHARD EJ, MUSCHEL RJ, HUGHES EN: Mr 92,000 gelatinase release correlates with the metastatic pheno-type in transformed rat embryo cells. Cancer Res. (1990) 50:3872–3877.
   PubMed Web of Science ®Google Scholar
• NAKAJIMA M, WELCH D, BELLONI PN, NICOLSON GL: Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary ade-nocarcinoma cell clones of differing metastatic poten-tials. Cancer Res. (1987) 47:4869–4876.
   PubMed Web of Science ®Google Scholar
• OKADA Y, MORODOMI T, ENGHILD B, SUZUKI K, YASUI A, NAKANISHSI I, SALVESEN G, NAGASE H: Matrix metal-loproteinase 2 from human rheumatoid synovial fi-broblasts. Eur. J. Biochem. (1990) 194:721–730.
   PubMedGoogle Scholar
• KAWAMATA H, KAMEYAMA S, DAWAI K, TANAKA Y, NAN L, BARCH DH: Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A. Int. J. Cancer (1995) 63:568–575.
   PubMed Web of Science ®Google Scholar
• OHORI NP, YOUSEM SA, GRIFFIN J, STANIS K, STETLER-STEVENSON WG, COLBY TV, SONMEZ AE: Comparison of extracellular matrix antigens in subtypes of bron-chioalveolar carcinoma and conventional pulmonary adenocarcinoma. An immunohistochemical study. Am. J. Surg. Pathol. (1992) 16:675–86.
   PubMed Web of Science ®Google Scholar
• CANETE-SOLAR R, LITZKY L, LUBENSKY I, MUSCHEL RJ:Localization of the 92 kd gelatinase mRNA in squamous cell and adenocarcinomas of the lung using in situ hybridization. Am. J. Path. (1994) 144:518–527.
   PubMed Web of Science ®Google Scholar
• PY10E C, RALFICIAER E, HUHTALA P, HURSKAINEN T, DAN:K, TRYGGVASON K: Loc21172tion of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization. Cancer Res (1992) 52:1336–1341.
   PubMedGoogle Scholar
• MONTEAGUDO C, MERINO MJ, SAN JJ, LIOTTA LA, STETLER-STEVENSON WG: Immunohistochemical distri-bution of type IV collagenase in normal, benign, and malignant breast tissue. Am. J. Pathol. (1990) 136:585–592.
   PubMed Web of Science ®Google Scholar
• D'ERRICO A, GARBISA S, LIOTTA LA, CASTRONOVO V,STETLER-STEVENSON WG, GRIGIONI WE: Augmentation of type IV collagenase, laminin receptor, and Ki67 proliferation antigen associated with human colon, gastric, and breast carcinoma progression. Mod. Pathol. (1991) 4:239–246.
   PubMed Web of Science ®Google Scholar
• TRYGGVASON K, HOYHTYA M, PYKE C: Type-IV col-lagenases in invasive tumors. Breast Cancer Res. Treat-ment (1993) 24:209–218.
   PubMed Web of Science ®Google Scholar
• BROWN PD, BLOXIDGE RE,ERSON F, HOWELL A: Expres-sion of activated gelatinase in human invasive breast carcinoma. Clin. Exp. Metastases (1993) 11:183–189.
   PubMed Web of Science ®Google Scholar
• DAVIES B, MILES DW, HAPPERFIELD LC, NAYLOR MS, BOBROW LG, RUBENS RD, BALKWILL FR: Activity of type iv collagenases in benign and malignant breast disease. Br. J. Cancer (1993) 67:1126–1131.
   PubMed Web of Science ®Google Scholar
• CHEN W-T et al.: Membrane proteases as potential diag-nostic and therapeutic targets for breast malignancy. Breast Cancer Res. Treatment (1994) 31:217–226.
   Google Scholar
• MONSKY WE, KELLY T, UN CY, YEH Y, STETLER-STEVEN-SON WG, MUELLER SC, CHEN WE: Binding and localiza-tion of Mr 72,000 matrix metalloproteinase at cell surface invadopodia. Cancer Res. (1993) 53:3159–3164.
   PubMed Web of Science ®Google Scholar
• MELCHIORI A, ALBINI A, RAY JM, STETLER-STEVENSONWG: Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metallo-proteinase enzyme prosegment. Cancer Res. (1992) 52:2353–6.
   PubMed Web of Science ®Google Scholar
• ALBINI A, MELCHIORI A, SANT1L, mo'rrA LA, BROWN PD,STETLER-STEVENSON WG: Tumor cell invasion inhibited by 11MP-2. J. Natl. Cancer Inst. (1991) 83:775–79.
   PubMed Web of Science ®Google Scholar
• SATO H, TAKINO T, OKADA Y, SHINAGAWA A, YAMAMOTO E, SEIKI M: A novel matrix metalloprotei-nase expressed on the invasive tumor cell surface. Nature (1994) 370:61–65.
   PubMed Web of Science ®Google Scholar
• OKADA A, BELLOCQ J-P, ROUYER N, CHENARD M-P, RIOM-C, CHAMBON P, BASSET P: Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stro-mal cells of human colon, breast, and head and neck carcinomas. Proc. Natl. Acad. Sci. USA (1995) 92:2730–2734.
   PubMed Web of Science ®Google Scholar
• NABESHIMA K, LANE WS, BISWAS C: Partial sequencingand characterization of the tumor cell-derived col-lagenase stimulatory factor. Arch. Biochem. Biophys. (1994) 285:90–96.
   Google Scholar
• EMONARD HP, REMACLE AG, NO:EL AC, GRIMALTD JA,STETLER-STEVENSON WG, FOIDART JM: Tumor cell sur-face-associated binding site for the M(r) 72,000 type IV collagenase. Cancer Res. (1992) 52:5845–5848.
   PubMed Web of Science ®Google Scholar
• BROWN PD, BLOXIDGE RE, STUART NSA, GATFER KC, CARMICHAEL J: Association between expression of acti-vated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma. J. Natl. Cancer Inst. (1993) 85:574–578.
   PubMed Web of Science ®Google Scholar
• EMMERT-BUCK MR, ROTH MJ, ZHUANG Z, CAMPO E, ROZHIN J, SLOANE BF, LIOTFA LA, STETLER-STEVENSON WG: Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples. Am. J. Pathol. (1994) 145:1285–1290.
   PubMed Web of Science ®Google Scholar
• EMMERT-BUCK MR, EMONARD HP, CORCORAN ML, KRUTZSCH HC, FOIDAR JM, STETLER-STEVENSON WG: Cell surface binding of TIMP-2 and pro-MMP-2/TIMP-2 complex. FEBS Lett. (1995) 364:28–32.
   PubMed Web of Science ®Google Scholar
• VASSALLI JD, PEPPER MS: Tumour biology. Membraneproteases in focus. Nature (1994) 370:14–15.
   PubMedGoogle Scholar
• BROWN PD: Preclinical and clinical studies on the matrix metalloprotelna se inhibitor, batimastat (BB-94). Ann. IVY Acad. Sci. (1994) 732:217–221.
   PubMedGoogle Scholar
• APTE SS, HAYASHI K, SELDIN MF, MATTEI MG, HAYASHI M, OLSEN BR: Gene encoding a novel murine tissue Inhibitor of metalloproteinases (TIMP), TIMP-3, is ex-pressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10. Dev. Dyn. (1994) 200:177–197.
   PubMed Web of Science ®Google Scholar
• APTE SS, MATIEI MG, OLSEN BR: Cloning of the cDNA encoding human tissue inhibitor of metalloprotei-nases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics (1994) 19:86–90.
   PubMed Web of Science ®Google Scholar
• CARMICHAEL DF, SOMMER A, THOMPSON RC,ERSON DC,SMITH CG, WELGUS HG, STRICKLIN GP: Primary struc-ture and cDNA clotting of human fibroblast collagenase Inhibitor. Proc. Natl. Acad. Sci. USA (1986) 83:2407–2411.
   PubMed Web of Science ®Google Scholar
• DECLERCK YA, YEAN T, RATZKIN BJ, LU HS, LANGLEY ICE:Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bo-vine aortic endothelial cells. J. Biol. Chem. (1989) 264:17445–17453.
   PubMed Web of Science ®Google Scholar
• DOCHERTY AJP, LYONS A, SMITH BJ, WRIGHT EM, STEPHENS PE, HARRIS TJR, MURPHY G, REYNOLDS JJ: Sequence of human tissue inhibitor of metalloprotei-nases and its identity to erythroid-potentiating activity. Nature (1985) 318:66–69.
   PubMed Web of Science ®Google Scholar
• LECO KJ, ICHOKHA R, PAVLOFF N, HAWKES SP, EDWARDS DR: Tissue inhibitor of metalloproteinases-3 (TIMP-3) Is an extracellular matrix-associated protein with a dis-tinctive pattern of expression in mouse cells and tis-sues. J. Biol. Chem. (1994) 269:9352–9360.
   PubMed Web of Science ®Google Scholar
• PAVLOFF N, STASKUS PW, KISHNANI NS, HAWKES SP: A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family. J. Biol. Chem. (1992) 267:17321–17326.
   Google Scholar
• STETLER-STEVENSON WG, KRUTZSCH HC, LIOTTA LA: Tissue inhibitor of metalloproteinase (TIMP-2): a new member of the metalloproteinase family. J. Biol. Chem. (1989) 264:17374–17378.
   PubMed Web of Science ®Google Scholar
• MURPHY G, WILLENBROCK F, WARD RV, COCKETT MI, EATON D, DOCHERTY AJ: The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates inter-actions with tissue inhibitors of metalloproteinases. Biochem. J. (1992) 283:637–641.
   PubMed Web of Science ®Google Scholar
• KLEINER DE, Jr., S1 hi LER-STEVENSON WG: Structural biochemistry and activation of matrix metallopro-teases. Curr. Opin. Cell Biol. (1993) 5:891–897.
   PubMed Web of Science ®Google Scholar
• KLEINER D, Jr., UNSWORTH EJ, KRUTZSCH HC, STETLER-STEVENSON WG: Higher-order complex formation be-tween the 72-kibdalton type IV collagenase and tissue Inhibitor of metalloproteinases-2. Biochemistry (1992) 31: 1665-1672.
   Google Scholar
• GOLDBERG GI, MARMER BL, GRANT GA, EISEN AZ, WIL-HELM A, HE C: Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metallopro-teinases designated TIMP-2. Proc. Natl. Acad. Sci. USA (1989) 86:8207–8211.
   PubMed Web of Science ®Google Scholar
• HAYAKAWA T, YAMASHITA K, TANZAWA K, UCHIJIMA E,IWATA K: Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum. FEBS Lett. (1992) 298:29–32.
   Google Scholar
• MURPHY AN, UNSWORTH EJ, S1h1LER-STEVENSON WG: Tissue inhibitor of metalloproteinases-2 inhibits bEGF-induced human microvascular endothelial cell prolif-eration. J. Cell Pbysiol. (1993) 157:351–358.
   PubMed Web of Science ®Google Scholar
• URIA JA, FERRANDO AA, VELASCO G, FREIJE JMP, LOPEZ-OTIN C: Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase family. Cancer Res. (1994) 54:2091–2094.
   PubMed Web of Science ®Google Scholar
• LECO KJ, HAYDEN LJ, SHARMA RR, ROCIIELEAU H, GREEN-BERG AH, EDWARDS DR: Differential regulation of TIMP-1 and TIMP-2 messenger RNA expression in normal and Ha-ras-transformed murine fibroblasts. Gene (Amst.) (1992) 117:209–217.
   PubMed Web of Science ®Google Scholar
• ALVAREZ OA, CARMICHAEL DF, DECLERCK YA: Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metallo-proteinases. J. Natl. Cancer Inst. (1990) 82:589–595.
   PubMed Web of Science ®Google Scholar
• KHOICHA R, ZIMMER MJ, GRAHAM CH, LALA PK, WATER-HOUSE P: Suppression of invasion by indudble expres-sion of tissue inhibitor of metalloproteinase-1 (TIMP-1) In B16-F10 melanoma cells. J. Natl. Cancer Inst. (1992) 84:1017–1022.
   PubMed Web of Science ®Google Scholar
• KHOICHA R, ZIMMER MJ, WILSON SM, CHAMBERS AF: Up-regulation of TIMP-1 expression in B16-F10 mela-noma cells suppresses their metastatic ability in chick embryo. Clin. Exp. Metastasis (1992) 10:365–370.
   PubMed Web of Science ®Google Scholar
• ICHOICHA R: Suppression of the tu.morigenic and metas-tatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. J. Natl. Cancer Inst. (1994) 86:299–304.
   Google Scholar
• SCHLTLTZ RM, SILBERMAN S, PERSKY B, BAJKOWSKI AS,CARMICHAEL DF: Inhibition by human recombinant tissue inhibitor of metalloproteinases of human am-nion invasion and lung colonization by murine B-16E10 melanoma cells. Cancer Res. (1988) 48:5539–5545.
   PubMed Web of Science ®Google Scholar
• ALEXANDER CM, WERB Z: Targeted disruption of thetissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro. J. Cell Biöl. (1992) 118:727–739.
   PubMed Web of Science ®Google Scholar
• ICHOICHA R, WATERHOUSE P, YAGEL S, LALA PK, OVERALLCM, NORTON G, DENHARDT DT: Antisense RNA-induced reduction in metalloproteinase inhibitor causes mouse 3T3 cells to become tumorigenic. Science (1989) 243:947–950.
   PubMedGoogle Scholar
• MONTGOMERY AM, MUELLER BM, REISFELD RA, TAYLORSM, DECLERCK YA: Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. Cancer Res. (1994) 54:5467–73.
   PubMed Web of Science ®Google Scholar
• DECLERCK YA, PEREZ N, SHIMADA H, BOONE TC, LAN-GLEY RE, TAYLOR SM: Inhibition of invasion and metas-tasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res. (1992) 52:701–708.
   PubMed Web of Science ®Google Scholar
• NUOVO GJ, MACCONNELL PB, SIMSIR A, VALEA F, FRENCH DL: Correlation of the in situ detection of polymerase chain reaction-amplified metalloproteinase comple-mentary DNAs and their inhibitors with prognosis in cervical carcinoma. Cancer Res. (1995) 55:267–275.
   PubMed Web of Science ®Google Scholar
• MOHANAM S et al.: Expression of tissue inhibitors ofmetalloproteinases: negative regulators of human glioblastoma invasion in vivo. Clin . Exp. Metastasis (1995) 13:57–62.
   PubMed Web of Science ®Google Scholar
• ALBINI A, FONTANINI G, MASIELLO L, TACCHETTI C, BININI D, LUZZI P, NOONAN DM, STETLER-STEVENSON WG: Angiogenic potential in vivo by Kaposi's sarcoma cell-free supernatants and HIV-1 tat product: inhibition of KS-like lesions by tissue inhibitor of metalloprotei-nase-2. AIDS (1994) 8(9):1237–1244.
   PubMed Web of Science ®Google Scholar
• MIGNATTI P, ROBBINS E, RIFKIN DB: Tumor invasion through the human amnion membrane: requirement for a proteinase cascade. Cell (1986) 47:487–498.
   PubMed Web of Science ®Google Scholar
• BRAUNHUT SJ, MOSES MA: Retinoids modulate endothe- lial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP). J. Biol. Chem. (1994) 269:13472–13479.
   PubMed Web of Science ®Google Scholar
• WEIDNER N, CARROLL PR, FLAX J, BLUMENFEID W, FOLK- MAN J: Tumor angiogenesis correlates with metastasis In invasive prostate carcinoma. Am. J. Pathol. (1993) 143:401–409.
   PubMed Web of Science ®Google Scholar
• MOSES MA, SUDHALTER J, LANGER R: Identification of an Inhibitor of neovascularization from cartilage. Science (1990) 248:1408–1410.
   PubMed Web of Science ®Google Scholar
• MOSES MA, LANGER R: Inhibitors of angiogenesis. • Biotech. (1991) 9:630–634.
   PubMedGoogle Scholar
• MOSES MA, LANGER R: A metalloproteinase inhibitor asan inhibitor of neovascularization. J. Cell Biochem. (1991) 47:230–235.
   PubMed Web of Science ®Google Scholar
• TAKIGAWA M, NISHIDA Y, SUZUKI F, KISHI J, YAMASHITAK, HAYAKAWA T: Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2). Biochem. Biophys. Res. Commun. (1990) 171:1264–1271.
   PubMed Web of Science ®Google Scholar
• SCHNAPER FINV et al.: Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro. J. Cell Physiol. (1993) 156:235–246.
   PubMed Web of Science ®Google Scholar
• DAVIES B, BROWN PD, EAST N, CRIMMIN MJ, BALICWILL FR: A synthetic matrix metalloproteinase inhibitor de-creases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts [publish-ed erratum appears in Cancer Res 1993 Aug 1;53(15)36521. Cancer Res (1993) 53:2087–2091.
   PubMed Web of Science ®Google Scholar
• FALKSON G, GELMAN R, GLICK J, FALKSON CI, HARRIS J: Reinduction with the same cytostatic treatment in pa-tients with metastatic breast cancer: an Eastern Coop-erative Oncology Group study. J. din. Oncol. (1994) 12:45–49.
   PubMed Web of Science ®Google Scholar
• HUYNH HT, TETENES E, WALLACE L, POLLAK M: In vivo inhibition of insulin-like growth factor I gene expres-sion by tamoxifen. Cancer Res. (1993) 53:1727–1730.
   PubMed Web of Science ®Google Scholar
• TEICHER BA, HOLDEN SA, ARA G, SOTOMAYOR EA, HUANG ZD, CHEN YN, BREM H: Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int. J. Cancer (1994) 57:920–925.
   PubMed Web of Science ®Google Scholar
• WANG X, FU X, BROWN PD, CR1MMIN MJ, HOFFMAN RM: Matrix metalloproteinase inhibitor BB-94 (batimastat) Inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. (1994) 54:4726–4728.
   PubMed Web of Science ®Google Scholar
• SLEDGE GWJ, QULALI M, GOULET R, BONE EA, FIFE R: Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice. J. Natl. Cancer Inst. (1995) 87:1546–1550.
   PubMed Web of Science ®Google Scholar
• TARABOLETTI G, GAROFALO A, BELOTTI D, DRUDIS T, BORSOTTI P, SCANZIANI E, BROWN PD, GIAVAZZI R: Inhibition of angiogenesis and murine hemangloma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases. J. Natl. Cancer Inst. (1995) 87:293–298.
   PubMed Web of Science ®Google Scholar
• DRUMMOND All, BEC10ETT P, BOONE EA, BROWN PD, DAVIS M, GALLOWAY WA, TAUPIN P, WOOD LM, DAVID-SON All: BB2516: an orally bloavallable matrix metallo-proteinase inhibitor with efficacy in animal cancer models. Proc. Am. Assoc. Cancer Res. (1995) 36:100.
   Google Scholar
• NAITO K, KANBAYASHI N, NAKAJIMA S, MURAI T, ARAK-AWA K, NISHIMURA S, OKUYAMA A: Inhibition of growth of human tumor cells in nude mice by a metalloprote-inase inhibitor. Intl. Cancer (1994) 58:730–735.
   PubMedGoogle Scholar
• OKUYAMA A, NAITO K, MORISHIMA H, SUDA H, NISHIMURA S, TANAKA N: Inhibition of growth of hu-man tumor cells in nude mice by a metalloproteinase Inhibitor. Ann. NY Acad. Sci. (1994) 732:408–410.
   PubMed Web of Science ®Google Scholar
• TRESSLER RJ, WEE J, SUMMERS B, GALARDY R: Galardin, a potent metalloproteinase inhibitor, prolongs survival time in a B16-F10 melanoma experimental metastasis model. din. K. Metastasis (1994) 12:28.
   Google Scholar
• BOGHAERT ER, CHAN SK, ZIMMER C, GROBELNEY D, GALARDY RE, VANAMAN TC, ZIMMER SG: Inhibition of collagenolytic activity relates to quantitative reduction of invasion in vitro in a c-Ha-ras transfected glial cell line. J. Neuro-Oncol. (1994) 21:141–150.
   PubMed Web of Science ®Google Scholar
• GALARDY RE, GROBELNY D, GOELLMER HG, FERNANDEZ LA: Inhibition of angiogenesis by the matrix metallo-protease inhibitor N-12R-2-(hydroxyatruldocarbonyl- methy0-4-methylpentanoy01-E-tryptophan methy-lamide. Cancer Res. (1994) 54:4715–4718.
   PubMed Web of Science ®Google Scholar
• HODGSON J: Remodeling MMPLs. Biorechnology (1995) 13:554–557.
   PubMedGoogle Scholar
• BEELEY NRA, ANSELL PRJ, DOCHERTY AP: Inhibitors of matrix metalloproteinases (MMPIs). Curr. Opin. Ther. Patents (1994) 4:7–16.
   Google Scholar
• DOCHERTY AJP et al.: Gelatinase inhibitors for the treatment of cancer. air". Exp. Metastasis (1994) 12: 12.
   Google Scholar
• STETLER-STEVENSON WG, KRUTZSCH WG, WACHER MP, MARGUILIES IMK, LIOTTA LA: The activation of human type IV collagenase proenzyme. J. Biol. Chem. (1989) 264:1353–1356.
   PubMed Web of Science ®Google Scholar
• STETLER-STEVENSON WG, TALANO JA, GALLAGHER ME, KRUTZSCH HC, LIOTTA LA: Inhibition of human type IV collagenase by a highly conserved peptide sequence derived from its prosegment. Am. J. Med. Sci. (1991) 302:163–170.
   PubMed Web of Science ®Google Scholar
• VAN WART H, BIRKEDAL HEE The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metal-loproteinase gene family. Proc. Natl. Acad. Sci. USA (1990) 87:5578–5582.
   PubMed Web of Science ®Google Scholar
• SANCHEZ-LOPEZ R, NICHOLSON R, GESNEL M-C, MA-'FRISIAN LM, BREATHNACH R: Structure-function rela-tionships in the collagenase gene family member transit'. J. Biol. Chem. (1988) 263:11892–11899.
   PubMedGoogle Scholar
• MUIR D: Metalloproteinase-dependent neurite out-growth within a synthetic extracellular matrix is in-duced by nerve growth factor. Exp. Cell Res. (1994) 210:243–252.
   PubMed Web of Science ®Google Scholar
• BENELLI R, ADATIA R, ENSOLI B, STETLER-STEVENSON WG, SANT1 L, ALBINI A: Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic ther-apy. Oncol. Res. (1994) 6:251–257.
   PubMed Web of Science ®Google Scholar
• HANGLOW AC, LUGO A, WALSKY R, VISNICK M, COFFEY JW, FOTOUBI N: Inhibition of human stromelysin by peptides based on the N-terminal domain of tissue Inhibitor of metalloproteinase-1. Biochem. Biophys. Res. Commun. (1994) 205:1156–1163.
   PubMed Web of Science ®Google Scholar
• HANGLOW AC, LUGO A, WALSKY R, FINCH-ARIETTA M, LUSCH L, VISNICK M, FOTOUHI N: Peptides based on the conserved predomain sequence of matrix metallopro-teinases inhibit human stromelysin and collagenase. Agents Actions (1993) 39(Sup pl.) :C 148–150.
   Google Scholar
• FOTOUHI N, LUGO A, VISNICK M, LUSCH L, WALSKY R, COFFEY, HANGLOW AC: Potent peptide inhibitors of stromelysin based on the prodomain region of matrix metalloproteinases. J. Biol. Chem. (1994) 269:30227–30231.
   PubMed Web of Science ®Google Scholar
• KELLOFF GJ, BOONE CW, STEELE VK, PERLOFF M, CROW-ELL J, DOODY LA: Development of chemopreventive agents for lung and upper aerodigesthre tract cancers. J. Cell. Biochem. (Suppl.) (1993) 17F:2–17.
   PubMedGoogle Scholar
• DE FLORA S, izzoTri A, D'AGOSTINI F, CESARONE CF: Antioxidant activity and other mechAnism of thiols in chemoprevention of mutation and can. Am. J. Med. (1991) 91(Suppl. 3C):122–130.
   Google Scholar
• DE FLORA S, IZZOTTI A, D'AGOSTINI F, BALANSKY RM, CESARONE CF: Chemopreventive properties of N-acetyl- eysteine and other thiols. In: Cancer Chemoprevention. Wattenberg L et al. (Eds.), CRC Press, Boca Raton (1992)183–194.
   Google Scholar
• DE FLORA S, BALANSKY R, BENNICELLI C, CAMOIRANO A, D'AGOSTINI F, IZZOTTI A, CESARONE CF: Mechanisms of anticarcinogenesis: the example of N-acetylcysteine. In: Drugs, Diet and Disease, Volume 1: Mechanistic Approaches to Cancer. Ioannides C (Ed.), Prentice Hall, Hemel Hempstead, Herts, UK (1994):151–203.
   Google Scholar
• ALBINI A, D'AGOSTIN1 FD, GIUNCIUGLIO D, PAGLIERI I, BALANSICY R, DE FLORA S: Inhibition of invasion, gelat-inase activity, tumor take and metastasis of malignant cells by N-acetylcysteine. Int.J. Cancer (1995) 61:121–129.
   PubMed Web of Science ®Google Scholar
• BERGELSON S, PINKUS R, DANIEL V: Intracellular glu-tathione levels regulate fos/jun induction and activa-tion of glutathione S-transferase gene expression. Cancer Res. (1994) 54:36–40.
   PubMed Web of Science ®Google Scholar
• KHOICHA R, WATERHOUSE P, LALA P, ZIMMER M, DEN-HARDT DT: Increased proteinase expression during tumor progression of tissue inhibitor of metalloprote-inases cell lines down-modulated for levels - A new transformation paradigm. J. Cancer Res. Clin. Oncol. (1991) 117:333–338.
   PubMed Web of Science ®Google Scholar