Ongoing and planned clinical trials of anti-arrhythmic drugs: an update

Bibliography

• SCHRON EB, FRIEDMAN LM, GREENE HL: Ongoing and planned clinical trials of antiarrhythmic drugs. Exp. Opin. Invest. Drugs (1995) 4:215–221.
   Google Scholar
• TEO KK, YUSUF S, FURBERG CD: Effects of prophylactic antiarrhythmic drug therapy in acute myocardial in-farction. An overview of results from randomized con-trolled trials. JAMA (1993) 270:1589–1595.
   Google Scholar
• •Though several years old, this overview is a good report of clinical trials of antiarrhythmic agents.
   Google Scholar
• SINGH SN, FLETCHER RD, FISHER SG et al. FOR THE SUR-VIVAL TRIAL OF ANTIARRHYTHMIC THERAPY IN CON-GESTIVE HEART FAILURE: Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. New Engl. J. Med. (1995) 333:77–82.
   PubMed Web of Science ®Google Scholar
• THE CASCADE INVESTIGATORS: Randomized antiar-rhythmic drug therapy in survivors of cardiac arrest (the CASCADE Study). Am. J. Cardiol (1993) 72:280–287.
   PubMed Web of Science ®Google Scholar
• CEREMUZYNSKI L, KLECZAR E, KRZEMINSKA-PAKULA M et al: Effect of amiodarone on mortality after myocar-dial infarction: a double-blind placebo-controlled pi-lot study. J. Am. Coll. Cardiol. (1992) 20:1056–1062.
   PubMed Web of Science ®Google Scholar
• DOVAL HC, NUL DR, GRANCELLI HO et al: Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA): randomized trial of low dose amiodarone in severe congestive heart failure. Lancet (1994) 344:493–498.
   PubMed Web of Science ®Google Scholar
• PFISTERER ME, KIOWSKI W, BRUNNER H, BURCKHARDT D, BURKART F: Long-term benefit of 1 year amiodarone treatment for persistent complex ventricular arrhyth-mias after myocardial infarction. Circulation (1993) 87:309–311.
   PubMed Web of Science ®Google Scholar
• THE AVID INVESTIGATORS: Antiarrhythmics VersusImplantable Defibrillators (AVID) - rationale, design, and methods. Am. J. Cardiol. (1995) 75:470–475.
   PubMed Web of Science ®Google Scholar
• THE ANTI-ARRHYTHMICS VERSUS IMPLANTABLE DEFI-BRILLATORS (AVID) INVESTIGATORS: A comparison of antiarrhythmic-drug therapy with implantable defi- rillators in patients resuscitated from near-fatal ven-tricular arrhythmias. New Engl. J. Med. (1997) 337:1576–1583.
   PubMed Web of Science ®Google Scholar
• •This trial of ICD versus AAD in VF/VT survivors demon-strated better survival in the ICD group.
   Google Scholar
• JENKINS LS, STEINBERG JS, KUTALEK SP et al.: Quality oflife in patients enrolled in the Antiarrhythmics Versus Implantable Defibrillators (AVID) Trial. Circulation (1997) 96:1–439.
   Google Scholar
• LARSEN GC, MCANULTY JH, HALLSTROM A et al.: Hospi-talization charges in the Antiarrhythmics Versus Im-plantable Defibrillators (AVID) trial; the AVID economic analysis study. Circulation (1997) 96:1–77.
   Google Scholar
• SIEBELS J, KUCK K-H: Implantable cardioverter defibril-lator compared with antiarrhythmic drug treatment in cardiac arrest survivors (the Cardiac Arrest Study Hamburg). Am. Heart J. (1994) 127:1139–1144.
   PubMed Web of Science ®Google Scholar
• CONNOLLY SJ, GENT M, ROBERTS RS et al.: Canadian Im-plantable Defibrillator Study (CIDS): study design and organization. Am. J. Cardiol. (1993) 72:103F–108F.
   Google Scholar
• MOSS AJ, HALL WJ, CANNOM DS et al. FOR THE MULTI-CENTER AUTOMATIC DEFIBRILLATOR IMPLANTATION TRIAL INVESTIGATORS: Improved survival with an im-plantable defibrillator in patients with coronary dis-ease at high risk for ventricular arrhythmia. New Engl. J. Med. (1996) 335:1933–1940.
   PubMed Web of Science ®Google Scholar
• •Trial of ICD versus conventional therapy in high-risk post-MI patients reported a survival benefit for the ICD arm.
   Google Scholar
• MYERBURG RJ, CASTELLANOS A: Clinical trials of im-plantable defibrillators. New EngI J. Med. (1997) 337:1621–1623.
   PubMed Web of Science ®Google Scholar
• BIGGER JT, Jr, FOR THE CORONARY ARTERY BYPASS GRAFT (CABG) PATCH TRIAL INVESTIGATORS: Prophy-lactic use of implanted cardiac defibrillators in pa-tients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery. New Engl. J. Med. (1997) 337:1509–1575.
   Google Scholar
• BUXTON AE, FISHER JD, JOSEPHSON ME et al. FOR THEMUSTT INVESTIGATORS: Prevention of sudden death in patients with coronary artery disease: the Multicenter Unsustained Tachycardia Trial (MUSTT). Frog. Cardio-vasc. Dis. (1993) 36:215–226.
   PubMed Web of Science ®Google Scholar
• CAIRNS JA, CONNOLLY SJ, ROBERTS R, GENT M FOR THECANADIAN AMIODARONE MYOCARDIAL INFARCTION ARRHYTHMIA TRIAL INVESTIGATORS: Randomized trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature de-polarisations: CAMIAT. Lancet (1997) 349:675–682.
   PubMed Web of Science ®Google Scholar
• JULIAN DG, CAMM AJ, FRANGIN G et al. FOR THE EURO-PEAN MYOCARDIAL INFARCT AMIODARONE TRIAL IN-VESTIGATORS: Randomized trial of the effect of amiodarone on mortality in patients with left ven-tricular dysfunction after recent myocardial infarc-tion: EMIAT. Lancet (1997) 349:667–674.
   PubMed Web of Science ®Google Scholar
• KUDENCHUK PJ: American Heart Association, 70th Scien-tific Session. Orlando, FL (November 1997).
   Google Scholar
• ELIZARI M, MARTINEZ JM, BELZITI C et al.: Mortality fol-lowing early administration of amiodarone in acute myocardial infarction. Results of GEMICA trial. Circu-lation (1996) 94:1–90.
   PubMedGoogle Scholar
• AMIODARONE TRIALS META-ANALYSIS INVESTIGATORS: Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 pa-tients in randomised trials. Lancet (1997) 350:1417–1424.
   PubMed Web of Science ®Google Scholar
• ••Recent overview of amiodarone trials in CHF and post-MIpatients.
   Google Scholar
• WALDO AL, CAMM AJ, DERUYTER H et al. FOR THE SWORD INVESTIGATORS: Effect of d-sotalol on mortal-ity in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet (1996) 348:7–12.
   PubMed Web of Science ®Google Scholar
• •Trial of class III agent showing harm in CHF and MI patients.
   Google Scholar
• MOLLER M: European Society of Cardiology Meeting. Stock-holm, Sweden (August 1997).
   Google Scholar
• BLOCH-THOMSEN PE: American Heart Association, 70th Scientific Session. Orlando, FL (November 1997).
   Google Scholar
• DOMANSKI MJ, ZIPES DP, SCHRON E: Treatment of sud-den cardiac death. Current understandings from ran-domized trials and future research directions. Circulation (1997) 95:2694–2699.
   Google Scholar
• ROSEN MR: Consequences of the Silician gambit. Eur. Heart J. (1995) (Suppl. G):32–36.
   Google Scholar
• MYERBURG RJ, KESSLER KM, CASTELLANOS A: Epidemi-ology of sudden cardiac death: population characteris-tics, conditioning risk factors, and dynamic risk factors. In: Ion Channels in the Cardiovascular System: Function and Dysfunction. Spooner PM, Brown AM (Eds.), Futura Publications (1994).
   Google Scholar
• MEMBERS OF THE SICILIAN GAMBIT: The search for novel antiarrhythmic strategies 2: clinical scientific is-sues. Eur. Heart1 (1998). (In Press.)
   Google Scholar