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Review

Interstitial cystitis: bladder pain and beyond

, MS MPhil PhD MD, , MD, , MD MS, , MD & , MD MPH
Pages 2979-2994 | Published online: 12 Nov 2008

Bibliography

  • Hanno PM. Painful bladder syndrome. In: Wein AJ, Kavossi LR, Novick AC, Partin AW, Peters CA ,editors,. Campbell's Urology, 9th edition. Philadelphia: Elsevier, 2007. p. 330-70
  • Phatak S, Foster HE Jr. The management of interstitial cystitis: an update. Nat Clin Pract Urol 2006;3(1):45-53
  • Theoharides TC. Treatment approaches for painful bladder syndrome/interstitial cystitis. Drugs 2007;67(2):215-35
  • Nickel JC. Interstitial cystitis: a chronic pelvic pain syndrome. Med Clin N Am 2004;88:467-81
  • Lukban JC, Whitmore KE, Sant GR. Current management of interstitial cystitis. Urol Clin N Am 2002;29:649-60
  • Hanno P, Nordling J, Van OA. What is new in bladder pain syndrome/interstitial cystitis? Curr Opin Urol 2008;18(4):353-8
  • Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Am J Obstet Gynecol 2002;187(1):116-26
  • Hanno P, Keay S, Moldwin R, Van OA. International consultation on IC – Rome, September 2004/Forging an international consensus: progress in painful bladder syndrome/interstitial cystitis. Report and abstracts. Int Urogynecol J Pelvic Floor Dysfunct 2005;16(Suppl 1):S2-34
  • Van De Merwe JP, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol 2008;53(1):60-7
  • Fitzgerald MP, Brensinger C, Brubaker L, Propert K. What is the pain of interstitial cystitis like? Int Urogynecol J Pelvic Floor Dysfunct 2006;17(1):69-72
  • Warren JW, Langenberg P, Greenberg P, et al. Sites of pain from interstitial cystitis/painful bladder syndrome. J Urol 2008;180(4):1373-7
  • Ness TJ, Powell-Boone T, Cannon R, et al. Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis. J Urol 2005;173:1983-7
  • Ottem DP, Teichman JM. What is the value of cystoscopy with hydrodistension for interstitial cystitis? Urology 2005;66(3):494-9
  • Abrams P, Baranowski A, Berger RE, et al. A new classification is needed for pelvic pain syndromes – are existing terminologies of spurious diagnostic authority bad for patients? J Urol 2006;175(6):1989-90
  • Kusek JW, Nyberg LM. The epidemiology of interstitial cystitis: is it time to expand our definition? Urology 2001;57:95-9
  • Forrest JB, Schmidt S. Interstitial cystitis, chronic nonbacterial prostatitis and chronic pelvic pain syndrome in men: a common and frequently identical clinical entity. J Urol 2004;172:2561-2
  • Lamale LM, Lutgendrof SK, Hoffman AN, Kreder KJ. Symptoms and cystoscopic findings in patients with untreated interstitial cystitis. Urology 2006;67:242-5
  • Diggs C, Meyer WA, Langenberg P, et al. Assessing urgency in interstitial cystitis/painful bladder syndrome. Urology 2007;69(2):210-4
  • Lutgendorf SK, Kreder KJ, Rothrock NE, et al. Stress and symptomatology in patients with interstitial cystitis: a laboratory stress model. J Urol 2000;164:1265-9
  • Kennedy CM, Bradley CS, Galask RP, Nygaard IE. Risk factors for painful bladder syndrome in women seeking gynecologic care. Int Urogynecol J Pelvic Floor Dysfunct 2006;17(1):73-8
  • Nguan C, Franciosi LG, Butterfield NN, et al. A prospective, double-blind, randomized cross-over study evaluating changes in urinary pH for relieving the symptoms of interstitial cystitis. BJU Int 2005;95:91-4
  • Warren JW, Brown J, Tracy JK, et al. Evidence-based criteria for pain of interstitial cystitis/painful bladder syndrome in women. Urology 2008;71(3):444-8
  • Minaglia S, Ozel B, Bizhang R, Mishell DR Jr. Increased prevalence of interstitial cystitis in women with detrusor overactivity refractory to anticholinergic therapy. Urology 2005;66(4):702-6
  • Koziol JA, Clark DC, Gittes RF, Tan EM. The natural history of interstitial cystitis: a survey of 374 patients. J Urol 1993;149:465-9
  • Alagiri M, Chottiner S, Ratner V, et al. Interstitial cystitis: unexplained associations with other chronic disease and pain syndromes. Urology 1997;49:52-7
  • Erickson DR, Morgan KC, Ordille S, et al. Nonbladder related symptoms in patients with interstitial cystitis. J Urol 2001;166:557-62
  • Peeker R, Atansiu L, Logadottir Y. Intercurrent autoimmune conditions in classic and non-ulcer interstitial cystitis. Scand J Urol Nephrol 2003;137:60-3
  • Aaron LA, Buchwald D. A review of the evidence for overlap among unexplained clinical conditions. Ann Intern Med 2001;134(Part 2):868-81
  • Clauw DJ, Schmidt M, Radulovic D, et al. The relationship between fibromyalgia and interstitial cystitis. J Psychiatr Res 1997;31:125-31
  • Yamada T. Significance of complications of allergic diseases in young patients with interstitial cystitis. Int J Urol 2003;10(Suppl):S56-8
  • Stanford EJ, Koziol J, Feng A. The prevalence of interstitial cystitis, endometriosis, adhesions, and vulvar pain in women with chronic pelvic pain. J Minim Invasive Gynecol 2005;12:43-9
  • Novi JM, Jeronis S, Srinivas S, et al. Risk of irritable bowel syndrome and depression in women with interstitial cystitis: a case–control study. J Urol 2005;174(3):937-40
  • Peters K, Girdler B, Carrico D, et al. Painful bladder syndrome/interstitial cystitis and vulvodynia: a clinical correlation. Int Urogynecol J Pelvic Floor Dysfunct 2008;19(5):665-9
  • Aaron LA, Herrell R, Ashton S, et al. Comorbid clinical conditions in chronic fatigue: a co-twin control study. J Gen Intern Med 2001;16:24-31
  • Wu EQ, Birnbaum H, Mareva M, et al. Interstitial cystitis: cost, treatment and co-morbidities in an employed population. Pharmacoeconomics 2006;24(1):55-65
  • Clemens JQ, Brown SO, Calhoun EA. Mental health diagnoses in patients with interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome: a case/control study. J Urol 2008;180(4):1378-82
  • Weissman MM, Gross R, Fyer A, et al. Interstitial cystitis and panic disorder: a potential genetic syndrome. Arch Gen Psychiatry 2004;61:273-9
  • Clemens JQ, Meenan RT, Rosetti MC, et al. Prevalence and incidence of interstitial cystitis in a managed care population. J Urol 2005;173:98-102
  • Leppilahti M, Sairanen J, Tammela TL, et al. Prevalence of clinically confirmed interstitial cystitis in women: a population based study in Finland. J Urol 2005;174(2):581-3
  • Temml C, Wehrberger C, Riedl C, et al. Prevalence and correlates for interstitial cystitis symptoms in women participating in a health screening project. Eur Urol 2006;51(803):809
  • Rosenberg MT, Hazzard M. Prevalence of interstitial cystitis symptoms in women: a population based study in the primary care office. J Urol 2005;174(6):2231-4
  • Ibrahim IA, Diokno AC, Killinger KA, et al. Prevalence of self-reported interstitial cystitis (IC) and interstitial-cystitis-like symptoms among adult women in the community. Int Urol Nephrol 2007;39(2):489-95
  • Shear S, Mayer R. Development of glomerulations in younger women with interstitial cystitis. Urology 2006;68(2):253-6
  • Nordling J, Anjum FH, Bade JJ, et al. Primary evaluation of patients suspected of having interstitial cystitis (IC). Eur Urol 2004;45(5):662-9
  • Erickson DR, Tomaszewski JE, Kunselman AR, et al. Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis? J Urol 2005;173:93-7
  • Latthe P, Mignini L, Gray R, et al. Factors predisposing women to chronic pelvic pain: systematic review. BMJ 2006;332(7544):749-55
  • Peters KM, Kalinowski SE, Carrico DJ, et al. Fact or fiction – is abuse prevalent in patients with interstitial cystitis? Results from a community survey and clinic population. J Urol 2007;178(3 Part 1):891-5
  • Peters KM, Carrico DJ, Ibrahim IA, Diokno AC. Characterization of a clinical cohort of 87 women with interstitial cystitis/painful bladder syndrome. Urology 2008;71:634-40
  • O'leary MP, Sant GR, Fowler FJ, JR, et al. The interstitial cystitis symptom index and problem index. Urology 1997;49(Suppl 5A):58-63
  • Sirinian E, Azevedo K, Payne CK. Correlation between 2 interstitial cystitis symptom instruments. J Urol 2005;173:835-40
  • Propert KJ, Mayer RD, Wang Y, et al. Responsiveness of symptom scales for interstitial cystitis. Urology 2006;67(1):55-9
  • Parsons CL, Dell J, Stanford EJ, et al. Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity. Urology 2002;60:573-8
  • Erickson DR, Xie SX, Bhavanandan VP, et al. A comparison of multiple urine markers for interstitial cystitis. J Urol 2002;167:2461-9
  • Wilkinson DR, Erickson AD. Urinary and serologic markers for interstitial cystitis: an update. Curr Urol Rep 2006;7(5):414-22
  • El-Mansoury M, Boucher W, Sant GR, Theoharides TC. Increased urine histamine and methylhistamine in interstitial cystitis. J Urol 1994;152:350-3
  • Boucher W, El-Mansoury M, Pang X, et al. Elevated mast cell tryptase in urine of interstitial cystitis patients. Br J Urol 1995;76:94-100
  • Felsen D, Frye S, Trimble LA, et al. Inflammatory mediator profile in urine and bladder wash fluid of patients with interstitial cystitis. Urology 1994;152:355-61
  • Lotz M, Villiger P, Hugli T, et al. Interleukin-6 and interstitial cystitis. J Urol 1994;152:869-73
  • Erickson DR, Belchis DA, Dabbs DJ. Inflammatory cell types and clinical features of interstitial cystitis. Urology 1997;158:790-3
  • Keay SK, Zhang CO, Shoenfelt J, et al. Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis. Urology 2001;57:9-14
  • Keay SK, Szekely Z, Conrads TP, et al. An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci USA 2004;101:11803-8
  • Zhang CO, Li ZL, Kong CZ. APF, HB-EGF, and EGF biomarkers in patients with ulcerative vs. non-ulcerative interstitial cystitis. BMC Urol 2005;5(1):7
  • Lamale LM, Lutgendorf SK, Hoffman AN, Kreder KJ. Symptoms and cystoscopic findings in patients with untreated interstitial cystitis. Urology 2006;67(2):242-5
  • Wei DC, Politano VA, Selzer MG, Lokeshwar VB. The association of elevated urinary total to sulfated glycosaminoglycan ratio and high molecular mass hyaluronic acid with interstitial cystitis. J Urol 2000;163:1577-83
  • Erickson DR, Sheykhnazari M, Ordille S, Bhavanandan VP. Increased urinary hyaluronic acid and interstitial cystitis. J Urol 1998;160:1282-4
  • Moskowitz MO, Byrne DS, Callahan HJ, et al. Decreased expression of a glycoprotein component of bladder surface mucin (GP1) in interestitial cystitis. J Urol 1994;151:343-5
  • Lokeshwar VB, Selzer MG, Cerwinka WH, et al. Urinary uronate and sulfated glycosaminoglycan levels: markers for interstitial cystitis severity. J Urol 2005;174(1):344-9
  • Abdel-Mageed AB, Ghoniem GM. Potential role of rel/nuclear factor-kappaB in the pathogenesis of interstitial cystitis. J Urol 1998;160(6 Part 1):2000-3
  • Erickson DR, Kunselman AR, Bentley CM, et al. Changes in urine markers and symptoms after bladder distension for interstitial cystitis. J Urol 2007;117(2):556-60
  • Erickson DR, Tomaszewski JE, Kunselman AR, et al. Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome. J Urol 2008;179(5):1850-6
  • Logadottir YR, Ehren I, Fall M, et al. Intravesical nitric oxide production discriminates between classic and nonulcer interstitial cystitis. J Urol 2004;171:1148-50
  • Smith SD, Wheeler MA, Foster HE, JR, Weiss RM. Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections. J Urol 1996;155:1432-5
  • Koskela LR, Thiel T, Ehren I, et al. Localization and expression of inducible nitric oxide synthase in biopsies from patients with interstitial cystitis. J Urol 2008;180(2):737-41
  • Hanno P. Is the potassium sensitivity test a valid and useful test for the diagnosis of interstitial cystitis? Against Int Urogynecol J Pelvic Floor Dysfunct 2005;16(6):428-9
  • Braunstein R, Shapiro E, Kaye J, Moldwin R. The role of cystoscopy in the diagnosis of Hunner's ulcer disease. J Urol 2008;180(4):1383-6
  • Bade J, Ishizuka O, Yoshida M. Future research needs for the definition/diagnosis of interstitial cystitis. Int J Urol 2003;10(Suppl):S31-4
  • Waxman JA, Sulak PJ, Kuehl TJ. Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation. J Urol 1998;160:1663-7
  • Leiby BE, Landis JR, Propert KJ, Tomaszewski JE. Discovery of morphological subgroups that correlate with severity of symptoms in interstitial cystitis: a proposed biopsy classification system. J Urol 2007;177(1):142-8
  • Tomaszewski JE, Landis JR, Russack V, et al. Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study. Urology 2001;57(Suppl. 6A):67-81
  • Larsen MS, Mortensen S, Nordling J, Horn T. Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis. BJU Int 2008;102(2):204-7
  • Theoharides TC, Pang X, Letourneau R, Sant GR. Interstitial cystitis: a neuroimmunoendocrine disorder. Ann NY Acad Sci 1998;840:619-34
  • Theoharides TC, Cochrane DE. Critical role of mast cells in inflammatory diseases and the effect of acute stress. J Neuroimmunol 2004;146:1-12
  • Warren JW, Jackson TL, Langenberg P, et al. Prevalence of interstitial cystitis in first-degree relatives of patients with interstitial cystitis. Urology 2004;63:17-21
  • Warren JW, Keay SK, Meyers D, Xu J. Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs. Urology 2001;57:22-5
  • Al-Hadithi HN, Williams H, Hart CA, et al. Absence of bacterial and viral DNA in bladder biopsies from patients with interstitial cystitis/chronic pelvic pain syndrome. J Urol 2005;174(1):151-4
  • Mayerhofer M, Aichberger KJ, Florian S, Valent P. Recognition sites for microbes and components of the immune system on human mast cells: relationship to CD antigens and implications for host defense. Int J Immunopathol Pharmacol 2007;20(3):421-34
  • Lundeberg T, Liedberg H, Nordling L, et al. Interstitial cystitis: correlation with nerve fibres, mast cells and histamine. Br J Urol 1993;71:427-9
  • Pang X, Marchand J, Sant GR, et al. Increased number of substance P positive nerve fibers in interstitial cystitis. Br J Urol 1995;75:744-50
  • Sant GR, Kempuraj D, Marchand JE, Theoharides TC. The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology 2007;69(Suppl 4A):34-40
  • Peeker R, Enerbäck L, Fall M, Aldenborg F. Recruitment, distribution and phenotypes of mast cells in interstitial cystitis. Urology 2000;163:1009-15
  • Theoharides TC, Sant GR, El-Mansoury M, et al. Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study. J Urol 1995;153:629-36
  • Bouchelouche K, Alvarez S, Andersen L, et al. Monocyte chemoattractant protein-1 production by human detrusor smooth muscle cells. J Urol 2004;171(1):462-6
  • Conti P, Pang X, Boucher W, et al. Impact of Rantes and MCP-1 chemokines on in vivo basophilic mast cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase. Blood 1997;89:4120-7
  • Pang X, Sant GR, Theoharides TC. Altered expression of bladder mast cell growth factor receptor (c-kit) expression in interstitial cystitis. Urology 1998;51:939-44
  • Cao J, Papadopoulou N, Kempuraj D, et al. Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol 2005;174:7665-75
  • Tamaki M, Saito R, Ogawa O, et al. Possible mechanisms inducing glomerulations in interstitial cystitis: relationship between endoscopic findings and expression of angiogenic growth factors. J Urol 2004;172:945-8
  • He S, Walls AF. Human mast cell tryptase: a stimulus of microvascular leakage and mast cell activation. Eur J Pharmacol 1997;328:89-97
  • Batler RA, Sengupta S, Forrestal SG, et al. Mast cell activation triggers a urothelial inflammatory response mediated by tumor necrosis factor-alpha. J Urol 2002;168:819-25
  • Parsons CL, Lilly JD, Stein P. Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis). J Urol 1991;145:732-5
  • Chelsky MJ, Rosen SI, Knight LC, et al. Bladder permeability in interstitial cystitis is similar to that of normal volunteers: direct measurement by transvesical absorption of 99mtechnetium-diethylenetriaminepentaacetic acid. J Urol 1994;151:346-9
  • Parsons CL, Greene RA, Chung M, et al. Abnormal urinary potassium metabolism in patients with interstitial cystitis. J Urol 2005;173:1182-5
  • Erickson DR, Ordille S, Martin A, Bhavanandan VP. Urinary chondroitin sulfates, heparan sulfate and total sulfated glycosaminoglycans in interstitial cystitis. J Urol 1997;157:61-4
  • Theoharides TC, Sant GR. Neuroimmune connections and regulation of function in the urinary bladder In: Bienenstock J, Goetzl E, Blennerhassett M, editors. Lausanne: Hardwood Academic Publishers, Auton Neuroimmunol 2003; p. 345-69
  • Pinter E, Szolcsanyi J. Plasma extravasation in the skin and pelvic organs evoked by antidromic stimulation of the lumbosacral dorsal roots of the rat. Neuroscience 1995;68:603-14
  • Jasmin L, Janni G, Ohara PT, Rabkin SD. CNS induced neurogenic cystitis is associated with bladder mast cell degranulation in the rat. J Urol 2000;164:852-5
  • Saban R, Saban MR, Nguyen NB, et al. Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. Am J Pathol 2000;156:775-80
  • Suzuki R, Furuno T, Mckay DM, et al. Direct neurite-mast cell communication in vitro occurs via the neuropeptide substance P. J Immunol 1999;163:2410-5
  • Spanos C, Pang X, Ligris K, et al. Stress-induced bladder mast cell activation: implications for interstitial cystitis. J Urol 1997;157:669-72
  • Ercan F, San T, Cavdar S. The effects of cold-restraint stress on urinary bladder wall compared with interstitial cystitis morphology. Urol Res 1999;27:454-61
  • Kawatani M, Suzuki T, De Groat WC. Corticotropin releasing factor-like immunoreactivity in afferent projections to the sacral spinal cord of the cat. J Auton Nerv Syst 1996;61(3):218-26
  • Theoharides TC, Singh LK, Boucher W, et al. Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its pro-inflammatory effects. Endocrinology 1998;139:403-13
  • Clifton VL, Crompton R, Smith R, Wright IM. Microvascular effects of CRH in human skin vary in relation to gender. J Clin Endocrinol Metab 2002;87:267-70
  • Cao J, Boucher W, Donelan JM, Theoharides TC. Acute stress and intravesical corticotropin-releasing hormone induces mast cell-dependent vascular endothelial growth factor release from mouse bladder explants. J Urol 2006;176:1208-13
  • Klausner AP, Steers WD. Corticotropin releasing factor: a mediator of emotional influences on bladder function. J Urol 2004;172:2570-3
  • Buffington CA. Comorbidity of interstitial cystitis with other unexplained conditions. J Urol 2004;172:1242-8
  • Theoharides TC, Sant GR. New agents for the medical treatment of interstitial cystitis. Exp Opin Invest Drugs 2001;10:521-46
  • Rovner E, Propert KJ, Brensinger C, et al. Treatments used in women with interstitial cystitis: the Interstitial Cystitis Data Base (ICDB) Study experience. Urology 2000;56:940-5
  • Dimitrakov J, Kroenke K, Steers WD, et al. Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med 2007;167(18):1922-9
  • Mulholland SG, Hanno PM, Parsons CL, et al. Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study. Urology 1990;35:552-8
  • Parsons CL, Benson G, Childs SJ, et al. A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate. J Urol 1993;150:845-8
  • Hwang P, Auclair B, Beechinor D, et al. Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis. Urology 1997;50:39-43
  • Sant GR, Propert KJ, Hanno PM, et al. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. J Urol 2003;170:810-5
  • Nickel JC, Barkin J, Forrest J, et al. Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis. Urology 2005;65:654-68
  • Sairanen J, Tammela TL, Leppilahti M, et al. Cyclosporin A and pentosan polysulfate sodium for the treatment of interstitial cystitis: a randomized comparative study. J Urol 2005;174(6):2235-8
  • Minogiannis P, El-Mansoury M, Betances JA, et al. Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol 1998;20:553-63
  • Theoharides TC. Hydroxyzine for interstitial cystitis. J Allergy Clin Immunol 1993;91:686-7
  • Theoharides TC, Sant GR. Hydroxyzine therapy for interstitial cystitis. Urology 1997;49(Suppl):108-10
  • Thilagarajah R, Witherow RO, Walker MM. Oral cimetidine gives effective symptom relief in painful bladder disease: a prospective, randomized, double-blind placebo-controlled trial. BJU Int 2001;87:207-12
  • Kelly JD, Young MR, Johnston SR, Keane PF. Clinical response to an oral prostaglandin analogue in patients with interstitial cystitis. Eur Urol 1998;34:53-6
  • Hanno PM, Buehler J, Wein AJ. Use of amitriptyline in the treatment of interstitial cystitis. J Urol 1989;141:846-8
  • Van Ophoven A, Pokupic S, Heinecke A, Hertle L. A prospective, randomized, placebo controlled, double-blind study of amitriptyline for the treatment of interstitial cystitis. J Urol 2004;172:533-6
  • Van Ophoven A, Hertle L. The dual serotonin and noradrenaline reuptake inhibitor duloxetine for the treatment of interstitial cystitis: results of an observational study. J Urol 2007;177(2):552-5
  • Powell-Boone T, Ness TJ, Cannon R, et al. Menstrual cycle affects bladder pain sensation in subjects with interstitial cystitis. J Urol 2005;174(5):1832-6
  • Spanos C, El-Mansoury M, Letourneau RJ, et al. Carbachol-induced activation of bladder mast cells is augmented by estradiol – implications for interstitial cystitis. Urology 1996;48:809-16
  • Pang X, Cotreau-Bibbo MM, Sant GR, Theoharides TC. Bladder mast cell expression of high affinity estrogen receptors in patients with interstitial cystitis. Br J Urol 1995;75:154-61
  • Ghose K. Cystitis and nonsteroidal antiinflammatory drugs: an incidental association or an adverse effect? NZ Med J 1993;106(968):501-3
  • Theoharides TC, Sant GR. Immunomodulators for the treatment of interstitial cystitis. Urology 2005;65:633-8
  • Soucy F, Gregoire M. Efficacy of prednisone for severe refractory ulcerative interstitial cystitis. J Urol 2005;173:841-3
  • Buffington CA. Re: cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis: a randomized comparative study. J Urol 2006;176(2):838
  • Kempuraj D, Madhappan B, Christodoulou S, et al. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol 2005;145:934-44
  • Theoharides TC, Sant GR. A pilot open label of CystoProtek® in interstitial cystitis. Int J Immunopathol Pharmacol 2005;18:183-8
  • Theoharides TC, Kempuraj D, Vakali S, Sant GR. Treatment of refractory interstitial cystitis/painful bladder syndrome with CystoProtek® - an oral multi-agent natural supplement. Can J Urol 2008; In press
  • Hosseini A, Ehren I, Wiklund NP. Nitric oxide as an objective marker for evaluation of treatment response in patients with classic interstitial cystitis. J Urol 2004;172:2261-5
  • Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65
  • Cartledge JJ, Davies AM, Eardley I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU Int 2000;85:421-6
  • Chen MC, Blunt LW, Pins MR, Klumpp DJ. Tumor necrosis factor promotes differential trafficking of bladder mast cells in neurogenic cystitis. J Urol 2006;175(2):754-9
  • Hupert C, Yacoub M, Turgeon LR. Effect of hydroxyzine on morphine analgesia for the treatment of postoperative pain. Anesth Analg 1980;59:690-6
  • Peeker R, Haghsheno MA, Holmang S, Fall M. Intravesical bacillus Calmette – Guerin and dimethyl sulfoxide for treatment of classic and nonulcer interstitial cystitis: a prospective, randomized double-blind study. J Urol 2000;164:1912-6
  • Rossberger J, Fall M, Peeker R. Critical appraisal of dimethyl sulfoxide treatment for interstitial cystitis discomfort, side-effects and treatment outcome. Scand J Urol Nephrol 2005;39:73-7
  • Payne CK, Mosbaugh PG, Forrest JB, et al. Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial. J Urol 2005;173:1590-4
  • Kuo HC. Preliminary results of suburothelial injection of botulinum a toxin in the treatment of chronic interstitial cystitis. Urol Int 2005;75(2):170-4
  • Cervigni M, Natale F, Nasta L, et al. A combined intravesical therapy with hyaluronic acid and chondroitin for refractory painful bladder syndrome/interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct 2008;19(7):943-7
  • Available from: www.icahelp.org
  • Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology 2005;65:45-8
  • Welk BK, Teichman JM. Dyspareunia response in patients with interstitial cystitis treated with intravesical lidocaine, bicarbonate, and heparin. Urology 2008;71(1):67-70
  • Taneja R, Jawade KK. A rational combination of intravesical and systemic agents for the treatment of interstitial cystitis. Scand J Urol Nephrol 2007;41(6):511-5
  • Comiter CV. Sacral neuromodulation for the symptomatic treatment of refractory interstitial cystitis: a prospective study. J Urol 2003;169(4):1369-73
  • Peters KM, Konstandt D. Sacral neuromodulation decreases narcotic requirements in refractory interstitial cystitis. BJU Int 2004;93(6):777-9
  • O'reilly BA, Dwyer PL, Hawthorne G, et al. Transdermal posterior tibial nerve laser therapy is not effective in women with interstitial cystitis. J Urol 2004;172:1880-3
  • Fall M, Oberpenning F, Peeker R. Treatment of bladder pain syndrome/interstitial cystitis 2008: can we make evidence-based decisions? Eur Urol 2008;541:65-75
  • Theoharides TC, Donelan JM, Papadopoulou N, et al. Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol Sci 2004;25:563-8

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