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Treatment strategies for myasthenia gravis

, MD, , MD PhD & , MD PhD
Pages 1329-1342 | Published online: 15 May 2009

Bibliography

  • Keesey JC. Clinical evaluation and management of myasthenia gravis. Muscle Nerve 2004;29(4):484-505
  • Vincent A, Palace J, Hilton-Jones D. Myasthenia gravis. Lancet 2001;357(9274):2122-8
  • Howard JF, Sanders DB. The management of patients with myasthenia gravis. In: Alburquerque, Eldefrawi AT, editors, Myasthenia gravis. London, New York: Chapman and Hall, 1983. p. 457-89
  • Jaretzki A 3rd, Barohn RJ, Ernstoff RM, et al. Myasthenia gravis: recommendations for clinical research standards. Task force of the medical scientific advisory board of the myasthenia gravis foundation of America. Neurology 2000;55:16-23
  • McConville J, Farrugia ME, Beeson D, et al. Detection and characterization of MuSK antibodies in seronegative myasthenia gravis. Ann Neurol 2004;55:580-4
  • Conti-Fine BM, Milani M, Kaminski HJ. Myasthenia gravis: past, present, and future. J Clin Invest 2006;116(11):2843-54
  • Sahashi K, Engel AG, Lambert EH, nd Howard FM Jr. Ultrastructural localization of the terminal and lytic ninth complement component (C9) at the motor end-plate in myasthenia gravis. J Neuropathol Exp Neurol 1980;39:160-72
  • Hoch W, McConville J, Helms S, et al. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001;7:365-68
  • Evoli A, Tonali PA, Padua L, et al. Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis. Brain 2003;126(10):2304-11
  • Sanders DB, El-Salem K, Massey JM, et al. Clinical aspects of MuSK antibody positive seronegative MG. Neurology 2003;60(12):1978-80
  • Illa I, Diaz-Manera JA, Juarez C, et al. Seronegative myasthenia gravis and antiMuSK positive antibodies: description of Spanish series. Med Clin (Barc) 2005;125(3):100-2
  • Wolfe GI, Oh SJ. Clinical phenotype of muscle-specific tyrosine kinase-antibody-positive myasthenia gravis. Ann NY Acad Sci 2008;1132:71-5
  • Evoli A, Bianchi MR, Riso R, et al. Response to therapy in myasthenia gravis with anti-MuSK antibodies. Ann NY Acad Sci 2008;1132:76-83
  • Engel AG, Lambert EH, Santa T. Study of long term anticholinesterase therapy. Neurology 1973;23:1273-81
  • Newsom-Davis J. Therapy in myasthenia gravis and Lambert-Eaton Myasthenic syndrome. Semin Neurol 2003;23:191-8
  • Evoli A, Batocchi AP, Minisci C, et al. Therapeutic options in ocular myasthenia gravis. Neuromuscul Disord 2001;11:208-16
  • Papatestas AE, Alpert LJ, Osserman KE, et al. Studies in myasthenia gravis. Effects of thymectomy. Results on 185 patients with non-thymoma and thymomathous myasthenia gravis. Am J Med 1971;50:465-74
  • Gronseth G, Barohn RJ. Practice parameter: thymectomy for autoinmune myasthenia gravis (an evidence-based review): report of the quality standards subcommittee of the American academy of neurology. Neurology 2000;55:7-15
  • Newsom-Davis J, Cutter G, Wolfe GI, et al. Status of the thymectomy trial for nonthymomatous myasthenia gravis patients receiving prednisone. Ann NY Acad Sci 2008;1132:344-7
  • Leite MI, Ströbel P, Jones M, et al. Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG. Ann Neurol 2005;57:444-8
  • Sonett JR, Jaretzki A 3rd. Thymectomy for nonthymomatous myasthenia gravis: a critical analysis. Ann NY Acad Sci 2008;1132:315-28
  • Nieto JP, Robledo JP, Pajuelo MC, et al. Prognostic factors for myasthenia gravis treated by thymectomy: review of 61 cases. Ann Thor Surg 1999;67:1568-71
  • Wright CD. Management of thymomas. Crit Rev Oncol Hematol 2007;65:109-20
  • Kesler KA, Wright CD, Loehrer PJS. Thymoma: current medical and surgical management. Semin Neurol 2004;24:63-73
  • Tindall RS. Humoral immunityin myasthenia gravis: effect of steroids and thymectomy. Neurolog 1980;30:554-57
  • Hohlfeld R, Dalakas M. Basic principles of immunotherapy for neurologic diseases. Semin Neurol 2003;23:121-31
  • Taylor AL, Watson CJE, Bradley A. Immunosuppressive agents in solid organ transplantation: mechanisms of action and therapeutic efficacy. Crit Rev Oncol Hematol 2005;56:23-46
  • Warmolts JR, Genkins G. Benefit from alternate day prednisone in myasthenia gravis. N Engl J Med 1972;286:17-20
  • Mount FW. Corticotropin in treatment of ocular myasthenia. Arch Neurol 1964;11:114-24
  • Howard JR JF, Duane DD, Lambert EH, Daube JR. Alternate day prednisone: preliminary report of a double-blind controlled study. Ann NY Acad Sci 1976;274:596-607
  • Lindberg C, Andersen O, Lefvert AK. Treatment of myasthenia gravis with methylprednisolone pulse: a double blind study. Acta Neurol Scand 1998;97:370-3
  • Zhang J, Wu H. Effectiveness of steroid treatment in juvenile myasthenia gravis. Chin J Ped 1998;36:612-4
  • Simon HE. Myasthenia gravis: effect of treatment with anterior pituitary extract. JAMA 1935;104:2065-6
  • Pascuzzi RM, Coslett HB, Johns TR. Long-term corticosteroid treatment of myasthenia gravis: report of 116 patients. Ann Neurol 1984;15:291-8
  • Sghirlanzoni A, Peluchetti D, Mantegazza R, et al. Myasthenia gravis: prolonged treatment with steroids. Neurology 1984;34:170-4
  • Cosi V, Citterio A, Lombardi M, et al. Effectiveness of steroid treatment in myasthenia gravis: a retrospective study. Acta Neurol Scand 1991;84:33-9
  • Evoli A, Batocchi AP, Palmisani MT, et al. Long term results of corticosteroid therapy in patients with myasthenia gravis. Eur Neurol 1992;32:37-43
  • Bu B, Yang M, Xu J, et al. A prospective study of effectiveness and safety of long-term prednisone therapy in patients with myasthenia gravis. Chin J Neurol 2000;33:28-31
  • Schneider-Gold C, Gajdos P, Toyka KV, Hohlfeld R. Corticosteroids for myasthenia gravis. Cochrane Database Syst Rev 2005;(2)
  • Sathasivam S. Steroids and immunosuppressant drugs in myasthenia gravis. Nat Clin Pract Neurol 2008;2008:317-27
  • Cara CJ, Pena AS, Sans M, et al. Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice. Med Sci Monit 2004;10:247-54
  • Ferrero S, Esposito F, Biamonti M, et al. Myasthenia gravis during pregnancy. Expert Rev Neurother 2008;8:979-88
  • Gajdos P. Myasthenia gravis clinical study group. A randomised clinical trial comparing prednisolone and azathioprine in myasthenia gravis. Results of a second interim analysis. J Neurol Neurosurg Psychiatry 1993;56:1157-63
  • Palace J, Newsom-Davis J, Lecky B. A randomized double-blind trial of prednisolone alone or with azathioprine in myasthenia gravis. Neurology 1998;50:1778-83
  • Delwaide PJ, Salmon J, Van Cauwenberge H. Preliminary observations of the treatment of myasthenia gravis by azathioprine. Acta Neurol Psychiatr Belg 1964;67:701-12
  • Matell G, Bergström K, Franksson C, et al. Effects of some immunosuppressive procedures in myasthenia gravis. Ann NY Acad Sci 1976;274:659-76
  • Witte AS, Cornblath DR, Parry GJ, et al. Azathioprine in the treatment of myasthenia gravis. Ann Neurol 1984;15:602-5
  • Hohlfeld R, Toyka KV, Besinger UA, et al. Myasthenia gravis: reactivation of clinical disease and autoimmune factors after discontinuation of long-term azathioprine. Ann Neurol 1985;17:238-42
  • Kuks JBM, Djojoatmodjo S, Oosterhuis HJ. Azathioprine in myasthenia gravis: observations in 41 patients and a review of literature. Neuromuscul Disord 1991;1:423-31
  • Mantegazza R, Antozzi C, Peluchetti D, et al. Azathioprine as a single drug or in combination with steroids in the treatment of myasthenia gravis. J Neurol 1988;235:449-53
  • Rezzani R. Cyclosporine A and adverse effects on organs: histochemical studies. Prog Histochem Cytochem 2004;39(2):85-128
  • Busauschina A, Schnuelle P, Van der Woude FJ. Cyclosporine nephrotoxicity. Transplant Proc 2004;36:229S-33S
  • Bechstein WO. Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl Int 2000;13(5):313-26
  • Tindall RS, Rollins JA, Phillips JT, et al. Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis. N Engl J Med 1987;316(12):719-24
  • Tindall RS, Phillips JT, Rollins JA, et al. A clinical therapeutic trial of cyclosporine in myasthenia gravis. Ann NY Acad Sci 1993;681:539-51
  • Goulon M, Elkharrat D, Lokiec F, Gajdos P. Results of a one-year open trial of cyclosporine in ten patients with severe myasthenia gravis. Transplant Proc 1988;20(3 Suppl 4):211-7
  • Bonifati DM, Angelini C. Long-term cyclosporine treatment in a group of severe myasthenia gravis patients. J Neurol 1997;244:542-7
  • Lavrnic D, Vujic A, Rakocevic-Stojanovic V, et al. Cyclosporine in the treatment of myasthenia gravis. Acta Neurol Scand 2005;111:247-52
  • Nagane Y, Utsugisawa K, Obara D, et al. Efficacy of low-dose FK506 in the treatment of myasthenia gravis: a randomized pilot study. Eur Neurol 2005;53:146-50
  • Konishi T, Yoshiyama Y, Takamori M, et al. Clinical study of FK506 in patients with myasthenia gravis. Muscle Nerve 2003;28:570-4
  • Konishi T, Yoshiyama Y, Takamori M, Saida T. Long-term treatment of generalised myasthenia gravis with FK506 (tacrolimus). J Neurol Neurosurg Psychiatry 2005;76:448-50
  • Kawaguchi N, Yoshiyama Y, Nemoto Y, et al. Low-dose tacrolimus treatment in thymectomised and steroid-dependent myasthenia gravis. Curr Med Res Opin 2004;20:1269-73
  • Ponseti JM, Azam J, Fort JM, et al. Long-term results of tacrolimus in cyclosporine- and prednisolone-dependent myasthenia gravis. Neurology 2005;64:1641-3
  • Allison C, Euqui EM. Mycophenolate mofetil and its mechanism of action. Immunopharmacology 2000;47:85-118
  • Sieb JP. Myasthenia gravis: emerging new therapy options. Curr Opin Pharmacol 2005;5:303-7
  • Meriggioli MN, Rowin J, Richman JG, Leurgans S. Mycophenolate mofetil for myasthenia gravis: a double-blind, placebo-controlled pilot study. Ann NY Acad Sci 2003;998:494-9
  • Sanders DB, Hart IK, Mantegazza R, et al. An international phase III, randomized trial of mycophenolate mofetil for myasthenia gravis. Neurology 2008;71:400-6
  • Group MS. A trial of mycophenolate mofetil with prednisone as initial imunotherapy in myasthenia gravis. Neurology 2008;71:394-9
  • Cos L, Mankodi AK, Tawil T, Thornton CA. Mycophenolate mofetil (MyM) is safe and well tolerated in myasthenia gravis (MG). Neurology;54(Suppl 3):A137
  • Ciafaloni E, Massey JM, Tucker-Lipscomb B, Sanders DB. Mycophenolate mofetil for myasthenia gravis: an open-label pilot study. Neurology 2001;56:97-9
  • Meriggioli MN, Ciafaloni E, Al-Hayk KA, et al. Mycophenolate mofetil for myasthenia gravis: an analysis of efficacy, safety, and tolerability. Neurology 2003;61:1438-40
  • De Feo LG, Schottlender J, Martelli NA, Molfino NA. Use of intravenous pulsed cyclophosphamide in severe, generalized myasthenia gravis. Muscle Nerve 2002;26:31-6
  • Perez MC, Buot WL, Mercado-Danguilan C, et al. Stable remissions in myasthenia gravis. Neurology 1981;31:32-7
  • Drachman DB, Jones RJ, Brodsky RA. Treatment of refractory myasthenia gravis: ‘rebooting’ with high-dose cyclophosphamide. Ann Neurol 2003;53:29-34
  • Drachman DB, Adams RN, Hu R, et al. Rebooting the immune system with high-dose cyclophosphamide for treatment of refractory myasthenia gravis. Ann NY Acad Sci 2008;1132:305-14
  • Hilton-Jones D. When the patient fails to respond to treatment: myasthenia gravis. Pract Neurol 2007;7:405-411
  • Pescovitz MD. Rituximab, an anti-cd20 monoclonal antibody: history and mechanism of action. Am J Trasnplant 2006;65:859-66
  • Harris HE. Progressive multifocal leucoencephalopathy in a patient with systemic lupus erythematosus treated with rituximab. Rheumatology (Oxford) 2008;47:224-5
  • Hain B, Jordan K, Deschauer M, Zierz S. Successful treatment of MuSK antibody-positive Myasthenia Gravis with rituximab. Muscle Nerve 2006;33:575-80
  • Gajra A, Vajpayee N, Grethlein SJ. Response of myasthenia gravis to rituximab in a patient with non-hodgkin lymphoma. Am J Hematol 2004;77:196-7
  • Diaz-Manera JA, Rojas-Garcia R, Gallardo E, et al. Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and morvan syndrome. Nat Clin Pract Neurol 2007;3:405-10
  • Illa I, Diaz-Manera JA, Rojas-Garcia R, et al. Sustained response to rituximab in anti-AChR and MuSK positive myasthenia gravis patients. J Neuroimmunol 2008;15(201-202):90-4
  • Gold R, Stangel M, Dalakas M. Drug Insight: the use of intravenous immunoglobulin in neurology—therapeutic considerations and practical issues. Nat Clin Pract Neurology 2006;3:36-44
  • Dalakas M. Intravenous immunoglobulin in autoimmune neuromuscular diseases. JAMA 2004;291:2367-75
  • Dalakas M. The use of intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: evidence-based indications and safety profile. Pharm Therap 2004;102:177-93
  • Lisak RP. Plasmaexchange in neurologic disease. Arch Neurol 1984;41:647-54
  • Lehmann HC, Hartung HP, Hetzel GR, et al. Plasma exchange in neuroimmunological disorders: part 1: rationale and treatment of inflammatory central nervous system disorders. Arch Neurol 2006;63(7):930-5
  • Gajdos P, Chevret S, Clair B, et al. Clinical trial of plasma exchange and high-dose intravenous immunoglobulin in myasthenia gravis. Ann Neurol 1997;41:789-96
  • Qureshi AI, Choudhry MA, Akbar MS, et al. Plasma exchange versus intravenous immunoglobulin treatment in myasthenic crisis. Neurology 1999;52:629-32
  • Zinman L, Ng E, Bril V. IV immunoglobulin in patients with myasthenia gravis: a randomized controlled trial. Neurology 2007;68:837-841
  • Perez Nellar J, Dominguez AM, Llorens-Figueroa JA, et al. A comparative study of intravenous immunoglobulin and plasmapheresis preoperatively in myasthenia. Rev Neurol 2001;33:413-6
  • Richman DP, Agius MA. Treatment of autoimmune myasthenia gravis. Neurology 2003;61:1652-61
  • Achiron A, Barak Y, Miron S, Sarova-Pinhas I. Immunoglobulin treatment in refractory Myasthenia gravis. Muscle Nerve 2000;23:551-5
  • Gajdos P, Chevret S, Toyka KV. Intravenous immunoglobulin for myasthenia gravis. Cochrane Database Syst Rev 2008, Issue1. Art. No.: CD002277. DOI: 10.1002/14651858.CD002277.pub3
  • Newson-Davis J, Vincent A, Wilson SG, et al. Plasmapheresis for myasthenia gravis. N Engl J Med 1978;298:456-7
  • Pinching AJ, Peters DK, Newson-Davis J. Remission of myasthenia gravis following plasma exchange. Lancet 1976;2(8000):1373-76
  • Behan PO, Shakir RA, Simpson JA, et al. Plasma exchange combined with immunosuppressive therapy in myasthenia gravis. Lancet 1979;2:438-40
  • Skeie GO, Apostolski S, Evoli A, et al. EFNS task force article: guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2006;13:691-9
  • Hart IK, Sathasivam S, Sharshar T. Immunosuppressive agents for myasthenia gravis. Cochrane Database Syst Rev 2007; Issue 4. Art. No:CD005224. DOI: 10.1002/14651858.CD005224.pub2
  • Romi F, Skeie GO, Gilhus NE, Aarli JA. Striational antibodies in myasthenia gravis: reactivity and possible clinical significance. Arch Neurol 2005;62:442-46
  • Davenport E, Malthaner RA. The role of surgery in the management of thymoma: a systematic review. Ann Thor Surg 2008;86:673-84
  • Evoli A, Minisci C, Di Schino C, et al. Thymoma in patients with MG: characteristics and long-term outcome. Neurology 2002;59:1844-50
  • Kuppersmith MJ, Ying G. Ocular motor dysfunction and ptosis in ocular myasthenia gravis: effects of treatment. Br J Opthamol 2005;89:1330-34
  • Luchanok U, Kaminski HJ. Ocular myasthenia: diagnostic and treatment recommendations and the evidence base. Curr Opin Neurol 2008;21:8-15
  • Chan JW. Mycophenolate mofetil for ocular myasthenia. J Neurol 2008;255:510-3
  • Seybold ME, Drachman DB. Gradually increasing doses of prednisone in myasthenia gravis reducing the hazards of treatment. N Engl J Med 1974;290:81-4
  • Illa I. IVIg in myasthenia gravis, Lambert Eaton myasthenic syndrome and inflammatory myopathies: current status. J Neurol 2005;252(Suppl 1):14-8
  • Elovaara I, Apostolski S, van Doorn P, et al. EFNS guidelines for the use of intravenous immunoglobulin in treatment of neurological diseases: EFNS Task Force on the use of intravenous immunoglobulin in treatment of neurological diseases. Eur J Neurol 2008;15:893-908
  • Flacke W. Treatment of myasthenia gravis. N Engl J Med1973;288:27-31

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