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Key Paper Evaluation

Telcagepant is a new oral treatment for migraine

Evaluation of Ho TW, Ferrari MD, Rodick DW et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomized, placebo-controlled, parallel-treatment trial. The Lancet 2008;372:2115-2123

, PhD DSc
Pages 1523-1526 | Published online: 08 Jun 2009

Bibliography

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  • Paone DV, Shaw AW, Nguyen DN, et al. Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(-2oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine-1-yl)piperidine-1-carboxamide (MK-0974). J Med Chem 2007;50:5564-7
  • Ho TW, Mannix LK, Fan X, et al. Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology 2008;70:1304-12
  • Ho TW, Ferrari MD, Rodick DW, et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 2008;372:2115-23
  • Gladstone JP, Gawel M. Newer formulations of the triptans: advances in migraine management. Drugs 2003;63:2285-305
  • Ferrari MD, Goadsby PJ, Roon KI, Lipton RB. Triptans (serotonin, 5HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials. Cephalalgia 2002;22:633-58
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