Advancing therapy for hypercholesterolemia

Bibliography

• Steinberg D. The statins in preventive cardiology. N Engl J Med 2008;359:1426-7
   PubMed Web of Science ®Google Scholar
• Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation 2008;118:672-7
   PubMed Web of Science ®Google Scholar
• Grundy SM. Promise of low-density lipoprotein-lowering therapy for primary and secondary prevention. Circulation 2008;117:569-73; discussion 573
   PubMed Web of Science ®Google Scholar
• Grundy SM, Cleeman JI, Merz CN, Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 2004;44:720-32
   PubMed Web of Science ®Google Scholar
• Hausenloy DJ, Yellon DM. Enhancing cardiovascular disease risk reduction: raising high-density lipoprotein levels. Curr Opin Cardiol 2009;24:473-82
   PubMed Web of Science ®Google Scholar
• Gordon T, Castelli WP, Hjortland MC, High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 1977;62:707-14
   PubMed Web of Science ®Google Scholar
• Dietschy JM, Turley SD, Spady DK. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 1993;34:1637-59
   PubMed Web of Science ®Google Scholar
• Levy E, Spahis S, Sinnett D, Intestinal cholesterol transport proteins: an update and beyond. Curr Opin Lipidol 2007;18:310-8
   PubMed Web of Science ®Google Scholar
• Olofsson SO, Stillemark-Billton P, Asp L. Intracellular assembly of VLDL: two major steps in separate cell compartments. Trends Cardiovasc Med 2000;10:338-45
   PubMed Web of Science ®Google Scholar
• Stampfer MJ, Krauss RM, Ma J, A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA 1996;276:882-8
   PubMed Web of Science ®Google Scholar
• Barter PJ, Brewer HB Jr, Chapman MJ, Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol 2003;23:160-7
   PubMed Web of Science ®Google Scholar
• Altmann SW, Davis HR Jr, Zhu LJ, Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004;303:1201-4
   PubMed Web of Science ®Google Scholar
• Wang DQ. Regulation of intestinal cholesterol absorption. Annu Rev Physiol 2007;69:221-48
   PubMed Web of Science ®Google Scholar
• Lambert MS, Avella MA, Berhane Y, The differential hepatic uptake of chylomicron remnants of different fatty acid composition is not mediated by hepatic lipase. Br J Nutr 2001;85:575-82
   PubMed Web of Science ®Google Scholar
• Huff MW, Pollex RL, Hegele RA. NPC1L1: evolution from pharmacological target to physiological sterol transporter. Arterioscler Thromb Vasc Biol 2006;26:2433-8
   PubMed Web of Science ®Google Scholar
• Cheung BM, Lauder IJ, Lau CP, Kumana CR. Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes. Br J Clin Pharmacol 2004;57:640-51
   PubMed Web of Science ®Google Scholar
• Smilde TJ, van Wissen S, Wollersheim H, Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 2001;357:577-81
   PubMed Web of Science ®Google Scholar
• Chong PH, Kezele R, Franklin C. High-density lipoprotein cholesterol and the role of statins. Circ J 2002;66:1037-44
   PubMed Web of Science ®Google Scholar
• Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003;326:1423
   PubMed Web of Science ®Google Scholar
• Rubins HB, Robins SJ, Collins D, Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT). Arch Intern Med 2002;162:2597-604
   PubMed Web of Science ®Google Scholar
• Sever PS, Dahlof B, Poulter NR, Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003;361:1149-58
   PubMed Web of Science ®Google Scholar
• Colhoun HM, Betteridge DJ, Durrington PN, Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004;364:685-96
   PubMed Web of Science ®Google Scholar
• Nissen SE, Nicholls SJ, Sipahi I, Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 2006;295:1556-65
   PubMed Web of Science ®Google Scholar
• Ridker PM, Cannon CP, Morrow D, C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005;352:20-8
   PubMed Web of Science ®Google Scholar
• Nissen SE, Tuzcu EM, Schoenhagen P, Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA 2004;291:1071-80
   PubMed Web of Science ®Google Scholar
• Nissen SE. Effect of intensive lipid lowering on progression of coronary atherosclerosis: evidence for an early benefit from the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial. Am J Cardiol 2005;96:61F-8F
   Google Scholar
• Stefanadis C, Toutouzas K, Vavuranakis M, Statin treatment is associated with reduced thermal heterogeneity in human atherosclerotic plaques. Eur Heart J 2002;23:1664-9
   PubMed Web of Science ®Google Scholar
• Toutouzas K, Drakopoulou M, Markou V, Correlation of systemic inflammation with local inflammatory activity in non-culprit lesions: Beneficial effect of statins. Int J Cardiol 2007;119:368-73
   PubMed Web of Science ®Google Scholar
• Shaw SM, Fildes JE, Yonan N, Williams SG. Pleiotropic effects and cholesterol-lowering therapy. Cardiology 2009;112:4-12
   PubMed Web of Science ®Google Scholar
• Robinson JG, Smith B, Maheshwari N, Schrott H. Pleiotropic effects of statins: benefit beyond cholesterol reduction? A meta-regression analysis. J Am Coll Cardiol 2005;46:1855-62
   PubMed Web of Science ®Google Scholar
• Do R, Kiss RS, Gaudet D, Engert JC. Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway. Clin Genet 2009;75:19-29
   PubMed Web of Science ®Google Scholar
• Seiki S, Frishman WH. Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia. Cardiol Rev 2009;17:70-6
   PubMed Web of Science ®Google Scholar
• Nishimoto T, Amano Y, Tozawa R, Lipid-lowering properties of TAK-475, a squalene synthase inhibitor, in vivo and in vitro. Br J Pharmacol 2003;139:911-8
   PubMed Web of Science ®Google Scholar
• Amano Y, Nishimoto T, Tozawa R, Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia. Eur J Pharmacol 2003;466:155-61
   PubMed Web of Science ®Google Scholar
• Piper E, Price G, Chen Y. TAK-475, a squalene synthase inhibitor, improves lipid profile in hyperlipidemic subjects. Circulation 2006;114
   PubMed Web of Science ®Google Scholar
• Perez A, Kupfer S, Chen Y. TAK-475 to atorvastatin provides incremental lipid benefits. Circulation 2006;114
   PubMed Web of Science ®Google Scholar
• Libby P, Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol 2003;91:4B-8B
   Web of Science ®Google Scholar
• Bays HE, Davidson M, Jones MR, Abby SL. Effects of colesevelam hydrochloride on low-density lipoprotein cholesterol and high-sensitivity C-reactive protein when added to statins in patients with hypercholesterolemia. Am J Cardiol 2006;97:1198-205
   PubMed Web of Science ®Google Scholar
• Jacobson TA, Armani A, McKenney JM, Guyton JR. Safety considerations with gastrointestinally active lipid-lowering drugs. Am J Cardiol 2007;99:47C-55C
   PubMed Web of Science ®Google Scholar
• The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 1984;251:351-64
   PubMed Web of Science ®Google Scholar
• Bell DS, O'Keefe JH. Rediscovering bile acid sequestrants. Diabetes Obes Metab 2009;11:1114-21
   PubMed Web of Science ®Google Scholar
• Staels B. A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus. Postgrad Med 2009;121:25-30
   PubMed Web of Science ®Google Scholar
• Levy P. Bile acid sequestrants as a therapeutic option for glucose lowering in type 2 diabetes mellitus. Endocr Pract 2008;14:644-7
   PubMedGoogle Scholar
• Wedlake L, Thomas K, Lalji A, Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: a retrospective chart review and patient questionnaire. Clin Ther 2009;31:2549-58
   PubMed Web of Science ®Google Scholar
• Filippatos TD, Mikhailidis DP. Lipid-lowering drugs acting at the level of the gastrointestinal tract. Curr Pharm Des 2009;15:490-516
   PubMed Web of Science ®Google Scholar
• Seedorf U, Engel T, Lueken A, Cholesterol absorption inhibitor Ezetimibe blocks uptake of oxidized LDL in human macrophages. Biochem Biophys Res Commun 2004;320:1337-41
   PubMed Web of Science ®Google Scholar
• Sudhop T, Reber M, Tribble D, Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men. J Lipid Res 2010. [Epub ahead of print]
   Web of Science ®Google Scholar
• Dujovne CA, Ettinger MP, McNeer JF, Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. Am J Cardiol 2002;90:1092-7
   PubMed Web of Science ®Google Scholar
• Knopp RH, Gitter H, Truitt T, Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. Eur Heart J 2003;24:729-41
   PubMed Web of Science ®Google Scholar
• Pandor A, Ara RM, Tumur I, Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials. J Intern Med 2009;265:568-80
   PubMed Web of Science ®Google Scholar
• Rizzo M, Rini GB, Spinas GA, Berneis K. The effects of ezetimibe on LDL-cholesterol: quantitative or qualitative changes? Atherosclerosis 2009;204:330-3
   PubMed Web of Science ®Google Scholar
• Kastelein JJ, Bots ML. Statin therapy with ezetimibe or niacin in high-risk patients. N Engl J Med 2009;361:2180-3
   PubMed Web of Science ®Google Scholar
• Kastelein JJ, Sager PT, de Groot E, Veltri E. Comparison of ezetimibe plus simvastatin versus simvastatin monotherapy on atherosclerosis progression in familial hypercholesterolemia. Design and rationale of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial. Am Heart J 2005;149:234-9
   PubMed Web of Science ®Google Scholar
• Pearson TA, Ballantyne CM, Veltri E, Pooled analyses of effects on C-reactive protein and low density lipoprotein cholesterol in placebo-controlled trials of ezetimibe monotherapy or ezetimibe added to baseline statin therapy. Am J Cardiol 2009;103:369-74
   PubMed Web of Science ®Google Scholar
• Pearson T, Ballantyne C, Sisk C, Comparison of effects of ezetimibe/simvastatin versus simvastatin versus atorvastatin in reducing C-reactive protein and low-density lipoprotein cholesterol levels. Am J Cardiol 2007;99:1706-13
   PubMed Web of Science ®Google Scholar
• Masana L, Mata P, Gagne C, Long-term safety and, tolerability profiles and lipid-modifying efficacy of ezetimibe coadministered with ongoing simvastatin treatment: a multicenter, randomized, double-blind, placebo-controlled, 48-week extension study. Clin Ther 2005;27:174-84
   PubMed Web of Science ®Google Scholar
• Davidson MH, Ballantyne CM, Kerzner B, Efficacy and safety of ezetimibe coadministered with statins: randomised, placebo-controlled, blinded experience in 2382 patients with primary hypercholesterolemia. Int J Clin Pract 2004;58:746-55
   PubMed Web of Science ®Google Scholar
• Goldberg AC, Sapre A, Liu J, Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: a randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2004;79:620-9
   PubMed Web of Science ®Google Scholar
• Goldberg RB, Guyton JR, Mazzone T, Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: the VYTAL study. Mayo Clin Proc 2006;81:1579-88
   PubMed Web of Science ®Google Scholar
• Feldman T, Koren M, Insull W Jr, Treatment of high-risk patients with ezetimibe plus simvastatin co-administration versus simvastatin alone to attain National Cholesterol Education Program Adult Treatment Panel III low-density lipoprotein cholesterol goals. Am J Cardiol 2004;93:1481-6
   PubMed Web of Science ®Google Scholar
• Ballantyne CM, Abate N, Yuan Z, Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: the Vytorin Versus Atorvastatin (VYVA) study. Am Heart J 2005;149:464-73
   PubMed Web of Science ®Google Scholar
• Ballantyne CM, Blazing MA, King TR, Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia. Am J Cardiol 2004;93:1487-94
   PubMed Web of Science ®Google Scholar
• Pitsavos C, Skoumas I, Tousoulis D, The impact of ezetimibe and high-dose of statin treatment on LDL levels in patients with heterozygous familial hypercholesterolemia. Int J Cardiol 2009;134:280-1
   PubMed Web of Science ®Google Scholar
• Catapano AL, Davidson MH, Ballantyne CM, Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus rosuvastatin in hypercholesterolemic patients. Curr Med Res Opin 2006;22:2041-53
   PubMed Web of Science ®Google Scholar
• Denke M, Pearson T, McBride P, Ezetimibe added to ongoing statin therapy improves LDL-C goal attainment and lipid profile in patients with diabetes or metabolic syndrome. Diabetes Vasc Dis Res 2006;3:93-102
   PubMedGoogle Scholar
• Ginsberg HN. REVIEW: Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia. J Clin Endocrinol Metab 2006;91:383-92
   PubMed Web of Science ®Google Scholar
• Manninen V, Elo MO, Frick MH, Lipid alterations and decline in the incidence of coronary heart disease in the Helsinki Heart Study. JAMA 1988;260:641-51
   PubMed Web of Science ®Google Scholar
• Robins SJ, Collins D, Wittes JT, Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. JAMA 2001;285:1585-91
   PubMed Web of Science ®Google Scholar
• The BIP Group. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 2000;102:21-7
   PubMed Web of Science ®Google Scholar
• Meade TW. Design and intermediate results of the Lower Extremity Arterial Disease Event Reduction (LEADER)* trial of bezafibrate in men with lower extremity arterial disease [ISRCTN4119421]. Curr Control Trials Cardiovasc Med 2001;2:195-204
   PubMedGoogle Scholar
• Keech A, Simes RJ, Barter P, Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005;366:1849-61
   PubMed Web of Science ®Google Scholar
• Feeman WE Jr. Statin-fibrate combination therapy. Am J Cardiol 2008;101:1521
   PubMed Web of Science ®Google Scholar
• Franssen R, Vergeer M, Stroes ES, Kastelein JJ. Combination statin-fibrate therapy: safety aspects. Diabetes Obes Metab 2009;11:89-94
   PubMed Web of Science ®Google Scholar
• Jacobson TA. Myopathy with statin-fibrate combination therapy: clinical considerations. Nat Rev Endocrinol 2009;5:507-18
   PubMed Web of Science ®Google Scholar
• Cuchel M, Bloedon LT, Szapary PO, Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med 2007;356:148-56
   PubMed Web of Science ®Google Scholar
• Ginsberg HN, Bonds DE, Lovato LC, Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol 2007;99:56i-67i
   PubMed Web of Science ®Google Scholar
• Prueksaritanont T, Zhao JJ, Ma B, Mechanistic studies on metabolic interactions between gemfibrozil and statins. J Pharmacol Exp Ther 2002;301:1042-51
   PubMed Web of Science ®Google Scholar
• Hooper L, Thompson RL, Harrison RA, Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 2006;332:752-60
   PubMed Web of Science ®Google Scholar
• Yokoyama M, Origasa H, Matsuzaki M, Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007;369:1090-8
   PubMed Web of Science ®Google Scholar
• Hu FB, Bronner L, Willett WC, Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002;287:1815-21
   PubMed Web of Science ®Google Scholar
• Davidson MH, Stein EA, Bays HE, Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther 2007;29:1354-67
   PubMed Web of Science ®Google Scholar
• Vega GL, Cater NB, Meguro S, Grundy SM. Influence of extended-release nicotinic acid on non-esterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia. Am J Cardiol 2005;95:1309-13
   PubMed Web of Science ®Google Scholar
• Meyers CD, Kamanna VS, Kashyap ML. Niacin therapy in atherosclerosis. Curr Opin Lipidol 2004;15:659-65
   PubMed Web of Science ®Google Scholar
• Carlson LA. Nicotinic acid and other therapies for raising high-density lipoprotein. Curr Opin Cardiol 2006;21:336-44
   PubMed Web of Science ®Google Scholar
• Brown BG, Zhao XQ. Nicotinic acid, alone and in combinations, for reduction of cardiovascular risk. Am J Cardiol 2008;101:58B-62B
   Web of Science ®Google Scholar
• Taylor AJ, Sullenberger LE, Lee HJ, Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 2004;110:3512-7
   PubMed Web of Science ®Google Scholar
• Taylor AJ, Lee HJ, Sullenberger LE. The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3. Curr Med Res Opin 2006;22:2243-50
   PubMed Web of Science ®Google Scholar
• Cefali EA, Simmons PD, Stanek EJ, Shamp TR. Improved control of niacin-induced flushing using an optimized once-daily, extended-release niacin formulation. Int J Clin Pharmacol Ther 2006;44:633-40
   PubMed Web of Science ®Google Scholar
• Allantyne CM, Raichlen JS, Nicholls SJ, Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden. Circulation 2008;117:2458-66
   PubMed Web of Science ®Google Scholar
• Aylor AJ, Villines TC, Stanek EJ, Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med 2009;361:2113-22
   PubMed Web of Science ®Google Scholar
• Handler CE, Wilder DE, Pettini JL, CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J Lipid Res 2003;44:1887-901
   PubMed Web of Science ®Google Scholar
• Eshima K, Akihisa-Umeno H, Nagayoshi A, Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation. Biol Pharm Bull 2005;28:247-52
   PubMed Web of Science ®Google Scholar
• Ousoulis D, Antoniades C, Katsi V, The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level. Int J Cardiol 2006;109:48-52
   PubMed Web of Science ®Google Scholar
• Ggarwal D, West KL, Zern TL, JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs. BMC Cardiovasc Disord 2005;5:30
   PubMedGoogle Scholar
• Urnett JR, Watts GF. MTP inhibition as a treatment for dyslipidaemias: time to deliver or empty promises? Expert Opin Ther Targets 2007;11:181-9
   PubMed Web of Science ®Google Scholar
• Oekholdt SM, Kuivenhoven JA, Wareham NJ, Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study. Circulation 2004;110:1418-23
   PubMed Web of Science ®Google Scholar
• Arter P. Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial. Am J Cardiol 2009;104:10E-5E
   Web of Science ®Google Scholar
• Ilani RV, Lavie CJ. Cholesteryl ester transfer protein inhibition: the next frontier in combating coronary artery disease? J Am Coll Cardiol 2006;48:1791-2
   PubMed Web of Science ®Google Scholar
• Astelein JJ, van Leuven SI, Burgess L, Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007;356:1620-30
   PubMed Web of Science ®Google Scholar
• Issen SE, Tardif JC, Nicholls SJ, Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med 2007;356:1304-16
   PubMed Web of Science ®Google Scholar
• Ots ML, Visseren FL, Evans GW, Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. Lancet 2007;370:153-60
   PubMed Web of Science ®Google Scholar
• Icholls SJ, Tuzcu EM, Brennan DM, Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation). Circulation 2008;118:2506-14
   PubMed Web of Science ®Google Scholar
• Uivenhoven JA, de Grooth GJ, Kawamura H, Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia. Am J Cardiol 2005;95:1085-8
   PubMed Web of Science ®Google Scholar
• Rundy SM, Cleeman JI, Merz CN, Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Arterioscler Thromb Vasc Biol 2004;24:e149-61
   Web of Science ®Google Scholar
• Asson D. Anacetrapib, a cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis. Curr Opin Investig Drugs 2009;10:980-7
   PubMedGoogle Scholar
• Omori T. CETi-1. AVANT. Curr Opin Investig Drugs 2004;5:334-8
   PubMedGoogle Scholar
• Chiesa G, Sirtori CR. Apolipoprotein A-I(Milano): current perspectives. Curr Opin Lipidol 2003;14:159-63
   PubMed Web of Science ®Google Scholar
• Alexander ET, Tanaka M, Kono M, Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I. J Lipid Res 2009;50:1409-19
   PubMed Web of Science ®Google Scholar
• Nissen SE, Tsunoda T, Tuzcu EM, Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA 2003;290:2292-300
   PubMed Web of Science ®Google Scholar