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Review

Treatment advances in non-Hodgkin’s lymphoma

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Pages 451-465 | Published online: 24 Feb 2005

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  • •Survival benefit demonstrated with the addition of IFN to a doxorubicin-containing regimen in indolent NHL.
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  • •The first human study on vaccines using dendritic cells pulsed with tumour-specific idiotypic protein eliciting specific cellular antitumour immune responses.
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  • BURCHMORE MJ, DOWDEN S: One year cost of treatment of rituximab compared to fludarabine for relapsed or refractory, low-grade or follicular non-Hodgkin's lymphoma. Proc. Am. Soc. Clin. Oncol. (1999) 18:25a.
  • BIERMAN PJ, VOSE JM, ANDERSON JR, BISHOP MR, KESSINGER A, ARMITAGE JP: High-dose therapy with autologous hematopoietic rescue for follicular low-grade non-Hodgkin's lymphoma. J. Clin. Oncol. (1997) 15(2):445–50.
  • GRIBBEN JG: Bone marrow transplantation forlow-grade B-cell malignancies. Curr. Opin. Oncol. (1997) 9(2):117–121.
  • •A good review on the use of high-dose therapy for indolent lymphomas.
  • APOSTOLIDIS J, FORAN JM, JOHNSON PW et al.: Patternsof outcome following recurrence after myeloablative therapy with autologous bone marrow transplanta-tion for follicular lymphoma. J. Clin. Oncol. (1999) 17 (1):216–221.
  • VERDONCK LF, DEKKER AW, LOKHORST HM, PETERSONEJ, NIEUWENHUIS HK: Allogeneic versus autologous bone marow transplantation for refractory and recurrent low-grade non-Hodgkin's lymphoma. Blood (1997) 90(104201–4205.
  • VAN BESIEN K, SOBOCINSKI KA, ROWLINGS PA et al.: Allogeneic bone marrow transplantation for low-grade lymphoma. Blood (1998) 92(5):1832–1836.
  • ••The International Bone Marrow Transplantation Registryreport on 155 patients with indolent lymphomas treated with allogeneic transplantation showing low recurrence rates.
  • FISHER RI, GAYNOR ER, DAHLBERG S et al: Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl. J. Med. (1993) 328(14):1002–1006.
  • ••CHOP remains the standard therapy for newly diagnosedaggressive lymphomas.
  • GORDON LI, HARRINGTON D, ANDERSEN J: Comparison of a second-generation combination chemotherapeutic regimen (m-BACOD) with a standard regimen (CHOP) for advanced diffuse non-Hodgkin's lymphoma. N Engl. J. Med. (1992) 327(19):1342–1349.
  • MILLER TP, DAHLBERG S, CASSADY JR et al. Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate-and high-grade non-Hodgkin's lymphoma. N Engl. J. Med. (1998) 339(1):21–26.
  • THE INTERNATIONAL NON-HODGKIN'S LYMPHOMA PROGNOSTIC FACTORS PROJECT: A predictive model for aggressive non-Hodgkin's lymphoma. N Engl. J. Med. (1993) 329(14):987–994.
  • ••Important project validating the International PrognosticIndex in aggressive lymphomas.
  • SHIPP MA, ABELOFF MD, ANTMAN KH et al.: Interna- tional consensus conference on high-dose therapy with hematologic stem cell transplantation in aggres-sive non-Hodgkin's lymphoma: Report of the jury. J. Clin. Oncol. (1999) 17(0:423–429.
  • ••A good overview of high-dose therapy with bone marrow orstem cell transplantation in various clinical settings for non-Hodgkin's lymphoma.
  • HAIOUN C, LEPAGE E, GISSELBRECT C et al.: Benefit of autologous bone marrow transplantation over sequential chemotherapy in poor-risk aggressive non-Hodgkin's lymphoma: updated results of the prospective study LNH87-2. Groupe d'Etude des Lymphomes de l'Adulte. J. Clin. Oncol. (1997) 15 (3):1131–1137.
  • •Survival benefit seen on retrospective analysis for HDT in a subset of high-risk newly diagnosed aggressive NHL.
  • SANTINI G, SALVAGNO L, LEONI PVACOP-B versusVACOP-B plus autologous bone marrow transplanta-tion for advanced diffuse non-Hodgkin's lymphoma: results of a prospective randomized trial by the Non-Hodgkin's Lymphoma Cooperative Study Group. Clin. Oncol. (1998) 16(8):2796–2802.
  • GIANNI AM, BREGNI M, SIENA S et al.: High-dosechemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggres-sive B-cell lymphoma. N. Engl. J. Med. (1997) 336(18)1290–1297.
  • •The use if upfront HDT as initial therapy for aggressive NHLL showed a superior 7-year PFS compared to conven-tional MACOP-B. However, no survival advantage was seen.
  • PHILIP T, GUGLIELMI C, HAGENBEEK A et al: Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy- sensitive non-Hodgkin's lymphoma. N Engl. J. Med. (1995) 333(23):1540–1545.
  • ••This study establishes the role of high dose chemotherapywith transplantation as standard salvage therapy for chemosensitive relapsed aggressive non-Hodgkin's lymphoma.

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