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Clinical Trial Evaluation

Mipomersen as a potential adjunctive therapy for hypercholesterolemia

Evaluation of: ‘Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial.’ Lancet 2010;375:998-1006

& , MD FRCPC FACP
Pages 2569-2572 | Published online: 13 Aug 2010

Bibliography

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  • Goldstein JL, Hobbs HH, Brown MS. Familial hypercholesterolemia. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular basis of inherited disease. 8th edition. McGraw Hill, New York; 2001. p. 2863-913
  • Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest 2003;111:1795-803
  • Thompson GR, Group H-UKLDLAW. Recommendations for the use of LDL apheresis. Atherosclerosis 2008;198:247-55
  • Cuchel M, Bloedon LT, Szapary PO, Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med 2007;356:148-56
  • Kastelein J, Wedel M, Baker B, Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. Circulation 2006;114:1729-35
  • Visser ME, Akdim F, Tribble DL, Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia. J Lipid Res 2010;51:1057-62

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