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Reviews

Management of varices in cirrhosis

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Pages 721-735 | Published online: 27 Jan 2011

Bibliography

  • Sherlock S, Dooley J. Diseases of the liver and biliary system. 11th edition. Oxford: Blackwell; 2002
  • Garcia-Tsao G, Groszmann RJ, Fisher RL, Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology 1985;5:419-24
  • Viallet A, Marleau D, Huet M, Hemodynamic evaluation of patients with intrahepatic portal hypertension. Relationship between bleeding varices and the portohepatic gradient. Gastroenterology 1975;69:1297-300
  • Zoli M, Berzigotti A. Natural history of formation and growth of oesophageal varices. In: de Franchis R, editor. Portal hypertension IV: proceedings of the Fourth Baveno International Consensus Workshop on methodology of diagnosis and treatment. Oxford: Blackwell; 2006. p. 118-22
  • Giannini EG, Zaman A, Kreil A, Platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices: results of a multicenter, prospective, validation study. Am J Gastroenterol 2006;101:2511-19
  • Bosch J, Abraldes JG, Berzigotti A, Garcia-Pagan JC. Portal hypertension and gastrointestinal bleeding. Semin Liver Dis 2008;28:3-25
  • Chalasani N, Kahi C, Francois F, Improved patient survival after acute variceal bleeding: a multicenter, cohort study. Am J Gastroenterol 2003;98:653-9
  • The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med 1988;319:983-9
  • Goulis J, Patch D, Burroughs AK. Bacterial infection in the pathogenesis of variceal bleeding. Lancet 1999;353:139-42
  • Thalheimer U, Triantos CK, Samonakis DN, Infection, coagulation, and variceal bleeding in cirrhosis. Gut 2005;54:556-63
  • Feu F, Bordas JM, Garcia-Pagan JC, Double-blind investigation of the effects of propranolol and placebo on the pressure of esophageal varices in patients with portal hypertension. Hepatology 1991;13:917-22
  • Cales P, Oberti F, Payen JL, Lack of effect of propranolol in the prevention of large oesophageal varices in patients with cirrhosis: a randomized trial. French-Speaking Club for the Study of Portal Hypertension. Eur J Gastroenterol Hepatol 1999;11:741-5
  • Merkel C, Marin R, Angeli P, A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis. Gastroenterol 2004;127(2):476-84
  • Groszmann RJ, Garcia-Tsao G, Bosch J, Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005;353:2254-61
  • de Franchis R. Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2005;43:167-76
  • Perez-Ayuso RM, Pique JM, Bosch J, Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis. Lancet 1991;337:1431-4
  • Propranolol prevents first gastrointestinal bleeding in non-ascitic cirrhotic patients. Final report of a multicenter randomized trial. The Italian Multicenter Project for Propranolol in Prevention of Bleeding. J Hepatol 1989;9:75-83
  • The PROVA Study Group. Prophylaxis of first hemorrhage from esophageal varices by sclerotherapy, propranolol or both in cirrhotic patients: a randomized multicenter trial. Hepatology 1991;14:1016-24
  • Andreani T, Poupon RE, Balkau BJ, Preventive therapy of first gastrointestinal bleeding in patients with cirrhosis: results of a controlled trial comparing propranolol, endoscopic sclerotherapy and placebo. Hepatology 1990;12:1413-19
  • Colman J, Jones P, Finch C, Dudley F. Propranolol in the prevention of variceal hemorrhage in alcoholic cirrhotic patients [abstract]. Hepatology 1990;12:851
  • Conn HO, Grace ND, Bosch J, ; Boston-New Haven-Barcelona Portal Hypertension Study Group. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: a multicenter, randomized clinical trial. Hepatology 1991;13:902-12
  • Pascal JP, Cales P. Propranolol in the prevention of first upper gastrointestinal tract hemorrhage in patients with cirrhosis of the liver and esophageal varices. N Engl J Med 1987;317:856-61
  • Strauss E, Desa MG, Albano A, A randomized controlled trial for the prevention of the 1st upper gastrointestinal bleeding due to portal hypertension in cirrhosis – sclerotherapy or propranolol versus cintrol groups [abstract]. Hepatology 1988;8:1395
  • Ideo G, Bellati G, Fesce E, Grimoldi D. Nadolol can prevent the first gastrointestinal bleeding in cirrhotics: a prospective, randomized study. Hepatology 1988;8:6-9
  • Lebrec D, Poynard T, Capron JP, Nadolol for prophylaxis of gastrointestinal bleeding in patients with cirrhosis. A randomized trial. J Hepatol 1988;7:118-25
  • Poynard T, Cales P, Pasta L, ; Franco-Italian Multicenter Study Group. Beta-adrenergic-antagonist drugs in the prevention of gastrointestinal bleeding in patients with cirrhosis and esophageal varices. An analysis of data and prognostic factors in 589 patients from four randomized clinical trials. N Engl J Med 1991;324:1532-8
  • Abraczinskas DR, Ookubo R, Grace ND, Propranolol for the prevention of first esophageal variceal hemorrhage: a lifetime commitment? Hepatology 2001;34:1096-102
  • Merkel C, Marin R, Enzo E, Randomised trial of nadolol alone or with isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Gruppo-Triveneto per L'ipertensione portale (GTIP). Lancet 1996;348:1677-81
  • Merkel C, Marin R, Sacerdoti D, Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2000;31:324-9
  • Garcia-Pagan JC, Morillas R, Banares R, Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: a double-blind RCT. Hepatology 2003;37:1260-6
  • Gluud LL, Langholz E, Krag A. Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices. Aliment Pharmacol Ther 2010;32:859-71
  • Piai G, Cipolletta L, Claar M, Prophylactic sclerotherapy of high-risk esophageal varices: results of a multicentric prospective controlled trial. Hepatology 1988;8:1495-500
  • Potzi R, Bauer P, Reichel W, Prophylactic endoscopic sclerotherapy of oesophageal varices in liver cirrhosis. A multicentre prospective controlled randomised trial in Vienna. Gut 1989;30:873-9
  • Witzel L, Wolbergs E, Merki H. Prophylactic endoscopic sclerotherapy of oesophageal varices. A prospective controlled study. Lancet 1985;1:773-5
  • Pagliaro L, D'Amico G, Sorensen TI, Prevention of first bleeding in cirrhosis. A meta-analysis of randomized trials of nonsurgical treatment. Ann Intern Med 1992;117:59-70
  • The Veterans Affairs Cooperative Variceal Sclerotherapy Group. Prophylactic sclerotherapy for esophageal varices in men with alcoholic liver disease. A randomized, single-blind, multicenter clinical trial. N Engl J Med 1991;324:1779-84
  • Chen C, Chang TT. Prophylactic endoscopic variceal ligation (EVL) for esophageal varices [abstract]. Gastroenterology 1997;112:A1240
  • Gameel K, Waked I, Saleh S, Prophylactic endoscopic variceal band ligation (EVL) versus sclerotherapy (ES) for the prevention of variceal bleeding: an interim report of a prospective randomized controlled trial in schistosomal portal hypertension [abstract]. Hepatology 1995;22:251A
  • Lay CS, Tsai YT, Teg CY, Endoscopic variceal ligation in prophylaxis of first variceal bleeding in cirrhotic patients with high-risk esophageal varices. Hepatology 1997;25:1346-50
  • Lo GH, Lai KH, Cheng JS, Prophylactic banding ligation of high-risk esophageal varices in patients with cirrhosis: a prospective, randomized trial. J Hepatol 1999;31:451-6
  • Omar MM, Attia MH, Mostafa IM. Prophylactic band ligation to prevent first bleeding from large esophageal varices [abstract]. Gastrointest Endosc 2000;51:AB122
  • Sarin SK, Guptan RK, Jain AK, Sundaram KR. A randomized controlled trial of endoscopic variceal band ligation for primary prophylaxis of variceal bleeding. Eur J Gastroenterol Hepatol 1996;8:337-42
  • Triantos C, Vlachogiannakos J, Armonis A, Primary prophylaxis of variceal bleeding in cirrhotics unable to take blockers: a randomized trial of ligation. Aliment Pharmacol Ther 2005;21:1435-43
  • Schepke M, Kleber G, Nurnberg D, Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004;40:65-72
  • Triantos C, Vlachogiannakos J, Manolakopoulos S, Is banding ligation for primary prevention of variceal bleeding as effective as beta-blockers, and is it safe? Hepatology 2006;43:196-7
  • Chen C, Sheu M, Su S. Prophylactic endoscopic variceal ligation (EVL) with multiple band ligator for esophageal varices [abstract]. Gastroenterology 1998;144:A1224
  • De la Mora J, Farca-Belsaguy A, Uribe M, De Hoyos-Garza A. Ligation vs propranolol for primary prophylaxis of variceal bleeding using a multiple band ligator and objective measurements of treatment adequacy: preliminary results [abstract]. Gastroenterology 2000;1118:6512
  • De BK, Ghoshal UC, Das T, Endoscopic variceal ligation for primary prophylaxis of oesophageal variceal bleed: preliminary report of a randomized controlled trial. J Gastroenterol Hepatol 1999;14:220-4
  • Drastich P, Lata J, Petryl J, Endoscopic variceal band ligation in comparison with propranolol in prophylaxis of first variceal bleeding in patients with liver cirrhosis [abstract]. J Hepatol 2005;42(suppl 2):79
  • Gheorge C, Gheorge L, Vadan R, Prophylactic banding ligation of high risk esophageal varices in patients on the waiting list for liver transplantation: an interim report [abstract]. J Hepatol 2002;36(suppl 1):38
  • Jutabha R, Jensen DM, Martin P, Randomized study comparing banding and propranolol to prevent initial variceal hemorrhage in cirrhotics with high-risk esophageal varices. Gastroenterology 2005;128:870-81
  • Lo GH, Chen WC, Chen MH, Endoscopic ligation vs. nadolol in the prevention of first variceal bleeding in patients with cirrhosis. Gastrointest Endosc 2004;59:333-8
  • Lui HF, Stanley AJ, Forrest EH, Primary prophylaxis of variceal hemorrhage: a randomized controlled trial comparing band ligation, propranolol, and isosorbide mononitrate. Gastroenterology 2002;123:735-44
  • Norberto L, Polese L, Cillo U, A randomized study comparing ligation with propranolol for primary prophylaxis of variceal bleeding in candidates for liver transplantation. Liver Transpl 2007;13:1272-8
  • Psilopoulos D, Galanis P, Goulas S, Endoscopic variceal ligation vs. propranolol for prevention of first variceal bleeding: a randomized controlled trial. Eur J Gastroenterol Hepatol 2005;17:1111-17
  • Sarin SK, Lamba GS, Kumar M, Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. N Engl J Med 1999;340:988-93
  • Song I, Shin J, Kim I, A prospective randomized trial between the prophylactic endoscopic variceal ligation and propranolol administration for prevention of first bleeding in cirrhotic patients with high risk esophageal varices [abstract]. J Hepatol 2000;32(suppl 2):41
  • Thuluvath PJ, Maheshwari A, Jagannath S, Arepally A. A randomized controlled trial of beta-blockers versus endoscopic band ligation for primary prophylaxis: a large sample size is required to show a difference in bleeding rates. Dig Dis Sci 2005;50:407-10
  • Abdelfattah M, Rased M, Elfakhry A, Endoscopic variceal ligation versus pharmacologic treatment for primary prophylaxis of variceal bleeding: a randomised trial. J Hepatol 2006;44:S83
  • Wang HM, Lo GH, Chen WC, Comparison of endoscopic variceal ligation and nadolol plus isosorbide-5-mononitrate in the prevention of first variceal bleeding in cirrhotic patients. J Chin Med Assoc 2006;69:453-60
  • Burroughs AK. Primary prevention of variceal haemorrhage: a pharmacological approach. J Hepatol 2010;52(6):946-8
  • Tripathi D, Ferguson JW, Kochar N, Randomized controlled trial of carvedilol versus variceal band ligation for the prevention of the first variceal bleed. Hepatology 2009;50:825-33
  • Tsochatzis EA, Triantos CK, Burroughs AK. Gastrointestinal bleeding: carvedilol – the best beta-blocker for primary prophylaxis? Nat Rev Gastroenterol Hepatol 2009;6:692-4
  • Bosch J. Carvedilol for portal hypertension in patients with cirrhosis. Hepatology 2010;51:2214-18
  • Lo GH, Chen WC, Wang HM, Lee CC. Controlled trial of ligation plus nadolol versus nadolol alone for the prevention of first variceal bleeding. Hepatology 2010;52:230-7
  • Gotoh Y, Iwakiri R, Sakata Y, Evaluation of endoscopic variceal ligation in prophylactic therapy for bleeding of oesophageal varices: a prospective, controlled trial compared with endoscopic injection sclerotherapy. J Gastroenterol Hepatol 1999;14:241-4
  • Svoboda P, Kantorova I, Ochmann J, A prospective randomized controlled trial of sclerotherapy vs ligation in the prophylactic treatment of high-risk esophageal varices. Surg Endosc 1999;13:580-4
  • Conn HO, Lindenmuth WW. Prophylactic portacaval anastomosis in cirrhotic patients with esophageal varices: a progress report of a continuing study. N Engl J Med 1965;272:1255-63
  • Conn HO, Lindenmuth WW, May CJ, Ramsby GR. Prophylactic portacaval anastomosis. Medicine (Baltimore) 1972;51:27-40
  • Jackson FC, Perrin EB, Smith AG, A clinical investigation of the portacaval shunt. II. Survival analysis of the prophylactic operation. Am J Surg 1968;115:22-42
  • Resnick RH, Chalmers TC, Ishihara AM, A controlled study of the prophylactic portacaval shunt. A final report. Ann Intern Med 1969;70:675-88
  • D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 1995;22:332-54
  • de Franchis R. Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2005;43:167-76
  • Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007;46:922-38
  • Bernard B, Lebrec D, Mathurin P, Beta-adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis: a meta-analysis. Hepatology 1997;25:63-70
  • Thalheimer U, Leandro G, Samonakis DN, Assessment of the agreement between wedge hepatic vein pressure and portal vein pressure in cirrhotic patients. Dig Liver Dis 2005;37:601-8
  • Perello A, Escorsell A, Bru C, Wedged hepatic venous pressure adequately reflects portal pressure in hepatitis C virus-related cirrhosis. Hepatology 1999;30:1393-7
  • Abraldes JG, Tarantino I, Turnes J, Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis. Hepatology 2003;37:902-8
  • Bosch J, Garcia-Pagan JC. Prevention of variceal rebleeding. Lancet 2003;361:952-4
  • Thalheimer U, Mela M, Patch D, Burroughs AK. Prevention of variceal rebleeding. Lancet 2003;361:2244-5
  • Thalheimer U, Mela M, Patch D, Burroughs AK. Targeting portal pressure measurements: a critical reappraisal. Hepatology 2004;39:286-90
  • Thalheimer U, Mela M, Patch D, Burroughs AK. Monitoring target reduction in hepatic venous pressure gradient during pharmacological therapy of portal hypertension: a close look at the evidence. Gut 2004;53:143-8
  • Thalheimer U, Leandro G, Mela M, Systematic review of HVPG measurement: statistics versus clinical applicability. Gastroenterology 2007;132:1201-2
  • D'Amico G, Garcia-Pagan JC, Luca A, Bosch J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology 2006;131:1611-24
  • D'Amico G, Luca A, Garcia-Pagan JC, Bosch J. Author reply. Gastroenterology 2007;132:1202-4
  • Albillos A, Banares R, Gonzalez M, Value of the hepatic venous pressure gradient to monitor drug therapy for portal hypertension: a meta-analysis. Am J Gastroenterol 2007;102:1116-26
  • Thalheimer U, Bosch J, Burroughs AK. How to prevent varices from bleeding: shades of grey – the case for nonselective beta blockers. Gastroenterology 2007;133:2029-36
  • Garcia-Pagan JC, Feu F, Bosch J, Rodes J. Propranolol compared with propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis. A randomized controlled study. Ann Intern Med 1991;114:869-73
  • Gonzalez-Abraldes J, Albillos A, Banares R, Randomized comparison of long-term losartan versus propranolol in lowering portal pressure in cirrhosis. Gastroenterology 2001;121:382-8
  • Albillos A, Garcia-Pagan JC, Iborra J, Propranolol plus prazosin compared with propranolol plus isosorbide-5-mononitrate in the treatment of portal hypertension. Gastroenterology 1998;115:116-23
  • Abecasis R, Kravetz D, Fassio E, Nadolol plus spironolactone in the prophylaxis of first variceal bleed in nonascitic cirrhotic patients: a preliminary study. Hepatology 2003;37:359-65
  • Gournay J, Masliah C, Martin T, Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding. Hepatology 2000;31:1239-45
  • Patti R, D'Amico G, Pasta H, Isosorbite mononitrate with nadolol compared to nadolol alone for prevention of recurrent bleeding in cirrhosis. Double-blind placebo controlled randomized trial [abstract]. J Hepatol 1999;30:81
  • Sclerotherapy after first variceal hemorrhage in cirrhosis. A randomized multicenter trial. The Copenhagen Esophageal Varices Sclerotherapy Project. N Engl J Med 1984;311:1594-600
  • Burroughs AK, McCormick PA, Siringo S, Prospective randomized trial of long term sclerotherapy for variceal rebleeding, using the same protocol to treat rebleeding in all patients. Final report [abstract]. J Hepatol 1989;9:S12
  • Korula J, Yellin A, Yamada S, A prospective randomized controlled comparison of chronic endoscopic variceal sclerotherapy and portalsystemic shunt for variceal hemorrhage in Child's class a cirrhotics [abstract]. Hepatology 1988;8:1242
  • Rossi V, Cales P, Burtin P, Prevention of recurrent variceal bleeding in alcoholic cirrhotic patients: prospective controlled trial of propranolol and sclerotherapy. J Hepatol 1991;12:283-9
  • Soderlund C, Ihre T. Endoscopic sclerotherapy v. conservative management of bleeding oesophageal varices. A 5-year prospective controlled trial of emergency and long-term treatment. Acta Chir Scand 1985;151:449-56
  • Terblanche J, Bornman PC, Kahn D, Failure of repeated injection sclerotherapy to improve long-term survival after oesophageal variceal bleeding. A five-year prospective controlled clinical trial. Lancet 1983;2:1328-32
  • Westaby D, Macdougall BR, Williams R. Improved survival following injection sclerotherapy for esophageal varices: final analysis of a controlled trial. Hepatology 1985;5:827-30
  • Triantos C, Goulis J, Burroughs AK. Portal hypertensive bleeding. Evidence-based gastroenterology and hepatology. 3rd edition. Oxford: Blackwell; 2010. p. 562-602
  • Avgerinos A, Armonis A, Manolakopoulos S, Endoscopic sclerotherapy versus variceal ligation in the long-term management of patients with cirrhosis after variceal bleeding. A prospective randomized study. J Hepatol 1997;26:1034-41
  • Baroncini D, Milandri GL, Borioni D, A prospective randomized trial of sclerotherapy versus ligation in the elective treatment of bleeding esophageal varices. Endoscopy 1997;29:235-40
  • Gimson AE, Ramage JK, Panos MZ, Randomised trial of variceal banding ligation versus injection sclerotherapy for bleeding oesophageal varices. Lancet 1993;342:391-4
  • Hou MC, Lin HC, Kuo BI, Comparison of endoscopic variceal injection sclerotherapy and ligation for the treatment of esophageal variceal hemorrhage: a prospective randomized trial. Hepatology 1995;21:1517-22
  • Jensen DM, Kovacs T, Randall GM, Initial results of a randomized prospective study of emergency banding vs sclerotherapy for bleeding gastric or esophageal varices [abstract]. Gastrointest Endosc 1993;39:128A
  • Jensen DM, Kovacs T, Jutabha R, Randomized, blinded prospective study of banding vs. sclerotherapy for preventing recurrent variceal hemorrhage for patients without active bleeding at endoscopy [abstract]. Gastrointest Endosc 1995;41:315A
  • Laine L, el Newihi HM, Migikovsky B, Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Ann Intern Med 1993;119:1-7
  • Lo GH, Lai KH, Cheng JS, A prospective, randomized trial of sclerotherapy versus ligation in the management of bleeding esophageal varices. Hepatology 1995;22:466-71
  • Lo GH, Lai KH, Cheng JS, Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices. Hepatology 1997;25:1101-4
  • Masci E, Norberto L, D'Imperio N, Prospective multicentric randomized trial comparing banding ligation with sclerotherapy of esophageal varices [abstract]. Gastrointest Endosc 1997;45:847A
  • Mundo F, Mitrani C, Rodriguez G, Farca A. Endoscopic variceal treatment, is band ligation taking over sclerotherapy? [abstract]. Am J Gastroenterol 1993;88:1493A
  • Stiegmann GV, Goff JS, Michaletz-Onody PA, Endoscopic sclerotherapy as compared with endoscopic ligation for bleeding esophageal varices. N Engl J Med 1992;326:1527-32
  • Young MF, Sanowski RA, Rasche R. Comparison and characterization of ulcerations induced by endoscopic ligation of esophageal varices versus endoscopic sclerotherapy. Gastrointest Endosc 1993;39:119-22
  • Jain AK, Ray RP, Gupta J. Management of acute variceal bleed: randomized trial of variceal ligation and sclerotherapy [abstract]. Hepatology 1996;23:I-51
  • Mostafa I, Omar M, Fakhry S, Prospective randomized comparative study of injection sclerotherapy and band ligation for bleeding esophageal varices [abstract]. Hepatology 1996;23:I-63
  • Salem S, Shiha G. A prospective randomized trial of sclerotherapy versus saeed six-shooter multiband ligation in the control of acute bleeding from oesophageal varices [abstract]. Gut 1999;44(Suppl 1):A19
  • Sarin SK, Govil A, Jain AK, Prospective randomized trial of endoscopic sclerotherapy versus variceal band ligation for esophageal varices: influence on gastropathy, gastric varices and variceal recurrence. J Hepatol 1997;26:826-32
  • Shafqat F, Khan AA, Alam A, Band ligation vs endoscopic sclerotherapy in esophageal varices: a prospective randomized comparison. J Pak Med Assoc 1998;48:192-6
  • Shiha GE, Farag FM. Endoscopic variceal ligation versus endoscopic sclerotherapy for the management of bleeding varices [abstract]. Hepatology 1997;26:136A
  • Fakhry S, Omar M, Mustafa A, Endoscopic sclerotherapy versus endoscopic variceal ligation in the management of bleeding esophageal varices: a final report of a prospective randomized study in schistosomal heaptic fibrosis [abstract]. Hepatology 1997;26:137A
  • Agrawall SR, Gupta R, Marthy NS, Comparable efficacy of propranolol plus isosorbide monitrate and endoscopic variceal ligation in prevention of variceal rebleed [abstract]. J Hepatol 2002;36:631A
  • Lo GH, Chen WC, Lin CK, Improved survival in patients receiving medical therapy as compared with banding ligation for the prevention of esophageal variceal rebleeding. Hepatology 2008;48:580-7
  • Minyana J, Gallego A, Sola V, Endoscopic ligation versus nadolol plus isosorbide-5-mononitrate for the prevention of variceal rebleeding. A prospective and randomized trial. Hepatology 1999;30:214A
  • Patch D, Sabin CA, Goulis J, A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis. Gastroenterology 2002;123:1013-19
  • Romero G, Kravetz D, Argonz J, Comparative study between nadolol and 5-isosorbide mononitrate vs. endoscopic band ligation plus sclerotherapy in the prevention of variceal rebleeding in cirrhotic patients: a randomized controlled trial. Aliment Pharmacol Ther 2006;24:601-11
  • Villanueva C, Minana J, Ortiz J, Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med 2001;345:647-55
  • Lo GH, Lai KH, Cheng JS, Endoscopic variceal ligation plus nadolol and sucralfate compared with ligation alone for the prevention of variceal rebleeding: a prospective, randomized trial. Hepatology 2000;32:461-5
  • de la PJ, Brullet E, Sanchez-Hernandez E, Variceal ligation plus nadolol compared with ligation for prophylaxis of variceal rebleeding: a multicenter trial. Hepatology 2005;41:572-8
  • Garcia-Pagan JC, Villanueva C, Albillos A, Nadolol plus isosorbide mononitrate alone or associated with band ligation in the prevention of recurrent bleeding: a multicentre randomised controlled trial. Gut 2009;58:1144-50
  • Villanueva C, Aracil C, Colomo A, Clinical trial: a randomized controlled study on prevention of variceal rebleeding comparing nadolol + ligation vs. hepatic venous pressure gradient-guided pharmacological therapy. Aliment Pharmacol Ther 2009;29:397-408
  • Escorsell A, Banares R, Garcia-Pagan JC, TIPS versus drug therapy in preventing variceal rebleeding in advanced cirrhosis: a randomized controlled trial. Hepatology 2002;35:385-92
  • Cabrera J, Maynar M, Granados R, Transjugular intrahepatic portosystemic shunt versus sclerotherapy in the elective treatment of variceal hemorrhage. Gastroenterology 1996;110:832-9
  • Cello JP, Ring EJ, Olcott EW, Endoscopic sclerotherapy compared with percutaneous transjugular intrahepatic portosystemic shunt after initial sclerotherapy in patients with acute variceal hemorrhage. A randomized, controlled trial. Ann Intern Med 1997;126:858-65
  • Garcia-Villarreal L, Martinez-Lagares F, Sierra A, Transjugular intrahepatic portosystemic shunt versus endoscopic sclerotherapy for the prevention of variceal rebleeding after recent variceal hemorrhage. Hepatology 1999;29:27-32
  • Groupe d Etude des Anastomoses Intrahepatiques. TIPS vs sclerotherapy plus propranolol in the prevention of variceal rebleeding – preliminary results of a multicenter randomized trial [abstract]. Hepatology 1995;22:761
  • Merli M, Salerno F, Riggio O, ; Gruppo Italiano Studio TIPS (GIST). Transjugular intrahepatic portosystemic shunt versus endoscopic sclerotherapy for the prevention of variceal bleeding in cirrhosis: a randomized multicenter trial. Hepatology 1998;27:48-53
  • Narahara Y, Kanazawa H, Kawamata H, A randomized clinical trial comparing transjugular intrahepatic portosystemic shunt with endoscopic sclerotherapy in the long-term management of patients with cirrhosis after recent variceal hemorrhage. Hepatol Res 2001;21:189-98
  • Rossle M, Deibert P, Haag K, Randomised trial of transjugular-intrahepatic-portosystemic shunt versus endoscopy plus propranolol for prevention of variceal rebleeding. Lancet 1997;349:1043-9
  • Sanyal AJ, Freedman AM, Luketic VA, Transjugular intrahepatic portosystemic shunts for patients with active variceal hemorrhage unresponsive to sclerotherapy. Gastroenterology 1996;111:138-46
  • Sauer P, Theilmann L, Stremmel W, Transjugular intrahepatic portosystemic stent shunt versus sclerotherapy plus propranolol for variceal rebleeding. Gastroenterology 1997;113:1623-31
  • Gulberg V, Schepke M, Geigenberger G, Transjugular intrahepatic portosystemic shunting is not superior to endoscopic variceal band ligation for prevention of variceal rebleeding in cirrhotic patients: a randomized, controlled trial. Scand J Gastroenterol 2002;37:338-43
  • Jalan R, Forrest EH, Stanley AJ, A randomized trial comparing transjugular intrahepatic portosystemic stent-shunt with variceal band ligation in the prevention of rebleeding from esophageal varices. Hepatology 1997;26:1115-22
  • Pomier-Layrargues G, Dufresne MP, Bui B, TIPS versus endoscopic variceal ligation in the prevention of variceal rebleeding in cirrhotic patients: a comparative randomized clinical trial (interim analysis) [abstract]. Hepatology 1997;26:3
  • Sauer P, Hansmann J, Richter GM, Endoscopic variceal ligation plus propranolol vs. transjugular intrahepatic portosystemic stent shunt: a long-term randomized trial. Endoscopy 2002;34:690-7
  • Casado M, Bosch J, Garcia-Pagan JC, Clinical events after transjugular intrahepatic portosystemic shunt: correlation with hemodynamic findings. Gastroenterology 1998;114:1296-303
  • Bureau C, Garcia-Pagan JC, Otal P, Improved clinical outcome using polytetrafluoroethylene-coated stents for TIPS: results of a randomized study. Gastroenterology 2004;126:469-75
  • Fernandez-Aguilar JL, Bondia Navarro JA, Santoyo SJ, Calibrated portacaval H-graft shunt in variceal hemorrhage. Long-term results. Hepatogastroenterology 2003;50:2000-4
  • Orozco H, Mercado MA, Chan C, A comparative study of the elective treatment of variceal hemorrhage with beta-blockers, transendoscopic sclerotherapy, and surgery: a prospective, controlled, and randomized trial during 10 years. Ann Surg 2000;232:216-19
  • Khaitiyar JS, Luthra SK, Prasad N, Transjugular intrahepatic portosystemic shunt versus distal splenorenal shunt – a comparative study. Hepatogastroenterology 2000;47:492-7
  • Rosemurgy AS, Goode SE, Zwiebel BR, A prospective trial of transjugular intrahepatic portasystemic stent shunts versus small-diameter prosthetic H-graft portacaval shunts in the treatment of bleeding varices. Ann Surg 1996;224:378-84
  • de Franchis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2010;53:762-8
  • Bernard B, Grange JD, Khac EN, Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology 1999;29:1655-61
  • Soares-Weiser K, Brezis M, Tur-Kaspa R, Antibiotic prophylaxis of bacterial infections in cirrhotic inpatients: a meta-analysis of randomized controlled trials. Scand J Gastroenterol 2003;38:193-200
  • Imperiale TF, Teran JC, McCullough AJ. A meta-analysis of somatostatin versus vasopressin in the management of acute esophageal variceal hemorrhage. Gastroenterology 1995;109:1289-94
  • Hou MC, Lin HC, Liu TT, Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial. Hepatology 2004;39:746-53
  • Fernandez J, Ruiz del AL, Gomez C, Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage. Gastroenterology 2006;131:1049-56
  • Sonnenberg GE, Keller U, Perruchoud A, Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology 1981;80:526-32
  • Bosch J, Kravetz D, Rodes J. Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis of the liver: comparison with vasopressin. Gastroenterology 1981;80:518-25
  • Jenkins SA, Baxter JN, Corbett WA, Shields R. Effects of a somatostatin analogue SMS 201-995 on hepatic haemodynamics in the pig and on intravariceal pressure in man. Br J Surg 1985;72:1009-12
  • McCormick PA, Biagini MR, Dick R, Octreotide inhibits the meal-induced increases in the portal venous pressure of cirrhotic patients with portal hypertension: a double-blind, placebo-controlled study. Hepatology 1992;16:1180-6
  • Escorsell A, Bandi JC, Andreu V, Desensitization to the effects of intravenous octreotide in cirrhotic patients with portal hypertension. Gastroenterology 2001;120:161-9
  • Freeman JG, Cobden I, Record CO. Placebo-controlled trial of terlipressin (glypressin) in the management of acute variceal bleeding. J Clin Gastroenterol 1989;11:58-60
  • Levacher S, Letoumelin P, Pateron D, Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients. Lancet 1995;346:865-8
  • Patch D, Caplin M, Greenslade L, Burroughs A. Randomized double blind controlled trial of 5 day terlipressin vs placebo in acute variceal hemorrhage [abstract]. J Hepatol 1999;30:55
  • Pauwels A, Florent C, Desaint B, Terlipressin and somatostatin in the treatment of hemorrhages from rupture of esophageal varices. Gastroenterol Clin Biol 1994;18:388-9
  • Soderlund C, Magnusson I, Torngren S, Lundell L. Terlipressin (triglycyl-lysine vasopressin) controls acute bleeding oesophageal varices. A double-blind, randomized, placebo-controlled trial. Scand J Gastroenterol 1990;25:622-30
  • Walker S, Stiehl A, Raedsch R, Kommerell B. Terlipressin in bleeding esophageal varices: a placebo-controlled, double-blind study. Hepatology 1986;6:112-15
  • Burroughs AK, McCormick PA, Hughes MD, Randomized, double-blind, placebo-controlled trial of somatostatin for variceal bleeding. Emergency control and prevention of early variceal rebleeding. Gastroenterology 1990;99:1388-95
  • Gotzsche PC, Gjorup I, Bonnen H, Somatostatin v placebo in bleeding oesophageal varices: randomised trial and meta-analysis. BMJ 1995;310:1495-8
  • Valenzuela JE, Schubert T, Fogel MR, A multicenter, randomized, double-blind trial of somatostatin in the management of acute hemorrhage from esophageal varices. Hepatology 1989;10:958-61
  • Moitinho E, Planas R, Banares R, Multicenter randomized controlled trial comparing different schedules of somatostatin in the treatment of acute variceal bleeding. J Hepatol 2001;35:712-18
  • Chelarescu D, Gabor O, Lunca C. Terlipressin vs somatostatin in acute variceal bleeding: a prospective, randomized trial. J Hepatol 2001;34(Suppl 1):78
  • Feu F, Ruiz DA, Banares R, ; Variceal Bleeding Study Group. Double-blind randomized controlled trial comparing terlipressin and somatostatin for acute variceal hemorrhage. Gastroenterology 1996;111:1291-9
  • Walker S, Kreichgauer HP, Bode JC. Terlipressin (glypressin) versus somatostatin in the treatment of bleeding esophageal varices – final report of a placebo-controlled, double-blind study. Z Gastroenterol 1996;34:692-8
  • Burroughs A; International Octreotide Varices Study Group. Double blind RCT of 5 day octreotide versus placebo, associated with sclerotherapy for trial failures [abstract]. Hepatology 1996;24:352A
  • D'Amico G, Politi F, Morabito A, Octreotide compared with placebo in a treatment strategy for early rebleeding in cirrhosis. A double blind, randomized pragmatic trial. Hepatology 1998;28:1206-14
  • Primignani M, Andreoni B, Carpinelli L, Sclerotherapy plus octreotide versus sclerotherapy alone in the prevention of early rebleeding from esophageal varices: a randomized, double-blind, placebo-controlled, multicenter trial. New Italian Endoscopic Club. Hepatology 1995;21:1322-7
  • Hubmann R, Bodlaj G, Czompo M, The use of self-expanding metal stents to treat acute esophageal variceal bleeding. Endoscopy 2006;38:896-901
  • Burroughs AK, Triantos CK. Predicting failure to control bleeding and mortality in acute variceal bleeding. J Hepatol 2008;48:185-8
  • Bosch J, Thabut D, Albillos A, Recombinant factor VIIA (RFVIIA) for active variceal bleeding in patients with advanced cirrhosis: a multi-centre randomized double-blind placebo-controlled trial. J Hepatol 2007;46(Suppl 1):295
  • Bosch J, Thabut D, Albillos A, Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: a randomized, controlled trial. Hepatology 2008;47:1604-14
  • Hartigan PM, Gebhard RL, Gregory PB.; Veterans Affairs Cooperative Variceal Sclerotherapy Group. Sclerotherapy for actively bleeding esophageal varices in male alcoholics with cirrhosis. Gastrointest Endosc 1997;46:1-7
  • Villanueva C, Piqueras M, Aracil C, A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding. J Hepatol 2006;45:560-7
  • Djurdjevic D, Janosevic S, Dapcevic B, Combined ligation and sclerotherapy versus ligation alone for eradication of bleeding esophageal varices: a randomized and prospective trial. Endoscopy 1999;31:286-90
  • Vangeli M, Patch D, Burroughs AK. Salvage tips for uncontrolled variceal bleeding. J Hepatol 2002;37:703-4
  • Monescillo A, Martinez-Lagares F, Ruiz-del-Arbol L, Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding. Hepatology 2004;40:793-801
  • Garcia-Pagan JC, Caca K, Bureau C, Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med 2010;362:2370-9
  • Abraldes JG, Villanueva C, Banares R, Hepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy. J Hepatol 2008;48:229-36
  • Guerrini GP, Pleguezuelo M, Maimone S, Impact of tips preliver transplantation for the outcome posttransplantation. Am J Transplant 2009;9:192-200
  • Colomo A, Hernandez-Gea V, Madoz P, Hemodynamic changes and transfusion strategies in cirrhotic patients with acute variceal bleeding [abstract]. Hepatology 2009;50(4 Suppl):403A
  • Sarin SK, Lahoti D, Saxena SP, Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology 1992;16:1343-9
  • Ramond MJ, Valla D, Mosnier JF, Successful endoscopic obturation of gastric varices with butyl cyanoacrylate. Hepatology 1989;10:488-93
  • Oho K, Iwao T, Sumino M, Ethanolamine oleate versus butyl cyanoacrylate for bleeding gastric varices: a nonrandomized study. Endoscopy 1995;27:349-54
  • Tan PC, Hou MC, Lin HC, A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation. Hepatology 2006;43:690-7
  • Lo GH, Lai KH, Cheng JS, A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices. Hepatology 2001;33:1060-4
  • Williams SG, Peters RA, Westaby D. Thrombin – an effective treatment for gastric variceal haemorrhage. Gut 1994;35:1287-9
  • Chau TN, Patch D, Chan YW, ‘Salvage’ transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding. Gastroenterology 1998;114:981-7
  • Cho SK, Shin SW, Lee IH, Balloon-occluded retrograde transvenous obliteration of gastric varices: outcomes and complications in 49 patients. AJR Am J Roentgenol 2007;189:W365-72
  • Ninoi T, Nishida N, Kaminou T, Balloon-occluded retrograde transvenous obliteration of gastric varices with gastrorenal shunt: long-term follow-up in 78 patients. AJR Am J Roentgenol 2005;184:1340-6
  • Lo GH, Liang HL, Chen WC, A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy 2007;39:679-85
  • Abraldes JG, Albillos A, Banares R, Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology 2009;136:1651-8
  • Tandon P, Abraldes JG, Berzigotti A, Renin-angiotensin-aldosterone inhibitors in the reduction of portal pressure: a systematic review and meta-analysis. J Hepatol 2010;53:273-82
  • Vlachogiannakos J, Tang AK, Patch D, Burroughs AK. Angiotensin converting enzyme inhibitors and angiotensin II antagonists as therapy in chronic liver disease. Gut 2001;49:303-8
  • Mejias M, Garcia-Pras E, Tiani C, Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology 2009;49:1245-56
  • de Franchis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2010;53:762-8
  • Thalheimer U, De Iorio F, Capra F, Altered intestinal function precedes the appearance of bacterial DNA in serum and ascites in patients with cirrhosis: a pilot study. Eur J Gastroenterol Hepatol 2010;22(10):1228-34
  • Tsochatzis EA, Triantos CK, Garcovich M, Burroughs AK. Primary prevention of variceal haemorrhage. Curr Gastroenterol Rep 2010; In press
  • Triantos C, Samonakis D, Thalheimer U, The relationship between liver function and portal pressure: what comes first, the chicken or the egg? J Hepatol 2005;42:146-7

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