Cough pharmacotherapy: current and future status

Bibliography

• Groneberg DA, Niimi A, Dinh QT, Increased espresssion of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 2004;12:1276-80
   Google Scholar
• Irwin RS. Introduction to the diagnosis and management of cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129:2S-7S
   Google Scholar
• Irwin RS, Boulet LP, Cloutier MM, Managing cough as a defense mechanism and as a symptom. Chest 1998;114:13s-81s
   Google Scholar
• Blanc F-X, Macedo P, Hew M, Chung KF. Capsaicin cough sensitivity in smokers with and without airflow obstruction. Respir Med 2009;103:786-90
   PubMedGoogle Scholar
• Haque RA, Usmani OS, Barnes PJ. Chronic idiopathic cough: a discrete clinical entity? Chest 2005;127:1710-13
   PubMed Web of Science ®Google Scholar
• Kardos P. Proposals for a rationale and for rational diagnosis of cough. Pneumologie 2000;54:110-15
   PubMedGoogle Scholar
• Vertigan AE, Gibson PG. Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers. J Voice 2010. [Epub ahead of print]
   PubMedGoogle Scholar
• Lee B, Woo P. Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment. Ann Otol Rhinol Laryngol 2005;114:253-7
   PubMed Web of Science ®Google Scholar
• Altman KW, Simpson CB, Amin MR, Cough and paradoxical vocal fold motion. Otolaryngol Head Neck Surg 2002;127:501-111
   PubMedGoogle Scholar
• Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med 2000;343:1715-21
   PubMed Web of Science ®Google Scholar
• Lawler WR. An office approach to the diagnosis of chronic cough. Am Fam Physician 1998;58:2015-22
   PubMed Web of Science ®Google Scholar
• Bastian RW, Vaidya AM, Delsupehe KG. Sensory neuropathic cough: a common and treatable cause of chronic cough. Otolaryngol Head Neck Surg 2006;135:17-21
   PubMed Web of Science ®Google Scholar
• Amin MR, Koufman JA. Vagal neuropathy after upper respiratory infection: a viral etiology? Am J Otolaryngol 2001;22:251-6
   PubMed Web of Science ®Google Scholar
• Jacoby DB, Fryer AD. Interaction of viral infections with muscarinic receptors. Clin Exp Allergy 1999;29:59-64S
   PubMed Web of Science ®Google Scholar
• Jeyakumar A, Brickman TM, Haben M. Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. Laryngoscope 2006;116:2108-112
   PubMed Web of Science ®Google Scholar
• Spring PJ, Kok C, Nicholson GA, Autosomal dominant hereditary sensory neuropathy with chronic cough and gastroesophageal reflux: clinical features in two families linked to chromosome 3p22-p24. Brain 2005;128:2797-810
   PubMedGoogle Scholar
• Mintz S, Lee JK. Gabapentin in the treatment of intractable idiopathic chronic cough: case reports. Am J Med 2006;119:e13-15
   PubMed Web of Science ®Google Scholar
• Dooley DJ, Donovan CM, Pugsley TA. Stimulus-dependent modulation of [3H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin. J Pharmacol Exp Ther 2000;295:1086-93
   PubMed Web of Science ®Google Scholar
• Rosenstock J, Tuchman M, LaMoreaux L, Sharma U. Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain 2004;110:628-38
   PubMed Web of Science ®Google Scholar
• Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16:274-7
   PubMed Web of Science ®Google Scholar
• Attal N, Gruccu G, Haanpaa M, EFNS guidelines on pharmacological treatment of neuropathic pain. Eur J Neurol 2006;13:1153-69
   PubMed Web of Science ®Google Scholar
• Guay DRP. Pregabalin in neuropathic pain: a more ‘pharmaceutically elegant’ gabapentin? Am J Geriatr Pharmacother 2005;3:274-87
   PubMedGoogle Scholar
• Tassone DM, Boyce E, Guyer J, Nauzum D. Pregabalin: a novel g-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther 2007;29:26-48
   PubMed Web of Science ®Google Scholar
• Halum SL, Sycamore DL, McRae BR. A new treatment option for laryngeal sensory neuropathy. Laryngoscope 2009; published online 24 Jun 2009, doi:10.1002/lary.20553
   Google Scholar
• Greene SM, Simpson CB. Evidence for sensory neuropathy and pharmacologic management. Otolaryngol Clin North Am 2010;43:67-72
   PubMedGoogle Scholar
• Morice AH. The cough hypersensitivity syndrome: a novel paradigm for understanding cough. Lung 2010;188(Suppl 1):S87-90
   PubMedGoogle Scholar
• Millqvist E, Ternesten-Hasseus E, Stahl A, Bende M. Changes in levels of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and chemicals. Environ Health Perspect 2005;113:849-52
   PubMed Web of Science ®Google Scholar
• Morice AH, Gepetti P. Cough 5: the type 1 vanilloid receptor; a sensory receptor for cough. Thorax 2004;59:257-8
   PubMed Web of Science ®Google Scholar
• Mitchell JE, Campbell AP, New NE, Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough. Exp Lung Res 2005;31:295-306
   PubMed Web of Science ®Google Scholar
• MacPherson LJ, Dubin AE, Evans MJ, Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 2007;445:541-5
   PubMed Web of Science ®Google Scholar
• Millqvist E. The airway sensory hyperreactivity sydrome. Pulm Pharmacol Ther 2010;8:1-4
   Google Scholar
• Bessac BF, Jordt S-E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 2008;23:360-70
   PubMed Web of Science ®Google Scholar
• Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007;6:357-72
   PubMed Web of Science ®Google Scholar
• Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007;87:165-217
   PubMed Web of Science ®Google Scholar
• Kim D, Baraniuk JN. Sensing the air around us: the voltage-gated-like ion channel family. Curr Allergy Asthma Rep 2007;7:85-92
   PubMedGoogle Scholar
• Birrell MA, Belvisi MG, Grace M, TRPA1 agonists evoke coughing in guinea pig and human volunteers. Am J Respir Crit Care Med 2009;180:1042-7
   PubMed Web of Science ®Google Scholar
• Nilius B. TRP channels in disease. Biochim Biophys Acta 2007;1772:805-12
   PubMed Web of Science ®Google Scholar
• Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem 2007;76:387-417
   PubMed Web of Science ®Google Scholar
• Kollarik M, Ru F, Undem BJ. Acid-sensitive vagal sensory pathways and cough. Pulm Pharmacol Ther 2007;20:402-11
   PubMedGoogle Scholar
• Seki N, Shirasaki H, Kikuchi M, Expression and localization of TRPV1 in human nasal mucosa. Rhinology 2006;44:128-34
   PubMed Web of Science ®Google Scholar
• Watanabe N, Horie S, Michael GJ, Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system. Pulm Pharmacol Ther 2005;18:187-97
   PubMed Web of Science ®Google Scholar
• Myers AC, Kajekar R, Undem BJ. Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 2002;282:L775-81
   PubMed Web of Science ®Google Scholar
• Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 2001;24:487-517
   PubMed Web of Science ®Google Scholar
• Laude EA, Higgins KS, Morice AH. A comparitive study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea pig and man. Pulm Pharmacol 1993;6:171-5
   PubMedGoogle Scholar
• McLeod RL, Fernandez X, Correll CC, TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs. Cough 2006;2:10
   PubMedGoogle Scholar
• Jia Y, McLeod RL, Wang X, Anandamide induces cough in conscious pig through VR1 receptors. Br J Pharmacol 2002;137:831-6
   PubMed Web of Science ®Google Scholar
• Bhattacharya A, Scott BP, Nasser N, Pharmacology and antitussive efficacy of 4 - (3 -Trifluoromethyl - pyridin - 2 - yl) - piperazine -1 - carboxylic Acid (5 -Trifluoromethyl - pyridin - 2 - yl) - amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs. J Pharmacol Exp Ther 2007;323:665-74
   PubMed Web of Science ®Google Scholar
• Lalloo UG, Fox AJ, Belvisi MG, Barnes PJ. Capsazepine inhibits cough indused by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol 1995;79:1082-92
   PubMed Web of Science ®Google Scholar
• Trevisani M, Milan A, Gatti R, Antitussive activity of iodo-resiniferatoxin in guinea pigs. Thorax 2004;59:769-72
   PubMed Web of Science ®Google Scholar
• Leung SY, Niimi A, Williams AS, Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. Cough 2007;3:10-14
   PubMedGoogle Scholar
• Valenzano KJ, Grant ER, Wu G, N-(4-Tertiarybutylphenyl)-4(3-cholorphyridin-2-yl)-tetrahydro-pyrazine (2H) - carboxamide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: 1. in vitro characterization and pharmacokinetic properties. J Pharmacol Exp Ther 2003;306:377-86
   PubMed Web of Science ®Google Scholar
• Tafesse L, Sun Q, Schmid L, Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists. Bioorg Med Chem Lett 2004;14:5513-19
   PubMed Web of Science ®Google Scholar
• Chung KF. Assessment and measurement of cough: the value of new tools. Pulm Pharmacol Ther 2002;15:267-72
   PubMedGoogle Scholar
• McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002;416:52-8
   PubMed Web of Science ®Google Scholar
• Peier AM, Moqrich A, Hergarden AC, A TRP channel that senses cold stimuli and menthol. Cell 2002;108:705-15
   PubMed Web of Science ®Google Scholar
• Bautista DM, Siemens J, Glazer JM, The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 2007;448:204-8
   PubMed Web of Science ®Google Scholar
• Story GM, Peier AM, Reeve AJ, ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003;112:819-29
   PubMed Web of Science ®Google Scholar
• Nassenstein C, Kwong K, Taylor-Clark T, Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 2008;586:1595-604
   PubMed Web of Science ®Google Scholar
• Jordt SE, Bautista DM, Chuang HH, Mustard oils and cannaboids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004;427:260-5
   PubMed Web of Science ®Google Scholar
• Nagata K, Duggan A, Kumar G, Garcia-Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 2005;25:4052-61
   PubMed Web of Science ®Google Scholar
• Bautista DM, Jordt SE, Nikai T, TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 2006;124:1269-82
   PubMed Web of Science ®Google Scholar
• Caterina MJ, Schumacher MA, Tominaga M, The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-24
   PubMed Web of Science ®Google Scholar
• Jancso N, Jancso-Gabor A, Szolcsanyi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol Chemother 1967;31:138-51
   PubMed Web of Science ®Google Scholar
• Bessac BF, Sivula M, von Hehn CA, TRPA1 is a major oxident sensor in murine airway sensory neurons. J Clin Invest 2008;118:1899-910
   PubMed Web of Science ®Google Scholar
• Cavanaugh EJ, Simkin D, Kim D. Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states. Neuroscience 2008;154:1467-76
   PubMed Web of Science ®Google Scholar
• Doerner JF, Gisselmann G, Hatt H, Wetzel CH. Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem 2007;282:13180-9
   PubMed Web of Science ®Google Scholar
• Wang Y, Chang R, Waters HN, The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem 2008;283:32691-703
   PubMed Web of Science ®Google Scholar
• Zurborg S, Yurgionas B, Jira JA, Direct activation of the ion channel TRPA1 by Ca2+. Nat Neurosci 2007;10:277-9
   PubMed Web of Science ®Google Scholar
• Abe K, Watanabe N, Kumagai N, Circulating kinin in patients with bronchial asthma. Experientia 1967;23:626-7
   PubMedGoogle Scholar
• Dolovich J, Back N, Arbesman CE. Kinin-like activity in nasal secretions of allergic patients. Int Arch Allergy Appl Immunol 1970;38:337-44
   PubMedGoogle Scholar
• Fox AJ, Lalloo UG, Belvisi MG, Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Nat Med 1996;2:814-17
   PubMed Web of Science ®Google Scholar
• Kollarik M, Undem BJ. Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1–/– mice. J Physiol 2004;555:115-23
   PubMedGoogle Scholar
• Carr MJ, Kollarik M, Meeker SN, Undem BJ. A role for TRPV1 in bradykinin-induced excitation of vagal airway afferent nerve terminals. J Pharmacol Exp Ther 2003;304:1275-9
   PubMedGoogle Scholar
• Bandell M, Story GM, Hwang SW, Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 2004;41:849-57
   PubMed Web of Science ®Google Scholar
• Wang S, Dai Y, Fukuoka T, Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain 2008;131:1241-51
   PubMed Web of Science ®Google Scholar
• Millqvist E, Bende M, Lowhagen O. Sensory hyperreactivity – a possible mechanism underlying cough and asthma-like symptoms. Allergy 1998;53:1208-112
   PubMed Web of Science ®Google Scholar
• Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2:655-61
   PubMedGoogle Scholar
• Hinman A, Chuang HH, Bautista DM, Julius D. TRP channel activation by reversible covalent modification. Proc Natl Acad Sci USA 2006;103:19564-8
   PubMed Web of Science ®Google Scholar
• Escalera J, von Hehn CA, Bessac BF, TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J Biol Chem 2008;283:24136-44
   PubMed Web of Science ®Google Scholar
• Trevisani M, Siemens J, Materazzi S, 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 2007;104:13519-24
   PubMed Web of Science ®Google Scholar
• McNamara CR, Mandel-Brehm J, Bautista DM, TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci USA 2007;104:13525-30
   PubMed Web of Science ®Google Scholar
• Bautista DM, Movahed P, Hinman A, Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci USA 2005;102:12248-52
   PubMed Web of Science ®Google Scholar
• MacPherson LJ, Geierstanger BH, Viswanath V, The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 2005;15:929-34
   PubMed Web of Science ®Google Scholar
• MacPherson LJ, Xiao B, Kwan KY, An ion channel essential for sensing chemical damage. J Neurosci 2007;27:11412-15
   PubMed Web of Science ®Google Scholar
• Namer B, Seifert F, Handwerker HO, Maihofner C. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. Neuroreport 2005;16:955-9
   PubMed Web of Science ®Google Scholar
• Ward L, Wright E, McMahon SB. A comparison of the effects of noxious and innocuous counterstimuli on experimentally induced itch and pain. Pain 1996;64:129-38
   PubMedGoogle Scholar
• Petrus MJ, Peier AM, Bandell M, A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain 2007;3:40
   PubMed Web of Science ®Google Scholar
• Eid SR, Crown ED, Moore EL, HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 2008;4:48
   PubMed Web of Science ®Google Scholar
• Stein C, Millan MJ, Herz A. Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive threshold. Pharmacol Biochem Behav 1988;31:445-51
   PubMed Web of Science ®Google Scholar
• Gajraj NM. Pregabalin: its pharmacology and use in pain management. Anesth Analg 2007;105:1805-15
   PubMed Web of Science ®Google Scholar
• Jiexian L, Hua B, Wenjin J. Involvement of TRPA1 in ET-1-induced pain-like behavior in mice. Neuroreport 2010;21:201-5
   PubMedGoogle Scholar
• Jason D'Souza, Glenmark, Mumbai, India. Glenmark announces the discovery of a novel chemical entity ‘GRC 17536’, a TRPA1 receptor antagonist, a potential first-in-class molecule globally. The Free Library; 2010. Available from: www.thefreelibrary.com. [Last accessed date 25 April 2011]
   Google Scholar
• Eccles R. Codeine, cough and upper respiratory infection. Pulm Pharmacol 1996;9.293-7
   PubMedGoogle Scholar
• Davies JN. Autonomous breathing. Arch Neurol 1974;30:480-4
   PubMedGoogle Scholar
• Hutchings HA, Eccles R, Smith AP, Jawad MS. Voluntary cough suppression as an indication of symptom severity in upper respiratory tract infections. Eur Respir J 1993;6.1449-54
   PubMedGoogle Scholar
• Lee PCL, Jawad MS, Hull JD, The effect of placebo treatment on cough associated with common cold. Br J Clin Pharmacol 2001;51:373P
   Google Scholar
• Hutchings HA, Morris S, Eccles R, Jawad MS. Voluntary suppression of cough induced by inhalation of capsaicin in healthy volunteers. Respir Med 1993;87:379-82
   PubMed Web of Science ®Google Scholar
• Bucher K. Pathophysiology and pharmacology of cough. Pharmacol Rev 1958;10:43-58
   PubMedGoogle Scholar
• Tedeschi RE, Tedeschi DH, Hitchens JT, A new antitussive method involving mechanical stimulation in unanesthetized dogs. J Pharmacol Exp Ther 1959;126:338-44
   PubMedGoogle Scholar
• Karlsson JA, Lanner AS, Persson CG. Airway opioid receptors mediate inhibition of cough and reflex bronchochonstriction in guinea pigs. J Pharmacol Exp Ther 1990;252:863-8
   PubMed Web of Science ®Google Scholar
• Adcock JJ, Schneider C, Smith TW. Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig. Br J Pharmacol 1988;93:93-100
   PubMed Web of Science ®Google Scholar
• Fuller RW. Cough. Br J Hosp Med 1991;45:100-1
   PubMedGoogle Scholar
• Sevelius H, McCoy JF, Colmore JP. Dose-response to codeine in patients with chronic cough. Clin Pharmacol Ther 1971;12:449-55
   PubMed Web of Science ®Google Scholar
• Eddy NB, Friebel H, Hahn KJ, Halbach H. Codeine and its alternates for pain and cough relief. 5. Discussion and summary. Bull World Health Organ 1969;40:721-30
   PubMedGoogle Scholar
• Adcock JJ. Peripheral opioid receptors and the cough reflex. Respir Med 1991;85:43-6
   PubMed Web of Science ®Google Scholar
• Bolser DC, DeGennaro FC. Effect of codeine on the inspiratory and expiratory burst pattern during fictive cough in cats. Brain Res 1994;662:25-30
   PubMedGoogle Scholar
• Morice AH, Menon MS, Mulrennan SA, Opiate therapy in chronic cough. Am J Respir Crit Care Med 2007;175:312-15
   PubMed Web of Science ®Google Scholar
• Birring SS, Prudon B, Carr AJ, Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire. Thorax 2003;58:339-43
   PubMed Web of Science ®Google Scholar
• Grattan TJ, Marshall AE, Higgins KS, Morice AH. The effect of inhaled and oral dextromethorphan on citric-acid induced cough in man. Br J Clin Pharmacol 1995;39:261-3
   PubMed Web of Science ®Google Scholar
• Lee PL, Jawad M, Eccles R. Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. J Pharm Pharmacol 2000;52:1137-42
   PubMed Web of Science ®Google Scholar