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Off-label use of atypical antipsychotics in personality disorders

, MD FRCPC & , MSc MD
Pages 1575-1585 | Published online: 20 Sep 2011

Bibliography

  • American Psychiatric Association Practice Guidelines. Practice guideline for the treatment of patients with borderline personality disorder. American Psychiatric Association. Am J Psychiatry 2001;158(10 Suppl):1-52
  • Zanarini MC. Psychotherapy of borderline personality disorder. Acta Psychiatr Scand 2009;120:373-7
  • Zanarini MC. Update on pharmacotherapy of borderline personality disorder. Curr Psychiatry Rep 2004;6:66-70
  • Bellino S, Paradiso E, Bogetto F. Efficacy and tolerability of pharmacotherapies for borderline personality disorder. CNS Drugs 2008;22:671-92
  • Buckley PF. Broad therapeutic uses of atypical antipsychotic medications. Biol Psychiatry 2001;50:912-24
  • Lieb K, Vollm B, Rucker G, Pharmacotherapy for borderline personality disorder: cochrane systematic review of randomised trials. Br J Psychiatry 2010;196:4-12
  • Abraham PF, Calabrese JR. Evidenced-based pharmacologic treatment of borderline personality disorder: a shift from SSRIs to anticonvulsants and atypical antipsychotics? J Affect Disord 2008;111:21-30
  • Grilo CM, McGlashan TH. ‘Course and outcome’. In: Oldhan JM, Skodol AE, Bender D. editors. Essentials of personality disorders. VA American Psychiatric Press; Arlington: 2009. p. 63-85
  • National Institute for Clinical Excellence (NICE). Borderline personality disorder: treatment and management. Clinical guideline. NICE; London: 2009
  • Nose M, Cipriani A, Biancosino B, Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials. Int Clin Psychopharmacol 2006;21:345-53
  • Stoffers J, Vollm BA, Rucker G, Pharmacological interventions for borderline personality disorder. Cochrane Database Syst Rev 2010;6:CD005653
  • Bogenschutz MP, Nurnberg H. Olanzapine versus placebo in the treatment of borderline personality disorder. J Clin Psychiatry 2004;65:104-9
  • Linehan MM, McDavid JD, Brown MZ, Olanzapine plus dialectical behavior therapy for women with high irritability who meet criteria for borderline personality disorder: a double-blind, placebo-controlled pilot study. J Clin Psychiatry 2008;69:999-1005
  • Schulz SC, Zanarini MC, Bateman A, Olanzapine for the treatment of borderline personality disorder: variable dose, 12-week, randomised doubleblind placebo-controlled study. Br J Psychiatry 2008;193:485-92
  • Zanarini MC, Frankenburg FR. Olanzapine treatment of female borderline personality disorder patients: a double-blind, placebo-controlled pilot study. J Clin Psychiatry 2001;62:849-54
  • Nickel MK, Muehlbacher M, Nickel C, Aripiprazole in the treatment of patients with borderline personality disorder: a double-blind, placebo-controlled study. Am J Psychiatry 2006;163:833-8
  • Pascual JC, Soler J, Puigdemont D, Ziprasidone in the treatment of borderline personality disorder: a double-blind, placebo-controlled, randomized study. J Clin Psychiatry 2008;69:603-8
  • Zanarini MC, Frankenburg FR, Parachini EA. A preliminary, randomized trial of fluoxetine, olanzapine, and the olanzapine-fluoxetine combination in women with borderline personality disorder. J Clin Psychiatry 2004;65:903-7
  • Soler J, Pascual JC, Campins J, Double-blind, placebo-controlled study of dialectical behavior therapy plus olanzapine for borderline personality disorder. Am J Psychiatry 2005;162:1221-4
  • Bellino S, Paradiso E, Bogetto F. Efficacy and tolerability of quetiapine in the treatment of borderline personality disorder: a pilot study. J Clin Psychiatry 2006;67:1042-6
  • Villeneuve E, Lemelin S. Open-label study of atypical neuroleptic quetiapine for treatment of borderline personality disorder: impulsivity as main target. J Clin Psychiatry 2005;66:1298-303
  • Perrella C, Carrus D, Costa E, Quetiapine for the treatment of borderline personality disorder; an open-label study. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:158-63
  • Van den Eynde F, Senturk V, Naudts K, Efficacy of quetiapine for impulsivity and affective symptoms in borderline personality disorder. J Clin Psychopharmacol 2008;28:147-55
  • Van den Eynde F, De Saedeleer S, Naudts K, Quetiapine treatment and improved cognitive functioning in borderline personality disorder. Hum Psychopharmacol 2009;24:646-9
  • Rocca P, Marchiaro L, Cocuzza E, Treatment of borderline personality disorder with risperidone. J Clin Psychiatry 2002;63:241-4
  • Ilardi S, Craighead W. Personality pathology and response to somatic treatments for major depression: a critical review. Depression 1995;2:200-17
  • Sanderson WC, Wetzler S, Beck AT, Prevalence of personality disorders in patients with major depression and dysthymia. Psychiatry Res 1992;42:93-9
  • Brieger P, Ehrt U, Marneros A. Frequency of comorbid personality disorders in bipolar and unipolar affective disorders. Compr Psychiatry 2003;44:28-34
  • Zanarini MC, Frankenburg FR, Hennen J, Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission. Am J Psychiatry 2004;161:2108-14
  • Fava M, Farabaugh AH, Sickinger AH, Personality disorders and depression. Psychol Med 2002;32:1049-57
  • Hirschfeld RM, Russell JM, Delgado PL, Predictors of response to acute treatment of chronic and double depression with sertraline or imipramine. J Clin Psychiatry 1998;59:669-75
  • Mullen LS, Blanco C, Vaughan SC, Defense mechanisms and personality in depression. Depress Anxiety 1999;10:168-74
  • Skodol AE, Grilo CM, Keyes KM, Relationship of personality disorders to the course of major depressive disorder in a nationally representative sample. Am J Psychiatry 2011;168:257-64
  • Grilo CM, Stout RL, Markowitz JC, Personality disorders predict relapse after remission from an episode of major depressive disorder: a 6-year prospective study. J Clin Psychiatry 2010;71:1629-35
  • Schulz SC, Camlin KL, Berry SA, Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia. Biol Psychiatry 1999;46:1429-35
  • Kool S, Dekker J, Duijsens IJ, Efficacy of combined therapy and pharmacotherapy for depressed patients with or without personality disorders. Harv Rev Psychiatry 2003;11:133-41
  • Newton-Howes G, Tyrer P. Pharmacotherapy for personality disorders. Expert Opin Pharmacother 2003;4:1643-9
  • Cardish RJ. Psychopharmacologic management of suicidality in personality disorders. Can J Psychiatry 2007;52(Suppl 1):115-27S
  • Black DW, Blum N, Pfohl B, Suicidal behavior in borderline personality disorder: prevalence, risk factors, prediction, and prevention. J Personal Disord 2004;18:226-39
  • Hennen J, Baldessarini RJ. Suicidal risk during treatment with clozapine: a meta-analysis. Schizophr Res 2005;73:139-45
  • Agid O, Foussias G, Singh S, Where to position clozapine: re-examining the evidence. Can J Psychiatry 2010;55:677-84
  • Nielsen J, Dahm M, Lublin H, Psychiatrists' attitude towards and knowledge of clozapine treatment. J Psychopharmacol 2010;24:965-71
  • Benedetti F, Sforzini L, Colombo C, Low dose clozapine in acute and continuation treatment of severe borderline personality disorder. J Clin Psychiatry 1998;59:103-7
  • Frankenburg FR, Zanarini MC. Clozapine treatment of borderline patients: a preliminary study. Compr Psychiatry 1993;34:402-5
  • Oumaya M, Friedman S, Pham A, Borderline personality disorder, self-mutilation and suicide: literature review. Encephale 2008;34:452-8
  • Chengappa KN, Ebeling T, Kang JS, Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder. J Clin Psychiatry 1999;60:477-84
  • Hori A. Pharmacotherapy for personality disorders. Psychiatry Clin Neurosci 1998;52:13-19
  • Baldessarini RJ, Tondo L. Lithium and suicidal risk. Bipolar Disord 2008;10:114-15
  • Khalifa N, Duggan C, Stoffers J, Pharmacological interventions for antisocial personality disorder. Cochrane Database Syst Rev 2010;8:CD007667
  • Hirose S. Effective treatment of aggression and impulsivity in antisocial personality disorder with risperidone. Psychiatry Clin Neurosci 2001;55:161-2
  • Alex R, Ferriter M, Jones H, Pharmacological interventions for obsessive-compulsive personality disorder (Protocol). Cochrane Database Syst Rev 2010;5:CD008517
  • Farooq S, Vollm BA, Husain N, Pharmacological interventions for schizotypal personality disorder (Protocol). Cochrane Database Syst Rev 2011;3:CD009047
  • Farooq S, Vollm BA, Stoffers J, Pharmacological interventions for schizoid personality disorder (Protocol). Cochrane Database Syst Rev 2011;3:CD009048
  • Koenigsberg HW, Reynolds D, Goodman M, Risperidone in the treatment of schizotypal personality disorder. J Clin Psychiatry 2003;64:628-34
  • Skodol AE, Bender DS, Morey LC, Personality disorder types proposed for DSM-5. J Personal Disord 2011;25:136-69
  • Citrome L, Volavka J. The promise of atypical antipsychotics: fewer side effects mean enhanced compliance and improved functioning. Postgrad Med 2004;116:49-63
  • Aia PG, Revuelta GJ, Cloud LJ, Tardive dyskinesia. Curr Treat Options Neurol 2011;13:231-41
  • Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs 2005;19(Suppl 1):1-93
  • Haddad PM, Sharma SG. Adverse effects of atypical antipsychotics: differential risk and clinical implications. CNS Drugs 2007;21:911-36
  • Soloff PH, Meltzer CC, Becker C, Impulsivity and prefrontal hypometabolism in borderline personality disorder. Psychiatry Res 2003;123:153-63
  • Tost H, Alam T, Meyer-Lindenberg A. Dopamine and psychosis: theory, pathomechanisms and intermediate phenotypes. Neurosci Biobehav Rev 2010;34:689-700
  • Gunderson JG. Pharmacotherapy for patients with borderline personality disorder. Arch Gen Psychiatry 1986;43:698-700
  • Links PS, Steiner M. Psychopharmacologic management of patients with borderline personality disorder. Can J Psychiatry 1988;33:355-9
  • Shafti SS, Shahveisi B. Olanzapine versus haloperidol in the management of borderline personality disorder: a randomized double-blind trial. J Clin Psychopharmacol 2010;30:44-7
  • Cowdry RW, Gardner DL. Pharmacotherapy of borderline personality disorder. Alprazolam, carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry 1988;45:111-19
  • Goldberg SC, Schulz SC, Schulz PM, Borderline and schizotypal personality disorders treated with low-dose thiothixene vs placebo. Arch Gen Psychiatry 1986;43:680-6
  • Leone N. Response of borderline patients to loxapine and chlorpromazine. J Clin Psychiatry 1982;43:148-50
  • Ingenhoven T, Lafay P, Rinne T, Effectiveness of pharmacotherapy for severe personality disorders: meta-analyses of randomized controlled trials. J Clin Psychiatry 2010;71:14-25
  • Mercer D, Douglass AB, Links PS. Meta-analyses of mood stabilizers, antidepressants and antipsychotics in the treatment of borderline personality disorder: effectiveness for depression and anger symptoms. J Personal Disord 2009;23:156-74
  • Perugi G, Fornaro M, Akiskal HS. Are atypical depression, borderline personality disorder and bipolar II disorder overlapping manifestations of a common cyclothymic diathesis? World Psychiatry 2011;10:45-51
  • Philipsen A, Schmahl C, Lieb K. Naloxone in the treatment of acute dissociative states in female patients with borderline personality disorder. Pharmacopsychiatry 2004;37:196-9
  • Bohus MJ, Landwehrmeyer GB, Stiglmayr CE, Naltrexone in the treatment of dissociative symptoms in patients with borderline personality disorder: an open-label trial. J Clin Psychiatry 1999;60:598-603
  • Philipsen A, Richter H, Schmahl C, Clonidine in acute aversive inner tension and self-injurious behavior in female patients with borderline personality disorder. J Clin Psychiatry 2004;65:1414-19
  • Golubchik P, Sever J, Zalsman G, Methylphenidate in the treatment of female adolescents with cooccurrence of attention deficit/hyperactivity disorder and borderline personality disorder: a preliminary open-label trial. Int Clin Psychopharmacol 2008;23:228-31
  • McClure MM, Barch DM, Romero MJ, The effects of guanfacine on context processing abnormalities in schizotypal personality disorder. Biol Psychiatry 2007;61:1157-60
  • Gunderson JG, Weinberg I, Daversa MT, Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder. Am J Psychiatry 2006;163:1173-8
  • Baldessarini RJ, Tondo L, Davis P, Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord 2006;8:625-39
  • Alexander GC, Gallagher SA, Mascola A, Increasing off-label use of antipsychotic medications in the United States, 1995 – 2008. Pharmacoepidemiol Drug Saf 2011;20:177-84

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