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Current and future evidence-based acne treatment: a review

, DO, , BS & , MD PhD

Bibliography

  • Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol 2013;168:474-85
  • Thiboutot D, Gollnick H, Bettoli V, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol 2009;60:S1-50
  • Eichenfield LF, Jarratt M, Schlessinger J, et al. Adapalene 0.1% lotion in the treatment of acne vulgaris: results from two placebo-controlled, multicenter, randomized double-blind, clinical studies. J Drugs Dermatol 2010;9:639-46
  • Tanghetti E, Dhawan S, Green L, et al. Randomized comparison of the safety and efficacy of tazarotene 0.1% cream and adapalene 0.3% gel in the treatment of patients with at least moderate facial acne vulgaris. J Drugs Dermatol 2010;9:549-58
  • Eichenfield LF, Hebert AA, Schachner L, et al. Tretinoin microsphere gel 0.04% pump for treating acne vulgaris in preadolescents: a randomized, controlled study. Pediatr Dermatol 2012;29:598-604
  • Leyden JJ, Nighland M, Rossi AB, Ramaswamy R. Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gel. J Drugs Dermatol 2010;9:998-1003
  • Zakaria AS, Paul HK, Rahman MA, et al. Topical tazarotene cream (0.1%) in the treatment of facial acne: an open clinical trial. Bangladesh Med Res Counc Bull 2010;36:43-6
  • Leyden JJ, Del Rosso JQ. The effect of benzoyl peroxide 9.8% emollient foam on reduction of Propionibacterium acnes on the back using a short contact therapy approach. J Drugs Dermatol 2012;11:830-3
  • Jung JY, Kwon HH, Yeom KB, et al. Clinical and histological evaluation of 1% nadifloxacin cream in the treatment of acne vulgaris in Korean patients. Int J Dermatol 2011;50:350-7
  • Tunca M, Akar A, Ozmen I, Erbil H. Topical nadifloxacin 1% cream vs. topical erythromycin 4% gel in the treatment of mild to moderate acne. Int J Dermatol 2010;49:1440-4
  • Tanghetti E, Harper JC, Oefelein MG. The efficacy and tolerability of dapsone 5% gel in female vs male patients with facial acne vulgaris: gender as a clinically relevant outcome variable. J Drugs Dermatol 2012;11:1417-21
  • Kircik LH. Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study. J Drugs Dermatol 2011;10:586-90
  • Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009;18:821-32
  • Trifu V, Tiplica GS, Naumescu E, et al. Cortexolone 17alpha-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0.05% cream. Br J Dermatol 2011;165:177-83
  • Afzali BM, Yaghoobi E, Yaghoobi R, et al. Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial. J Dermatolog Treat 2012;23:21-5
  • Sarici G, Cinar S, Armutcu F, et al. Oxidative stress in acne vulgaris. J Eur Acad Dermatol Venereol 2010;24:763-7
  • Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol 2012;11:742-6
  • Inui S, Aoshima H, Nishiyama A, Itami S. Improvement of acne vulgaris by topical fullerene application: unique impact on skin care. Nanomedicine 2011;7:238-41
  • Woolery-Lloyd H, Baumann L, Ikeno H. Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial. J Cosmet Dermatol 2010;9:22-7
  • Moy RL, Levenson C, So JJ, Rock JA. Single-center, open-label study of a proprietary topical 0.5% salicylic acid-based treatment regimen containing sandalwood oil in adolescents and adults with mild to moderate acne. J Drugs Dermatol 2012;11:1403-8
  • Baldo A, Bezzola P, Curatolo S, et al. Efficacy of an alpha-hydroxy acid (AHA)-based cream, even in monotherapy, in patients with mild-moderate acne. G Ital Dermatol Venereol 2010;145:319-22
  • Montes LF, Wilborn WH, Montes CM. Topical acne treatment with acetylcysteine: clinical and experimental effects. Skinmed 2012;10:348-51
  • Fabbrocini G, Staibano S, De RG, et al. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin Dermatol 2011;12:133-41
  • Poulin Y, Sanchez NP, Bucko A, et al. A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial. Br J Dermatol 2011;164:1376-82
  • Feldman SR, Fried RG, Herndon JH Jr, et al. Digital videography assessment of patients' experiences using adapalene-benzoyl peroxide gel in the treatment of acne vulgaris. J Drugs Dermatol 2012;11:919-25
  • Troielli PA, Asis B, Bermejo A, et al. Community study of fixed-combination adapalene 0.1% and benzoyl peroxide 2.5% in acne. Skinmed 2010;8:17-22
  • Pariser D, Bucko A, Fried R, et al. Tretinoin gel microsphere pump 0.04% plus 5% benzoyl peroxide wash for treatment of acne vulgaris: morning/morning regimen is as effective and safe as morning/evening regimen. J Drugs Dermatol 2010;9:805-13
  • Alexis AF. Clinical considerations on the use of concomitant therapy in the treatment of acne. J Dermatolog Treat 2008;19:199-209
  • Nighland M, Yusuf M, Wisniewski S, et al. The effect of simulated solar UV irradiation on tretinoin in tretinoin gel microsphere 0.1% and tretinoin gel 0.025%. Cutis 2006;77:313-16
  • Gonzalez P, Vila R, Cirigliano M. The tolerability profile of clindamycin 1%/benzoyl peroxide 5% gel vs. adapalene 0.1%/benzoyl peroxide 2.5% gel for facial acne: results of a randomized, single-blind, split-face study. J Cosmet Dermatol 2012;11:251-60
  • Ting W. Randomized, observer-blind, split-face study to compare the irritation potential of 2 topical acne formulations over a 14-day treatment period. Cutis 2012;90:91-6
  • Eichenfield LF, Krakowski AC. Moderate to severe acne in adolescents with skin of color: benefits of a fixed combination clindamycin phosphate 1.2% and benzoyl peroxide 2.5% aqueous gel. J Drugs Dermatol 2012;11:818-24
  • Callender VD. Fitzpatrick skin types and clindamycin phosphate 1.2%/benzoyl peroxide gel: efficacy and tolerability of treatment in moderate to severe acne. J Drugs Dermatol 2012;11:643-8
  • Cook-Bolden FE. Treatment of moderate to severe acne vulgaris in a Hispanic population: a post-hoc analysis of efficacy and tolerability of clindamycin phosphate 1.2%/benzoyl peroxide 2.5% gel. J Drugs Dermatol 2012;11:455-9
  • Jarratt MT, Brundage T. Efficacy and safety of clindamycin-tretinoin gel versus clindamycin or tretinoin alone in acne vulgaris: a randomized, double-blind, vehicle-controlled study. J Drugs Dermatol 2012;11:318-26
  • Tanghetti E, Dhawan S, Green L, et al. Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene cream 0.1% in patients with acne vulgaris. J Drugs Dermatol 2011;10:783-92
  • Prasad S, Mukhopadhyay A, Kubavat A, et al. Efficacy and safety of a nano-emulsion gel formulation of adapalene 0.1% and clindamycin 1% combination in acne vulgaris: a randomized, open label, active-controlled, multicentric, phase IV clinical trial. Indian J Dermatol Venereol Leprol 2012;78:459-67
  • Kubota Y, Munehiro A, Shirahige Y, et al. Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris. J Dermatolog Treat 2012;23:37-45
  • Draelos ZD, Potts A, Alio Saenz AB. Randomized tolerability analysis of clindamycin phosphate 1.2%-tretinoin 0.025% gel used with benzoyl peroxide wash 4% for acne vulgaris. Cutis 2010;86:310-18
  • Pazoki-Toroudi H, Nilforoushzadeh MA, Ajami M, et al. Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris. Cutan Ocul Toxicol 2011;30:286-91
  • Pazoki-Toroudi H, Nassiri-Kashani M, Tabatabaie H, et al. Combination of azelaic acid 5% and erythromycin 2% in the treatment of acne vulgaris. J Dermatolog Treat 2010;21:212-16
  • Wilhelm KP, Wilhelm D, Neumeister C, et al. Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents. Clin Exp Dermatol 2012;37:112-17
  • Babaeinejad S, Khodaeiani E, Fouladi RF. Comparison of therapeutic effects of oral doxycycline and azithromycin in patients with moderate acne vulgaris: what is the role of age? J Dermatolog Treat 2011;22:206-10
  • Maleszka R, Turek-Urasinska K, Oremus M, et al. Pulsed azithromycin treatment is as effective and safe as 2-week-longer daily doxycycline treatment of acne vulgaris: a randomized, double-blind, noninferiority study. Skinmed 2011;9:86-94
  • Kawada A, Wada T, Oiso N. Clinical effectiveness of once-daily levofloxacin for inflammatory acne with high concentrations in the lesions. J Dermatol 2012;39:94-6
  • Agarwal US, Besarwal RK, Bhola K. Oral isotretinoin in different dose regimens for acne vulgaris: a randomized comparative trial. Indian J Dermatol Venereol Leprol 2011;77:688-94
  • Lee JW, Yoo KH, Park KY, et al. Effectiveness of conventional, low-dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study. Br J Dermatol 2011;164:1369-75
  • Borghi A, Mantovani L, Minghetti S, et al. Low-cumulative dose isotretinoin treatment in mild-to-moderate acne: efficacy in achieving stable remission. J Eur Acad Dermatol Venereol 2011;25:1094-8
  • Fouladi RF. Aqueous extract of dried fruit of Berberis vulgaris L. in acne vulgaris, a clinical trial. J Diet Suppl 2012;9:253-61
  • Mueller EA, Trapp S, Frentzel A, et al. Efficacy and tolerability of oral lactoferrin supplementation in mild to moderate acne vulgaris: an exploratory study. Curr Med Res Opin 2011;27:793-7
  • Sardana K, Garg VK. An observational study of methionine-bound zinc with antioxidants for mild to moderate acne vulgaris. Dermatol Ther 2010;23:411-18
  • Shalita AR, Falcon R, Olansky A, et al. Inflammatory acne management with a novel prescription dietary supplement. J Drugs Dermatol 2012;11:1428-33
  • Surjana D, Damian DL. Nicotinamide in dermatology and photoprotection. Skinmed 2011;9:360-5
  • De D, Kanwar AJ. Combination of low-dose isotretinoin and pulsed oral azithromycin in the management of moderate to severe acne: a preliminary open-label, prospective, non-comparative, single-centre study. Clin Drug Investig 2011;31:599-604
  • Arowojolu AO, Gallo MF, Lopez LM, et al. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev 2009(3):CD004425: published online; doi:10.1002/14651858.CD004425.pub4
  • Koltun W, Maloney JM, Marr J, Kunz M. Treatment of moderate acne vulgaris using a combined oral contraceptive containing ethinylestradiol 20 mug plus drospirenone 3 mg administered in a 24/4 regimen: a pooled analysis. Eur J Obstet Gynecol Reprod Biol 2011;155:171-5
  • Brucker C, Hedon B, The HS, et al. Long-term efficacy and safety of a monophasic combined oral contraceptive containing 0.02 mg ethinylestradiol and 2 mg chlormadinone acetate administered in a 24/4-day regimen. Contraception 2010;81:501-9
  • Hayashi N, Kawashima M. Multicenter randomized controlled trial on combination therapy with 0.1% adapalene gel and oral antibiotics for acne vulgaris: comparison of the efficacy of adapalene gel alone and in combination with oral faropenem. J Dermatol 2012;39:511-15
  • Brodell RT, Schlosser BJ, Rafal E, et al. A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne. J Dermatolog Treat 2012;23:26-34
  • Tan J, Stein GL, Schlessinger J, et al. Short-term combination therapy and long-term relapse prevention in the treatment of severe acne vulgaris. J Drugs Dermatol 2012;11:174-80
  • Gold LS, Cruz A, Eichenfield L, et al. Effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, double-blind study of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg. Cutis 2010;85:94-104
  • Dreno B, Kaufmann R, Talarico S, et al. Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study. Br J Dermatol 2011;165:383-90
  • Eichenfield LF, Draelos Z, Lucky AW, et al. Preadolescent moderate acne vulgaris: a randomized trial of the efficacy and safety of topical adapalene-benzoyl peroxides. J Drugs Dermatol 2013;12:611-18
  • Davis SA, Sandoval LF, Gustafson CJ, et al. Treatment of preadolescent acne in the United States: an analysis of nationally representative data. Pediatr Dermatol 2013; published online; doi:10.1111/pde.12201
  • Shaw JC. Acne: effect of hormones on pathogenesis and management. Am J Clin Dermatol 2002;3:571-8
  • Shalita AR, Falcon R, Olansky A, et al. Inflammatory acne management with a novel prescription dietary supplement. J Drugs Dermatol 2012;11:1428-33
  • Zouboulis CC. The truth behind this undeniable efficacy–recurrence rates and relapse risk factors of acne treatment with oral isotretinoin. Dermatology 2006;212:99-100
  • Zouboulis CC. The truth behind this undeniable efficacy–recurrence rates and relapse risk factors of acne treatment with oral isotretinoin. Dermatology 2006;212:99-100
  • Eichenfield LF, Alio Saenz AB. Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. J Drugs Dermatol 2011;10:1382-96
  • Kircik LH. Importance of vehicles in acne therapy. J Drugs Dermatol 2011;10:s17-23
  • Thielitz A, Abdel-Naser MB, Fluhr JW, et al. Topical retinoids in acne–an evidence-based overview. J Dtsch Dermatol Ges 2008;6:1023-31
  • Feldman SR, Chen DM. How patients experience and manage dryness and irritation from acne treatment. J Drugs Dermatol 2011;10:605-8
  • Fernandez JR, Rouzard K, Voronkov M, et al. SIG1273: a new cosmetic functional ingredient to reduce blemishes and Propionibacterium acnes in acne prone skin. J Cosmet Dermatol 2012;11:272-8
  • Webster G, Thiboutot DM, Chen DM, Merikle E. Impact of a fixed combination of clindamycin phosphate 1.2%-benzoyl peroxide 2.5% aqueous gel on health-related quality of life in moderate to severe acne vulgaris. Cutis 2010;86:263-7
  • Harper JC. Gender as a clinically relevant outcome variable in acne: benefits of a fixed combination clindamycin phosphate (1.2%) and benzoyl peroxide (2.5%) aqueous gel. J Drugs Dermatol 2012;11:1440-5
  • Guerra-Tapia A. Effects of benzoyl peroxide 5% clindamycin combination gel versus adapalene 0.1% on quality of life in patients with mild to moderate acne vulgaris: a randomized single-blind study. J Drugs Dermatol 2012;11:714-22
  • Jackson JM, Fu JJ, Almekinder JL. A randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris. J Drugs Dermatol 2010;9:131-6
  • Goreshi R, Samrao A, Ehst BD. A double-blind, randomized, bilateral comparison of skin irritancy following application of the combination acne products clindamycin/tretinoin and benzoyl peroxide/adapalene. J Drugs Dermatol 2012;11:1422-6
  • Babayeva L, Akarsu S, Fetil E, Gunes AT. Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris. J Eur Acad Dermatol Venereol 2011;25:328-33
  • Fleischer AB Jr, Shalita A, Eichenfield LF, et al. Dapsone gel 5% in combination with adapalene gel 0.1%, benzoyl peroxide gel 4% or moisturizer for the treatment of acne vulgaris: a 12-week, randomized, double-blind study. J Drugs Dermatol 2010;9:33-40
  • Kobayashi M, Nakagawa T, Fukamachi K, et al. Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: a randomized study. J Dermatol 2011;38:1163-6
  • Choi YS, Suh HS, Yoon MY, et al. A study of the efficacy of cleansers for acne vulgaris. J Dermatolog Treat 2010;21:201-5
  • Hayashi N, Kawashima M. Efficacy of oral antibiotics on acne vulgaris and their effects on quality of life: a multicenter randomized controlled trial using minocycline, roxithromycin and faropenem. J Dermatol 2011;38:111-19

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