Otitis media: an update on current pharmacotherapy and future perspectives

Bibliography

• Rovers MM, Schilder AG, Zielhuis GA, et al. Otitis Media. Lancet 2004;363:465-73
   PubMed Web of Science ®Google Scholar
• Schwartz RH, Stool SE, Rodriguez WJ, Grundfast KM. Acute otitis media: toward a more precise definition. Clin Pediatr (Phila) 1981;20:549-54
   PubMed Web of Science ®Google Scholar
• McCormick DP, Lim-Melia E, Saeed K, et al. Otitis media:can clinical findings predict bacterial or viral etiology? Pediatr Infect Dis J 2000;19:256-8
   Google Scholar
• Hoberman A, Paradise JL, Rockette HE, et al. Treatment of acute otitis media in children under 2 years of age. N Engl J Med 2011;364:105-15
   PubMed Web of Science ®Google Scholar
• Tähtinen PA, Laine MK, Huovinen P, et al. A placebo controlled trial of antimicrobial treatment for acute otitis media. N Engl J Med 2011;364:116-26
   PubMed Web of Science ®Google Scholar
• Swanson JA, Hoecker JL. Otitis Media in young children. Mayo Clin Proc 1996;71:179-83
   Google Scholar
• Bluestone CD. Definitions, terminology, and classification. In: Bluestone CD, Klein JO, editors. Otitis media in infants and children. 4th edition. BC Decker, Hamilton, Canada; 2007
   Google Scholar
• Hoffman HJ, Daly KA, Bainbridge KE, et al. Panel 1: epidemiology, natural history, and risk factors. Otolaryngol Head Neck Surg 2013;148:E1-E25
   PubMedGoogle Scholar
• Swarts DJ, Alper CM, Luntz M, et al. Panel 2: eustachian tube, middle ear, and mastoid--anatomy, physiology, pathophysiology, and pathogenesis. Otolaryngol Head Neck Surg 2013;148:E26-36
   PubMed Web of Science ®Google Scholar
• Chronic Otitis media. Available from: www.clinicalkey.com.2012
   Google Scholar
• Monasta L, Ronfani L, Marchetti F, et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One 2012;7:e36226
   PubMed Web of Science ®Google Scholar
• Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA 2009;302:758-66
   PubMed Web of Science ®Google Scholar
• Klein JO. The burden of otitis media. Vaccine 2000;19:S2-8
   Google Scholar
• Gonzales R, Malone DC, Maselli JH, Sande MA. Excessive antibiotic use for acute respiratory infections in the United States. Clin Infect Dis 2001;33:757-62
   PubMed Web of Science ®Google Scholar
• Agency for Healthcare Research & Quality. Measuring quality of care for middle ear infection has many pitfalls. Jan 2012 no 377. Available from: www.ahrq.gov
   Google Scholar
• Kilpi T, Schuerman L. Acute otitis media and its sequelae. In: Siber GR, Klugman KP, Mä keläPH, editors. Pneumococcal vaccines: the impact of conjugated vaccine. ASM Press, Washington DC; 2008. p. 301-15
   Google Scholar
• Chonmaitree T. Acute otitis media is not a pure bacterial disease. Clin Infect Dis 2006;43:1423-5
   Google Scholar
• Chonmaitree T, Heikkinen T. Role of viruses in middle-ear disease. Ann NY Acad Sci 1997;830:143-57
   PubMed Web of Science ®Google Scholar
• Chonmaitree T, Revai K, Grady JJ, et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis 2008;46:815-23
   PubMed Web of Science ®Google Scholar
• Jacobs SE, Lamson DM, St George K, et al. Human rhinoviruses. Clin Microbiol Rev 2013;26:135-62
   PubMed Web of Science ®Google Scholar
• Rashid M. Rationale and feasibility of intranasal delivery of drugs to the Eustachian tube orifice. Curr Allergy Asthma Rep 2012;12:541-6
   Google Scholar
• Lieberthal AS, Carroll AE, Chonmaitree T, et al. The Diagnosis and Management of Acute Otitis Media. Pediatrics 2013;131:e964-99
   PubMed Web of Science ®Google Scholar
• Cayé-Thomasen P, Hermansson A, Bakaletz L, et al. Panel 3: recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis. Otolaryngol Head Neck Surg 2013;148:E37-51
   PubMedGoogle Scholar
• Winther B, Alper CM, Mandel EM, et al. Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season. Pediatrics 2007;119:1069-75
   Google Scholar
• Bakaletz LO. Immunopathogenesis of polymicrobial otitis media. J Leukoc Biol 2010;87:213-22
   PubMed Web of Science ®Google Scholar
• Li JD, Hermansson A, Ryan AF, et al. Panel 4: recent advances in Otitis media in molecular biology, biochemistry, genetics, and animal models. Otolaryngol Head Neck Surg 2013;148:E52-63
   Google Scholar
• Ruohola A, Pettigrew MM, Lindhold L, et al. Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media. J Infect 2013;66:247-54
   PubMed Web of Science ®Google Scholar
• Murphy TM, Chonmaitree T, Barenkamp S, et al. Panel 5 : microbiology and immunology panel. Otolaryngol Head Neck Surg 2013;148:E64-89
   Google Scholar
• Wang JH, Kwon HJ, Jang YJ. Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously. Laryngoscope 2009;119:1406-11
   PubMed Web of Science ®Google Scholar
• Passariello C, Schippa S, Conti C, et al. Rhinoviruses promote internalization of Staphylococcus aureus into non-fully permissive cultured pneumocytes. Microbes Infect 2006;8:758-66
   PubMed Web of Science ®Google Scholar
• Oliver BGG, Lim S, Wark P, et al. Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax 2008;63:519-25
   PubMed Web of Science ®Google Scholar
• Short KR, Reading PC, Brown LE, et al. Influenza-Induced Inflammation drives Pneumococcal otitis media. Infect Immun 2013;81:645-52
   PubMedGoogle Scholar
• Karagama Y, Rashid M, Lancaster J, et al. Intranasal delivery of drugs to eustachian tube orifice. J Laryngol Otol 2011;125:934-9
   Google Scholar
• Heikkinen T. The role of respiratory viruses in otitis media. Vaccine 2001;19:S51-5
   Google Scholar
• Heikkinen T, Chonmaitree T. Importance of respiratory viruses in acute otitis media. Clin Microbiol Rev 2003;16:230-41
   PubMed Web of Science ®Google Scholar
• Wine TM, Cuneyt AM. Cytokine responses in the common cold and otitis media. Curr Allergy Asthma Rep 2012;12:574-81
   PubMed Web of Science ®Google Scholar
• Chonmaitree T, Revai K, Grady JJ, et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis 2008;46:815-23
   PubMed Web of Science ®Google Scholar
• Anderson MJ, Parks PJ, Peterson ML. A mucosal model to study microbial biofilm development and anti-biofilm therapeutics. J Microbiol Methods 2013;92:201-8
   PubMed Web of Science ®Google Scholar
• Vijayasekaran S, Coates H, Thornton RB, et al. New findings in the pathogenesis of otitis media. Laryngoscope 2012;122:S61-2
   Google Scholar
• Daniel M, Imtiaz-Umer S, Fergie N, et al. Bacterial involvement in otitis media with effusion. Int J Pediatr Otorhinolaryngol 2012;76:1416-22
   Google Scholar
• Ruohola A, Meurman O, Nikkari S, et al. Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria and viruses. Clin Infect Dis 2006;43:1417-22
   PubMed Web of Science ®Google Scholar
• Berkun Y, Nir-PazAmi AB, Deutsch E, et al. Acute otitis media in the first two months of life:characteristics and diagnostic difficulties. Arch Dis Child 2008;93:690-4
   PubMed Web of Science ®Google Scholar
• Turner D, Leibovitz E, Aran A, et al. Acute otitis media in infants younger than two months of age: microbiology, clinical presentation and therapeutic approach. Pediatr Infect Dis J 2002;21:669-74
   PubMed Web of Science ®Google Scholar
• Casey JR, Adlowitz DG, Pichichero ME. New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J 2010;29:304-9
   PubMed Web of Science ®Google Scholar
• Casey JR, Ravinder K, Friedel VC, Pichichero ME. Acute otitis media otopathogogens during 2008-2010 in Rochester NY. Pediatr Infect Dis J 2013. [Epub ahead of print]
   Google Scholar
• Leibovitz E, Serebro M, Givon-Lavi N, et al. Epidemiologic and microbiologic characteristics of culture-positive spontaneous otorrhea in children with acute otitis media. Pediatr Infect Dis J 2009;28:381-4
   PubMed Web of Science ®Google Scholar
• Brook I, Gober AE. Bacteriology of spontaneously draining acute otitis media in children before and after the introduction of pneumococcal vaccination. Pediatr Infect Dis J 2009;28:640-2
   PubMedGoogle Scholar
• Kaur R, Adlowitz DG, Casey JR, et al. Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media. Pediatr Infect Dis J 2010;29:741-5
   PubMed Web of Science ®Google Scholar
• Palmu AA, Kotikoski MJ, Kaijalainen TH, Puhakka HJ. Bacterial etiology of acute myringitis in children less than two years of age. Pediatr Infect Dis J 2001;20:607-11
   Google Scholar
• Drendel M, Yakirevitch A, Kerimis P, et al. Hearing loss in bullous myringitis. Aurus Nasus Larynx 2012;39:28-30
   Google Scholar
• Cramer L, Emara DM, Gadre AK. Mycoplasma an unlikely cause of bullous myringitis. Ear Nose Throat J 2012;91:30-1
   Google Scholar
• Barkai G, Leibovitz E, Givon-Lavi N, et al. Potential contribution by nontypable Haemophilus influenzae in protracted and recurrent acute otitis media. Pediatr Infect Dis J 2009;28:466-71
   PubMed Web of Science ®Google Scholar
• Segal N, Givon-Lavi N, Leibovitz E, et al. Acute otitis media caused by Streptococcus pyogenes in children. Clin Infect Dis 2005;41:35-41
   PubMed Web of Science ®Google Scholar
• Alonso M, Marimon JM, Ercibengoa M, et al. Dynamics of Streptococcus pneumoniae serotypes causing acute otitis media isolated from children with spontaneous middle-ear drainage over a 12-year period (1999–2010) in a region of northern Spain. PLOS One 2013;8:1-10
   Google Scholar
• Madana J, Yolmo D, Kalaiarasi R, et al. Microbiological profile with antibiotic sensitivity pattern of cholesteatomatous chronic suppurutive otitis media among children. Int J Pediatr Otorhinolaryngol 2011;75:1105-472
   Google Scholar
• Roland PS, Parry DA, Stroman DW. Microbiology of acute otitis media with tympanostomy tubes. Otolaryngol Head Neck Surg 2005;133:585-95
   PubMed Web of Science ®Google Scholar
• Black S, Shinefield H, Baxter R, et al. Postlicensure surveillance for pneumococcal invasive disease after use of heptavalent pneumococcal conjugate vaccine in Northern California Kaiser Permanente. Pediatr Infect Dis J 2004;23:485-9
   PubMed Web of Science ®Google Scholar
• Pichichero ME, Casey JR. Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children. JAMA 2007;298:1772-8
   PubMed Web of Science ®Google Scholar
• Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease following pneumococcal vaccination: a discussion of the evidence. Lancet 2011;378:1962-73
   PubMed Web of Science ®Google Scholar
• Kaplan SL, Barson WJ, Lin PL, et al. Early trends for invasive pneumococcal infections in children after the introduction of the 13-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2013;32:203-7
   PubMed Web of Science ®Google Scholar
• Impact of Prevnar 13 on Ear infections in children. Clinical Trials.gov NCT01272999
   Google Scholar
• Effect of Prevnar 13 on Ear infections in children. Clinical Trials.gov NCT01199016
   Google Scholar
• De Wals P, Erickson L, Poirier B, et al. How to compare the efficacy of conjugate vaccines to prevent acute otitis media? Vaccine 2009;27:2877-83
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention (CDC). Licensure of a 13-valent pneumococcal conjugate vaccine (PCV13) and recommendations for use among children—Advisory Committee on Immunization Practices (ACIP), 2010. MMWR Morb Mortal Wkly Rep 2010;59:258-61
   PubMedGoogle Scholar
• Bertin L, Pons G, d'Athis P, et al. A randomized, double-blind, multicenter controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. Fundam Clin Pharmacol 1996;10:387-92
   PubMed Web of Science ®Google Scholar
• Van den Anker JN. Optimising the management of fever and pain in children. Int J Clin Pract Suppl 2013;178:26-32
   Google Scholar
• Bolt P, Barnett P, Babl FE, et al. Topical lignocaine for pain relief in acute otitis media: results of a double-blind placebo-controlled randomized trial. Arch Dis Child 2008;93:40-4
   Google Scholar
• Foxlee R, Johansson A, Wejfalk J, et al. Topical analgesia for acute otitis media. Cochrane Database Syst Rev 2006(3):CD005657
   Google Scholar
• Wood DN, Nakas N, Gregory CW. Clinical trials assessing ototopical agents in the treatment of pain associated with acute otitis media. Int J Pediatr Otorhinolaryngol 2012;76:1229-35
   Google Scholar
• FDA News Release. U.S. Marshals seize Auralgan otic solution. Feb 16 2011. Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm243638.htm
   Google Scholar
• Levi JR, Brody RM, McKee-Cole K, et al. Complementary and alternative medicine for pediatric otitis media. Int J Pediatr Otorhinolaryngol 2013;77:926-31
   Google Scholar
• Taylor JA, Jacobs J. Homeopathic ear drops as an adjunct to standard therapy in children with acute otitis media. Homeopathy 2011;100:109-15
   Google Scholar
• McCormick DP, Chonmaitree T, Pittman C, et al. Nonsevere acute otitis media: a clinical trial comparing outcomes of watchful waiting versus immediate antibiotic treatment. Pediatrics 2005;115:1455-65
   PubMed Web of Science ®Google Scholar
• Le Saux N, Gaboury I, Baird M, et al. A randomized, double-blind, placebo controlled noninferiority trial of amoxicillin for clinically diagnosed acute otitis media in children 6 months to 5 years of age. CMAJ 2005;172:335-41
   PubMed Web of Science ®Google Scholar
• Glasziou PP, DelMar CB, Sanders SL, et al. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev 2013(1):CD000219
   Google Scholar
• McCormick DP, Chandler SM, Chonmaitree T. Laterality of acute otitis media: different clinical and microbiologic characteristics. Pediatr Infect Dis J 2007;26:583-8
   Google Scholar
• Rovers MM, Glasziou P, Appelman CL, et al. Antibiotics for acute otitis media: an individual patient data meta-analysis. Lancet 2006;368:1429-35
   PubMed Web of Science ®Google Scholar
• Little P, Gould C, Williamson I, et al. Pragmatic randomized controlled trial of two prescribing strategies for childhood acute otitis media. BMJ 2001;322:336-42
   PubMed Web of Science ®Google Scholar
• Venekamp RP, Sanders S, Glasziou PP, et al. Antibiotics for acute otitis media in children (Review). Cochrane Database Syst Rev 2013;1:CD000219
   Google Scholar
• Tähtinen PA, Laine MK, Ruuskanen O, et al. Delayed versus immediate antimicrobial treatment for acute otitis media. Pediatr Infect Dis J 2012;31:1227-32
   Google Scholar
• Spiro DM, Tay KY, Arnold DH, et al. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA 2006;296:1235-41
   PubMed Web of Science ®Google Scholar
• Chao JH, Kunkov S, Reyes LB, et al. Comparison of two approaches to observation therapy for acute otitis media in the emergency department. Pediatrics 2008;121:e1352-6
   Google Scholar
• Kozyrskyj AL, Klassen TP, Moffatt M, Harvey K. Short-course antibiotics for acute otitis media. Cochrane Database Syst Rev 2010(9):CD001095
   Google Scholar
• Critchley IA, Jacobs MR, Brown SD, et al. Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005≠2006 and activity of faropenem. Antimicrob Agents Chemother 2008;52:2639-43
   PubMed Web of Science ®Google Scholar
• Jacobs MR, Good CE, Windau AR, et al. Activity of ceftaroline against emerging serotypes of Streptococcus pneumoniae. Antimicrob Agents Chemother 2010;54:2716-19
   PubMed Web of Science ®Google Scholar
• Jacobs MR. Antimicrobial-resistant Streptococcus pneumoniae: trends and management. Expert Rev Anti Infect Ther 2008;6:619-35
   PubMed Web of Science ®Google Scholar
• Piglansky L, Leibovitz E, Raiz S, et al. Bacteriologic and clinical efficacy of high dose amoxicillin for therapy of acute otitis media in children. Pediatr Infect Dis J 2003;22:405-13
   PubMed Web of Science ®Google Scholar
• Christian-Kopp S, Sinha M, Rosenberg DI, et al. Antibiotic dosing for acute otitis media in children: a weighty issue. Pediatr Emerg Care 2010;26:19-25
   PubMed Web of Science ®Google Scholar
• Tristram S, Jacobs MR, Appelbaum PC. Antimicrobial resistance in Haemophilus influenzae. Clin Microbiol Rev 2007;20:368-89
   PubMed Web of Science ®Google Scholar
• Jones RN, Farrell DJ, Mendes RE, et al. Comparative ceftaroline activity tested against pathogens associated with community-acquired pneumonia: results from an international surveillance study. J Antimicrob Chemother 2011;66:iii69-80
   PubMedGoogle Scholar
• Harrison CJ, Woods C, Stout G, et al. Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. J Antimicrob Chemother 2009;63:511-19
   PubMedGoogle Scholar
• Klein JO. Microbiologic efficacy of antibacterial drugs for acute otitis media. Pediatr Infect Dis J 1993;12:973-5
   PubMedGoogle Scholar
• Pichichero ME, Casey JR. Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis. Otolaryngol Head Neck Surg 2007;136:340-7
   PubMed Web of Science ®Google Scholar
• Leibovitz E, Piglansky L, Raiz S. Bacteriologic and clinical efficacy of one day vs. three day intramuscular ceftriaxone for treatment of nonresponsive acute otitis media in children. Pediatr Infect Dis J 2000;19:1040-5
   PubMedGoogle Scholar
• Arguedas A, Soley C, Kamicker BJ, Jorgensen DM. Single dose extended-release azithromycin versus a 10-day regimen of amoxicillin/clavulanate for the treatment of children with acute otitis media. Int J Infect Dis 2011;15:e240-8
   Google Scholar
• Courter JD, Baker WL, Nowak KS, et al. Increased clinical failures when treating acute otitis media with macrolides: a meta-analysis. Ann Pharmacother 2010;44:471-8
   PubMed Web of Science ®Google Scholar
• Hoberman A, Dagan R, Leibovitz E, et al. Large dosage amoxicillin/clavulanate, compared with azithromycin, for the treatment of bacterial acute otitis media in children. Pediatr Infect Dis J 2005;24:525-32
   PubMed Web of Science ®Google Scholar
• Casey JR, Block SL, Hedrick J, et al. Comparison of amoxicillin/clavulanic acid high dose with cefdinir in the treatment of acute otitis media. Drugs 2012;72:1991-7
   Google Scholar
• Pichichero ME. Advances in the diagnosis and treatment of pediatric infectious diseases otitis media. Pediatr Clin North Am 2013;60:391-407
   PubMed Web of Science ®Google Scholar
• Noel GJ, Blumer JL, Pichichero ME, et al. A randomized comparative study of levofloxacin versus amoxicillin/clavulanate for treatment of infants and young children with recurrent or persistent acute otitis media. Pediatr Infect Dis J 2008;27:483-9; was 56, then became 61. Now needs to be 97/101
   PubMed Web of Science ®Google Scholar
• Roland PS, Stewart MG, Hannley M, et al. Consensus panel on the role of potentially ototoxic antibiotics for topical middle ear use: introduction, methodology and recommendations. Otolaryngol Head Neck Surg 2004;130:S51-6
   Google Scholar
• Haynes DS, Rutka J, Hawke M, et al. Ototoxicity of Ototopical drops-An Update. Otolaryngol Clin North Am 2007;40:669-83
   PubMed Web of Science ®Google Scholar
• Wall MG, Stroman DW, Roland PS. Ciprofloxacin 0.3%/Dexamethasone 0.1% sterile otic suspension for the topical treatment of ear infections. Pediatr Infect Dis J 2009;28:141-4
   PubMed Web of Science ®Google Scholar
• Berenholz LP, Rossi DL, Lippy WH, et al. Is there an ototoxicity risk from Cortisporin and comparable otic suspensions? Distortion-produce otoacoustic emission findings. Ear Nose Throat J 2012;91:106-35
   Google Scholar
• Macfadyen CA, Acuin JM, Gample C. Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations. Cochrane Database Syst Rev 2006(1):CD005608
   Google Scholar
• Magomedov MM, Starostina AE, Madomedov MG. Comparative characteristic of the local application of anti-inflammatory agents for the treatment of otitis externa and otitis media. Vestn Otorinolaringol 2012;5:69-72; Article in Russian
   Google Scholar
• Dohar J, Giles W, Roland PS, et al. Topical ciprofloxacin/dexamethasone superior to oral amoxicillin/clavulanic acid in acute otitis media with otorrhea through tympanostomy tube. Pediatrics 2006;118:e561-9
   PubMed Web of Science ®Google Scholar
• Roland PS, Kreisler LS, Reese B, et al. Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tube. Pediatrics 2004;113:e40-6
   PubMed Web of Science ®Google Scholar
• Roland PS, Anon JB, Moe RD, et al. Topical ciprofloxacin/dexamethasone is superior to ciprofloxacin alone in pediatric patients with acute otitis media and otorrhea through tympanostomy tube. Laryngoscope 2003;113:2116-22
   PubMed Web of Science ®Google Scholar
• Jinnouchi O, Kuwahara T, Ishida S, et al. Anti-microbial and therapeutic effects of modified Burow's solution on refractory otorrhea. Auris Nasus Larynx 2012;39:374-7
   Google Scholar
• Loock JW. A randomised controlled trial of active chronic otitis media comparing courses of eardrops versus one-off topical treatments suitable for primary, secondary and tertiary healthcare settings. Clin Otolaryngol 2012;37:261-70
   PubMed Web of Science ®Google Scholar
• Skovbjerg S, Roos K, Holm SE, et al. Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media. Arch Dis Child 2009;94:92-8
   PubMed Web of Science ®Google Scholar
• Daniel M, Chessman R, Al-Zahid S, et al. Biofilm eradication with biodegradable modified-release antibiotic pellets: a potential treatment for glue ear. Arch Otolaryngol Head Neck Surg 2012;138:942-9
   PubMedGoogle Scholar
• Balatsouras DG, Eliopoulos P, Rallis E, et al. Improvement of otitis media with effusion after treatment of asthma with leukotriene antagonists in children with co-existing disease. Drugs Exp Clin Res 2005;31:S7-S10
   Google Scholar
• Schoem SR, Willard A, Combs JT. A prospective, randomized, placebo-controlled, double-blind study of montelukast's effect on persistent MEF. Ear Nose Throat J 2010;89:434-7
   PubMed Web of Science ®Google Scholar
• Marchisio P, Chonmaitree T, Leivovitz E, et al. Panel 7: treatment and comparative effectiveness research. Otolaryngol Head Neck Surg 2013;148(4S):E122-43
   Google Scholar
• Griffin G, Flynn CA, Bailey RE, Schultz JK. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2006(4):CD003423
   Google Scholar
• Coleman C, Moore M. Decongestants and antihistamines for acute otitis media in children. Cochrane Database Syst Rev 2008(3):CD001727
   Google Scholar
• Heinonen S, Silvennoinen H, Lehtinen P, et al. Early oseltamivir treatment of influenza in children 1-3 years of age: a randomized controlled trial. Clin Infect Dis 2010;51:887-94
   PubMed Web of Science ®Google Scholar
• Rosenfeld RM, Culpepper L, Doyle KJ, et al. American Academy of Pediatrics Subcommittee on Otitis Media with Effusion; American Academy of Family Physicians; American Academy of Otolaryngology—Head and Neck Surgery. Clinical practice guideline: otitis media with effusion. Otolaryngol Head Neck Surg 2004;130:S95-S118
   PubMed Web of Science ®Google Scholar
• Leach AJ, Morris PS. Antibiotics for the prevention of acute and chronic suppurative otitis media in children. Cochrane Database Syst Rev 2006(4):CD004401
   Google Scholar
• McDonald S, Langton Hewer CD, Nunez DA. Grommets (ventilation tubes) for recurrent recurrent acute otitis media in children. Cochrane Database Syst Rev 2008;(4): CD004741
   Google Scholar
• Rosenfeld RM, Bhaya MH, Bower CM, et al. Impact of tympanostomy tubes on child quality of life. Arch Otolaryngol Head Neck Surg 2000;126:585-92
   Google Scholar
• Duplessis C, Fothergill D, Gertner J, et al. A pilot study evaluating surfactant on Eustachian tube function in divers. Mil Med 2008;173:1225-32
   Google Scholar
• Azarpazhooh A, Limeback H, Lawrence HP, Shah PS. Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev 2011(11):CD007095
   Google Scholar
• Kurola P, Tapiainen T, Sevander J, et al. Effect of xylitol and other carbon sources on Streptococcus pneumoniae biofilm formation and gene expression in vitro. APMIS 2011;119:135-42
   PubMed Web of Science ®Google Scholar
• Xylitol syrup for the prevention of acute otitis media in otitis-prone children. Clinical trials.gov NCT01044030
   Google Scholar
• John M, Dunne EM, Licciardi PV, et al. Otitis media among high-risk populations: can probiotics inhibit Streptococcus pneumoniae colonization and the risk of disease? Eur J Clin Microbiol Infect Dis 2013;32(9):1101-10
   Google Scholar
• Niittynen L, Pitkäranta A, Korpela R. Probiotics and otitis media in children. Int J Pediatr Otorhinolaryngol 2012;76:465-70
   Web of Science ®Google Scholar
• Stecksen-Blicks C, Sjostrom I, Twetman S. Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study. Caries Res 2009;43:374-81
   PubMed Web of Science ®Google Scholar
• Rautava S, Salminen S, Isolauri E. Specific probiotics in reducing the risk of acute infections in infancy – a randomised, double-blind, placebo-controlled study. Br J Nutr 2009;101:1722-6
   PubMed Web of Science ®Google Scholar
• Hatakka K, Blomgren K, Pohjavuori S, et al. Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomized study. Clin Nutr 2007;26:314-21
   PubMed Web of Science ®Google Scholar
• Abba K, Gulani A, Sachdev HS. Zinc supplements for preventing otitis media. Cochrane Database Syst Rev 2010(2):CD006639
   Google Scholar
• Available from: http://otitismedia.hawkelibrary.com
   Google Scholar