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Treatment of central sensitization in patients with ‘unexplained’ chronic pain: an update

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Bibliography

  • Wall B, Melzack R. Textbook of pain. 3rd edition. Churchill Livingstone; Edinburgh, UK: 1994
  • Van Oosterwijck J, Nijs J, Meeus M, Paul L. Evidence for central sensitization in chronic whiplash: a systematic literature review. Eur J Pain 2013;17(3):299-312
  • Roussel NA, Nijs J, Meeus M, et al. Central sensitization and altered central pain processing in chronic low back pain: fact or myth? Clin J Pain 2013;29(7):625-38
  • Lluch Girbes E, Nijs J, Torres-Cueco R, Lopez Cubas C. Pain treatment for patients with osteoarthritis and central sensitization. Phys Ther 2013;93(6):842-51
  • Ashina S, Bendtsen L, Ashina M. Pathophysiology of tension-type headache. Curr Pain Headache Rep 2005;9(6):415-22
  • Perrotta A, Serrao M, Sandrini G, et al. Sensitisation of spinal cord pain processing in medication overuse headache involves supraspinal pain control. Cephalalgia 2010;30(3):272-84
  • Price DD, Staud R, Robinson ME, et al. Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients. Pain 2002;99(1-2):49-59
  • Nijs J, Meeus M, Van Oosterwijck J, et al. In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome. Eur J Clin Invest 2012;42(2):203-12
  • Meeus M, Vervisch S, De Clerck LS, et al. Central sensitization in patients with rheumatoid arthritis: a systematic literature review. Semin Arthritis Rheum 2012;41(4):556-67
  • van Wilgen CP, Konopka KH, Keizer D, et al. Do patients with chronic patellar tendinopathy have an altered somatosensory profile? - a Quantitative Sensory Testing (QST) study. Scand J Med Sci Sports 2013;23(2):149-55
  • Coombes BK, Bisset L, Vicenzino B. Thermal hyperalgesia distinguishes those with severe pain and disability in unilateral lateral epicondylalgia. Clin J Pain 2012;28(7):595-601
  • Fernandez-Carnero J, Fernandez-de-Las-Penas C, de la Llave-Rincon AI, et al. Widespread mechanical pain hypersensitivity as sign of central sensitization in unilateral epicondylalgia: a blinded, controlled study. Clin J Pain 2009;25(7):555-61
  • Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain 2011;152(3 Suppl):S2-15
  • Meyer RA, Campbell IT, Raja SN. Peripheral neural mechanisms of nociception. In: Wall PD, Melzack R, editors. Textbook of pain. 3rd edition. Churchill Livingstone; Edinburgh, UK: 1995. p. 13-44
  • Nijs J, Van Houdenhove B, Oostendorp RA. Recognition of central sensitization in patients with musculoskeletal pain: application of pain neurophysiology in manual therapy practice. Man Ther 2010;15(2):135-41
  • Staud R, Craggs JG, Perlstein WM, et al. Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls. Eur J Pain 2008;12(8):1078-89
  • Yarnitsky D. Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states. Curr Opin Anaesthesiol 2010;23(5):611-15
  • Meeus M, Nijs J, Van de Wauwer N, et al. Diffuse noxious inhibitory control is delayed in chronic fatigue syndrome: an experimental study. Pain 2008;139(2):439-48
  • Filatova E, Latysheva N, Kurenkov A. Evidence of persistent central sensitization in chronic headaches: a multi-method study. J Headache Pain 2008;9(5):295-300
  • Raphael KG, Janal MN, Anathan S, et al. Temporal summation of heat pain in temporomandibular disorder patients. J Orofac Pain 2009;23(1):54-64
  • Le Bars D, Bouhassira D, Villanueva L. [Diffuse noxious inhibitory controls: theoretical aspects applied to the effects of regional administration of morphine]. Neurochirurgie 1990;36(6):329-35
  • Le Bars D, Dickenson AH, Besson JM. Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications. Pain 1979;6(3):305-27
  • Le Bars D, Dickenson AH, Besson JM. Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain 1979;6(3):283-304
  • Seifert F, Maihofner C. Central mechanisms of experimental and chronic neuropathic pain: findings from functional imaging studies. Cell Mol Life Sci 2009;66(3):375-90
  • Zhuo M. A synaptic model for pain: long-term potentiation in the anterior cingulate cortex. Mol Cells 2007;23(3):259-71
  • Suarez-Roca H, Leal L, Silva JA, et al. Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. Behav Brain Res 2008;189(1):159-69
  • Nijs J, Meeus M, Van Oosterwijck J, et al. Treatment of central sensitization in patients with ’unexplained’ chronic pain: what options do we have? Expert Opin Pharmacother 2011;12(7):1087-98
  • Van Oosterwijck J, Meeus M, Paul L, et al. Pain physiology education improves health status and endogenous pain inhibition in fibromyalgia: a double-blind randomized controlled trial. Clin J Pain 2013;29(10):873-82
  • Jull G, Sterling M, Kenardy J, Beller E. Does the presence of sensory hypersensitivity influence outcomes of physical rehabilitation for chronic whiplash? – a preliminary RCT. Pain 2007;129(1-2):28-34
  • Michaleff ZA, Maher CG, Jull G, et al. A randomised clinical trial of a comprehensive exercise program for chronic whiplash: trial protocol. BMC Musculoskelet Disord 2009;10:149
  • Beckwee D, De Hertogh W, Lievens P, et al. Effect of tens on pain in relation to central sensitization in patients with osteoarthritis of the knee: study protocol of a randomized controlled trial. Trials 2012;13:21
  • Schabrun SM, Jones E, Elgueta Cancino EL, Hodges PW. Targeting chronic recurrent low back pain from the top-down and the bottom-up: a combined transcranial direct current stimulation and peripheral electrical stimulation intervention. Brain Stimul 2014;7(3):451-9
  • Bialosky JE, George SZ, Horn ME, et al. Spinal manipulative therapy-specific changes in pain sensitivity in individuals with low back pain (NCT01168999). J Pain 2014;15(2):136-48
  • Anderson SE, Boesch C, Zimmermann H, et al. Are there cervical spine findings at MR imaging that are specific to acute symptomatic whiplash injury? A prospective controlled study with four experienced blinded readers. Radiology 2012;262(2):567-75
  • Van Oosterwijck J, Nijs J, Meeus M, Paul L. Evidence for central sensitization in chronic whiplash: a systematic literature review. Eur J Pain 2013;17(3):299-312
  • Curatolo M, Bogduk N, Ivancic PC, et al. The role of tissue damage in whiplash-associated disorders: discussion paper 1. Spine 2011;36(25 Suppl):S309-15
  • Dong L, Quindlen JC, Lipschutz DE, Winkelstein BA. Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity. Brain Res 2012;1461:51-63
  • Bogduk N. On cervical zygapophysial joint pain after whiplash. Spine 2011;36(25 Suppl):S194-9
  • Smith AD, Jull G, Schneider G, et al. Cervical radiofrequency neurotomy reduces central hyperexcitability and improves neck movement in individuals with chronic whiplash. Pain Med 2014;15(1):128-41
  • Smith AD, Jull G, Schneider G, et al. A comparison of physical and psychological features of responders and non-responders to cervical facet blocks in chronic whiplash. BMC Musculoskelet Disord 2013;14:313
  • Aranda-Villalobos P, Fernandez-de-Las-Penas C, Navarro-Espigares JL, et al. Normalization of widespread pressure pain hypersensitivity after total hip replacement in patients with hip osteoarthritis is associated with clinical and functional improvements. Arthritis Rheum 2013;65(5):1262-70
  • Wylde V, Dieppe P, Hewlett S, Learmonth ID. Total knee replacement: is it really an effective procedure for all? Knee 2007;14(6):417-23
  • Scott CE, Howie CR, MacDonald D, Biant LC. Predicting dissatisfaction following total knee replacement: a prospective study of 1217 patients. J Bone Joint Surg Br 2010;92(9):1253-8
  • Lundblad H, Kreicbergs A, Jansson KA. Prediction of persistent pain after total knee replacement for osteoarthritis. J Bone Joint Surg Br 2008;90(2):166-71
  • Labek G, Thaler M, Janda W, et al. Revision rates after total joint replacement: cumulative results from worldwide joint register datasets. J Bone Joint Surg Br 2011;93(3):293-7
  • Skou ST, Graven-Nielsen T, Rasmussen S, et al. Widespread sensitization in patients with chronic pain after revision total knee arthroplasty. Pain 2013;154(9):1588-94
  • Nijs J, Van Houdenhove B. From acute musculoskeletal pain to chronic widespread pain and fibromyalgia: application of pain neurophysiology in manual therapy practice. Man Ther 2009;14(1):3-12
  • Shah JP, Gilliams EA. Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: an application of muscle pain concepts to myofascial pain syndrome. J Bodyw Mov Ther 2008;12(4):371-84
  • Cagnie B, Dewitte V, Barbe T, et al. Physiologic effects of dry needling. Curr Pain Headache Rep 2013;17(8):348
  • Shah JP, Danoff JV, Desai MJ, et al. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil 2008;89(1):16-23
  • Mejuto-Vazquez MJ, Salom-Moreno J, Ortega-Santiago R, et al. Short-term changes in neck pain, widespread pressure pain sensitivity, and cervical range of motion after the application of trigger point dry needling in patients with acute mechanical neck pain: a randomized clinical trial. J Orthop Sports Phys Ther 2014;44(4):252-60
  • Affaitati G, Costantini R, Fabrizio A, et al. Effects of treatment of peripheral pain generators in fibromyalgia patients. Eur J Pain 2011;15(1):61-9
  • D’Mello R, Dickenson AH. Spinal cord mechanisms of pain. Br J Anaesth 2008;101(1):8-16
  • Millan MJ. Descending control of pain. Prog Neurobiol 2002;66(6):355-474
  • Pickering G, Esteve V, Loriot MA, et al. Acetaminophen reinforces descending inhibitory pain pathways. Clin Pharmacol Ther 2008;84(1):47-51
  • Mauger AR, Jones AM, Williams CA. Influence of acetaminophen on performance during time trial cycling. J Appl Physiol 2010;108(1):98-104
  • Anderson BJ. Paracetamol (Acetaminophen): mechanisms of action. Paediatr Anaesth 2008;18(10):915-21
  • Hama AT, Sagen J. Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain. Neuropharmacology 2010;58(4-5):758-66
  • Meeus M, Ickmans K, Struyf F, et al. Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome/fibromyalgia and rheumatoid arthritis? A double-blind randomized controlled cross-over trial. Pain Physician 2013;16(2):E61-70
  • Meeus M, Hermans L, Ickmans K, et al. Endogenous pain modulation in response to exercise in patients with rheumatoid arthritis, patients with chronic fatigue syndrome and comorbid fibromyalgia, and healthy controls: a double-blind randomized controlled trial. Pain Pract 2014. [ Epub ahead of print]
  • Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984;7:309-38
  • Quintero L, Moreno M, Avila C, et al. Long-lasting delayed hyperalgesia after subchronic swim stress. Pharmacol Biochem Behav 2000;67(3):449-58
  • Le Bars D, Dickenson AH, Rivot JP, et al. [Are bulbo-spinal serotonergic systems involved in the detection of nociceptive messages? (author’s transl)]. J Physiol (Paris) 1981;77(2-3):463-71
  • Dworkin RH, O’Connor AB, Backonja M, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007;132(3):237-51
  • Lunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. Cochrane Database Syst Rev 2014;1:CD007115
  • Chappell AS, Ossanna MJ, Liu-Seifert H, et al. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain 2009;146(3):253-60
  • Staud R, Robinson ME, Vierck CJ Jr, Price DD. Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients. Pain 2003;101(1-2):167-74
  • Przewlocki R. Opioid abuse and brain gene expression. Eur J Pharmacol 2004;500(1-3):331-49
  • Koppert W, Ihmsen H, Korber N, et al. Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model. Pain 2005;118(1-2):15-22
  • Compton P, Kehoe P, Sinha K, et al. Gabapentin improves cold-pressor pain responses in methadone-maintained patients. Drug Alcohol Depend 2010;109(1-3):213-19
  • Crofford LJ. Adverse effects of chronic opioid therapy for chronic musculoskeletal pain. Nat Rev Rheumatol 2010;6(4):191-7
  • Vanderah TW, Ossipov MH, Lai J, et al. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain 2001;92(1-2):5-9
  • Nuckols TK, Anderson L, Popescu I, et al. Opioid prescribing: a systematic review and critical appraisal of guidelines for chronic pain. Ann Intern Med 2014;160(1):38-47
  • Goldenberg DL. Pharmacological treatment of fibromyalgia and other chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 2007;21(3):499-511
  • Bianchi M, Panerai AE. Anti-hyperalgesic effects of tramadol in the rat. Brain Res 1998;797(1):163-6
  • Tzschentke TM, Christoph T, Kogel BY. The Mu-Opioid Receptor Agonist/Noradrenaline Reuptake Inhibition (MOR-NRI) concept in analgesia: the case of tapentadol. CNS Drugs 2014;28(4):319-29
  • Portenoy RK. Evolving role of NMDA-receptor antagonists in analgesia. J Pain Symptom Manage 2000;19(1 Suppl):S1-64
  • Sang CN. NMDA-receptor antagonists in neuropathic pain: experimental methods to clinical trials. J Pain Symptom Manage 2000;19(1 Suppl):S21-5
  • Price DD, Mayer DJ, Mao J, Caruso FS. NMDA-receptor antagonists and opioid receptor interactions as related to analgesia and tolerance. J Pain Symptom Manage 2000;19(1 Suppl):S7-11
  • Hardy J, Quinn S, Fazekas B, et al. Randomized, double-blind, placebo-controlled study to assess the efficacy and toxicity of subcutaneous ketamine in the management of cancer pain. J Clin Oncol 2012;30(29):3611-17
  • Hardy J, Quinn S, Fazekas B, et al. Reply to K. Jackson et al and W. Leppert. J Clin Oncol 2013;31(10):1375-6
  • Hardy JR, Spruyt O, Quinn SJ, et al. Implementing practice change in chronic cancer pain management - clinician response to a phase III study of ketamine. Intern Med J 2014. [ Epub ahead of print]
  • Quintero L, Cardenas R, Suarez-Roca H. Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. Pain 2011;152(8):1909-22
  • Jiang Y, Wei N, Zhu J, et al. Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat. Mediators Inflamm 2010;2010:372423
  • Ferrer I, Krupinski J, Goutan E, et al. Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat. Acta Neuropathol 2001;101(3):229-38
  • Geng SJ, Liao FF, Dang WH, et al. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Exp Neurol 2010;222(2):256-66
  • Zhang Z, Wang X, Wang W, et al. Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation. Mol Pharmacol 2013;84(4):511-20
  • Wu J, Renn CL, Faden AI, Dorsey SG. TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways. J Neurosci 2013;33(30):12447-63
  • Schwertner A, Conceicao Dos Santos CC, Costa GD, et al. Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial. Pain 2013;154(6):874-81
  • Arnstein PM. The future of topical analgesics. Postgrad Med 2013;125(4 Suppl 1):34-41
  • Catterall WA. Molecular mechanisms of gating and drug block of sodium channels. Novartis Found Symp 2002;241:206-18. discussion 18-32
  • Ruskin DN, Masino SA. The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy. Front Neurosci 2012;6:33
  • Bodnar RJ, Kelly DD, Glusman M. 2-Deoxy-D-glucose analgesia: influences of opiate and non-opiate factors. Pharmacol Biochem Behav 1979;11(3):297-301
  • Bodnar RJ, Merrigan KP, Wallace MM. Analgesia following intraventricular administration of 2-deoxy-D-glucose. Pharmacol Biochem Behav 1981;14(4):579-81
  • Zhao ZQ, Todd JC, Sato H, et al. Adenosine inhibition of neutrophil damage during reperfusion does not involve K(ATP)-channel activation. Am J Physiol 1997;273(4 Pt 2):H1677-87
  • Minor TR, Rowe MK, Soames Job RF, Ferguson EC. Escape deficits induced by inescapable shock and metabolic stress are reversed by adenosine receptor antagonists. Behav Brain Res 2001;120(2):203-12
  • Calcutt NA. Potential mechanisms of neuropathic pain in diabetes. Int Rev Neurobiol 2002;50:205-28
  • Feldman EL. Oxidative stress and diabetic neuropathy: a new understanding of an old problem. J Clin Invest 2003;111(4):431-3
  • Wang D, Couture R, Hong Y. Activated microglia in the spinal cord underlies diabetic neuropathic pain. Eur J Pharmacol 2014;728:59-66
  • Masino SA, Ruskin DN. Ketogenic diets and pain. J Child Neurol 2013;28(8):993-1001
  • Cantello R, Varrasi C, Tarletti R, et al. Ketogenic diet: electrophysiological effects on the normal human cortex. Epilepsia 2007;48(9):1756-63
  • Hartman AL, Gasior M, Vining EP, Rogawski MA. The neuropharmacology of the ketogenic diet. Pediatr Neurol 2007;36(5):281-92
  • Juge N, Gray JA, Omote H, et al. Metabolic control of vesicular glutamate transport and release. Neuron 2010;68(1):99-112
  • Ma W, Berg J, Yellen G. Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels. J Neurosci 2007;27(14):3618-25
  • Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol 1998;347(1):1-11
  • Sollevi A. Adenosine for pain control. Acta Anaesthesiol Scand Suppl 1997;110:135-6
  • Welch SP, Dunlow LD. Antinociceptive activity of intrathecally administered potassium channel openers and opioid agonists: a common mechanism of action? J Pharmacol Exp Ther 1993;267(1):390-9
  • Louw A, Diener I, Butler DS, Puentedura EJ. The effect of neuroscience education on pain, disability, anxiety, and stress in chronic musculoskeletal pain. Arch Phys Med Rehabil 2011;92(12):2041-56
  • Nijs J, Paul van Wilgen C, Van Oosterwijck J, et al. How to explain central sensitization to patients with ’unexplained’ chronic musculoskeletal pain: practice guidelines. Man Ther 2011;16(5):413-18
  • Moseley GL. Unraveling the barriers to reconceptualization of the problem in chronic pain: the actual and perceived ability of patients and health professionals to understand the neurophysiology. J Pain 2003;4(4):184-9
  • Moseley GL. Evidence for a direct relationship between cognitive and physical change during an education intervention in people with chronic low back pain. Eur J Pain 2004;8(1):39-45
  • Meeus M, Nijs J, Van Oosterwijck J, et al. Pain physiology education improves pain beliefs in patients with chronic fatigue syndrome compared with pacing and self-management education: a double-blind randomized controlled trial. Arch Phys Med Rehabil 2010;91(8):1153-9
  • Van Oosterwijck J, Nijs J, Meeus M, et al. Pain neurophysiology education improves cognitions, pain thresholds and movement performance in people with chronic whiplash: a pilot study. J Rehabil Res Dev 2011;48(1):43-58
  • Zusman M. Forebrain-mediated sensitization of central pain pathways: ’non-specific’ pain and a new image for MT. Man Ther 2002;7(2):80-8
  • Burgmer M, Petzke F, Giesecke T, et al. Cerebral activation and catastrophizing during pain anticipation in patients with fibromyalgia. Psychosom Med 2011;73(9):751-9
  • Gracely RH, Geisser ME, Giesecke T, et al. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 2004;127(Pt 4):835-43
  • Sjors A, Larsson B, Persson AL, Gerdle B. An increased response to experimental muscle pain is related to psychological status in women with chronic non-traumatic neck-shoulder pain. BMC Musculoskelet Disord 2011;12:230
  • Ang DC, Chakr R, Mazzuca S, et al. Cognitive-behavioral therapy attenuates nociceptive responding in patients with fibromyalgia: a pilot study. Arthritis Care Res 2010;62(5):618-23
  • de Lange FP, Koers A, Kalkman JS, et al. Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with chronic fatigue syndrome. Brain 2008;131(Pt 8):2172-80
  • Nijs J, Kosek E, Vanoosterwijck J, Meeus M. Dysfunctional endogenous analgesia during exercise in patients with chronic pain: to exercise or not to exercise? Pain Physician 2012;15(3 Suppl)):ES205-13
  • Hoffman MD, Shepanski MA, Mackenzie SP, Clifford PS. Experimentally induced pain perception is acutely reduced by aerobic exercise in people with chronic low back pain. J Rehabil Res Dev 2005;42(2):183-90
  • Meeus M, Roussel NA, Truijen S, Nijs J. Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study. J Rehabil Med 2010;42(9):884-90
  • Lannersten L, Kosek E. Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia. Pain 2010;151(1):77-86
  • Koltyn KF. Analgesia following exercise: a review. Sports Med 2000;29(2):85-98
  • Van Oosterwijck J, Nijs J, Meeus M, et al. Lack of endogenous pain inhibition during exercise in people with chronic whiplash associated disorders: an experimental study. J Pain 2012;13(3):242-54
  • Van Oosterwijck J, Nijs J, Meeus M, et al. Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study. J Intern Med 2010;268(3):265-78
  • Forsgren S, Grimsholm O, Dalen T, Rantapaa-Dahlqvist S. Measurements in the blood of BDNF for RA patients and in response to anti-TNF treatment help us to clarify the magnitude of centrally related pain and to explain the relief of this pain upon treatment. Inter J Inflam 2011;2011:650685
  • Vase L, Nikolajsen L, Christensen B, et al. Cognitive-emotional sensitization contributes to wind-up-like pain in phantom limb pain patients. Pain 2011;152(1):157-62
  • Pfau DB, Krumova EK, Treede RD, et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): reference data for the trunk and application in patients with chronic postherpetic neuralgia. Pain 2014;155(5):1002-15
  • Arendt-Nielsen L, Brennum J, Sindrup S, Bak P. Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system. Eur J Appl Physiol Occup Physiol 1994;68(3):266-73
  • Valeriani M, Le Pera D, Restuccia D, et al. Segmental inhibition of cutaneous heat sensation and of laser-evoked potentials by experimental muscle pain. Neuroscience 2005;136(1):301-9
  • Neziri AY, Andersen OK, Petersen-Felix S, et al. The nociceptive withdrawal reflex: normative values of thresholds and reflex receptive fields. Eur J Pain 2010;14(2):134-41
  • Neblett R, Cohen H, Choi Y, et al. The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample. J Pain 2013;14(5):438-45
  • Lemming D, Sorensen J, Graven-Nielsen T, et al. The responses to pharmacological challenges and experimental pain in patients with chronic whiplash-associated pain. Clin J Pain 2005;21(5):412-21
  • Picarelli H, Teixeira MJ, de Andrade DC, et al. Repetitive transcranial magnetic stimulation is efficacious as an add-on to pharmacological therapy in complex regional pain syndrome (CRPS) type I. J Pain 2010;11(11):1203-10
  • Nijs J, Meeus M, Cagnie B, et al. A modern neuroscience approach to chronic spinal pain: combining pain neuroscience education with cognition-targeted motor control training. Phys Ther 2014;94(5):730-8

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