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Pharmacotherapy for premature ejaculation

Bibliography

  • Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.
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  • Althof SE, McMahon CG, Waldinger MD, et al. An update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). J Sex Med. 2014. [Epub ahead of print]

•• This article reports on the ISSM guideline for the diagnosis and treatment of premature ejaculation.

  • Serefoglu EC, McMahon CG, Waldinger MD, et al. An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation. J Sex Med. 2014;11:1423–1441

•• This article reports on the ISSM consensus meeting on the most recent definition of lifelong and acquired premature ejaculation.

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  • Waldinger MD, Schweitzer DH, Changing paradigms from an historical DSM-III and DSM-IV view towards an evidence based definition of premature ejaculation. Part II: proposals for DSM-V and ICD-11. J Sex Med. 2006;3:693–705
  • Waldinger MD. History of premature ejaculation. In: Jannini EA, McMahon CG, Waldinger MD, editors. Premature ejaculation. From etiology to diagnosis and treatment. Milan: Springer-Verlag Italia; 2013. p. 5–24.
  • Waldinger MD, Quinn P, Dilleen M, et al. Multinational population survey of Intravaginal Ejaculation Latency Time. J Sex Medicine. 2005;2:492–497
  • Waldinger MD, McIntosh J, Schweitzer DH. A five-nation survey to assess the distribution of the intravaginal ejaculatory latency time among the general male population. J Sex Med. 2009;6:2888–2895
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  • Gao J, Zhang X, Su P, et al. Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes: a large observational study in China. J Sex Med. 2013;10:1874–1881
  • Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. Intern J of Psychiatry in Clin Practice. 1998;2:287–293

• This is the first stopwatch study of the intravaginal ejaculation latency time in men with lifelong PE.

  • McMahon CG, Althof SE, Waldinger MD, et al. An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med. 2008;5:1590–1606
  • Waldinger MD, Berendsen HHG, Blok BFM, et al. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res. 1998;92:111–118

• This article describes the neurobiological serotonin hypothesis on lifelong premature ejaculation.

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  • Waldinger MD, Schweitzer DH, Olivier B. On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Medicine. 2005;2:120–131
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  • Waldinger MD. Ejaculatio praecox, erectio praecox, and detumescentia praecox as symptoms of a hypertonic state in lifelong premature ejaculation: a new hypothesis. Pharmacol Biochem Behav. 2014;121:189–194
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  • Corona G, Jannini EA, Vignozzi L, et al. The hormonal control of ejaculation. Nat Rev Urol. 2012;9(9):508–519
  • Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Thyroid stimulating hormone assessments in a Dutch cohort of 620 men with lifelong premature ejaculation without erectile dysfunction. J Sex Medicine. 2005;2:865–870
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  • Waldinger MD, Zwinderman AH, Schweitzer DH, et al. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res. 2004;16:369–381

•• This systematic review and meta-analysis reports on the efficacy of SSRIs and other drugs to treat premature ejaculation.

  • Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy. J Sex Med. 2008;5:492–499
  • Waldinger MD. Premature ejaculation: definition and drug treatment. Drugs. 2007;67:547–568
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  • Waldinger MD, van Coevorden RS, Schweitzer DH, Georgiadis J. Penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) responds to low-power laser irradiation: a case study and hypothesis about the role of transient receptor potential (TRP) ion channels. Eur J Pharmacol. 2015;753:263–268
  • Koyuncu HH, Serefoglu EC, Yencilek E, et al. Escitalopram treatment for premature ejaculation has a negative effect on semen parameters. Int J Impot Res. 2011;23:257–261
  • Koyuncu H, Serefoglu EC, Ozdemir AT, Hellstrom WJ. Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation. Int J Impot Res. 2012;24:171–173
  • Buvat J, Tesfaye F, Rothman M, et al. Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol. 2009;55:957–967
  • McMahon C, Kim SW, Park NC, et al. Dapoxetine 3003 Study Investigators. Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med. 2010;7(1 Pt 1):256–268
  • Kaufman JM, Rosen RC, Mudumbi RV, et al. Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial. BJU Int. 2009;103:651–658
  • McMahon CG, Althof SE, Kaufman JM, et al. Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials. J Sex Med. 2011;8:524–539
  • Mirone V, Arcaniolo D, Rivas D, et al. PAUSE study team. Results from a prospective observational study of men with premature ejaculation treated with dapoxetine or alternative care: the PAUSE study. Eur Urol. 2014;65:733–739
  • Xia JD, Han YF, Zhou LH, et al. Efficacy and safety of local anaesthetics for premature ejaculation: a systematic review and meta-analysis. Asian J Androl. 2013;15(4):497–502

•• This is a meta-analysis reporting on the methodology and design of studies on topical anesthetics for treatment of premature ejaculation.

  • Pu C, Yang L, Liu L, et al. Topical anesthetic agents for premature ejaculation: a systematic review and meta-analysis. Urology. 2013;81:799–804

•• This is a meta-analysis reporting on the methodology and design of studies on topical anesthetics for treatment of premature ejaculation.

  • Busato W, Galindo CC. Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. BJU Int. 2004;93:1018–1021
  • Dinsmore WW, Hackett G, Goldmeier D, et al. Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int. 2007;99:369–375
  • Dinsmore WW, Wyllie MG. PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before inter course in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. BJU Int. 2009;103:940–949
  • Carson C, Wyllie M. Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study. J Sex Med. 2010;7:3179–3189
  • Wu T, Yue X, Duan X, et al. Efficacy and safety of tramadol for premature ejaculation: a systematic review and meta-analysis. Urology. 2012;80:618–624

•• This is a meta-analysis on the efficacy of tramadol for treatment of premature ejaculation.

•• This is a meta-analysis on the efficacy of tramadol for treatment of premature ejaculation.

  • Martyn-St James M, Cooper K, Kaltenthaler E, et al. Tramadol for premature ejaculation: a systematic review and meta-analysis. BMC Urol. 2015;15(1):6

•• This is a meta-analysis on the efficacy of tramadol for treatment of premature ejaculation.

  • Asimakopoulos AD, Miano R, FinazziAgrò E, et al. Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? A systematic review and meta-analysis. J Sex Med. 2012;9:2404–2416

•• This is a meta-analysis on the efficacy of PDE-5 inhibitors for treatment of premature ejaculation.

  • Waldinger MD. Future treatments of premature ejaculation. In: Jannini EA, McMahon CG, Waldinger MD, editors. Premature ejaculation. From etiology to diagnosis and treatment. Milan: Springer-Verlag Italia; 2013. p. 359–369.

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