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Miscellaneous

Advances in the treatment of rheumatoid arthritis: old versus new therapies

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Pages 845-856 | Published online: 25 Feb 2005

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  • ••Anakinra used in combination withmethotrexate significantly better than methotrexate alone in this trial.
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  • ••Guidance for using anti-TNF therapy in RA by BSR.
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  • ••Guidance for using anti-TNF therapy inRA by NICE committee as per British society for rheumatology guidelines.
  • KEANE J, GERSHON S, WISE RP et al.: Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl. J. Med. (2001) 345:1098–1104.
  • •A study by the FDA of 70 cases of tuberculosis with infliximab in RA.
  • ARNASON BJW: TNF neutralization in MS: results of a randomized, placebo-controlled multicentre study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology (1999) 53:457–465.
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  • •Two-year follow up with infliximab shows no increase in incidence of malignancy and lymphoma.
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  • •Five-year follow up with etanercept shows no increase in incidence of malignancy and lymphoma.

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