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- •A study demonstrating the presence of T cells, macrophages and TNF-a mRNA in the sacroiliac joints of AS patients.
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- •A proposition for criteria of symptomatic improvement in AS.
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- •A study of the differential effects of sulfasalazine on axial and peripheral manifestations of spondylarthropathies based upon the analysis of a large, controlled, randomised trial involving 619 patients.
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- ••The first study that reported the dramaticimprovement of AS patients with refractory and severe disease with the monoclonal antibody infliximab.
- VAN DER BOSCH F, KRUITHOF E, BAETEN D, DE KEYSER F, MIELANTS H, VEYS EM: Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumor necrosis factor a (infliximab) in spondylarthropathy: an open pilot study. Ann. Rheum. Dis. (2000) 59(6):428–433.
- ••A second open study with infliximabconfirming the results of [42] and extending the treatment to the other spondylarthropathies (psoriatic arthritis and undifferenciated spondylarthropathy).
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- •A study showing the imaging amelioration of synovitis with infliximab treatment.
- KRUITHOF E, VAN DEN BOSCH F, BAETEN D et al.: Repeated infusions of infliximab, a chimeric anti-TNEcc monoclonal antibody in patients with active spondylarthropathy: one year follow up. Ann. Rheum. Dis. (2002) 61(3):207–212.
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- ••The first placebo controlled trialconfirming the strong efficacy of infliximab in spondylarthropathy.
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- ••The first open study of pamidronate in ASpatients giving favourable results on axial symptoms.
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- ••A comparative study showing the clinicaleffects of pamidronate in refractory AS patients.
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- •A recent, open study of methotrexate therapy in AS with a long-term follow-up.
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- •Another recent open study of methotrexate therapy in AS giving contrasting results to [59].
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- •The first study evaluating the effects and tolerability of a new anti-COX-2 selective agent - celecoxib.
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- KRUITHOF E, KESTELYN P, ELEWAUT C et al.: Successful use of infliximab in a patient with treatment resistant spondylarthropathy related uveitis. Ann. Rheum. Dis. (2002) 61(5):470.
- MEASE PJ, GOFFE BS, METZ J et al: Etanerept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet (2000) 356(9227):385–390.
- ••A placebo-controlled trial demonstratingthe efficacy of etanercept on both skin and joint manifestations in psoriatic arthritis patients.