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Review

Recent progress in ankylosing spondylitis treatment

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Pages 1-12 | Published online: 02 Mar 2005

Bibliography

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  • •A study demonstrating the presence of T cells, macrophages and TNF-a mRNA in the sacroiliac joints of AS patients.
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  • •A cross-sectional study showing the impact of AS on work status.
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  • ••A literature review of pharmacotherapy inAS, especially the use of NSAIDs.
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  • •A proposition for criteria of symptomatic improvement in AS.
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  • ••A recent literature review of the drugtreatment in AS, including the second-line treatments.
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  • •A study of the differential effects of sulfasalazine on axial and peripheral manifestations of spondylarthropathies based upon the analysis of a large, controlled, randomised trial involving 619 patients.
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  • ••The first study that reported the dramaticimprovement of AS patients with refractory and severe disease with the monoclonal antibody infliximab.
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  • ••A second open study with infliximabconfirming the results of [42] and extending the treatment to the other spondylarthropathies (psoriatic arthritis and undifferenciated spondylarthropathy).
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  • •A study showing the imaging amelioration of synovitis with infliximab treatment.
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  • MAKSYMOWYCH W, JHANGRI GS, LAMBERT RG et al.: Infliximab in ankylosing spondylitis: a prospective bservational inception cohort analalysis of efficacy and safety. Rheumatul. (2002) 29(5)959–965.
  • VAN DEN BOSCH, KRUITHOF E, BAETEN D et al.: Randomised double blind comparison of chimeric monoclonal antibody to tumor necrosis factor a (infliximab) versus placebo in active spondylarthropathy. Arthritic Rheum. (2002) 46(3):755–765.
  • ••The first placebo controlled trialconfirming the strong efficacy of infliximab in spondylarthropathy.
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  • ••The first open study of pamidronate in ASpatients giving favourable results on axial symptoms.
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  • MAKSYMOWYCH WP, JHANGRI GS, FITZGERALD AA et al.: A six-month randomized, controlled, double-blind, dose response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis. Arthritic Rheum. (2002) 46(3):766–773.
  • ••A comparative study showing the clinicaleffects of pamidronate in refractory AS patients.
  • CREEMERS MCW, FRANSEN MJAM, VAN DE PUTTE LBA et al.: Methotrexate in severe ankylosing spondylitis: an open study. Rheumatul. (1995) 22(6):1104–1107.
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  • •A recent, open study of methotrexate therapy in AS with a long-term follow-up.
  • SAMPAIO-BARROS PD, COSTALLAT LTL, BERTOLO M et al.: Methotrexate in the treatment of ankylosing spondylitis. Scand. Rheumatul. (2000) 29(3):160–162.
  • •Another recent open study of methotrexate therapy in AS giving contrasting results to [59].
  • ALTAN L, BINGOL U, KARAKOC Y et al.: Clinical investigation of methotrexate in the treatment of ankylosing spondylitis. Scand. Rheumatul. (2001) 30(5):255–259.
  • BREBAN M, GOMBERT B, AMOR B, DOUGADOS M: Efficacy of thalidomide in the treatment of refractory ankylosing spondylitis. Arthritic Rheum. (1999) 42(3):580–581.
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  • DOUGADOS M, BEHIERJ, JOLCHINE I et al.: Efficacy of celecoxib, a COX-2 specific inhibitor in the treatment of ankylosing spondylitis: a six-week controlled study with comparison against placebo and against conventional nonsteroidal antiinflammatory drug. Arthritis Rheum. (2001) 44(1):180–185.
  • •The first study evaluating the effects and tolerability of a new anti-COX-2 selective agent - celecoxib.
  • DOUGADOS M, GUEGUEN A, NAKACHE JP et al.: Ankylosing spondylitis: what is the optimum duration of a clinical study? A one year versus a 6 weeks non-steroidal anti-inflammatory drug trial. Rheumatalogy (1999) 38(3):235–244.
  • TOUSSIROT E, WENDLING D: Bone mass in ankylosing spondylitis. Clin. Exp. Rheumatul. (2000) 18\(Suppl. 21):S16–S20.
  • KRUITHOF E, KESTELYN P, ELEWAUT C et al.: Successful use of infliximab in a patient with treatment resistant spondylarthropathy related uveitis. Ann. Rheum. Dis. (2002) 61(5):470.
  • MEASE PJ, GOFFE BS, METZ J et al: Etanerept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet (2000) 356(9227):385–390.
  • ••A placebo-controlled trial demonstratingthe efficacy of etanercept on both skin and joint manifestations in psoriatic arthritis patients.

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