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- ••Step-down trial introducing the concept ofMAD.
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- ••First trial evaluating the combination ofFP and salmeterol.
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- ••Benefits of a fixed dose of FP andsalmeterol in a single inhaler on steroid naive patients.
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- ••Trial evaluating salmeterol or salbutamolas add-on therapies for ICS.
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- ••First trial comparing the combinationtherapy in one single inhaler or two different inhalers.
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- ••Only trial comparing the combination therapy using one or two inhalers in children.
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- ••First trial using the combinationformoterol and BUD in a single inhaler.
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- ••Extensive trial comparing the combinationof salmeterol and FP to montelukast.
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- ••Comparison of two different inhalers withthe combination salmeterol and FR
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- ••Comparison of salmeterol and zafirlukastas add-on therapy to ICS.
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- ••Comparison of zafirlukast, salmeterol andtheophylline as add-on therapies to BUD.
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- ••Experimental trial showing the effect ofsalmeterol on the translocation of corticosteroid receptors into the nuclear cell from the cytosol.
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- ORSIDA BE, WARD C, LI X et al.: Effect of a long-acting 132-agonist over three months on airway wall vascular remodeling in asthma. Am. J Respir. Grit. Care Med. (2001) 164:117–121.
- ••Single trial comparing the effect ofsalmeterol and FP on the vascular component on airway remodelling.
- BONNER JC, BADGETT A, LINDROOS PM, COIN PG: Basic fibroblast growth factor induces expression of the PDGF receptor-a on human bronchial smooth muscle cells. Am. J Physiol. (1996) 271:L880–L888.
- Guidelines for the diagnosis and management of asthma. Update on selected topics-2002. National Institutes of Health. National Heart, Lung, and Blood Institute. National asthma education and prevention program (2002) Bethseda, MD, USA.
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- PRIMHAK RA, SMITH CM, YONG SC et al.: The bronchoprotective effect of inhaled salmeterol in preschool children: a dose-ranging study. Eur. Respir. J. (1999) 13:78–81.
- BISGAARD H, GILLIES J, GROENEWALD M, MADEN C: The effect of inhaled fluticasone propionate in the treatment of young asthmatic children: a dose comparison study. Am. J Respir. Grit. Care Med. (1999) 160:126–131.
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- PAO CS, MCKENZIE SA: Randomized controlled trial of fluticasone in preschool children with intermittent wheeze. Am. J Respir. Grit. Care Med. (2002) 166:945–949.
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