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Review

Inhaled corticosteroids plus long-acting β2-agonists as a combined therapy in asthma

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Pages 23-39 | Published online: 02 Mar 2005

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  • ••Extensive meta-analysis including most ofthe trials involving BDP and FR
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  • ••First trial comparing formoterol plus BUDto higher doses of BUD.
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  • ••First trial evaluating a LABA added to anICS in relation to a double dose of ICS.
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  • ••First trial on the combination of LABAsand ICS in children.
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  • ••Step-down trial introducing the concept ofMAD.
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  • ••Trial on the combination of BUD andformoterol centred on the quality of life improvements of the combination therapy.
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  • ••Evaluates steroid naive patients andpatients already on ICS. Combination of BUD and formoterol.
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  • ••First trial evaluating the combination ofFP and salmeterol.
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  • ••Benefits of a fixed dose of FP andsalmeterol in a single inhaler on steroid naive patients.
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  • ••Trial evaluating salmeterol or salbutamolas add-on therapies for ICS.
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  • ••First trial comparing the combinationtherapy in one single inhaler or two different inhalers.
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  • ••Only trial comparing the combination therapy using one or two inhalers in children.
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  • ••First trial using the combinationformoterol and BUD in a single inhaler.
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  • ••Extensive trial comparing the combinationof salmeterol and FP to montelukast.
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  • ••Comparison of two different inhalers withthe combination salmeterol and FR
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  • ••Comparison of salmeterol and zafirlukastas add-on therapy to ICS.
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  • ••Comparison of zafirlukast, salmeterol andtheophylline as add-on therapies to BUD.
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  • ••First trial comparing salmeterol andmontelukast as add-on therapies to ICS.
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  • ••Experimental trial showing the effect ofsalmeterol on the translocation of corticosteroid receptors into the nuclear cell from the cytosol.
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  • ••Single trial comparing the effect ofsalmeterol and FP on the vascular component on airway remodelling.
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