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Review

The management of bacterial meningitis in children

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Pages 1227-1240 | Published online: 02 Mar 2005

Bibliography

  • MURRAY CJL, LOPEZ AD: Global and regional cause-of-death patterns in 1990. In: Global comparative assessments in the health sector: disease burden, expenditures and intervention packages. Murray CJL, Lopez AD (Eds), World Health Organization, Geneva, Switzerland (1994):21–55.
  • ROHDENBURG GL, VANDER VEER A: The spinal fluid in pneumonia. JAMA (1915) 64:1227–1228.
  • DUKE T, POKA H, FRANK D, MICHAEL A, MGONE J, WAL T: Chloramphenicol versus benzylpenicillin and gentamicin for the treatment of severe pneumonia in children in Papua New Guinea: a randomised trial. Lancet (2002) 359:4474–4480.
  • MOHAMMED I, NASIDI A, ALKALI AS, et al.: A severe epidemic of meningococcal meningitis in Nigeria, 1996. Trans. R. Soc. Bop. Med. Hyg. (2000) 94:265–270.
  • MACALUSO A, PIVETTA S, MAGGI RS, TAMBURLINI G, CATTANEO A: Dexamethasone adjunctive therapy for bacterial meningitis in children: a retrospective study in Brazil. Ann. Bop. Paediatr. (1996) 16:193–198.
  • QAZI SA, KHAN MA, MUGHAL N et al.: Dexamethasone and bacterial meningitis in Pakistan. Arch. Dis. Child. (1996) 75:482–488.
  • AKPEDE GO, AKUHWA RT, OGIJI EO, AMBE JP: Risk factors for an adverse outcome in bacterial meningitis in the tropics: a reappraisal with focus on the significance and risk of seizures. Ann. Bop. Paediatr. (1999) 19:151–159.
  • SHANN F, BARKER J, POORE P: Chloramphenicol alone verses chloramphenicol plus penicillin for bacterial meningitis in children. Lancet (1985) ii:681–684.
  • LEHMANN D, YEKA W, RONGAP T et al.: Aetiology and clinical signs of bacterial meningitis in children admitted to Goroka Base Hospital Papua New Guinea, 1989-1992. Ann. Bop. Paediatr. (1999) 19:21–32.
  • IMANANAGHA KK, PETERS EJ, PHILIP-EPHRAIM EE et al.: Acute bacterial meningitis in a developing country: diagnosis related mortality among paediatric patients. Cent. Afr. J. Med. (1998) 44:11–15.
  • DUKE T, MOKELA D, FRANK D et al: Management of meningitis in children with oral fluid restriction or intravenous fluid at maintenance volumes: a randomised trial. Ann. Bop. Paediatr. (2002) 22:145–147.
  • •A randomised, controlled trial showing that moderate or severe fluid restriction does not improve the outcome from meningitis, but over-hydration is very dangerous.
  • MOLYNEUX EM, WALSH AL, FORSYTH H et al.: Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet (2002) 360:211–218.
  • ••The largest randomised, controlled trial ofcorticosteroids in meningitis, showing no overall beneficial effect. This important study is highly relevant in many settings in the developing world.
  • CHAKRABORTY R, PULVER A, PULVER LS et al.: The post-mortem pathology of HIV-1-infected African children. Ann. Bop. Paediatr. (2002) 22:125–131.
  • •An autopsy study of 33 HIV-infected children showing that bacterial meningitis and pyogenic pneumonia are the major infections causing death.
  • GRIMWOOD K, ANDERSON P, TAN L, NOLAN T: Twelve year outcomes following bacterial meningitis: further evidence for persisting effects. Arch. Dis. Child. (2000) 83:111–116.
  • •This study supports the need for long-term follow up of children with meningitis to detect problems that may interfere with later education, employment or socialisation.
  • SHANN F, STEINHOFF MC: Vaccines for children in rich and poor countries. Lancet (1999) 354:SI17–S1111.
  • •This article highlights the discrepancy between rich and poor countries in terms of the vaccines they need, and those they can afford.
  • MCCRACKEN GH Jr: Rich nations, poornations and bacterial meningitis.Lancet (2002) 360:183.
  • ADEGBOLA RA, USEN SO, WEBER M et al.: Haemophilus influenzae Type b meningitis in The Gambia after introduction of a conjugate vaccine. Lancet (1999) 354:1091–1092.
  • SHANN F: Pneumococcal vaccine: time foranother controlled trial. Lancet (1998) 351:1600–1601.
  • VEEKEN H, RITMEIJER K,HAUSMAN B: Priority during a meningitis epidemic: vaccination or treatment. Bull. World Health Organ. (1998) 76:135–141.
  • KLUGMAN KP, MADHI SA: Emergence of drug resistance. Impact on meningitis. Infect. Dis. Clin. North Am. (1999) 13:637–646.
  • •This study summarises the mechanisms of antibiotic resistance among the common meningitis pathogens.
  • FRIEDLAND IR, KLUGMAN KP: Failure of chloramphenicol therapy in penicillin-resistant pneumococcal meningitis. Lancet (1992) 339:405–408.
  • FRIEDLAND IR, SHELTON S, MCCRACKEN GH: Chloramphenicol in penicillin-resistant pneumococcal meningitis. Lancet (1993) 342:240–241.
  • DEL RIO MA, CHRANE D, SHELTON S, MCCRACKEN GH, NELSON JD: Ceftriaxone versus ampicillin and chloramphenicol for treatment of bacterial meningitis in children. Lancet (1983) 1:1241–1244.
  • STEELE RW, BRADSHER RW: Comparison of ceftriaxone with standard therapy for bacterial meningitis. Pediatr. (1983) 103:138–141.
  • CONGENI BL: Comparison of ceftriaxone and traditional therapy of bacterial meningitis. Antimicrob. Agents Chemother. (1984) 25:40–44.
  • WELLS TG, TRANG JM, BROWN AL, MARMER BC, JACOBS RF: Cefotaxime therapy of bacterial meningitis in children. Antimicrob. Cheme (1984) 14(Suppl. B):181–189.
  • ARONOFF SC, REED MD, O'BRIEN CA, BLUMER JL: Comparison of the efficacy and safety of ceftriaxone to ampicillinichloramphenicol in the treatment of childhood meningitis. Antimicrob. Chemother. (1984) 13:143–151.
  • BRYAN JP, ROCHA H, DA SILVA HR,TAVERES A, SANDE MA, SCHELD WM: Comparison of ceftriaxone and ampicillin plus chloramphenicol for the therapy of acute bacterial meningitis. Antimicrob. Agents Chemother. (1985) 28:361–368.
  • BARSON WJ, MILLER MA, BRADY MT, POWELL DA: Prospective comparative trial of ceftriaxone versus conventional therapy for treatment of bacterial meningitis in children. Pediatr. Infect. Dis. J. (1985) 4:362–368.
  • JACOBS RF, WELLS TG, STEELE RW, YAMAUCHI T: A prospective randomized comparison of cefotaxime versus ampicillin and chloramphenicol for bacterial meningitis in children. J. Pediatr. (1985) 107:129–133.
  • ODIO CM, FAINGEZICHT I, DALAS JL, GUEVARA J, MOHS E, MCCRACKEN GH: Cefotaxime versus conventional therapy for the treatment of bacterial meningitis of infants and children. Pediatr. Infect. Dis. J. (1986) 5:402–407.
  • RODRIGEUZ WJ, PUIG JR, KHAN WN, FERIS J, GOLD BG, STURLA C: Ceftazadime versus standard therapy for pediatric meningitis: therapeutic, pharmacologic and epidemiologic observations. Pediatr. Infect. Dis. J. (1986) 5:408–415.
  • NGU J, YOUMBISSI T: A comparative study of ceftriaxone (Rocephin) versus ampicillin and chloramphenicol in children with bacterial meningitis. Chemiopterapia (1987) 6(2 Suppl.):417–418.
  • HAFFEJEE IE: Cefotaxime versus penicillin-chloramphenicol in purulent meningitis: a controlled single-blind trial. Ann. Bop. Paediam. (1988) 8:225–229.
  • GIRGIS NI, ABU EL ELLA AH, FARID Z, HABERBERGER RL, GALAL FS, WOODY JN: Intramuscular ceftriaxone versus ampicillin-chloramphenicol in childhood bacterial meningitis. Scand. I InfeciDis. (1988) 20:613–617.
  • PELTOLA H, ANTILLA M, RENKONEN OV: Randomised comparison of chloramphenicol, ampicillin, cefotaxime and ceftriaxone for childhood bacterial meningitis. Lancet (1989) 1:1281–1287.
  • SHARMA PR, ADHIKARI RK, JOSHI MP et al: Intravenous chloramphenicol plus penicillin versus intramuscular ceftriaxone for the treatment of pyogenic meningitis in Nepalese children. Bop. Duct. (1996) 26:84–85.
  • Antimicrobial and support therapy for bacterial meningitis in children. Division of Child Health and Development. World Health Organization, Geneva, Switzerland (1998) 1:10–15.
  • SCHREIBER JR, JACOBS MR: Antibiotic-resistant pneumococci (Review). Pediatr. Clin. North Am. (1995) 42:519–537.
  • COLLINGNON PJ, BELL JM: Drug-resistant Streptococcus pneumoniae: the beginning of the end for many antibiotics? Med. J. Aust. (1996) 164:64–67.
  • TAN TQ, MASON EO, KAPLAN SL: Penicillin-resistant systemic pneumococcal infections in children: a retrospective case-control study. Pediatrics (1993) 92:761–767.
  • DAGAN R, YAGUPSKY P, GOLDBLAT A, WASAS A, KLUGMAN K: Increasing prevalence of penicillin-resistant pneumococcal infections in children in southern Israel: implications for future immunisation policies. Pediatr. Infect. Dis. J. (1994) 13:782–786.
  • BREIMAN RE BUTLER JC, TENOVER FC, ELLIOT JA, FACKLAM RR: Emergence of drug resistant pneumococcal infections in the United States. JAMA (1994) 271:1831–1835.
  • GOLD HS, MOELLERING RC Jr: Antimicrobial-drug resistance (Review). N Engl. J. Med. (1996) 335:1445–1153.
  • BOGAERTS J, LEPAGE P, TAELMAN H et al.: Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae from Rwanda, 1984-1990. J. Infect. (1993) 27:157–168.
  • KLUGMAN KP: Epidemiology, control and treatment of multiresistant pneumococci. Drugs (1996) 52:S42–S46.
  • APPELBAUM PC: World-wide development of antibiotic resistance in pneumococci. Ear: Clin. Microbiol (1987) 6:367–377.
  • MCCRACKEN GH Jr: Emergence of resistant Streptococcus pneumoniae: a problem in paediatrics. Pediatr. Infect. Dis.J. (1995) 14:424–428.
  • WEINBERG GA, SPITZER ED, MURRAY PR et al.: Antimicrobial susceptibility patterns of Haemophilus isolates from children in eleven developing nations. BOSTID Haemophilus Susceptibility Group. Bull. World Health Organ. (1990) 68:179–184.
  • MUHE L, KLUGMAN KP: Pneumococcal and Haemophilus influenzae meningitis in a children's hospital in Ethiopia: serotypes and susceptibility patterns. Bop. Med. Int. Health (2002) 4:421–427.
  • GRATTEN M, MONTGOMERY J: The bacteriologiy of acute pneumonia and meningitis in Papua New Guinea: assumptions, facts and technical strategies. PNG Med. J. (1991) 34:185–198.
  • DE JUAN ME CAMPOS CC, BUSTILLO AM, BALDOVIN BALLESTEROS I, BELLO AE, ELVIRO ML: Invasive Haemophilus influenzae Type b infections in children (1981-1990). An. Esp. Pediatr. (1993) 39:111–115.
  • AL-JURAYYAN NAM, AL MAZYAD AS, AL-NASSER MNS et al.: Childhood bacterial meningitis in Al-Baha province, Saudi Arabia. J. Bop. Med. Hygeine (1992) 95:185.
  • AKPEDE 0, ABIODUN PO, SYKES M, SALAMI CE: Childhood bacterial meningitis beyond the neonatal period in Southern Nigeria: changes in organisms/antibiotic susceptibility. East Afr. Med. J. (1994) 71:14–20.
  • ROCA J, CAMPOS J, MONSO G et al:Pediatric meningitis: clinical and epidemiologic study of 173 cases. Enf Infec. MicrobiolClin. (1992) 10:79–88.
  • SINGH R, THOMAS S, KIRUBAKARAN C, LALITHA MK, RAGHUPATHY P: Occurrence of multiple antimicrobial resistance among Haemophilus influenzae Type b causing meningitis. Indian J. Med. Res. (1992) 95:230–233.
  • TETANYE E, YONDO A, BERNARD-BONNIN AC et al:Initial treatment of bacterial meningitis in Yaounde, Cameroon: theoretical benefits of the ampicillin-chloramphenicol combination versus chloramphenicol alone. Ann. Bop. Paediatr. (1990) 10:285–291.
  • AKPEDE GO, ADEYEMI 0, ABBA AA, SYKES RM: Pattern and antibiotic susceptibility of bacteria in pyogenic meningitis in a children's emergency room population in Maiduguri, Nigeria, 1988-1992. Acta Paediatr. (1994) 83:719–723.
  • ONYEMELUKWE NF: Haemophilus influenzae meningitis in parts of eastern nigeria. East Afr. Med. J. (1994) 71:129–131.
  • NIK KHAIRULDIN NY, CHOO KE, JOHARI MR: Epidemiology of Haemophilus influenzae invasive disease in hospitalized Kelananese children, 1985-1994. Singapore Med. 1 (1999) 40:96–100.
  • BARTON-FORBES MA, SAMMS-VAUGHAN M, IRONS B: Epidemiology of Haemophilus influenzae disease in Jamaica, 1990-1993. West Indian Med. (2000) 49:200–204.
  • NGO TT: Bacterial meningitis by Haemophilus influenzae on children under 5 years old isolated in institute for protection of children's health from 1988-1995. Tap Chi Hoc Thuc Hanh - So Ky Yeu Bvskte (2002) 124–128.
  • HUSSEY G, HITCHCOCK J, HANSLO Det al.: Serotypes and antimicrobial susceptibility of Haemophilus influenzae. Antimicrob. Chemo. (1994) 34:1031–1036.
  • CASAGRANDE ST, VICENTE EJ, LANGRAF IM, KOBATA AMM: Antimicrobial resistance patterns of Haemophilus influenzae isolated from patients with meningitis in Sao Paulo, Brazil. Brazj Med. Biol. Res. (2002) 33:295–300.
  • COMMEY JOO, RODRIGUES OP, AKITA FA, NEWMAN M: Bacterial meningitis in children in Southern Ghana. East Air. Med. J. (1994) 71:113–117.
  • LLANES R, AZAHARES LE, PEREZ ME MARTINEZ I, PATTON AS: Antimicrobial resistance in Haemophilus influenzae in Habana City, Cuba. Rev Argent. Microbiol (1996) 28:17–21.
  • Invasive Haemophilus influenzae disease in India: a preliminary report of prospective multihospital surveillance. IBIS (Invasive Bacterial Infections Surveillance) Group. Pediatr. Infect. Dis. (1998) 17:S172–S175.
  • WANYOIKE MN, WAIYAKI S, MCLIGEYO SO, WAFULA EM: Bacteriology and sensitivity patterns of pyogenic meningitis at Keyatta National Hospital, Nairobi, Kenya. East Air. Med. j (1995) 72:658–660.
  • MOLYNEUX E, WALSH A, PHIRI A, MOLYNEUX M: Acute bacterial meningitis in children admitted to the Queen Elizabeth Central Hospital, Blantyre, Malawi in 1996-1997. Bop. Med. hat. Health (1998) 3:610–618.
  • MWANGI I, BERKLEY J, LOWE B, PESHU N, MARSH K, NEWTON CR: Acute bacterial meningitis in children admitted to a rural Kenyan hospital: increasing antibiotic resistance and outcome. Pediatr. Infect. Dis. (2002) 21:1042–1048.
  • ••This study reports an 80% incidence ofchloramphenicol resistance among Hibisolates from children with meningitis in one hospital in Kenya.
  • REIS JN, LIMA JB, RIBEIRO GS et al:Antimicrobial resistance in Haemophilus influenzae isolated during population-based surveillance for meningitis in Salvador, Brazil. Antimicrob. Agents Chemo. (2002) 46:3641–3643.
  • CASAGRANDE ST, LANDGRAF IM, KOBATA AMM, ZANELLA RC, BOKERIVIANN S: Antimicrobial resistance among invasive Haemophilus influenzae strains: results of a brazilian study carried out from 1996 through 2000. Brazj Med. Biel Res. (2002) 35:1293–1300.
  • SHOMA S, RAHMAN M, YASMIN M: Rapid detection of Haemophilus influenzae type b in Bangladeshi children with pneumonia and meningitis by PCR and analysis of antimicrobial resistance.' Health Pop& Num. (2001) 19:268–274.
  • DUKE T: Antibiotic-resistant bacterial sepsis in Papua New Guinea. PNG Med. (2000) 43:82–90.
  • MIGLIANI R, CLOUZEAU J, DEC OUSSER JW et al.: Bacterial meningitis in children in Antananarivo, Madagascar. Arch. Pediatr. (2002) 9:892–897.
  • GONZALES GARCIA E, CASADO FLORES J, GARCIA LARINO P, MENENDEZ RIVAS M: Meningitis por Haemophilus influenzae: estudio de 28 cases. An. Esp. Pediatr. (1990) 33:413–417.
  • DUKE T, MICHAEL A, MOKELA D, WAL T, REEDER J: Chloramphenicol or ceftriaxone, or both, as treatment for meningitis in developing countries? Arch. Dis. Child. (2003) 88:536–539.
  • CURTIS N, DUKE T, FULLER D, SHANN F: Bacterial meningitis in developing countries - the problem worsens. Lancet (2003) 361:1564.
  • •This article summarises the rising incidence of chlorarnphenicol-resistance among H influenzae meningitis worldwide in the last 13 years.
  • TUBAU F, LINARES J, ARDANUY C et al.: In vitro bactericide activity of different antibiotic combinations to Streptococcus pneumoniae resistant to penicillin and cefotaxime. Enferm. Infecc. Microbiol Clin. (1996) 14:590–595.
  • PARRY CM, DUONG NM, ZHOU J et al.: Emergence in Vietnam of Streptococcus pneumoniae resistant to multiple antimicrobial agents as a result of dissemination of the multiresistant Spain (23F)-1 clone. Antimicrob. Agents Chemo. (2002) 46:3512–3517.
  • JAING TH, CHIU CH, HUNG IJ: Successful treatment of meningitis caused by highly-penicillin resistant Streptococcus mitis in a leukemic child. Chang Gung Med. (2002) 25:190–193.
  • AL-AQEELI AA, GUY ML, AL-JUMAAH SA: Streptococcus pneumoniae resistant to penicillion and ceftriaxone in a tertiary care centre in Saudi Arabia. Saudi Med.' (2002) 23:400–404.
  • TURNIDGE JD, BELL JM, COLLIGNON PJ: Rapidly emerging antimicrobial resistances in Streptococcus pneumoniae in Australia. Pneumococcal Study Group. Med. J. Aust. (1999) 170:152–155.
  • KLUGMAN KP, SAUNDERS J: Pneumococci resistant to extended-spectrum cephalosporins in South Africa (Letter). Lancet (1993) 341:1164.
  • CHESNEY PJ, WILLIAMS JA, PRESBURY G et al.: Penicillin- and cephalosporin-resistant strains of Streptococcus pneumoniae causing sepsis and meningitis in children with sickle cell disease. I Pediatr. (1995) 127:526–532.
  • MUNOZ M, VALDERRABANOS ES, DIAZ E et al: Appearance of resistance to beta-lactam antibiotics during therapy for Streptococcus Pneumoniae meningitis. Pediatr. (1995) 127:98–99.
  • KLUGMAN KP, FRIEDLAND IR, BRADLEY JS: Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrob. Agents Chemo. (1995) 39:1988–1992.
  • KIM BN, WOO JH, KIM YS, RYU J, KIM MN, PAI CH: Time-kill studies of antimicrobial combinations including cefotaxime, ceftriaxone, vancomycin and meropenem against cephalosporin-resistant Streptococcus pneumoniae. Chemotherapy (2000) 46:303–308.
  • GERBER CM, COTTAGNOUD M, NEFTEL KA, TAUBER MG, COTTAGNOUD P: Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain. Eur. Clin. Microbiol Infect. Dis. (1999) 18:866-870. Expert Op/n. Pharmacother. (2003) 4(8)
  • FITOUSSI F, DOIT C, BENALI K, BONACORSI S, GESLIN P, BINGEN E: Comparative in vitro activities of meropenem, imepenem, cefotaxime and ceftriaxone plus vancomycin at clinically achievable cerebrospinal fluid concentrations against penicillin-resistant Streptococcus pneumoniae isolates from children with meningitis. Antimicrob. Agents Chemo. (2003) 42:942–944.
  • FRIEDLAND IR, PARIS M, EHRETT S, HICKEY S, OLSEN K, MCCRACKEN GH Jr: Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob. Agents Chemo. (1993) 37:1630–1636.
  • ODIO CM, PUIG JR, FERIS JM et al.: Prospective randomized, investigator-blided study of the efficacy and safety of meropenem versus cefotaxime therapy in bacterial meningitis in children. Meropenem Meningitis Study Group. Pediatr. Infect. Dis. J. (1999) 18:581–590.
  • KLUGMAN KP, DAGAN R: Randomized comparison of meropenem with cefotaxime for treatment of bacterial meningitis. Meropenem Study Group. Antimicrob. Agents Chemo. (2003) 39:1140–1146.
  • SCMUTZHARD E, WILLIAMS KJ, VUKMIROVITS G, CHMELIK V, PFAUSLER B, FEATHERSTONE A: A randomized comparison of meropenem with cefotaxime or ceftriaxone for the treatment of bacterial meningitis in adults. Meropenem Meningitis Study Group. .1. Antimicrob Chemo. (1995) 36(Suppl. A):85–97.
  • VANDECASTEELE SJ, VERHAEGEN J, COLAERT J, VAN CASTER A, DEVLIEGER H: Failure of cefotaxime and meropenem to eradicate meningitis caused by an intermediately susceptible Streptococcus pneumoniae strain. Eur: Clin. Microbial. Infect. Dis. (2001) 20:751–752.
  • KLUGMAN KP, GOOTZ TD: In vitro and in vivo activity of trovafloxacin against Streptococcus pneumoniae. .1 Antimicrob. Chemo. (1997) 39(Suppl.):B51–B55.
  • COTTAGNOUD P, ACOSTA F, COTTAGNOUD M, NEFTEL K, TAUBER MG: Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in a rabbit meningitis model and in vitro. Antimicrob. Agents Chemo. (2000) 44:2179–2181.
  • ROD ONI D, HANNI F, GERBER CMet al.: Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in a rabbit meningitis model. Antimicrob. Agents Chemo. (1999) 43:963–965.
  • NAU R, ZYSK G, SCHMIDT H et al.: Trovafloxacin delays the antibiotic-induced inflammatory response in experimental pneumococcal meningitis. Antimicrob. Chemo. (1997) 39:781–788.
  • SAEZ-LLORENS X, MCCOIG C, FERIS JM et al: Quinolone treatment for pediatric bacterial meningitis: a comparative study of trovafloxacin and ceftriaxone with or without vancomycin. The Trovan Meningitis Study Group. Pediatr. Infect. Dis. J. (2002) 21:14–22.
  • BINGEN E, LAMBERT-ZECHOVSKY N, AUJARD Y et al.: Early synergistic killing activity at concentrations attainable in CSF of amoxycillin or cefotaxime and aminoglycosides against Haemophilus influenzae. Infection (1998) 16:121–125.
  • ANADIOTIS L, MASKELL JP, SEFTON AM: Comparative in vitro activity of penicillin alone and combined with gentamicin against clinical isolates of Streptococcus pneumoniae with decreased susceptibility to penicillin. Intl Antimicrob. Agents (2002) 19:173–181.
  • SCHLEGEL L, SISSIA G, FREMAUX A, GESLIN P: In vitro killing activity of combinations of beta-lactam agents with aminoglycosides against penicillin-resistant pneumococci. .1. Antimicrob. Chemo. (1997) 39:95–98.
  • GROSS ME, GIRON KP, SEPTIMUS JD, MASON EO Jr, MUSHER DM: Antimicrobial activities of beta-lactam antibiotics and gentamicin against penicillin-susceptible and penicillin-resistant pneumococci. Antimicrob. Agents Chemo. (1995) 39:1166–1168.
  • COTTAGNOUD P, GERBER CM, COTTAGNOUD M, TAUBER MG: Gentamicin increases the efficacy of vancomycin against penicillin-resistant pneumococci in a rabbit meningitis model. Antimicrob. Agents Chemo. (2002) 46:188–190.
  • ROINE I, LEDERMANN W, FONCEA LM, BANFI A, COHEN J, PELTOLA H: Randomized trial of four versus seven days of ceftriaxone treatment for bacterial meningitis in children with rapid recovery. Pediatr. Infect. Dis. .1 (2000) 19:219–222.
  • COCHI SL, MARKOWITZ LE, JOSHI DD et al.: Control of epidemic group A meningococcal meningitis in Nepal. Int. J. Epidemiol (1987) 16:91–97.
  • SANDERSON PJ: Gentamicin and chloramphenicol in neonatal meningitis. Lancet (1978) 2:210.
  • MOLYNEUX EM, WALSH AL, MALENGA G, ROGERSON S, MOLYNEUX ME: Salmonella meningitis in children in Blantyre, Malawi, 1996-1999. Ann. Trop. Paediatr. (2000) 20:41–44.
  • •A large series of Salmonella meningitis from Malawi highlighting clinical features and complications and a case fatality of 58%.
  • HONNAS A, PETERSON LT: Bacterial meningitis in a rural Kenyan hospital. East Afr. Med. J. (1998) 75:396–401.
  • CHOTPITAYASUNONDH T: Bacterial meningitis in children: etiology and clinical features, an 11-year review of 618 cases. Southeast Asian I Trop. Med. Public Health (1994) 25:107–115.
  • MUHE L, TILAHUN M, LULSEGED S et al.: Etiology of pneumonia, sepsis and meningitis in infants younger than three months of age in Ethiopia. Pediatr. Infect. Dis. (1999) 18:S56–S61.
  • OWUSU-OFORI A, SCHELD WM: Treatment of Salmonella meningitis: two case reports and a review of the literature. Int. Infect. Dis. (2003) 7:53–57.
  • LEE WS, PUTHUCHEARY SD, OMAR A: Salmonella meningitis and its complications in infants. I Paediatr. Child Health (1999) 35:379–382.
  • SAHAI S, MAHADEVAN S, SRINIVASAN S, KANUNGO R: Childhood bacterial meningitis in Pondicherry, South India. Indian j Pediatr. (2001) 68:839–841.
  • MADHI SA, MADHI A, PETERSON K, KHOOSAL M, KLUGMAN KP: Impact of human immunodeficiency virus Type 1 on the epidemiology and outcome of bacterial meningitis in South African children. Int. .1. Infect. Dis. (2001) 5:119–125.
  • •A controlled observational study of HIV and meningitis showing a higher proportion of S. pneumoniae infection and higher case fatality among HIV-infected children, with a mortality rate from HIV and pneumococcal meningitis of 60%.
  • BERGEMANN A, KARSTAEDT AS: The spectrum of meningitis in a population with high prevalence of HIV disease. Q/M(1996) 89:499–504.
  • SUBRAMANYAM VR, MTITIMILA E, HART CA, BROADHEAD RL: Cryptococcal meningitis in African children. Ann. Trop. Paediatr. (1997) 17:165–167.
  • JEAN SS, PAPE JVV, VERDIER RI et al: The natural history of human immunodeficiency virus 1 infection in Haitian infants. Pediatr. Infect. Dis. (1999) 18:58–63.
  • Meningococcal disease. WHO Report on Global Surveillance of Epidemic-prone Infectious Diseases. WHO/CDS/CSR/ISR/2000. (2000) 1:1–8.
  • •An important summary of meningococcal disease epidemics globally.
  • MOORE PS, REEVES MW, SCHWARTZ B, GELLIN BG, BROOME CV: Intercontinental spread of an epidemic group A Neisseria meningitidis strain. Lancet (1989) 29:260–263.
  • Meningococcal Disease, Serogroup W135, Burkina Faso: Preliminary Report 2002. Wkly Epidemiol Rec. (2002) 18:152–155.
  • WOODS CW, ARMSTRONG G, SACKEY SO et al.: Emergency vaccination against epidemic meningitis in Ghana: implications for the control of meningococcal disease in West Africa. Lancet (2000) 355:30–33.
  • SPIEGEL A, MOREN A, VARAINE F, BAUDON D, REY M: Epidemiological and control aspects of meningococcal meningitis epidemics in Africa. Sante (1994) 4:231–236.
  • CHIPPAUX JP, SOULA G, CAMPAGNE G, REY M: Optimizing the response to epidemics of meningococcal meningitis: report of a workshop of experts at CERMES (Niamey, Niger, 12-14 1998). Sante (1998) 8:245–248.
  • LEWIS R, NATHAN N, DIARRA L, BALANGER F, PAQUET C: Timely detection of meningococcal meningitis epidemics in Africa. Lancet (2001) 358:287–293.
  • LEWIS RF, DORLENCOURT F, PINEL J: Long-acting oily chloramphenicol for meningococcal meningitis. Lancet (1998) 352:823.
  • PUDDICOMBE JB, WALI SS, GREENWOOD BM: A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis. Trans. R. Soc. Trop. Med. Hyg. (1984) 78:399–3403.
  • HUSSEIN AA, ABDEL RAHMAN SI: Meningococcal meningitis epidemic. A new role for single-dose oily chloramphenicol. Saudi Med. J. (2002) 7:797–801.
  • PECOUL B, VARAINE F, KEITA M et al.: Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis. Lancet (1991) 338:862–866.
  • CAMPAGNE G, CHIPPAUX JP, DJIBO S, ISSA 0, GARBA A: Epidemiology and control of bacterial meningitis in children less than one year in Niamey (Niger). Buff Soc. Athol Exot. (1999) 92:118–122.
  • PRASAD K, HAINES T: Dexamethasone treatment for acute bacterial meningitis: how strong is the evidence for routine use. Neurol Neurosurg. Psych. (1995) 59:31–37.
  • MCINTYRE PB, BERKEY CS, KING SM et al.: Dexamethasone as adjunctive therapy in bacterial meningitis: a meta-analysis of randomized clinical trials since 1988. JA/VIA (1997) 278:925–931.
  • DE GANS J, VAN DE BEEK D: Dexamethasone in adults with bacterial meningitis. The European Dexamethasone In Adulthood Bacterial Meningitis Study Investigators. N Engl. J. Med. (2002) 347:1549–1556.
  • •A large randomised, controlled trial showing a very substantial benefit of early dexamethasone treatment on the mortality and complications of meningitis caused by S. pneumoniae in European adults.
  • CABELLOS C, MARTINEZ-LACASA J, MARTOS A et al.: Influence of dexamethasone on efficacy of ceftriaxone and vancomycin therapy in expereimental pneumococcal meningitis. Antimicrob. Agents Chemo. (1995) 39:2158–2160.
  • MARINEZ-LACASA J, CABELLOS C, MARTOS A et al.: Experimental study of the efficacy of vancomycin, rifampicin and dexamethasone in the therapy of pneumococcal meningitis. Antimicrob. Chemo. (2002) 49:507–513.
  • TUNKEL AR, SCHELD WM: Corticosteroids for everyone with meningitis? N Engl. J. Med. (2002) 347:1613–1615.
  • DOIT CP, BONACORSI SP, FREMAUX AJ et al.: In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis. Antimicrob. Agents Chemo. (1994) 38:2655–2659.
  • DUKE T: Fluid management of bacterial meningitis in developing countries. Arch. Dis. Child. (1998) 79:181–185.
  • SHANN F, GERMER S: Hyponatremia associated with pneumonia or bacterial meningitis. Arch. Dis. Child. (1985) 60:963–966.
  • DOBSON SRM, MOXON ER: Haemophilus influenzae: syndromes and Treatment. In: Infections of the Central Nervous System. Lambert HP (Ed.), BC Decker, Philadelphia, USA (1991) 111–112.
  • SHANN F, GERMER S: Treatment of bacterial meningitis without intravenous fluids. Med. J. Aust. (1983) 1(7):305 (Letter).
  • POWELL KR, MILLER M:. Fluid management and arginine vasopressin in bacterial meningitis. Am. J. Dis. Child. (1992) 146:540-541 (Letter).
  • SINGHI SC, SINGHI PD, SRINIVAS B et al.: Fluid restriction does not improve the outcome of acute meningitis. Pediati: Infect. Dis. J. (1995) 14:495–503.
  • •A randomised, controlled trial of fluid restriction versus 100% maintenance fluids in children with meningitis, showing that a reduction in extracellular fluid volume during treatment was associated with a worse neurological outcome.
  • Fever: management of the child with a serious infection or severe malnutrition: guidelines for care at the first-referral level in developing countries. World Health Organization, Geneva, Switzerland, (2000) 57–73.
  • BILBREY GL, BEISEL WR: Depression of free water clearance during pneumococcal bacteraemia. Ann. &rig. (1973) 177(1):112–120.
  • DUKE T, BLASCHKE AJ, SIALIS S, BONKOWSKY JL: Hypoxaemia in acute respiratory and non-respiratory illness in neonates and children in a developing country. Arch. Dis.Child. (2002) 86:108–112.
  • MCJUNKIN JE, DE LOS REYES EC, IRAZUZTA JE et al.: La Crosse encephalitis in children. N Engl. I Med. (2001) 344:801–807.
  • HOROWITZ SJ, BOXERBAUM B, O'BELL J: Cerebral herniation in bacterial meningitis in childhood. Ann. Neurol 1980.
  • SINGHI S, SINGHI P, BARANWAL AK: Bacterial meningitis in children: critical care needs. Indianj Pediatr. (2001) 68:737–747.
  • FLORET D: Suppurative meningitis in infants and children: adjuvant treatments of neurological forms. Pediatrie (1993) 48:21–27.
  • MINNS RA, ENGLEMANN HM: The use of CSF pressure recordings in acute puralent meningitis. Z Kinderchir: (1988) 43:S28–S29.
  • LORENZL S, KOEDEL U, PFISTER HW: Mannitol, but not allopurinol, modulates changes in cerebral blood flow, intracranial pressure, and brain water content during pneumococcal meningitis in the rat. Grit. Care Med. (1996) 24:1874–1880.
  • SYROGIANNOPOULOS GA, OLSEN KD, MCCRACKEN GH Jr: Mannitol treatment in experimental Haemophilus influenzae type b meningitis. Pediatr. Res. (1987) 22:118–122.
  • SHACKFORD SR, BOURGUIGNON PR, WALD SL, ROGERS FB, OSLER TM, CLARK DE: Hypertonic saline resuscitation of patients with head injury: a prospective, randomized clinical trial. J. Trauma (1998) 44:50–58.
  • TEFUARANI N, VINCE JD: Purulent meningitis in children: outcome using a standard management regimen with chloramphenicol. Ann. Bop. Paediatr. (1992) 12:375–383.
  • CRAWLEY J, WARUIRU C, MITHWANI S et al: Effect of phenobarbital on seizure frequency and mortality in childhood malaria: a randomised, controlled intervention trial. Lancet (2000) 355:701–706.
  • CULLINAN TR, PIETERICK C: Packaged treatment for first-line care in cerebral malaria and meningitis. Bull. World Health Organ. (1998) 76:257–264.
  • FIJNVANDRAAT K, DERKX B, PETERS M et al: Coagulation activation and tissue necrosis in meningococcal septic shock: severely reduced protein C levels predict a high mortality. Throm. Haemost. (1995) 73:15–20.
  • BERNARD GR, VINCENT J-L, LATERRE P-F et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl.' Med. (2001) 344:699–6709.
  • WHITE B, LIVINGSTONE W, MURPHY C, HOD GSON A, RAFFERTY M, SMITH OP: An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcaemia. Blood (2000) 96:3719–3724.
  • ALEJANDRIA MM, LANSANG MA, DANS LF, AND MANTARING JBV: Intravenous immunoglobulin for treating sepsis and septic shock (Cochrane Review). The Cochrane Library 1 (2002). Oxford, Update Software.
  • OHLSSON A, LACY JB: Intravenous immunoglobulin for suspected or subsequently proven infection in neonates. The Cochrane Library 1 (2003). Oxford: Update Software.

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