27
Views
1
CrossRef citations to date
0
Altmetric
Review

Platelet glycoprotein IIb/IIIa inhibitors during percutaneous coronary interventions: a pharmacological and clinical review

&
Pages 335-348 | Published online: 02 Mar 2005

Bibliography

  • FURIE B, FURIE BC: Molecular and cellular biology of blood coagulation.N Engl. J. Med. (1992) 326:800–806.
  • SCHWARTZ L, BOURASSA MG, LESPERANCE J et al.: Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. N Engl. I Med. (1988) 318:1714–1719.
  • SAVAGE MP, GOLDBERG S, BOVE AAet al.: Effect of thromboxane A2 blockade on clinical outcome and restenosis after successful coronary angioplasty: Multi-Hospital Eastern Atlantic Restenosis Trail(M-HEART II). Circulation (1995) 93:3194–3200.
  • FLATHER MD, VVEITZ JI, YUSUF S et al.: Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation: results of a randomized trial. OASIS Pilot Study Investigators. Eur: Heart J. (2000) 21:1473–1481.
  • SCHOMIG A, NEUMANN FJ, KASTRATI A et al.: A randomized comparison of antiplatelet and anticoagulant therapy after placement of coronary-artery stents. N Engl. J. Med.(1996) 334:1084–1089.
  • HALL P, NAKAMURA S, MAIELLO L et al.: A randomized comparison of ticlopidine and aspirin therapy versus aspirin alone after successful intravascular ultrasound guided stent implantation.Circulation (1996) 93:215–222.
  • URBAN P, MACAYA C, RUPPRECHT H et al.: randomized evaluation of anticoagulation versus antiplatelet therapy after coronary stent implantation in high risk-patients: the Multicenter Aspirin andTiclopidine Trial after Intracoronary Stenting (MATTIS). Circulation (1998) 98:2126–2132.
  • LEON M, BAIM D, POPMA J et al.: A clinical trial comparing three antithrombotic drug regimens after coronary artery stenting. N Engl. J. Med. (1998) 339:1671–1678.
  • MEHTA SR, YUSUF S, PETERS RJG et al., on behalf of the CURE Investigators: Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary interventions: the PCI-CURE study. Lancet (2001) 358:527–33.
  • STEINHUBL SR, BERGER PB, MANN JT 3' et al.: CREDO Investigators: Clopidogrel for the Reduction of Events During Observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA (2002) 288:2411–2420.
  • NO AUTHORS LISTED: Randomized placebo-controlled trial of abciximab before and during coronary intervention in refractory unstable angina: the CAPTURE study. Lancet (1997) 349:1429-1435 [Erratum in: Lancet (1997) 350(9079):7441.
  • TOPOL EJ, CALIFF RIVI, WEISMAN HF et al.: Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. The EPIC Investigators. Lancet (1994) 343:881–886.
  • THE EPILOG INVESTIGATORS: Platelet glycoprotein IIb/IIIa receptor blockade and low dose heparin during percutaneous coronary revascularization.N Engl. J. Med. (1997) 336: 1689-1696.
  • LINCOFF AM, CALIFF RM,MOLITERNO DJ et al: Complementary clinical benefits of coronary-artery stenting and blockade of glycoprotein IIb/IIIa receptors. Evaluation of Platelet IIb/IIIa Inhibition in Stenting Investigators.N. Engl. J. Med. (1999) 341:319–327.
  • NO AUTHORS LISTED: Randomizedaplacebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT-II. Integrelin to Minimise Platelet Aggregation and Coronary Thrombosis-II.Lancet (1997) 349:1422–1428.
  • THE RESTORE INVESTIGATORS: Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis. Effect of Platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty. Circulation (1997) 96:1445–1453.
  • THE EPISTENT INVESTIGATORS: Randomized placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa receptor blockade. Lancet (1998) 352:87–92.
  • THE ESPRIT INVESTIGATORS: Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomized, placebo-controlled trial.aLancet (2000) 256:2037–2044.
  • TOPOL E, MOLITERNO D,HERRMANN H et al.: Comparison of two platelet glycoprotein-IIb/Illa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization.aN. Engl. J. Med. (2001) 344:1888-1894.a345
  • GOGSTAD GO, BROSSTAD F, KRUTNES MB, HAGEN I, SOLUM NO: Fibrinogen binding properties of the human platelet glycoprotein-IIb/IIIa complex: a study using crossed- radio-immuno-electrophoresis. Blood (1982) 60:663–671.
  • PLOW EF, GINSBERG MH: GP IIb-IIIa as a prototypic adhesion receptor.Frog. Hemost. Thromb. (1989) 9:117–156.
  • PLOW EF, GINSBERG MH: Specific and saturable binding of plasma fibronectin to thrombin-stimulated platelets.Biol. Chem. (1981) 256:9477–9482.
  • PLOW EF, MC EVER RP, COLLER BS, WOODS VL Jr, MAGUERIE GA, GINSBERG MH: Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets. Blood (1985) 66:724–727.
  • PHILLIPS DR, CHARO IF, PARISE LV, FITZGERALD LA: The platelet membrane glycoprotein-IIb/IIIa complex. Blood(1988) 71:831–843.
  • PIERSCHBACHER MD, RUOSLAHTI E: Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature (1984) 309:30–33.
  • KLOCZEWIAK M, TIMMONS S, HAWIGER J: Recognition site of the platelet receptor is present on the 15-residue carboxy-terminal fragment of the 7 chain of human fibrinogen and is not involved in the fibrin polymerization reaction.Thromb. Res. (1983) 29:249–255.
  • PLOW EF, D'SOUZA SE,aGINSBERG MH: Ligand binding to GP IIb-IIIa: a status report. Semin. Thromb. Hemost. (1992) 18:324–332.
  • COLLER BS, PEERSCHKE El, SOUDDER LE, SULLIVAN CA: A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoprotein IIb and or IIIa.Clin. Invest. (1983) 72:325–338.
  • KLEIMAN NS, RAIZNER AE,aJORDAN R et al.: Differential inhibition of platelet aggregation induced by adenosine diphosphate or a thrombin receptor-activating peptide in patients treated with bolus chimeric c7E3 Fab: implications for inhibition of the internal pool ofGP IIb/IIIa receptors. J. Am. Coll. Cardiol(1995) 26:1665–1671.
  • MASCELLI MA, LANCE ET, DAMARAJU L et al.: Pharmacodynamic profile of short-term abciximab treatment demonstrates prolonged platelet inhibition with gradual recovery of glycoprotein IIb/IIIa receptor blockade.Circulation (1998) 97:1680–1688.
  • HARRINGTON RA, KLEIMAN NS, KOTTKE-MARCHAUT K et al.: Immediate and reversible platelet inhibition of intravenous administration of a peptide glycoprotein IIb/IIIa inhibitor during percutaneous coronary intervention. Am.j Cardiol (1995) 76:1222–1227.
  • KEREIAKES DJ, KLEIMAN NS, AMBROSE J et al.: Randomized, double blind, placebo-controlled dose-ranging study of tirofiban (MK-383) platelet IIb/IIIa blockade in high risk patients undergoing coronary angioplasty. J. Am. Coll. Cardiol (1996) 27:536–542.
  • ALIG L, EDENHOFER A, HAD VARY P et al.: Low molecular weight, non peptide fibrinogen receptor antagonists. Med. Chem. (1992) 35:4393–4407.
  • TCHENG JE, ELLIS SG, GEORGE BS et al.: Pharmacodynamics of chimeric glycoprotein IIb/IIIa integrin antiplatelet antibody fab 7e3 in high-risk coronary angioplasty. Circulation (1994) 90: 1757-1764.
  • GRUBERG L, LANSKY AJ, DANGAS G, STONE GW: Glycoprotein IIb/IIIa inhibitors during primary angioplasty for acute myocardial infarction. Carr. Interv. Cardiol Rep. (1999) 1:359–367.
  • GRINES CL, BROWNE KF, MARCO J et al: A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study group. N Engl. J. Med. (1993) 328:673–679.
  • GIBBONS RJ, HOLMES DR,REEDER GS, BAILEY KR,HOPFENSPIRGER MR, GERSH BJ: Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary care Unit and Catheterization Laboratory Groups. N Engl. J. Med. (1993) 328:685–691.
  • RODRIGUEZ A, BERNARDI V, FERNANDEZ M et al.: In-hospital and late results of coronary stents versus conventional balloon angioplasty in acute myocardial infarction (GRAMI Gianturco-Roubin in Acute MycardialInfarction. Am. J. Cardiol (1998) 81:1286–1291.
  • MAILLARD L, HAMON M, KHALIFE K et al.: A comparison of systemic stenting and conventional balloon angioplasty durin primary percutaneous transluminal coronary angioplasty for acute myocardial infarction. STENTIM-2 Investigators. J. Am. Coll. Cardiol (2000) 35:1729–1736.
  • STONE GW, BRODIE BR, GRIFFIN JJ et al.: Clinical and angiographic follow-up after Primary stenting in Acute Myocardial Infarction (PAMI) stent pilot trial. Circulation (1999) 99:1548–1554.
  • STONE GW, LANSKY AJ, MEHRAN R et al.: Beyond TIMI-3 flow: the importance of restored myocardial perfusion for survival in high risk patients undergoing primary or rescue PTCA. J. Am. Coll. Cardiol (2000) 35(Suppl. A):403A (Abstract).
  • BRENER SJ, BARR LA,BURCHENAL JEB et al. on behalf of the RAPPORT Investigators: Radomized, placebo controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction. Circulation (1998) 98:734–741.
  • AZAR RR, MCKAY RG, THOMPSON PD et al: Abciximab in primary coronary angioplasty for acute myocardial infarction improves short-and medium-term outcomes. J. Am. Coll. Cardiol (1998) 32:1996–2002.
  • VAN DEN MERKHOF LFM, ZIJLSTRA F, OLSSON H et al.: Abciximab in the treatment of acute myocardial infarction eligible for primary percutaneous transluminal coronary angioplasty. Results of the glycoprotein receptor antagonist patency evaluation (GRAPE) Pilot Study. J. AM. Coll. Cardiol (1999) 33:1528–1532.
  • MONTALESCOT G, BARRAGAN P, WITTENBERG 0 et al.: Platelet glycoprotein IIb/IIIa inhibitors with coronary stenting for Acute Myocardial Infarction. N Engl. J. Med. (2001) 344:1895–1903.
  • NEUMANN FJ, KASTRATI A, SCHMITT C et al.: Effect of glycoprotein IIb/IIIa receptor blockade with abciximab on clinical and angiographic restenosis rate after the placement of coronary stents following acute myocardial infarction. J. Am. Coll. Cardiol (2000) 35:915–921.
  • THE CADILLAC INVESTIGATORS: Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complication (CADILLAC) trial. N Engl. J. Med. (2002) 346:957–966.
  • CUTUP DE, COVE CJ, IRONS D et al:Emergency room administration of eptifibatide before primary angioplasty for ST elevation acute myocardial infarction and its effect on baseline coronary flow and procedure outcomes. Am. J. Cardiol (2001) 88:A6:62–64.
  • LEE DP, HERITY NA, HIATT BL et al. TIrofiban Given in the Emergency Room before Primary Angioplasty: Adjunctive platelet glycoprotein IIb/IIIa receptor inhibition with tirofiban before primary angioplasty improves angiographic outcomes: results of the TIrofiban Given in the Emergency Room before Primary Angioplasty (TIGER-PA) Pilot Trial. Circulation (2003) 107:1497–1501.
  • MILLER JM, SMALLING R, OHMAN M et al. for the GUSTO-III Investigators: Effectiveness of early coronary angioplasty and abciximab for failed thrombolysis (reteplase or alteplase) during acute myocardial infarction (results of the GUSTO-III Trial). Am. Cardiol (1999) 84:779–784.
  • PRISM-PLUS STUDYINVESTIGATORS: Inhibition of platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q wave myocardial infarction. N Engl. I Med. (1998) 338:1488–1497.
  • BOERSMA E, AKKERHUIS KM, THEROUX P, CALIFF RM, TOPOL EJ, SIMOONS ML: Platelet glycoprotein IIb/IIIa receptor inhibition in non-ST-elevation acute coronary syndromes: early benefit during medical treatment only, with additional protection during percutaneous coronary intervention. Circulation (1999) 100:2045–2048.
  • NO AUTHORS LISTED: Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes. The PURSUIT trial Investigators. Platelet glycoprotein IIb/IIIa in unstable angina; receptor suppression using integrilin treatment. N Engl. I Med. (1998) 339:436–443.
  • O'SHEA JC, BULLER CE, CANTOR WJ et al. on behalf of the ESPRIT Investigators: Long-term efficacy of platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention.JAMA (2002) 287:618–621.
  • SULEIMAN M, GRUBERG L, HAMMERMAN H et al.: Comparison of two platelet glycoprotein IIb/IIIa inhibitors, eptifibatide and abciximab: outcomes,complications and thrombocytopenia during percutaneous coronary intervention..1 Invas. Cardiol (2003) 15:319–323.
  • THE ERASER INVESTIGATORS: Acute platelet inhibition with abciximab does not reduce in-stent restenosis (ERASER study). Circulation (1999) 100:799–806.
  • MANSO SP, LINCOFF AM, ELLIS G et al.: Optimizing the percutaneous interventional outcomes for patients with diabetes mellitus: results of EPISTENT (Evaluation of Platelet IIb/IIIa Inhibition for Stenting Trial) diabetic substudy. Circulation (1999) 100:2477–2484.
  • ROFFI M, MOLITERNO D, MEIER B et al.: Impact of different platelet glycoprotein IIb/IIIa receptor inhibitors among diabetic patients undergoing percutaneous intervention: Do Tirofiban and ReoPro Give similar Efficacy outcomes Trial (TARGET) 1-year follow-up. Circulation (2002) 105:2730–2736.
  • BRENER SJ, ELLIS SG, SCHNEIDER TOPOL EJ: Frequency and long-term impact of myonecrosis after coronary stenting. Eur: Heart I. (2002) 23:869–876.
  • ADGEY AA, MATHEW TP,HARBINSON MT: Periprocedural creatine kinase-MB elevations: long-term impact and clinical implications. Clin. Cardiol (1999) 22:257–265.
  • ISLAM MA, BLANKENSHIP JC, BALOG C et al.: Effect of abciximab on angiographic complications during percutaneous coronary stenting in the Evaluation of Platelet IIb/IIIa inhibition in Stenting Trial (EPISTENT). Am. I Cardiol (2002) 90:916–921.
  • BLANKENSHIP JC, TASISSA G, O'SHEA JC et al.: Effect of glycoprotein IIb/IIIa receptor inhibition on angiographic complications during percutaneous coronary stenting in the ESPRIT trial. J. Am. Coll Cardiol (2001) 38:653–658.
  • BLANKENSHIP JC, SIGMON KN, PIEPER KS: Effect of eptifibatide on angiographic complications during percutaneous coronary stenting in the IMPACT- (Integrilin to Minimise Platelet Aggregation and Coronary Thrombosis) II Trial. Am.! Cardiol (2001) 88:969–973.
  • TARDIFF BE, CALIFF RM, TCHENG JE et al.: Clinical outcomes after detection of elevated cardiac enzymes in patients undergoing percutaneous coronary intervention. IMPACT-II Investigators. Integrelin (eptifibatide) to Minimise PlateletaAggregation and Coronary Thrombosis II.aJ. Am. Coll. Cardiol (1999) 33:88–96.
  • ANDERSON KM, CALIFF RM, STONE GW et al.: Long-term mortality benefit with abciximab in patients undergoing percutaneous coronary intervention. I Am. Coll Cardiol (2001) 37:2059–2065.
  • MANDAK JS, BLANKENSHIP JC, GARDNER LH et al.: Modifiable risk factors for vascular access site complications in the IMPACT-II Trial of angioplasty with versus without eptifibatide. Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis. I Am. Coll. Cardiol (1998) 31:1518–1524.
  • AGUIRRE FU, TOPOL EJ,FERGUSON JJ et al.: Bleeding complications with the chimeric antibody to platelet glycoprotein IIb/IIIa- integrin in patients undergoing percutaneous coronary intervention. EPIC Investigators. Circulation (1995) 91:2882–2890.
  • BLANKENSHIP JC, HELLKAMP AS, AGUIRRE FU et al.: Vascular access site complication after percutaneous coronary intervention with abciximab in the Evaluation of c7EC for the Prevention of Ischemic Complications (EPIC) trial. kn. Cardiol (1998) 81:36–40.
  • KEREIAKES DJ, GRINES C, FRY E: Enoxaparin and abciximab adjunctive pharmacotherapy during percutaneous coronary intervention. Invasive Cardiol (2001) 13:272–278.
  • CALIFF RM: Combination therapy for acute myocardial infarction: fibrinolytic therapy and glycoprotein IIb/IIIa inhibition. Am. Heart! (2000) 139:S33–S37.
  • LINCOFF AM, CALIFF RM, VAN DE VVERF F et al. Global Use of Strategies To Open Coronary Arteries Investigators (GUSTO): Mortality at 1 year with combination platelet glycoprotein IIb/IIIa inhibition and reduced-dose fibrinolytic therapy versus conventional fibrinolytic therapy for acute myocardial infarction: GUSTO V randomized trial. JAMA (2002) 288:2130–2135.
  • ANTMAN EM, GIBSON CM, DE LEMOS JA et al. on behalf of The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators: Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. Ear. Heart J. (2000) 23:1944–1953.
  • BERKOWITZ SD, HARRINTON RA, RUND MM et al.: Acute profound thrombocytopenia after c7E3 Fab (abciximab) therapy. Circulation (1997) 95:809–813.
  • DASGUPTA H, BLANKENSHIP JC, WOOD GC et al.: Thrombocytopenia complicating treatment with intravenous glycoprotein IIb/IIIa receptor inhibitors: a pooled analysis. Am. Heart" (2000) 140:206–211.
  • HONGO RH, BRENT BN: Association ofeptifibatide and acute profoundathrombocytopenia. Am. ". aCardiol (2001) 88:428–431.
  • JUERGENE CP, YEUNG AC, OESTERLE SN: Routine platelet transfusion in patients undergoing emergency coronary bypass surgery after receiving abciximab. Am. Cardiol (1997) 80:74–75.
  • TCHENG JE, KEREIAKES DJ, BRADEN GA et al.: safety of abciximab retreatment- final clinical report of the ReoPro Readministration Registry (R3). Circulation (1998) 98:1-17 (Abstract).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.