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Drug Evaluation

Levocetirizine: the allergist’s arsenal grows larger

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Pages 1581-1588 | Published online: 25 Feb 2005

Bibliography

  • WEINER JM, ABRAMSON MJ, PUY RM: Intranasal corticosteroids versus oral H1 Receptor antagonists in allergic rhinitis: systematic review of randomized controlled trials. BE Med. .1 (1998) 317:1624–1626.
  • THOMPSON AK, JUNIPER E, MELTZER EO: Quality of life in patients with allergic rhinitis. Ann. Allergy Asthma Immunol (2000) 85:338–347.
  • MELTZER EO: Quality of life in adults and children with allergic rhinitis. I Allergy Clin. Immunol (2001) 108:s45–s53.
  • ZUBERBIER R, GREAVES M, JUHLIN L et al: Definition, classification, and routine diagnosis of urticaria: a consensus report. Invest. Berm. Symp. Proceed. (2001) 6:123–127.
  • POON E, SEED PT, GREAVES MW, KOBZA-BLACK A: The extent and nature of disability in different urticarial conditions. Br. .1. Berm. (1999) 140:667–671.
  • WEILER JM, BLOOMFIELD JR, WOODWORH GG et al: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann. Intern. Med. (2000) 132:354–363.
  • •This study illustrates the safety of levocetirizine compared with diphenhydramine.
  • TIMMERMAN H: Why are nonsedating antihistamines nonsedating? Allergy (1999) 29\(Suppl. 3):13–18.
  • SALMUN LM: Antihistamines in late-phase clinical development for allergic disease. Expert Opin. Investig Drugs (2002) 11(2):259–273.
  • ••An excellent review of antihistaminescurrently undergoing investigation.
  • STROLIN-BENEDETTI MS, PLISNIER M, KAISE J et al.: Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine in healthy volunteers. Eur. Clin. Pharmacol (2001) 57:571–582.
  • GILLARD M, VAN DER PERREN C, MOGUILEVSKY N, MASSINGHAM R, CHATELAIN P: Binding characteristics of cetirizine and levocetirizine to human H1 histamine receptors: contribution of Lys191 and thr194. Mol. Pharmacol (2002) 61(2):391–399.
  • GILLARD M, VAN DER PERREN C, MOGUILEVSKY N, MASSINGHAM R, CHATELAIN P: Major role for the carboxylic function of cetirizine and levocetirizine in their binding characteristics to human Hl-histamine receptors. Inflamm. Res. (2002) 51\(Suppl. 1):579–580.
  • JAZRAWI E, STIRLIN R, CHUNG F: Effects of levocetirizine in an in-vitro model of eosinophil chemotaxis induced by eotaxin. XX Congress of the European Academy of Allergology and Clinical Immunology Berlin, Germany (2001).
  • THOMSON L, BLAYLOCK MG, SEXTON DW, CAMPBELL A, WALSH GM: Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells. Clin. Exp. Allergy (2002) 32:1187–1192.
  • YING S, MENG Q, KAY AB: The effect of levocetirizine on histamine and cytokine-induced upregulation of eotaxin by endothelial cells. XU Congress of the European Academy of Allergy and Clinical Immunology Naples, Italy (2002).
  • GUTZMER R, WITTMANN M, KAPP A, WERFEL T: Direct immunomodulatory effects of levocetirizine on lymphocytes. XXII Congress of the European Academy of Allergy and Clinical Immunology Paris, France (2003).
  • MICHEL L, JEAN-LOUIS F, DUBERTRET L: Pharmacological study of levocetirizine in IgE-dependent hypersensitivity cutaneous reaction in grass pollen allergic volunteers: demonstration of mediator release and eosinophil recruitment modulation by levocetirizine. XX Congress of the European Academy of Allergology and Clinical Immunology Berlin, Germany (2001).
  • MICHEL L, JEAN-LOUIS F, BOLAND S, PELLET C, DUBERTRET L: Inhibition by levocetirizine of VCAM-1 production in human dermal endothelial cells in vitro blockage of NF-KB and possible mechanism of antiallergic action. XXII Congress of the European Academy of Allergy and Clinical Immunology Paris, France (2003).
  • DEVALIA JL, DE VOS C, HANOTTE F, BALTES E: A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine- induced cutaneous responses in healthy adult volunteers. Allergy (2001) 56:50–57.
  • CLOUGH GE BOUTSIOUKI P, CHURCH MK: Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin. Allergy (2001): 56:985–988.
  • HINDMARCH I, JOHNSON S, MEADOWS R, KIRKPATRICK T, SHAMSI Z: The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare. Curr. Med. Res. Opin. (2001) 17(4):241–255.
  • DENHAM KJ, BOUSIOUKI P, CLOUGH GE CHURCH MK: Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin: Intlamm. Res. (2003) 52:424–427.
  • PUROHIT A, MELAC M, PAULI G, FROSSARD N: Twenty-four hour activity and consistency of activity of levocetirizine and desloratadine in the skin. Br. I Clin. Pharmacol (2003) 56:388–394.
  • GRANT JA, RIETHUISEN J, MOULAERT B, DEVOS C: A double blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. Ann. Allergy Asthma Immunol (2002) 88:190–197.
  • WANG DY, HANOTTE F, DEVOS C, CLEMENT P: Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers. Allergy (2001) 56:339–343.
  • LARBIG M, STAMM H, HOHLFELD J, KRUG N: Levocetirizine but not desloratadine inhibits histamine-induced changes of nasal temperature measured by facial thermography: a pilot study. XXII Congress of the European Academy of Allergy and Clinical Immunology Paris, France (2003).
  • BALTES E, COUPEZ R, GIEZEK H, VOSS G, MEYERHOFF C, STROLIN-BENEDETTI M: Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. Fundam. Pharmacol (2001) 15:269–277.
  • BREE F, THIAULT L, GAUTIERS G: Blood distribution of levocetirizine, a new non-sedating histamine Hi-receptor antagonist, in humans. Fundam. Pharmacol (2002) 16:471–478.
  • TILLEMENT JP, TESTA B, BREE F: Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine Hl-receptor antagonists. Biochem. Pharmacol (2003) 66:1123–1126.
  • MOLLIMARD M, DIQUET B, STROLIN BENEDETTI M: Comparison of pharmacokinetic and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. XXII Congress of the European Academy of Allergy and Clinical Immunology Paris, France (2003).
  • HORAK F, STUBNER UP, ZIEGLMAYER R, MOSER M, KAVINA A, ENGLBRECHT W: Effect of levocetirizine and loratadine on symptom relief in house-dust mite allergic patients exposed to allergen in the Vienna Challenge Chamber. XX Congress of the European Academy of Allergology and Clinical Immunology Berlin, Germany (2001).
  • DAY JH, BRISCOE MP, RAFEIRO E, RATZ JD: Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the environmental exposure unit (EEU). Int. I Clin. Pract. (2004) 58(2)109–118.
  • LEYNADIER F, MEES K, ARENDT C, PINELLI ME: Efficacy and safety of levocetirizine in seasonal allergic rhinitis. Acta Otorhinolaryngol Belg. (2001) 55:305–312.
  • POTTER PC, on behalf of the Study Group: Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites. Allergy (2003) 58:893–899.
  • POTTER PC: Levocetirizine relieves symptoms of perennial allergic rhinitis in children. 2'd European Congress in Paediatrics, Prague, Chech Republic (2003).
  • BACHERT C, BOUSQUET J, CANONICA GW et al.: Xpert: levocetirizine long-term treatment in patients suffering from persistent allergic rhinitis. XXII Congress of the European Academy of Allergy and Clinical Immunology, Paris, France (2003).
  • KAPP A, PICHLER WJ: Levocetirizine is a potent treatment in patients suffering from chronic idiopathic urticaria; a randomized double-blind placebo-controlled parallel multicentric study. XXII Congress of the European Academy of Allergy and Clinical Immunology Paris, France (2003).
  • GRANT JA, NICODEMUS CF, FINDLAY SR et al.: Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial. j Allergy Clin. Immunol (1995) 95:923–932.
  • •Results from this study show comparative efficacy of many antihistamines.
  • LEE DKC, BATES CE, CURRIE GP, LIPWORTH BJ: Comparative in vivo bioactivity of modern Hl-antihistmines on AMP challenge in atopic asthma. I Allergy Clin. Immunol (2003) 111:337–341.
  • GANDON JM, ALLAIN H: Lack of effectof single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor function in healthy volunteers. Clin. Parmacol (2002) 54:51–58.
  • VERSTER JC, VOLKERTS ER, VAN OOSTERWIJCK AWAA et al.:Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. Allergy Clin. Immunol (2003) 111:623–627.
  • VERSTER JC, VOLKERTS ER, DE WEERT MM et al.: Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine. Psychopharmacology (2003) 169:84–90.
  • SIMONS FE: Comparative pharmacology of H1 antihistamines: clinical relevance. Am. J. Med. (2002) 113(Suppl. 9A):385–465.
  • ••An excellent review of comparativepharmacology of antihistamines.

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