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Review

Controversies in breast cancer: adjuvant and neoadjuvant therapy

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Pages 1055-1072 | Published online: 15 Jun 2005

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  • ••Switching to anastrozole after 2 years ofadjuvant endocrine therapy with tamoxifen results in improved DFS in post-menopausal women with endocrine sensitive breast cancer.
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  • •A very intriguing paper reviewing potential mechanisms of resistance to endocrine agents used in the treatment of breast cancer.
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  • ••The first large randomised trial comparingadjuvant with neoadjuvant anthracydine-based chemotherapy for operable breast cancer. The study showed that the two arms had equal OS rates.
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  • ••This study showed that, despite apathological complete remission rate that was doubled by the addition of preoperative docetaxel to AC compared with AC alone, OS was not influenced by the preoperative or postoperative addition of docetaxel.
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Websites

  • http://www.asco.org ROMOND EH, PEREZ EA, BYANT J et al.: Doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab as adjuvant therapy for HER-2 positive operable breast cancer: combined analysis of NSABP-B31/NCCTG-N9831. Presented at the 2005 annual meeting of the American Society of Clinical Oncology, Orlando, FL, USA (2005).
  • http://www.asco.org PEREZ EA, SUMAN VJ, DAVIDSON N et al.: NCCTG N9831: May 2005 update. Presented at the 2005 annual meeting of the American Society of Clinical Oncology Orlando FL, USA (2005).
  • http://www.asco.org PICCART-GEBHART MJ, ON BEHALF OF THE BREAST INTERNATIONAL GROUP (BIG) N-BpgisFH-LRL: First Results of the HERA Trial. Presented at the 2005 annual meeting of the American Society of Clinical Oncology, Orlando FL, USA (2005)

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