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Review

The role of taxanes in the treatment of breast cancer

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Pages 1073-1094 | Published online: 15 Jun 2005

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  • ••Paditaxel and anthracydine combinationsPhase III trials/advanced breast cancer.
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  • ••Paditaxel and anthracydine combinationsPhase III trials/advanced breast cancer.
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  • •Paditaxel and anthracydine combinations Phase III trials/advanced breast cancer.
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  • •Paditaxel and anthracydine combinations Phase III trials/advanced breast cancer.
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  • ••Docetaxel and anthracydine combinationsPhase III trials/advanced breast cancer.
  • NABHOLTZ J, PATERSON A, DIRIX L et al.: A Phase III randomized trial comparing docetaxel (T), doxorubicin (A) and cyclophosphamide (C) to FAC as first line chemotherapy (CT) for patients (pts) with metastatic breast cancer (MBC). Proc. Am. Soc. Clin. Oncol (2001): 20-22a.
  • •Docetaxel and anthracydine combinations Phase III trials/advanced breast cancer.
  • MACKEY JR, PATERSON A, DIRIX LY et al.: Final results of the Phase III trial comparing docetaxel (T),doxorubicin (A) and cyclophosphamide (C) FAC as first line chemotherapy (CT) for patients (pts) with metastatic breast cancer (MBC). Proc. Am. Soc. Clin. Oncol.2002): 21-35a.
  • •Docetaxel and anthracydine combinations Phase III trials/advanced breast cancer.
  • BONTENBAL M, BRAUN JJ, CREEMERS GJ et al.: Phase III study comparing AT (adriamycin, docetaxel) to FAC (fluorouracil, adriamycin,) as first-line chemotherapy (CT) in patients with metastatic breast cancer (MBC). Eur. J. Cancer (2003) 1:S201 Docetaxel and anthracydine combinations Phase III trials/advanced breast cancer.
  • BONNETERRE J, DIERAS V, TUBIANA-HULIN M et al.: Phase II multicentre randomised study of docetaxel plus epirubicin versus 5-fluorouracil plus epirubicin and cyclophosphamide in metastatic breast cancer. Br. J. Cancer. (2004) 91:1466–1471.
  • •Docetaxel and anthracydine combinations Phase III trials/advanced breast cancer.
  • SPIELMANN M, TUBIANA-HULIN M, NAMER M et al.: Sequential or alternating administration of docetaxel (Taxotere) combined with FEC in metastatic breast cancer: a randomised Phase II trial.. J. Cancer. (2002) 86:692–697.
  • CRESTA S, GRASSELLI G, Met al.: A randomized Phase II study of combination, alternating and sequential regimens of doxorubicin and docetaxel as first-line chemotherapy for women with metastatic breast cancer. Ann. Oncol (2004) 15:433–439.
  • BRIA E, GIANNARELLI D, FELICI A et al.: Taxanes with anthracyclines as first-line chemotherapy for metastatic breast carcinoma. Cancer (2005) 103:672–679.
  • O'SHAUGHNESSY J, MILES D, VUKELJA S et al.: Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: Phase III trial results. J. Clin. Oncol (2002) 20:2812–2823.
  • ••Docetaxel plus capecitabine Phase III trial/advanced breast cancer.
  • ALBAIN KS, NAG S,-RUIZ G et al.: Global Phase III study of gemcitabine plus paclitaxel (GT) versus paclitaxel (T) as frontline therapy for metastatic breast cancer (MBC): First report of overall survival. Proc. Am. Soc. Clin. Oncol (2004) 22:510a.
  • ••Paditaxel plus gemcitabine Phase III trial/advanced breast cancer.
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  • SLAMON DJ, LEYLAND-JONES B, SHAK S et al.: Use of chemotherapy plus a monoclonal antibody against HER2 for breast cancer that overexpresses HER2. N EngL J. Med. (2001) 344:783–792.
  • •• Registration trial of trastuzumab/advanced breast cancer.
  • EXTRA JM, COGNETTI F, CHAN S et al.: Randomized Phase II trial (M77001) trastuzumab (Trastuzumab) plus106. versus docetaxel alone, as first line in patients with Her-2 positive breast cancer. Eur. J. Cancer2003) I:672a.
  • PEGRAM MD: Docetaxel and herceptin: for future strategies. Oncologist107.(2001) 6\(Suppl. 3):22–25.
  • NABHOLTZ J-M, PIENKOWSKI T, NORTHFELT D et al.: Results of two open-label multicentre Phase II pilot studies with Herceptin in combination with docetaxel and platinum salts (cis or) (TCH) as therapy for advanced breast cancer (ABC) in women with tumors-expressing the HER2-neu108.proto-oncogene. Eur. j Cancer (2001) 37\(Suppl. 6):695a.
  • HURLEY JE, DOLINY P, VELEZ Pet aL: High rate of axillary node clearance with neoadjuvant Herceptin, Taxotere, and cisplatin in locally advanced and breast cancer. Breast Cancer109.Res. Treat. (2001) 69:516a.
  • YARDLEY DA, GRECO FA, JD et al.: Final results of the Minnie Pearl Cancer Research Network first-line trial of weekly paclitaxel/ carboplatin/herceptin in metastatic breast cancer. Breast Cancer Res. Treat.2002) 76:439a.
  • ROBERT N, LEYLAND-JONES B, ASMAR Let al.: Phase III comparative of herceptin and paclitaxel with and110.without carboplatin in patients with-2/neu positive advanced breast cancer. Cancer Res. Treat. (2002) 76:35a.111.
  • •Paditaxel plustrastuzumab plus Phase III trial/advanced breast cancer.
  • HENDERSON IC, BERRY DA, DEMETRI GD et al.: Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.. OncoL (2003) 21:976–983.
  • ••Registration trial of paclitaxel/early breastcancer.
  • MAMOUNAS E, BRYANT J, LEMBERSKY B et al.: Paclitaxel (T) doxorubicin/cyclophosphamide (AC) as adjuvant chemotherapy for node-positive breast cancer: Results from NSABP B-28. Proc. Am. Soc. Clin. OncoL2003) 22:12a.
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  • •Paditaxel Phase III trial/early breast cancer. KS, GREEN SJ, RAVDIN PM et al.: Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent: initial results from intergroup trial 0100 (SWOG-8814). Proc. Am. Soc. Clin. OncoL (2002) 21:143A. B,
  • FISHER B,ANDERSON S, WICKERHAM DL et al.: Increased intensification and total dose of cyclophosphamide in a doxorubicin-cyclophosphamide regimen for the treatment of primary breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-22. J. Clin. OncoL (1997) 15:1858–1869.
  • FISHER B, ANDERSON S, DECILLIS A et al.: Further evaluation of intensified and increased total dose of cyclophosphamide for the treatment of primary breast cancer: Findings from the national surgical adjuvant breast and bowel project B-25.. Clin. OncoL (1999) 17:3374–3388.
  • GREEN M, BUZDAR A, SMITH T et al.: Weekly paclitaxel (P) followed by FAC as primary systemic chemotherapy of operable breast cancer improves pathologic complete remission rates when compared to every 3 week (Q3 wk) P therapy followed by FAC - Final results of a prospective Phase III randomized trial. Proc. Am. Soc. Clin. OncoL (2002) 21:135a.
  • • Paclitaxel randomised trial/neoadjuvant setting.
  • GASPARINI G: Metronomic scheduling: the future of chemotherapy? Lancet OncoL (2001) 2:733–740.
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