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Review

Current treatment options for myeloma

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Pages 1127-1142 | Published online: 15 Jun 2005

Bibliography

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  • ••A randomised trial comparing twoconditioning regimen for autologous stem cell transplantation in MM.
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  • ••A comprehensive review for the treatmentof patients with MM.
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  • ••The role of cytogenetics in the survival ofpatients who received total therapy I (a scheme introduced by Arkansas group).
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  • ••The role of the combination ofchromosome 13 abnormalities and 132-microglobulin in survival of myeloma patients who received high-dose therapy.
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  • ••A randomised comparison between singleand double autologous transplantation.
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  • •A retrospective analysis of the EBMT registry for the role of double autologous transplantation in patients with MM.
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  • •The role of autologous transplantation in patients with MM and renal failure.
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  • ••A comparison between allogeneic andautologous transplantation for myeloma.
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  • ••The effect of a planned ASCT followed byRIG allogeneic transplantation on myeloma patients.
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  • ••The first paper to describe the effect ofthalidomide on patients with relapsed/ refractory myeloma.
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  • •A detailed review for the role of thalidomide in the management of MM.
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  • ••The role of a novel combination therapy(DT-PACE) in relapsed/refractory myeloma.
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  • ZERVAS K, DIMOPOULOS MA, HATZICHARISSI E et al.: Primary treatment of multiple myeloma with thalidomide, vincristine, liposomal doxorubicin and dexamethasone (T-VAD doxil): a phase II multicenter study. Ann. OncoL (2004) 15(1):134–138.
  • PALUMBO A, BERTOLA A, MUSTO P et al.: A prospective randomized trial of oral melphalan, prednisone, thalidomide (MPT) vs oral melphalan, prednisone (MP): an interin analysis. Blood (2004) 104(11):63a (Abstract).
  • DIMOPOULOS MA, REPOUSSIS P, TERPOS E et al.: Primary treatment with pulsed melphalan, dexamethasone, thalidomide (MDT) for symptomatic patients with multiple myeloma 75 years of age. Blood (2004) 104(11):414a (Abstract).
  • DIMOPOULOS MA, ELEUTHERAKIS PAPAIAKOVOU V: Adverse effects of thalidomide administration in patients with neoplastic diseases. Am. J. Med. (2004) 117(7):508–515.
  • ••A detailed review for the adverse effects of thalidomide in cancer patients.
  • HIDESHIMA T, CHAUHAN D, HAYASHI T et al.: Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. Oncogene (2003) 22(52):8386–8393.
  • MITSIADES N, MITSIADES CS, POULAKI V et al.: Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc. Nail. Ac. Sci. USA (2002) 99(22):14374–14379.
  • ••The role of proteasome inhibition inmyeloma cells.
  • RICHARDSON PG, BARLOGIE B, BERENSON J et al.: A Phase 2 study of bortezomib in relapsed, refractory myeloma. N EngL J. Med. (2003) 348(20:2609–2617.
  • ••The first study to describe the effect ofbortezomib on relapsed/refractory myeloma.
  • JAGANNATH S, BARLOGIE B, BERENSON J et al.: A Phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br. J. HaematoL (2004) 127(2):165–172.
  • •A randomised trial comparing two doses of bortezomib 1 versus 1.3 mg/m2 in relapsed/refractory myeloma.
  • RICHARDSON P, SONNEVELD P, SCHUSTER MW et al.: Bortezomib vs. dexamethasone in relapsed multiple myeloma: a Phase 3 randomized study. Proc. Am. Soc. Clin. OncoL (2004) 23:558 (Abstract).
  • BERENSON J, YANG H, SWIFT R et al.: Bortezomib in combination with melphalan in the treatment of relapsed or refractory multiple myeloma: a phase I/II study. Blood (2004) 104(11):64a (Abstract).
  • ORLOWSKI RZ, VOORHEES PM, GARCIA RA et al.: Phase I trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood (2005) (In press).
  • JAGANNATH S, BRIAN D, WOLF JL et al.: A Phase 2 study of bortezomib as first line therapy in patients with multiple myeloma. Blood (2004) 104(11):98a-99a (Abstract).
  • ALEXANIAN R, WANG LM, WEBER DM, DELASALLE KB: VTD (velcade, thalidomide, dexamethasone) as primary therapy for newly-diagnosed multiple myeloma. Blood (2004) 104(11):64a (Abstract).
  • BARLOGIE B, HOLLMIG K, ZANGARI M et al.: Total therapy 3 (TT 3) for newly diagnosed myeloma, incorporating Velcade into remission induction with DT-PACE: early results regarding efficacy, PBSC mobilization and toxicities. Blood (2004) 104(11):156a (Abstract).
  • TERPOS E, RAHEMTULLA A: Bisphosphonate treatment for multiple myeloma. Drugs Today (2004) 40(1):29–40.
  • •A detailed review for the role of bisphosphonates in MM.
  • DJULBEGOVIC B, WHEATLEY K, ROSS J et al.: Bisphosphonates in multiple myeloma. Cochrane Database Syst. Rev. (2002) 3:CD003188.
  • BERENSON JR, HILLNER BE, KYLE RA et al.: American Society of Clin. OncoL clinical practice guidelines: the role of bisphosphonates in multiple myeloma. Clin. OncoL (2002) 20(17):3719–3736.
  • ••The guidelines of the American Society ofClinical Oncology for the role of bisphosphonates in the management of MM.
  • TERPOS E, POLITOU M, RAHEMTULLA A: New insights into the pathophysiology and management of bone disease in multiple myeloma. Br. J. HaematoL (2003) 123(5):758–769.
  • ••A detailed review for myeloma bone disease.
  • MUSTO P, FALCONE A, SANPAOLO G et al.: Pamidronate reduces skeletal events but does not improve progression-free survival in early-stage untreated myeloma: results of a randomized trial. Leuk. Lymphoma (2003) 44(9):1545–1548.
  • CAPARROTTI G, CATALANO L, EEO C et al.: Perspective study on pamidronate in stage I multiple myeloma. HematoL (2003) 4(61:459–460.
  • RICHARDSON PG, SCHLOSSMAN RL, WELLER E et al.: Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood (2002) 100(9):3063–3067.
  • ••The first study to describe the effect of anovel IMiD, lenalidomide, on refractory/ relapsed myeloma.
  • HUSSEIN MA, KARAM MA, BRAND C et al.: Doxil (D), vincristine (V), reduced frequency dexamethasone (d) and Revlimid® (DVd-R): a phase I/II trial in advanced relapsed/refractory multiple myeloma (RMM) patients. Blood (2004) 104(11):63a-64a (Abstract).
  • RAJKUMAR SV, HAYMAN SR, LACY MQ et al.: Combination therapy with CC-5013 (lenalidomide; RevlimidTm) plus dexamethasone (Rev/Dex) for newly diagnosed myeloma (MM). Blood (2004) 104(11):98a (Abstract).
  • SCHEY SA, FIELDS P, BARTLETT JB et al.: Phase I study of an immunomodulatory thalidomide analog CC-4047 in relapsed or refractory multiple myeloma. J. Clin. Oncol (2004) 22(10:3269-3276. The first study describing the effect of a novel IMiD, CC-4047, on refractory/ relapsed myeloma.
  • ROUSSELOT P, LARGHERO J, ARNULF B et al.: A clinical and pharmacological study of arsenic trioxide in advanced multiple myeloma patients. Leukemia (2004) 18(9):1518–1521.

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