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Review

Review of current treatment practices for carcinoma of the head and neck

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Pages 1143-1155 | Published online: 15 Jun 2005

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  • •First study to show the utility of infusional 5-FU and cisplatin in head and neck cancer.
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  • •One of two trials demonstrating improvement in OS using induction therapy in SCCHN.
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  • •One of two trials demonstrating improvement in OS using induction therapy in SCCHN.
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  • •Demonstrates the benefit of chemotherapy combined with hyperfractionated irradiation.
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  • ••Only study to compare a cisplatin plus RTarm versus cisplatin/5-FU/RT arm for the treatment of head and neck cancer.
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  • ••Only trial to show an OS advantage withadjuvant chemoradiotherapy for fully resected head and neck cancer.
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  • •First large randomised study to demonstrate the larynx-sparing capabilities of chemoradiation.
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  • ••Study that confirmed CCRT as the initialmodality treatment of resectable laryngeal cancer.
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  • •Pivotal study that changed the standard of care to a cisplatin-containing regimen for the treatment of locally advanced head and neck cancer.
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  • HARAF DJ, ROSEN FR, STENSON K et al.: Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer. Clin. Cancer Res. (2003) 9:5936–5943.
  • CHAO KS, MAJHAIL M, HUANG CJ et al.: Intensity modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother. Oncol. (2001) 61:275–280.
  • •Demonstrates the benefit of IMRT in terms of salivary preservation in oropharynegeal cancer.
  • LEE N, XIA P, QUIVEY JM: Intensity modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Intl. Radiat. Oncol. Biol. Phys. (2002) 53:12–21.
  • •Largest experience of IMRT in nasopharyngeal cancer.
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  • •Important study that demonstrates the benefits of dose-intensification of RT for the treatment of head and neck cancer.
  • JEREMIC B, SHIBAMOTO Y, MILICIC B: Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: a prospective randomized trial. J. Clin. Oncol. (2000) 18:1458–1464.
  • HARRISON LB, RABEN A, PFISTER D: A prospective Phase II trial of concomitant chemotherapy and radiotherapy with delayed accelerated fractionation in unresectable tumors of the head and neck. Head Neck (1998) 20:497–503.
  • CHMURA SJ, MILANO MT, HARAF DJ: Reirradiation of recurrent head and neck cancers with curative intent. Semin. Oncol (2004) 6:816–821.
  • DE CREVOISIER R, BOURHIS J, DOMENGE C et al.: Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients. J. Clin. Oncol. (1998) 16:3556–3562.
  • MILANO MT, VOKES EE, STENSON KM et al.: Twice-daily re-irradiation of recurrent and second primary head and neck cancer with gemcitabine, paclitaxel and fluorouracil chemotherapy. Proceedings from the American Society Clinical Oncology Annual Meeting. New Orleans, LA, USA (2004):5510.
  • DE CREVOISIER R, DOMENGE C, WIBAULT P et al.: Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma. Cancer (2001) 91:2071–2076.
  • MACHTAY M, ROSENTHAL DI, CHALIAN AA. Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and- neck cancer. Int. J. Radiat. Oncol Biol. Phys. (2004) 59:72–77.
  • LEIBEL SA, FUKS Z, ZELEFSKY MJ et al.: Intensity-modulated radiotherapy. Cancer J. (2002) 8:164–176.
  • •Review of IMRT technology and implementation.
  • XING L, WU Q, YANG Yet al: Physics of IMRT. In: IMRT A Clinical Perspective. AJ Mundt, JC Roeske (Eds). BC Decker Toronto, Canada (2005).
  • FURIE B, CASSILETH PA, ATKINS MB et al.: Clinical Hematology and Oncology: Presentation, Diagnosis and Treatment. TS Lawrence, GT Henning (Eds). Elsevier Philadelphia, PA, USA:355 (2003).
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  • VERMOKEN JB, REMENAR E, VAN HERPEN Get al.: Standard cisplatin/ infusional 5-fluorouracil (PF) versus docetaxel (T) plus PF (TPF) as neoadjuvant chemotherapy for nonresectable locally advanced squamous cell carcinoma of the head and neck: A Phase III trial of the EORTC Head and Neck Cancer Group (EORTC 24971). Proceedings from the American Society Clinical Oncology Annual Meeting. New Orleans, LA, USA (2004) 22:5508.
  • ROBBINS KT, MEDINA JE, WOLFE GT et al.: Standardizing neck dissection terminology: official report of the Academy's Committee for Head Neck Surgery and Oncology. Arch. Otolaryngol Head Neck Surg (1991) 117:601–605.
  • COOPER JS, PAJAK TF, FORASTIERE A et al.: Precisely defining high-risk operable head and neck tumors based on RTOG 85–03 and 88–24: targets for postoperative radiochemotherapy? Head Neck (1998) 20:588–594.
  • POSNER MR, GLISSON B, FRENETTE G et al.: Multicenter Phase I-II trial of docetaxel, cisplatin and fluorouracil induction chemotherapy for patients with locally advanced squamous cell cancer of the head and neck. J. Clin. Oncol (2001) 19:1091–1104.
  • SCHRIJVERS D: Phase I-II trial of docetaxel, cisplatin and fluorouracil in patients with locally advanced inoperable squamous cell carcinoma of the head and neck. Proceedings from the American Society Clinical Oncology Annual Meeting. Atlanta, GA, USA (1999) 18:394q.
  • VOKES EE, STENSON K, ROSEN FR et al.: Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer. J. Clin. Oncol. (2003) 21:320–326.
  • ARGIRIS A, Stenson KM, Brockstein BE et al.: Neck dissection in the combined-modality therapy of patients with locoregionally advanced head and neck cancer. Head Neck (2004) 26:447–455.
  • MCHAM SA, ADELSTEIN DJ, RYBICKI LA et al.: Who merits a neck dissection after definitive chemoradiotherapy for N2-N3 squamous cell head and neck cancer? Head Neck (2003) 25:791–798.
  • STENSON KM, HARAF DJ, PELZER H et al.: The role of cervical lymphadenectomy after aggressive concomitant chemoradiotherapy: The feasibility of selective neck dissection. Arch. Otolaryngol Head Neck Surg. (2000) 126:950–956.
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  • HITT R, LOPEZ-POUSA A, RODRIGUEZ M et al.: Phase III trial comparing cisplatin and 5-fluorouracil versus cisplatin, 5-fluorouracil and paclitaxel as induction therapy in locally advanced head and neck cancer. Proceedings from the American Society Clinical Oncology Annual Meeting. Chicago, IL, USA (2003) 22:1997.
  • VERMORKEN JB, REMENAR E, VAN HERPEN J et al.: Standard cisplatin/ infitsional 5-fluorouracil (PF) versus docetaxel (T) plus PF (TPF) as neoadjuvant chemotherapy for nonresectable locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): a Phase III trial of the EORTC Head Neck Cancer Group (EORTC 24971). Proceedings from the American Society Clinical Oncology Annual Meeting. New Orleans, LA, USA (2004) 22:5508.
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