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Expert Opinion on Pharmacotherapy Volume 9, 2008 - Issue 11
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Review

Nitric oxide: new evidence for novel therapeutic indications

Sunil J Wimalawansa University Professor Professor of Medicine, Physiology, and Pharmacology, Chief of Endocrinology, Metabolism & Nutrition Robert Wood Johnson Medical School, Department of Medicine, New Brunswick, NJ 08903, USA +1 732 235 9584; +1 732 235 8892; [email protected]
, MD PhD MBA MRCPath FACP FRCP DSc
Pages 1935-1954 | Published online: 16 Jul 2008

Bibliography

  • Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med 1994;120(3):227-37
  • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43(2):109-42
  • Ignarro LJ, Buga GM, Wood KS, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84(24):9265-9
  • Wimalawansa SJ. Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans. Ann NY Acad Sci 2007;1117:283-97
  • Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327(6122):524-6
  • Margolis RN, Wimalawansa SJ. Novel targets and therapeutics for bone loss. Ann NY Acad Sci 2006;1068:402-9
  • Moncada S, Higgs A, Furchgott R. International union of pharmacology nomenclature in nitric oxide research. Pharmacol Rev 1997;49(2):137-42
  • Brunori M, Giuffrè A, Sarti P, et al. Nitric oxide and cellular respiration. Cell Mol Life Sci 1999;56(7-8):549-57
  • Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329(27):2002-12
  • Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994;298(Pt 2):249-58
  • Gross SS, Wolin MS. Nitric oxide: pathophysiological mechanisms. Ann Rev Physiol 1995;57:737-69
  • Stacey E, Korkia P, Hukkanen MV, et al. Decreased nitric oxide levels and bone turnover in amenorrheic athletes with spinal osteopenia. J Clin Endocrinol Metab 1998;83(9):3056-61
  • Rosselli M, Imthurn B, Keller PJ, et al. Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17 beta-estradiol and norethisterone acetate. A two-year follow-up study. Hypertension 1995;25(4 Pt 2):848-53
  • Cicinelli E, Ignarro LJ, Lograno M et al. Circulating levels of nitric oxide in fertile women in relation to the menstrual cycle. Fertil Steril 1996;66(6):1036-8
  • Cicinelli E, Ignarro LJ, Schönauer LM, et al. Effects of short-term transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women. Fertil Steril 1998;69(1):58-61
  • Moncada S, Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995;9(13):1319-30
  • Brown GC. Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 2001;1504(1):46-57
  • Webb AJ, Patel N, Loukogeorgakis S, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 2008;51(3):784-90
  • Futter LE, al-Swayeh OA, Moore PK. A comparison of the effect of nitroparacetamol and paracetamol on liver injury. Br J Pharmacol 2001;132(1):10-2
  • Wallace JL, McKnight W, Wilson TL, et al. Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils. Am J Physiol 1997;273(6 Pt 1):G1246-51
  • Wallace JL, Cirino G. The development of gastrointestinal-sparing nonsteroidal anti-inflammatory drugs. Trends Pharmacol Sci 1994;15(11):405-6
  • Wallace JL, McKnight W, Del Soldato P, et al. Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative. J Clin Invest 1995;96(6):2711-8
  • Wallace JL, Cirino G, McKnight GW, Elliott SN. Reduction of gastrointestinal injury in acute endotoxic shock by flurbiprofen nitroxybutylester. Eur J Pharmacol 1995;280(1):63-8
  • Wallace JL, Del Soldato P, Cirino G. Nitric oxide-releasing non-steroidal anti-inflammatory drugs: a new generation of antithrombotics? Expert Opin Investig Drugs 1997;6(5):533-8
  • Wallace JL, et al. In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX-4016. Thromb Res 1999;93(1):43-50
  • Armour KJ, et al. Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen nitroxybutylester (HCT1026). Arthritis Rheum 2001;44(9):2185-92
  • Fujihara CK, Malheiros DM, Donato JL, et al. Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney. Am J Physiol 1998;274(3 Pt 2):F573-9
  • Takeuchi K, Ukawa H, Konaka A, et al. Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin. J Pharmacol Exp Ther 1998;286(1):115-21
  • Benoni G, Terzi M, Adami A, et al. Plasma concentrations and pharmacokinetic parameters of nitrofenac using a simple and sensitive HPLC method. J Pharm Sci 1995;84(1):93-5
  • al-Swayeh OA, Futter LE, Clifford RH, Moore PK. Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity. Br J Pharmacol 2000;130(7):1453-6
  • Cuzzolin L, Conforti A, Adami A, et al. Anti-inflammatory potency and gastrointestinal toxicity of a new compound, nitronaproxen. Pharmacol Res 1995;31(1):61-5
  • Elliott SN, McKnight W, Cirino G, Wallace JL. A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995;109(2):524-30
  • Momi S, Emerson M, Paul W, et al. Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin. Eur J Pharmacol 2000;397(1):177-85
  • Davies NM, Røseth AG, Appleyard CB, et al. NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects. Aliment Pharmacol Ther 1997;11(1):69-79
  • Davis R, Brogden RN. Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1994;48(3):431-54
  • Fredduzzi S, Mariucci G, Tantucci M, et al. Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat. Neurosci Lett 2001;302(2-3):121-4
  • Rossoni G, et al. The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischemia–reperfusion in the anesthetized rat. J Pharmacol Exp Ther 2001;297(1):380-7
  • Wimalawansa SJ. Nitric oxide: novel therapy of osteoporosis. Expert Opin Pharmacother 2008;9(11):1947-65
  • Wallace JL, Reuter B, Cicala C, et al. A diclofenac derivative without ulcerogenic properties. Eur J Pharmacol 1994;257(3):249-55
  • Muscará MN, McKnight W, Del Soldato P, Wallace JL. Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat. Life Sci 1998;62(15):PL235-40
  • Hauss-Wegrzyniak B, Vraniak P, Wenk GL. The effects of a novel NSAID on chronic neuroinflammation are age dependent. Neurobiol Aging 1999;20(3):305-13
  • Lechi C, Gaino S, Tommasoli R, et al. In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid. Blood Coagul Fibrinolysis 1996;7(2):206-9
  • Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 1990;87(2):682-5
  • Weitzberg E, Lundberg JO. Nonenzymatic nitric oxide production in humans. Nitric Oxide 1998;2(1):1-7
  • Murad F, Mittal CK, Arnold WP, et al. Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv Cyclic Nucleotides Res 1978;9:145-58
  • Ignarro LJ, Fukuto JM, Griscavage JM, et al. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA 1993;90(17):8103-7
  • Green LC, Glogowski J, Skipper PL, et al. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982;126(1):131-8
  • Stuehr DJ, Marletta MA. Synthesis of nitrite and nitrate in murine macrophage cell lines. Cancer Res 1987;47(21):5590-4
  • Archer S. Measurement of nitric oxide in biological models. FASEB J 1993;7(2):349-60
  • Beckman JS, et al. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87(4):1620-4
  • Tewari RK, Hahn EJ, Paek KY. Function of nitric oxide and superoxide anion in the adventitious root development and antioxidant defence in Panax ginseng. Plant Cell Rep 2008;27(3):563-73
  • Beckman JS, Chen J, Ischiropoulos H, Crow JP. Oxidative chemistry of peroxynitrite. Methods Enzymol 1994;233:229-40
  • Zhang J, Dawson VL, Dawson TM, Snyder SH. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 1994;263(5147):687-9
  • Freeman B. Free radical chemistry of nitric oxide. Looking at the dark side. Chest 1994;105(3 Suppl):S79-84
  • Kaur H, Halliwell B. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett 1994;350(1):9-12
  • Wimalawansa SJ. Antihypertensive effects of oral calcium supplementation may be mediated through the potent vasodilator CGRP. Am J Hypertens 1993;6(12):996-1002
  • Gratton J-P, Fontana J, Sessa WC. Molecular control of endothelial derived nitric oxide. In: LJ Ignarro, editor, “Nitric oxide: biology and pathobiology” 2000. p. 157-66
  • Ganster RW, Geller DA. Molecular regulation of inducible nitric oxide synthase. In: LJ Ignarro, editor, “Nitric oxide: biology and pathobiology” 2000. p. 129-55
  • Calder J, et al. Elevated nitric oxide levels in osteonecrotic bone. J Pathol 2001;190:A1-69
  • Coers W, Timens W, Kempinga C, et al. Specificity of antibodies to nitric oxide synthase isoforms in human, guinea pig, rat, and mouse tissues. J Histochem Cytochem 1998;46(12):1385-92
  • Huang PL, Dawson TM, Bredt DS, et al. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 1993;75(7):1273-86
  • Nelson RJ, Demas GE, Huang PL, et al. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 1995;378(6555):383-6
  • Griffith OW, Stuehr DJ. Nitric oxide synthases: properties and catalytic mechanism. Ann Rev Physiol 1995;57:707-36
  • Garcia-Cardena G, Oh P, Liu J, et al. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci USA 1996;93(13):6448-53
  • Vallance P, Leone A, Calver A, et al. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol 1992;20(Suppl 12):S60-2
  • Carini M, Aldini G, Stefani R, et al. Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin: in vitro and in vivo studies in the rat by ESR spectroscopy. J Pharm Biomed Anal 2001;26(4):509-18
  • Jourd'heuil D, Mills L, Miles AM, Grisham MB. Effect of nitric oxide on hemoprotein-catalyzed oxidative reactions. Nitric Oxide 1998;2(1):37-44
  • Jia L, Bonaventura C, Bonaventura J, Stamler JS. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 1996;380(6571):221-6
  • Lander HM. An essential role for free radicals and derived species in signal transduction. FASEB J 1997;11(2):118-24
  • Calder J, et al. Osteonecrosis or osteo-apoptosis? J Pathol 2000;190:A1-69
  • Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288(5789):373-6
  • Lechi C, Andrioli G, Gaino S, et al. The antiplatelet effects of a new nitroderivative of acetylsalicylic acid – an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production. Thromb Haemost 1996;76(5):791-8
  • Federico A, Filippelli A, Falciani M, et al. Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: in vivo and in vitro studies. World J Gastroenterol 2007;13(27):3677-83
  • Abiru T, Watanabe Y, Kamata K, et al. Decrease in endothelium-dependent relaxation and levels of cyclic nucleotides in aorta from rabbits with alloxan-induced diabetes. Res Commun Chem Pathol Pharmacol 1990;68(1):13-25
  • Huang PL, Huang Z, Mashimo H, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995;377(6546):239-42
  • Chen K, Pittman RN, Popel AS. Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal 2008;10(7):1185-98
  • Munzel T. Does nitroglycerin therapy hit the endothelium? J Am Coll Cardiol 2001;38(4):1102-5
  • Lefer AM, Siegfried MR, Ma XL. Protection of ischemia–reperfusion injury by sydnonimine NO donors via inhibition of neutrophil–endothelium interaction. J Cardiovasc Pharmacol 1993;22(Suppl 7):S27-33
  • Meredith IT, Anderson TJ, Uehata A, et al. Role of endothelium in ischemic coronary syndromes. Am J Cardiol 1993;72(8):27C-31C; discussion 31C-32C
  • Napoli C, Cirino G, Del Soldato P, et al. Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proc Natl Acad Sci USA 2001;98(5):2860-4
  • Ignarro LJ, Buga GM, Wei LH, et al. Role of the arginine–nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc Natl Acad Sci USA 2001;98(7):4202-8
  • Hibbs JB Jr, Taintor RR, Vavrin Z, et al. Syntheses of nitric oxide from a terminal guanidino nitrogen atom of L-arginine: a molecular mechanism regulating cellular proliferation that targets intracellular iron. In: Moncada S, Higgs EA, editors, Nitric oxide from L-arginine: a bioregulatory system. 1990. p. 189-223
  • Wainwright CL, Martorana PA. Pirsidomine, a novel nitric oxide donor, suppresses ischemic arrhythmias in anesthetized pigs. J Cardiovasc Pharmacol 1993;22(Suppl 7):S44-50
  • Lattimore JD, Wilcox I, Adams MR, et al. Treatment of obstructive sleep apnoea leads to enhanced pulmonary vascular nitric oxide release. Int J Cardiol 2008;126(2):229-33
  • de Buys Roessingh AS, de Lagausie P, Ibrahima T, et al. Neuronal nitric oxide synthase does not contribute to the modulation of pulmonary vascular tone in fetal lambs with congenital diaphragmatic hernia (nNOS in CDH lambs). Pediatr Pulmonol 2008;43(4):313-21
  • Michils A, Baldassarre S, Van Muylem A. Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients. Eur Respir J 2008;31(3):539-46
  • Cobos Barroso N, Pérez-Yarza EG, Sardón Prado O, et al. Exhaled nitric oxide in children: a noninvasive marker of airway inflammation. Arch Bronconeumol 2008;44(1):41-51
  • Chen Z, Zhang J, Stamler JS. Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci USA 2002;99(12):8306-11
  • Conen D, Glynn RJ, Buring JE, et al. Renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study. J Intern Med 2008;263(4):376-85
  • Karabay G, Nacar A, Kiyici H, et al. Ultrastructural examination of glomerular and tubular changes in renal allografts with acute rejection. Ren Fail 2007;29(1):61-5
  • Gomez SI, Strick DM, Romero JC. Role of nitric oxide and prostaglandin in the maintenance of cortical and renal medullary blood flow. Braz J Med Biol Res 2008;41(2):170-5
  • Theobald RJ Jr. The effect of NG-monomethyl-L-arginine on bladder function. Eur J Pharmacol 1996;311(1):73-8
  • Smith SD, Wheeler MA, Foster HE Jr, Weiss RM. et al. Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine. J Urol 1997;158(3 Pt 1):703-8
  • Kinoshita T, Kobayashi S, Ebara S, et al. Phosphodiesterase inhibitors, pentoxifylline and rolipram, increase bone mass mainly by promoting bone formation in normal mice. Bone 2000;27(6):811-7
  • Wimalawansa SJ. Nitroglycerin therapy is as efficacious as standard estrogen replacement therapy (Premarin) in prevention of oophorectomy-induced bone loss: a human pilot clinical study. 2000;15(11):2240-4
  • The NOVEL Study. Nitroglycerin as an Option: Value in Early Bone Loss. Available from: http://www2.umdnj.edu/novelweb/NOVEL
  • Nitroglycerin Ointment for Preventing Bone Loss in Postmenopausal Women. Available from: http://clinicaltrials.gov/show/NCT00043719
  • Wimalawansa SJ, Grimes J, Chen F, et al. Osteoporosis in postmenapausal women: development of a cost-effective novel therapy NOVEL clinical study. Targeting bone remodelling for the treatment of osteoporosis [abstract 37]. ASBMR/NIH Symposium; December 2007; Washington DC, USA
  • Wimalawansa SJ, Grimes J, Hoover D, Wilson A. Use of nitric oxide donor, nitroglycerin as a therapeutic agent for osteoporosis: NOVEL 1. Am Med J 2008; Submitted
  • Fang L, Nowicki BJ, Dong YL, Yallampalli C. Localized increase in nitric oxide production and the expression of nitric oxide synthase isoforms in rat uterus with experimental intrauterine infection. Am J Obstet Gynecol 1999;181(3):601-9
  • Wimalawansa SJ, Yallampalli C. Pre-eclamptic toxemia: potential new therapy based on animal studies. Ceylon Med J 1998;43(3):138-46
  • Thakor AS, Giussani DA. Role of nitric oxide in mediating in vivo vascular responses to calcitonin gene-related peptide in essential and peripheral circulations in the fetus. Circulation 2005;112(16):2510-6
  • Chauhan M, Thota CS, Kondapaka S, et al. Evidence for the existence of a new receptor for CGRP, which is not CRLR. Peptides 2003;24(1):65-71
  • Amatatongchai M, Hofmann O, Nacapricha D, et al. A microfluidic system for evaluation of antioxidant capacity based on a peroxyoxalate chemiluminescence assay. Anal Bioanal Chem 2007;387(1):277-85
  • Gangula PR, Zhao H, Supowit S, et al. Pregnancy and steroid hormones enhance the vasodilation responses to CGRP in rats. Am J Physiol 1999;276(1 Pt 2):H284-8
  • Morara S, Wimalawansa SJ, Rosina A. Monoclonal antibodies reveal expression of the CGRP receptor in Purkinje cells, interneurons and astrocytes of rat cerebellar cortex. Neuroreport 1998;9(16):3755-9
  • Waldow T, Witt W, Ulmer A, et al. Preconditioning by inhaled nitric oxide prevents hyperoxic and ischemia/reperfusion injury in rat lungs. Pulm Pharmacol Ther 2008;21(2):418-29
  • Self CH, Wimalawansa SJ, Johannsson A, et al. A new sensitive and fast peptide immunoassay based on enzyme amplification used in the determination of CGRP and the demonstration of its presence in the thyroid. Peptides 1985;6(4):627-30
  • Wimalawansa SJ. CGRP radioreceptor assay: a new diagnostic tool for medullary thyroid carcinoma. J Bone Miner Res 1993;8(4):467-73
  • Wimalawansa SJ. The effects of neonatal capsaicin on plasma levels and tissue contents of CGRP. Peptides 1993;14(2):247-52
  • Weiner CP, Knowles RG, Moncada S. Induction of nitric oxide synthases early in pregnancy. Am J Obstet Gynecol 1994;171(3):838-43
  • Norman JE, Cameron IT. Nitric oxide in the human uterus. Rev Reprod 1996;1(1):61-8
  • Sioutas A, Ehrén I, Lundberg JO, et al. Intrauterine nitric oxide in pelvic inflammatory disease. Fertil Steril 2008;89(4):948-52
  • Kim EK, Kwon KB, Song MY, et al. Genistein protects pancreatic beta cells against cytokine-mediated toxicity. Mol Cell Endocrinol 2007;278(1-2):18-28
  • Brown JF, Hanson PJ, Whittle BJ. Nitric oxide donors increase mucus gel thickness in rat stomach. Eur J Pharmacol 1992;223(1):103-4
  • Hattori Y, Kawasaki H, Abe K, Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 1991;261(4 Pt 2):H1086-94
  • Galli F, Rovidati S, Ghibelli L, Canestrari F. S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase decreases the enzyme affinity to the erythrocyte membrane. Nitric Oxide 1998;2(1):17-27
  • Radomski MW, Salas E. Nitric oxide – biological mediator, modulator and factor of injury: its role in the pathogenesis of atherosclerosis. Atherosclerosis 1995;118(Suppl):S69-80
  • Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev 1996;17(5):533-85
  • Wimalawansa SJ, De Marco G, Gangula P, Yallampalli C. Nitric oxide donor alleviates ovariectomy-induced bone loss. Bone 1996;18(4):301-4
  • Yallampalli C, Dong YL, Wimalawansa SJ. Calcitonin gene-related peptide reverses the hypertension and significantly decreases the fetal mortality in pre-eclampsia rats induced by N(G)-nitro-L-arginine methyl ester. Hum Reprod 1996;11(4):895-9
  • Wimalawansa SJ. Age-related changes in tissue contents of immunoreactive calcitonin gene-related peptide. Aging (Milano) 1992;4(3):211-7
  • Wimalawansa SJ. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Rev Neurobiol 1997;11(2-3):167-239
  • Kerwin JF Jr, Lancaster JR Jr, Feldman PL. Nitric oxide: a new paradigm for second messengers. J Med Chem 1995;38(22):4343-62
  • Iversen HK, Olesen J. Nitroglycerin-induced headache is not dependent on histamine release: support for a direct nociceptive action of nitric oxide. Cephalalgia 1994;14(6):437-42
  • Fang FC. Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. J Clin Invest 1997;99(12):2818-25
  • Kim SK, Kim HJ, Choi SE, et al. Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E(2) (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg. Arch Pharm Res 2008;31(4):424-8
  • McCarthy SM, Bove PF, Matthews DE, et al. Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch. Biochemistry 2008;47(21):5832-40
  • Kikkawa I, Saito S, Tominaga K, et al. Lipopolysaccharide (LPS) stimulates the production of tumor necrosis factor (TNF)-alpha and expression of inducible nitric oxide synthase (iNOS) by osteoclasts (OCL) in murine bone marrow cell culture. Microbiol Immunol 1998;42(9):591-8
  • Akaike T. Role of free radicals in viral pathogenesis and mutation. Rev Med Virol 2001;11(2):87-101
  • Kostrzewska A, Modzelewska B, Kleszczewski T, Batra S. Effect of nitric oxide on responses of the human uterine arteries to vasopressin. Vascul Pharmacol 2008;48(1):9-13
  • De Groote MA, Fang FC. NO inhibitions: antimicrobial properties of nitric oxide. Clin Infect Dis 1995;21(Suppl 2):S162-5
  • Fang L, Nowicki BJ, Urvil P, et al. Epithelial invasion by Escherichia coli bearing Dr fimbriae is controlled by nitric oxide-regulated expression of CD55. Infect Immun 2004;72(5):2907-14
  • Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101(6):1644-55
  • Yallampalli C, Wimalawansa SJ. Calcitonin gene-related peptide (CGRP) is a mediator of vascular adaptations during hypertension in pregnancy. Trends Endocrinol Metab 1998;9(3):113-7
  • Gangula PR, Dong YL, Wimalawansa SJ, Yallampalli C. Infusion of pregnant rats with calcitonin gene-related peptide (CGRP)(8-37), a CGRP receptor antagonist, increases blood pressure and fetal mortality and decreases fetal growth. Biol Reprod 2002;67(2):624-9
  • Qing X, Wimalawansa SJ, Keith IM. Specific N-terminal CGRP fragments mitigate chronic hypoxic pulmonary hypertension in rats. Regul Pept 2003;110(2):93-9
  • Tesfamariam B, Brown ML, Cohen RA. Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest 1991;87(5):1643-8
  • Tesfamariam B, Gupta S, Oates PJ, et al. Reduced Na(+)-K+ pump activity in diabetic rabbit carotid artery: reversal by aldose reductase inhibition. Am J Physiol 1993;265(4 Pt 2):H1189-94
  • Leung TM, Tipoe GL, Liong EC, et al. Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis. Int J Exp Pathol 2008
  • Williams JL, Borgo S, Hasan I, et al. Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs: implications for colon cancer chemoprevention. Cancer Res 2001;61(8):3285-9
  • Gorfine SR. Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum 1995;38(5):p.453-6; discussion 456-7
  • Lund JN, Armitage NC, Scholefield JH, Use of glyceryl trinitrate ointment in the treatment of anal fissure. Br J Surg 1996;83(6):776-7
  • Watson SJ, et al. Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 1996;83(6):771-5
  • Tarnoff M, Goodman M, Cataldo T, et al. Successful treatment of fissure in ano using topical nitroglycerin. J Clin Gastroenterol 1997;25(1):399-400
  • Fruehauf H, Fried M, Wegmueller B, et al., Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study. Am J Gastroenterol 2006;101(9):2107-12
  • Ghasemi M, Sadeghipour H, Mosleh A, et al. Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. Eur Neuropsychopharmacol 2008;18(5):323-32
  • Thatcher GR, Bennett BM, Dringenberg HC, Reynolds JN. Novel nitrates as NO mimetics directed at Alzheimer's disease. J Alzheimers Dis 2004; 6(6 Suppl):S75-84
  • Kim D, Kim MA, Cho IH, et al. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem 2007;282(20):14975-83
  • Alonso MJ, Salaices M, Sanchez-Ferrer CF, Marin J. Predominant role for nitric oxide in the relaxation induced by acetylcholine in cat cerebral arteries. J Pharmacol Exp Ther 1992;261(1):12-20
  • Kelly PA, Ritchie IM, Collins FM. Cerebrovascular consequences of repeated exposure to NG-nitro-L-arginine methyl ester. Br J Pharmacol 1995;116(6):2771-7
  • Dalkara T, Yoshida T, Irikura K, Moskowitz MA. Dual role of nitric oxide in focal cerebral ischemia. Neuropharmacology 1994;33(11):1447-52
  • Thompson LP, Pinkas G, Weiner CP, Chronic 17beta-estradiol replacement increases nitric oxide-mediated vasodilation of guinea pig coronary microcirculation. Circulation 2000;102(4):445-51
  • Thomsen LL, Iversen HK, Brinck TA, Olesen J. Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. Cephalalgia 1993;13(6):395-9; discussion 376
  • Olesen J, Iversen HK, Thomsen LL, Nitric oxide supersensitivity: a possible molecular mechanism of migraine pain. Neuroreport 1993;4(8):1027-30
  • Olesen J, Thomsen LL, Iversen H. Nitric oxide is a key molecule in migraine and other vascular headaches. Trends Pharmacol Sci 1994;15(5):149-53
  • Zhao ML, Kim MO, Morgello S, Lee SC. Expression of inducible nitric oxide synthase, interleukin-1 and caspase-1 in HIV-1 encephalitis. J Neuroimmunol, 2001;115(1-2):182-91
  • An HJ, Um JY, Na HJ, et al. Activation of inducible nitric oxide synthase by Kagamjuaguiem in peritoneal macrophages in mice. Indian J Med Res 2007;125(6):740-6
  • Scheidegger R, Pande AK, Bounds PL, Koppenol WH. The reaction of peroxynitrite with zeaxanthin. Nitric Oxide 1998;2(1):8-16
  • Goluszko P, et al. Dr fi mbriae operon of uropathogenic Escherichia coli mediate microtubule-dependent invasion to the HeLa epithelial cell line. J Infect Dis 1997;176(1):58-67
  • Armour KJ, Armour KE, van't Hof RJ, et al. Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis. Arthritis Rheum 2001;44(12):2790-6
  • Burgaud JL, et al. Treatment of septic shock, treatment of urinary incontinence, treatment of osteoporosis, nitric oxide donor. Drugs Future 1999;24(8):858
  • Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993;328(20):1471-7
  • Cobb JP, Danner RL. Nitric oxide and septic shock. JAMA 1996;275(15):1192-6

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