315
Views
30
CrossRef citations to date
0
Altmetric
Drug Evaluation

Therapeutic potential of icatibant (HOE-140, JE-049)

&
Pages 2383-2390 | Published online: 19 Aug 2008

Bibliography

  • Lembeck F, Griesbacher T, Eckhardt M, et al. New, long-acting, potent bradykinin antagonists. Br J Pharmacol 1991;102:297-304
  • Hock FJ, Wirth K, Albus U, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol 1991;102:769-73
  • Wirth K, Hock FJ, Albus U, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies. Br J Pharmacol 1991;102:774-7
  • Leeb-Lundberg LM, Marceau F, Muller-Esterl W, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 2005;57:27-77
  • Moreau ME, Garbacki N, Molinaro G, et al. The kallikrein–kinin system: current and future pharmacological targets. J Pharmacol Sci 2005;99:6-38
  • Bas M, Adams V, Suvorava T, et al. Nonallergic angioedema: role of bradykinin. Allergy 2007;62:842-56
  • McLean PG, Perretti M, Ahluwalia A. Kinin B(1) receptors and the cardiovascular system: regulation of expression and function. Cardiovasc Res 2000;48:194-210
  • Marin-Castano ME, Schanstra JP, Neau E, et al. Induction of functional bradykinin b(1)-receptors in normotensive rats and mice under chronic angiotensin-converting enzyme inhibitor treatment. Circulation 2002;105:627-32
  • Bachvarov DR, Saint-Jacques E, Larrivee JF, et al. Cloning and pharmacological characterization of the rabbit bradykinin B2 receptor. J Pharmacol Exp Ther 1995;275:1623-30
  • Wagner F, Rosenkranz B, Knolle J. Absolute bioavailability of subcutaneously administered icatibant, a selective and potent bradykinin B2 receptor antagonist. J Allergy Clin Immunol 2007;119:S274
  • Cockcroft JR, Chowienczyk PJ, Brett SE, et al. Inhibition of bradykinin-induced vasodilation in human forearm vasculature by icatibant, a potent B2-receptor antagonist. Br J Clin Pharmacol 1994;38:317-21
  • Proud D, Bathon JM, Togias AG, Naclerio RM. Inhibition of the response to nasal provocation with bradykinin by HOE-140: effi cacy and duration of action. Can J Physiol Pharmacol 1995;73:820-6
  • Brown NJ, Gainer JV, Murphey LJ, Vaughan DE. Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B(2) receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway. Circulation 2000;102:2190-6
  • Bork K, Frank J, Grundt B, et al. Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant). J Allergy Clin Immunol 2007;119:1497-503
  • Witherow FN, Helmy A, Webb DJ, et al. Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure. Circulation 2001;104:2177-81
  • Davie AP, Dargie HJ, McMurray JJ. Role of bradykinin in the vasodilator effects of losartan and enalapril in patients with heart failure. Circulation 1999;100:268-73
  • Squire IB, O'Kane KP, Anderson N, Reid JL. Bradykinin B(2) receptor antagonism attenuates blood pressure response to acute angiotensin-converting enzyme inhibition in normal men. Hypertension 2000;36:132-6
  • Gainer F, JV, Morrow JD, Loveland A, et al. Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. N Engl J Med 1998;339:1286-92
  • Cruden NL, Witherow FN, Webb DJ, et al. Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure. Arterioscler Thromb Vasc Biol 2004;24:1043-8
  • Murphey LJ, Kumar S, Brown NJ. Endogenous bradykinin and the renin and pressor responses to furosemide in humans. J Pharmacol Exp Ther 2000;295:644-8
  • Kaplan AP, Greaves MW. Angioedema. J Am Acad Dermatol 2005;53:373-88; quiz 389-92
  • Bowen T, Cicardi M, Bork K, et al. Hereditary angiodema: a current state-of-the-art review. VII. Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Ann Allergy Asthma Immunol 2008;100:S30-40
  • Bas M, Bier H, Greve J, et al. Novel pharmacotherapy of acute hereditary angioedema with bradykinin B2-receptor antagonist icatibant. Allergy 2006;61:1490-2
  • Schreiber AD, Kaplan AP, Austen KF. Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation. J Clin Invest 1973;52:1402-9
  • Ratnoff OD, Pensky J, Ogston D, Naff GB. The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor. J Exp Med 1969;129:315-31
  • Gigli I, Mason JW, Colman RW, Austen KF. Interaction of plasma kallikrein with the C1 inhibitor. J Immunol 1970;104:574-81
  • Schapira M, Silver LD, Scott CF, et al. Prekallikrein activation and high-molecular-weight kininogen consumption in hereditary angioedema. N Engl J Med 1983;308:1050-3
  • Nussberger J, Cugno M, Amstutz C, et al. Plasma bradykinin in angio-oedema. Lancet 1998;351:1693-7
  • Kaplan AP, Silverberg M, Ghebrehiwet B, et al. Pathways of kinin formation and role in allergic diseases. Clin Immunol Immunopathol 1989;50:S41-51
  • Nussberger J, Cugno M, Cicardi M, Agostoni A. Local bradykinin generation in hereditary angioedema. J Allergy Clin Immunol 1999;104:1321-2
  • Lung CC, Chan EK, Zuraw BL. Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency. J Allergy Clin Immunol 1997;99:134-46
  • Han ED, MacFarlane RC, Mulligan AN, et al. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest 2002;109:1057-63
  • Boehm T, Lumry WR. Resolution of symptoms in a patient with hereditary angioedema (HAE) following treatment with icatibant, a potent and selective bradykinin-2 receptor antagonist. J Allergy Clin Immunol 2007;119:S279
  • JERINI. Jerini announces positive results from two phase III trials of icatibant for the treatment of hereditary angioedema. Available from: http://www.jerini.com/ cms/en/pdfreleases/060921_toplineresults_EN.pdf [Last accessed 22 April 2008]
  • Byrd JB, Adam A, Brown NJ. Angiotensin-converting enzyme inhibitor-associated angioedema. Immunol Allergy Clin North Am 2006;26:725-37
  • Emanueli C, Grady EF, Madeddu P, et al. Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P. Hypertension 1998;31:1299-304
  • Cugno M, Nussberger J, Cicardi M, Agostoni A. Bradykinin and the pathophysiology of angioedema. Int Immunopharmacol 2003;3:311-7
  • Agostoni A, Cicardi M, Cugno M, et al. Angioedema due to angiotensin-converting enzyme inhibitors. Immunopharmacology 1999;44:21-5
  • Molinaro G, Cugno M, Perez M, et al. Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin. J Pharmacol Exp Ther 2002;303:232-7
  • Coats AJ. Omapatrilat: the story of overture and octave. Int J Cardiol 2002;86:1-4
  • Byrd JB, Touzin K, Sile S, et al. Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Hypertension 2008;51:141-7
  • Bas M, Hoffmann TK, Bier H, Kojda G. Increased C-reactive protein in ACE-inhibitor-induced angioedema. Br J Clin Pharmacol 2005;59:233-8
  • Bas M, Kirchhartz N, Hochfeld J, et al. Potential role of vasomotor effects of fibrinogen in bradykinin-induced angioedema. J Allergy Clin Immunol 2008;121:969-75, e2
  • Sakamoto T, Elwood W, Barnes PJ, Chung KF. Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. Eur J Pharmacol 1992;213:367-73
  • Sakamoto T, Sun J, Barnes PJ, Chung KF. Effect of a bradykinin receptor antagonist, HOE 140, against bradykinin- and vagal stimulation-induced airway responses in the guinea-pig. Eur J Pharmacol 1994;251:137-42
  • Turner P, Dear J, Scadding G, Foreman JC. Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen. J Allergy Clin Immunol 2001;107:105-13
  • Akbary AM, Wirth KJ, Scholkens BA. Efficacy and tolerability of icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma. Immunopharmacology 1996;33:238-42
  • Cugno M, Salerno F, Nussberger J, et al. Bradykinin in the ascitic fluid of patients with liver cirrhosis. Clin Sci (Lond) 2001;101:651-7
  • Wirth KJ, Bickel M, Hropot M, et al. The bradykinin B2 receptor antagonist Icatibant (HOE 140) corrects avid Na+ retention in rats with CCl4-induced liver cirrhosis: possible role of enhanced microvascular leakage. Eur J Pharmacol 1997;337:45-53
  • Russman S, Decosterd L, Buclin T, et al. The bradykinin antagonist icatibant increases electrolyte and water excretion in patients with liver cirrhosis. Clin Pharmacol Ther 2004;75:P12
  • Jonkam CC, Enkhbaatar P, Nakano Y, et al. Effects of the bradykinin B2 receptor antagonist icatibant on microvascular permeability after thermal injury in sheep. Shock 2007;28:704-9
  • Yekebas E, Treede H, Jochum M, et al. Bradykinin B2-receptor antagonism attenuates fatal cardiocirculatory breakdown induced by severe experimental pancreatitis. Crit Care Med 2000;28:1119-27
  • Hirata M, Hayashi I, Yoshimura K, et al. Blockade of bradykinin B(2) receptor suppresses acute pancreatitis induced by obstruction of the pancreaticobiliary duct in rats. Br J Pharmacol 2002;135:29-36
  • Feletou M, Jamonneau I, Germain M, et al. Bradykinin B2 receptor involvement in rabbit and murine models of septic shock. J Cardiovasc Pharmacol 1996;27:500-7
  • Siebeck M, Spannagl E, Schorr M, et al. Effect of combined B1 and B2 kinin receptor blockade in porcine endotoxin shock. Immunopharmacology 1996;33:81-4
  • Schouten JW. Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature. Curr Opin Crit Care 2007;13:134-42
  • XYTIS. Xytis begins phase II clinical study with anatibant (XY2405) for traumatic brain injury ‘Brain Trial’ (Bradykinin B2 Receptor-Antagonist-‘Anatibant’ In Neurotrauma). Available from: http://www.xytis.com/Media/phase2tbijan2007.html [Last accessed 22 April 2008]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.