Emerging role for the vitamin D receptor activator (VDRA), paricalcitol, in the treatment of secondary hyperparathyroidism

Bibliography

• Parfitt AM. The hyperparathyroidism of chronic renal failure: a disorder of growth. Kidney Int 1997;52:3-9
   PubMedGoogle Scholar
• Silver J, Bar Sela S, Naveh-Many T. Regulation of parathyroid cell proliferation. Curr Opin Nephrol Hypertens 1997;6:321-6
   PubMedGoogle Scholar
• Cozzolino M, Brancaccio D, Gallieni M, et al. Pathogenesis of parathyroid hyperplasia in renal failure. J Nephrol 2005;18:5-8
   PubMed Web of Science ®Google Scholar
• Denda M, Finch J, Slatopolsky E. Phosphorus accelerated the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure. Am J Kidney Dis 1996;28:596-602
   PubMed Web of Science ®Google Scholar
• Tominaga Y, Tsuzuki T, Uchida K, et al. Expression of Prad1/cyclin D1, retinoblastoma gene product, and Ki67 in parathyroid hyperplasia caused by chronic renal failure versus primary adenoma. Kidney Int 1999;55:1375-83
   PubMed Web of Science ®Google Scholar
• Reinhart TA, Ramberg CF, Horst RL. Comparison of receptor binding, biological activity, and in vivo tracer kinetics for 1,25-dihydroxyvitamin D3 and, 1,25-dihydroxyvitamin D2, and its 24 epimer. Arch Biochem Biophys 1989;273:64-71
   PubMedGoogle Scholar
• Watson KE, Abrolat ML, Malone LL, et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation 1997;96:1755-60
   PubMed Web of Science ®Google Scholar
• Delmez JA, Slatopolsky E. Hyperphosphatemia: its consequences and treatment in patients with chronic renal disease. Am J Kidney Dis 1992;19:303-17
   PubMedGoogle Scholar
• Rodriguez M, Almaden Y, Hernandez A, Torres A. Effect of phosphate on the parathyroid gland: direct and indirect? Curr Opin Nephrol Hypertens 1996;5:321-8
   PubMedGoogle Scholar
• Portale AA, Halloran BP, Morris RC Jr. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 1989;83:1494-9
   PubMed Web of Science ®Google Scholar
• Moallem E, Kilav R, Silver J, Naveh-Many T. RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 1998;273:5253-9
   PubMed Web of Science ®Google Scholar
• Wang Q, Palnitkar S, Parfitt AM. Parathyroid cell proliferation in normal human parathyroid tissue: implications for the pathogenesis of hyperparathyroidism. Clin Endocrinol 1997;46:343-9
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Lu Y, Finch J, et al. p21WAF1 and TGF-alpha mediate parathyroid growth arrest by vitamin D and high calcium. Kidney Int 2001;60:2109-17
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Lu Y, Sato T, et al. A critical role for enhanced-TGFα and EGFR expression in the initiation of parathyroid hyperplasia in experimental kidney disease. Am J Physiol Renal Physiol 2005;289:1096-102
   PubMed Web of Science ®Google Scholar
• Brown EM. Calcium receptor and regulation of parathyroid hormone secretion. Rev Endocr Metab Disord 2000;1:307-15
   PubMedGoogle Scholar
• Ho C, Conner DA, Pollak MR, et al. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 1995;11:389-94
   PubMed Web of Science ®Google Scholar
• Li YC, Amling M, Pirro AE, et al. Normalization of mineral on homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 1998;139:4391-6
   PubMed Web of Science ®Google Scholar
• Kremer R, Bolivar I, Golztman D, Hendly GN. Influence of calcium and 1,25-dihydroxycholecalciferol on proliferation and proto-oncogene expression in primary cultures of bovine parathyroid cells. Endocrinology 1989;125:935-41
   PubMedGoogle Scholar
• Szabo A, Merke J, Beier E, et al. 1,25(OH)2 vitamin D3 inhibits parathyroid cell proliferation in experimental uremia. Kidney Int 1989;35:1049-56
   PubMed Web of Science ®Google Scholar
• Naveh-Many T, Silver J. Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Clin Invest 1990;86:1313-9
   PubMed Web of Science ®Google Scholar
• Tokumoto M, Tsuruya K, Fukuda K, et al. Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism. Kidney Int 2002;62:1196-207
   PubMed Web of Science ®Google Scholar
• Dusso A, Cozzolino M, Lu Y, et al. 1,25-Dihydroxyvitamin D downregulation of TGFα/EGFR expression and growth signaling: a mechanism for the antiproliferative actions of the sterol in parathyroid hyperplasia of renal failure. J Steroid Biochem Mol Biol 2004;89-90:507-11
   PubMedGoogle Scholar
• Cordero JB, Cozzolino M, Lu Y, et al. 1,25-Dihydroxyvitamin D downregulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptor. J Biol Chem 2002;277:38965-71
   PubMedGoogle Scholar
• Cogan MG, Covey CM, Arieff AI, et al. Central nervous system manifestations of hyperparathyroidism. Am J Med 1978;65:963-70
   PubMed Web of Science ®Google Scholar
• Mak RH, Bettinelli A, Turner C, et al. The influence of hyperparathyroidism on glucose metabolism in uremia. J Clin Endocrinol Metab 1985;60:229-33
   PubMed Web of Science ®Google Scholar
• Elder G. Pathophysiology and recent advances in the management of renal osteodystrophy. J Bone Miner Res 2002;17:2094-105
   PubMed Web of Science ®Google Scholar
• Ganesh SK, Stack AG, Levin NW, et al. Association of elevated serum PO(4), Ca × PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephol 2001;12:2131-8
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Dusso A, Slatopolsky E. Role of calcium x phosphate product and bone associated proteins on vascular calcification in renal failure. J Am Soc Nephrol 2001;12:2511-6
   PubMed Web of Science ®Google Scholar
• London GM. Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 2003;14:S305-9
   PubMed Web of Science ®Google Scholar
• Blacher J, Safar ME, Guerin AP, et al. Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int 2003;63:1852-60
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Brancaccio D, Gallieni M, Slatopolsky E. Pathogenesis of vascular calcification in chronic kidney disease. Kidney Int 2005;68:429-36
   PubMed Web of Science ®Google Scholar
• Jakoby MG 4th, Semenkovich CF. The role of osteoprogenitors in vascular calcification. Curr Opin Nephrol Hypertens 2000;9:11-5
   PubMed Web of Science ®Google Scholar
• Brancaccio D, Cozzolino M. The mechanism of calcium deposition in soft tissues. Contrib Nephrol 2005;149:279-86
   PubMed Web of Science ®Google Scholar
• Block GA, Port FK. Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendations for a change in management. Am J Kidney Dis 2000;35:1226-37
   PubMed Web of Science ®Google Scholar
• London GM, Guerin AP, Marchais SJ, et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003;18:1731-40
   PubMed Web of Science ®Google Scholar
• Goodman WG, Goldin J, Kuizon BD, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000;342:1478-83
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Dusso AS, Liapis H, et al. The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats. J Am Soc Nephrol 2002;13:2299-308
   PubMedGoogle Scholar
• Cozzolino M, Staniforth ME, Liapis H, et al. Sevelamer hydrochloride attenuates kidney and cardiovascular calcifications in long-term experimental uremia. Kidney Int 2003;64:1653-61
   PubMed Web of Science ®Google Scholar
• Chertow GM, Burke SK, Raggi P. Treat to Goal Working Group. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 2002;62:245-52
   PubMed Web of Science ®Google Scholar
• Ishimura E, Nishizawa Y, Inaba M, et al. Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in non dialyzed patients with chronic renal failure. Kidney Int 1999;55:1019-27
   PubMed Web of Science ®Google Scholar
• Messa P, Vallone C, Meoni G, et al. Direct in vivo assessment of parathyroid hormone calcium relationship curve in renal patients. Kidney Int 1994;46:1713-20
   PubMed Web of Science ®Google Scholar
• Papapoulos SE, Clemens TL, Fraher LJ, et al. Metabolites of vitamin D in human vitamin D deficiency. Effect of vitamin D or 1,25-dihydroxycolecalciferol. Lancet 1980;2:612-5
   PubMed Web of Science ®Google Scholar
• National Kidney Foundation. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003;42(Suppl 3):63-200
   Google Scholar
• Massry SG, Coburn JW, Lee DB, et al. Skeletal resistance to parathyroid hormone in renal failure. Studies in 105 human subjects. Ann Intern Med 1973;78:357-64
   PubMed Web of Science ®Google Scholar
• Disthabanchong S, Hassan H, McConkey CL, et al. Regulation of PTH1 receptor expression by uremic ultrafiltrate in UMR 106-101 osteoblast-like cells. Kidney Int 2004;65:897-903
   PubMedGoogle Scholar
• Hercz G, Pei Y, Greenwood C, et al. Aplastic osteodystrophy without aluminum: the role of ‘suppressed’ parathyroid function. Kidney Int 1993;44:860-6
   PubMed Web of Science ®Google Scholar
• Coco M, Rush H. Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone. Am J Kidney Dis 2000;36:1115-21
   PubMed Web of Science ®Google Scholar
• Cournot-Witmer G, Zingraff J, Plachot JJ, et al. Aluminum localization in bone from hemodialyzed patients: relationship to matrix mineralization. Kidney Int 1981;20:375-8
   PubMed Web of Science ®Google Scholar
• Llach F, Yudd M. Paricalcitol in dialysis patients with calcitriol resistant secondary hyperparathyroidism. Am J Kidney Dis 2001;38:45-50
   PubMed Web of Science ®Google Scholar
• Martin KJ, Gonzales E, Lindberg J, et al. Paricalcitol dosing according to body weight or severity of hyperparathyroidism: a vitamin D analogues for secondary hyperparathyroidism: a double-blind multicenter randomized trial. Am J Kidney Dis 2001;38:s57-63
   PubMed Web of Science ®Google Scholar
• Lindberg J, Martin KJ, Gonzalez EA, et al. A long-term, multicenter study of the efficacy and safety of paricalcitol in end-stage renal disease. Clin Nephrol 2001;56:315-23
   PubMed Web of Science ®Google Scholar
• Sprague SM, Llach F, Amdhal M, et al. Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism. Kidney Int 2003;63:1483-90
   PubMed Web of Science ®Google Scholar
• Teng M, Wolf M, Lowrie E, et al. Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med 2003;349:446-56
   PubMed Web of Science ®Google Scholar
• Dobrez DG, Mathes A, Amdahl M, et al. Paricalcitol-treated patients experience improved hospitalization outcomes compared with calcitriol-treated patients. Nephrol Dial Transplant 2004;19:1174-81
   PubMed Web of Science ®Google Scholar
• Brown AJ, Finch J, Slatopolsky E. Differential effects of 19-nor-1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 on intestinal calcium and phosphate transport. J Lab Clin Med 2002;139:279-84
   PubMed Web of Science ®Google Scholar
• Finch J, Brown AJ, Slatopolsky E. Differential effects of 1,25-dihydroxy-vitamin D3 and 19-nor-1,25-dihydroxy-vitamin D2 on calcium and phosphorus resorption in bone. J Am Soc Nephrol 1999;10:980-5
   PubMed Web of Science ®Google Scholar
• Cardus A, Panizo S, Parisi E, et al. Differential effects of vitamin D analogs on vascular calcification. J Bone Miner Res 2007;22:860-6
   PubMed Web of Science ®Google Scholar
• Mizobuchi M, Finch JL, Martin DR, Slatopolsky E. Differential effects of vitamin D receptor activators on vascular calcification in uremic rats. Kidney Int 2007;72:709-15
   PubMed Web of Science ®Google Scholar