Search in:

Expert Opinion on Biological Therapy Volume 9, 2009 - Issue 5

Submit an article Journal homepage

304

Views

CrossRef citations to date

Altmetric

Drug Evaluations

Recombinant FSH in the treatment of oligozoospermia

Carlo Foresta University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology & Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy +39 049 8218517; +39 049 8218520; [email protected]

Riccardo Selice University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology & Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy +39 049 8218517; +39 049 8218520; [email protected]

Alberto Ferlin University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology & Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy +39 049 8218517; +39 049 8218520; [email protected]

Andrea Garolla University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology & Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy +39 049 8218517; +39 049 8218520; [email protected]

Pages 659-666 | Published online: 21 Apr 2009

Cite this article
https://doi.org/10.1517/14712590902932673

Full Article
Figures & data
References
Citations
Metrics
Reprints & Permissions

Bibliography

Van Alphen MMA, Van de Kant HJG, De Roojj DG. Follicle-stimulating hormone stimulates spermatogenesis in the adult monkey. Endocrinology 1988;123(3):1449-55
PubMed Web of Science ®Google Scholar
Dias JA, Lindau-Shepard B, Hauer C, et al. Human follicle-stimulating hormone structure–activity relationships. Biol Reprod 1998;58(6):1331-6
PubMed Web of Science ®Google Scholar
Ulloa-Aguirre A, Timossi C, Damián-Matsumura P, et al. Role of glycosylation in function of follicle-stimulating hormone. Endocrine 1999;11(3):205-15
PubMed Web of Science ®Google Scholar
Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr Rev 1997;18(6):739-73
PubMed Web of Science ®Google Scholar
Gorczynska E, Spaliviero J, Handelsman DJ. The relationship between 3′,5′-cyclic adenosine monophosphate and calcium in mediating follicle-stimulating hormone signal transduction in Sertoli cells. Endocrinology 1994;134(1):293-300
PubMed Web of Science ®Google Scholar
Crépieux P, Marion S, Martinat N, et al. The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation. Oncogene 2001;20(34):4696-709
PubMed Web of Science ®Google Scholar
Tena-Sempere M, Manna PR, Huhtaniemi I. Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence. Biol Reprod 1999;60(6):1515-27
PubMed Web of Science ®Google Scholar
Moudgal NR, Sairam MR. Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates? Hum Reprod 1998;13(4):916-9
PubMed Web of Science ®Google Scholar
Matsumoto AM, Karpas AE, Bremner WJ. Chronic human chorionic gonadotropin administration in normal men: evidence that follicle stimulating hormone is necessary for the maintenance of quantitative normal spermatogenesis in men. J Clin Endocrinol Metab 1986;62(6):1184-90
PubMed Web of Science ®Google Scholar
Mastrogiacomo I, Motta RG, Botteon S, et al. Achievement of spermatogenesis and genital tract maturation in hypogonadotropic hypogonadic subjects during long term treatment with gonadotropins or LHRH. Andrologia 1991;23(4):285-9
PubMed Web of Science ®Google Scholar
Burgues S, Calderon MD. Subcutaneous self-administration of highly purified follicle stimulating hormone and human chorionic gonadotrophin for the treatment of male hypogonadotrophic hypogonadism. Spanish collaborative group on male hypogonadotrophic hypogonadism. Hum Reprod 1997;12(5):980-6
PubMed Web of Science ®Google Scholar
Acosta AA, Khalifa E, Oehninger S. Pure human follicle stimulating hormone has a role in the treatment of severe male infertility by assisted reproduction: norfolk's total experience. Hum Reprod 1992;7(8):1067-72
PubMed Web of Science ®Google Scholar
Bartoov B, Eltes F, Lunenfeld E, et al. Sperm quality of subfertile males before and after treatment with human follicle-stimulating hormone. Fertil Steril 1994;61(4):727-34
PubMed Web of Science ®Google Scholar
Sigg C, Baciu M. Improvement of sperm concentration and bovine mucus penetration in idiopathic oligozoospermia by administration of pure FSH. Hum Reprod 1994;9:47
PubMed Web of Science ®Google Scholar
Merino G, Carranza-Lira S, Martinez-Chequer JC. Sperm characteristics and hormonal profile before and after treatment with follicle-stimulating hormone in infertile patients. Arch Androl 1996;37(3):197-200
PubMed Web of Science ®Google Scholar
Glander HJ, Kratzsch J. Effects of pure human follicle-stimulating hormone (pFSH) on sperm quality correlate with the hypophyseal response to gonadotropin-releasing hormone (GnRH). Andrologia 1997;29(1):23-8
PubMed Web of Science ®Google Scholar
Strehler E, Sterzik K, De Santo M, et al. The effect of follicle-stimulating hormone therapy on sperm quality: an ultrastructural mathematical evaluation. J Androl 1997;18(4):439-47
PubMed Web of Science ®Google Scholar
Paradisi R, Busacchi P, Seracchioli R, et al. Effects of high doses of recombinant human follicle-stimulating hormone in the treatment of male factor infertility: results of a pilot study. Fertil Steril 2006;86(3):728-31
PubMed Web of Science ®Google Scholar
Baccetti B, Strehler E, Capitani S, et al. The effect of follicle stimulating hormone therapy on human sperm structure (Notulae seminologicae 11). Hum Reprod 1997;12(9):1955-968
PubMed Web of Science ®Google Scholar
Acosta AA, Oehninger S, Ertunc H, et al. Possible role of pure human follicle-stimulating hormone in the treatment of severe male infertility by assisted reproduction: preliminary report. Fertil Steril 1991;55(6):1150-6
PubMed Web of Science ®Google Scholar
Matorras R, Perez C, Corcostegui B, et al. Treatment of the male with follicle-stimulating hormone in intrauterine insemination with husband's spermatozoa: a randomized study. Hum Reprod 1997;12(1):24-8
PubMed Web of Science ®Google Scholar
Kamischke A, Behre HM, Bergmann M, et al. Recombinant human follicle stimulating hormone for treatment of male idiopathic infertility: a randomized, double-blind, placebo-controlled, clinical trial. Hum Reprod 1998;13(3):596-603
PubMed Web of Science ®Google Scholar
Ben-Rafael Z, Farhi J, Feldberg D, et al. Follicle-stimulating hormone treatment for men with idiopathic oligoteratoasthenozoospermia before in vitro fertilization: the impact on sperm microstructure and fertilization potential. Fertil Steril 2000;73(1):24-30
PubMed Web of Science ®Google Scholar
Ashkenazi J, Bar-Hava I, Farhi J, et al. The role of purified follicle stimulating hormone therapy in the male partner before intracytoplasmic sperm injection. Fertil Steril 1999;72(4):670-3
PubMed Web of Science ®Google Scholar
Ulloa-Aguirre A, Espinoza R, Damian-Matsumura P, et al. Immunological and biological potencies of the different molecular species of gonadotrophins. Hum Reprod 1988;3(4):491-501
PubMed Web of Science ®Google Scholar
Dahl KD, Stone MP. FSH isoforms, radioimmunoassays, bioassays, and their significance. J Androl 1992;13(1):11-22
PubMed Web of Science ®Google Scholar
de Leeuw R, Mulders J, Voortman G, et al. Structure-function relationship of recombinant follicle stimulating hormone (Puregon). Mol Hum Reprod 1996;2(5):361-9
PubMed Web of Science ®Google Scholar
Schoot DC, Coelingh Bennink HJ, Mannaerts BM, et al. Human recombinant follicle-stimulating hormone induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiency. J Clin Endocrinol Metab 1992;74(6):1471-3
PubMed Web of Science ®Google Scholar
Schoot DC, Harlin J, Shoham Z, et al. Recombinant human follicle-stimulating hormone and ovarian response in gonadotrophin-deficient women. Hum Reprod 1994;9(7):1237-42
PubMed Web of Science ®Google Scholar
Matikainen T, De Leeuw R, Mannaerts B, et al. Circulating bioactive and immunoreactive recombinant human follicle stimulating hormone (Org 32489) after administration to gonadotropin-deficient subjects. Fertil Steril 1994;61(1):62-9
PubMed Web of Science ®Google Scholar
Shoham Z, Mannaerts B, Insler V, et al. Induction of follicular growth using recombinant human follicle-stimulating hormone in two volunteer women with hypogonadotropic hypogonadism. Fertil Steril 1993;59(4):738-42
PubMed Web of Science ®Google Scholar
Mannaerts B, Shoham Z, Schoot D, et al. Single-dose pharmacokinetics and pharmacodynamics of recombinant human follicle-stimulating hormone (Org 32489*) in gonadotropin-deficient volunteers. Fertil Steril 1993;59(1):108-14
PubMed Web of Science ®Google Scholar
Devroey P, Mannaerts B, Smitz J, et al. Clinical outcome of a pilot efficacy study on recombinant human follicle-stimulating hormone (Org 32489) combined with various gonadotrophin-releasing hormone agonist regimens. Hum Reprod 1994;9(6):1064-9
PubMed Web of Science ®Google Scholar
Hedon B, Out HJ, Hugues JN, et al. Efficacy and safety of recombinant follicle stimulating hormone (Puregon) in infertile women pituitary-suppressed with triptorelin undergoing in-vitro fertilization: a prospective, randomized, assessor-blind, multicentre trial. Hum Reprod 1995;10(12):3102-6
PubMed Web of Science ®Google Scholar
Out HJ, Mannaerts BM, Driessen SG, et al. A prospective, randomized, assessor-blind, multicentre study comparing recombinant and urinary follicle stimulating hormone (Puregon versus Metrodin) in in-vitro fertilization. Hum Reprod 1995;10(10):2534-40
PubMed Web of Science ®Google Scholar
Balen A, Platteau P, Andersen AN, et al. Highly purified FSH is as efficacious as recombinant FSH for ovulation induction in women with WHO Group II anovulatory infertility: a randomized controlled non-inferiority trial. Hum Reprod 2007;22(7):1816-23
PubMed Web of Science ®Google Scholar
Baker VL, Fujimoto VY, Kettel LM, et al. Clinical efficacy of highly purified urinary FSH versus recombinant FSH in volunteers undergoing controlled ovarian stimulation for in vitro fertilization: a randomized, multicenter, investigator-blind trial. Fertil Steril 2009;91(4):1005-11
PubMed Web of Science ®Google Scholar
Kliesch S, Behre HM, Nieschlag E. Recombinant human follicle-stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadotropic male. Fertil Steril 1995;63(6):1326-8
PubMed Web of Science ®Google Scholar
Mannaerts B, Fauser B, Lahlou N, et al. Serum hormone concentrations during treatment with multiple rising doses of recombinant follicle stimulating hormone (Puregon) in men with hypogonadotropic hypogonadism. Fertil Steril 1996;65(2):406-10
PubMed Web of Science ®Google Scholar
Bouloux PM, Nieschlag E, Burger HG, et al. Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone. J Androl 2003;24(4):604-11
PubMed Web of Science ®Google Scholar
Foresta C, Bettella A, Ferlin A, et al. Evidence for a stimulatory role of follicle-stimulating hormone on the spermatogonial population in adult males. Fertil Steril 1998;69(4):636-42
PubMed Web of Science ®Google Scholar
Foresta C, Bettella A, Rossato M, et al. Inhibin B plasma concentrations in oligozoospermic subjects before and after therapy with follicle stimulating hormone. Hum Reprod 1999;14(4):906-12
PubMed Web of Science ®Google Scholar
Foresta C, Bettella A, Merico M, et al. FSH in the treatment of oligozoospermia. Mol Cell Endocrinol 2000;161(1-2):89-97
PubMed Web of Science ®Google Scholar
Foresta C, Bettella A, Merico M, et al. Use of recombinant human follicle-stimulating hormone in the treatment of male factor infertility. Fertil Steril 2002;77(2):238-44
PubMed Web of Science ®Google Scholar
Foresta C, Bettella A, Garolla A, et al. Treatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study. Fertil Steril 2005;84(3):654-61
PubMed Web of Science ®Google Scholar
Aittomaki K, Lucena JL, Pakarinen P, et al. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 1995;82(6):959-68
PubMed Web of Science ®Google Scholar
Greb RR, Grieshaber K, Gromoll J, et al. A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle. J Clin Endocrinol Metab 2005;90(8):4866-72
PubMed Web of Science ®Google Scholar
Behre HM, Greb RR, Mempel A, et al. Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation. Pharmacogenet Genomics 2005;15(7):451-6
PubMed Web of Science ®Google Scholar
Simoni M, Gromoll J, Höppner W, et al. Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men: identification and characterization of two discrete FSH receptor isoforms. J Clin Endocrinol Metab 1999;84(2):751-5
PubMed Web of Science ®Google Scholar
Asatiani K, Gromoll J, Eckardstein SV, et al. Distribution and function of FSH receptor genetic variants in normal men. Andrologia 2002;34(3):172-6
PubMed Web of Science ®Google Scholar
Ahda Y, Gromoll J, Wunsch A, et al. Follicle-stimulating hormone receptor gene haplotype distribution in normozoospermic and azoospermic men. J Androl 2005;26(4):494-9
PubMed Web of Science ®Google Scholar
Pengo M, Ferlin A, Arredi B, et al. FSH receptor gene polymorphisms in fertile and infertile Italian men. Reprod Biomed Online 2006;13(6):795-800
PubMed Web of Science ®Google Scholar
Perez Mayorga M, Gromoll J, Behre HM, et al. Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. J Clin Endocrinol Metab 2000;85(9):3365-9
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Recombinant FSH in the treatment of oligozoospermia

Bibliography

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Recombinant FSH in the treatment of oligozoospermia

Bibliography

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date