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Expert Opinion on Biological Therapy Volume 9, 2009 - Issue 6

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MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases

Maria Angelica Cortez Faculty of Medicine of Ribeirão Preto, Department of Genetics, Sao Paulo, Brazil

, MSc &

George Adrian Calin Associate Professor The University of Texas M. D. Anderson Cancer Center, Department of Experimental Therapeutics, Unit 422, 1515 Holcombe Blvd, Houston, Texas 77030, USA +1 713 792 5461; +1 713 745 4528; [email protected]

, MD PhD

Pages 703-711 | Published online: 09 May 2009

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https://doi.org/10.1517/14712590902932889

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Ambros V. The functions of animal microRNAs. Nature 2004;431:350-5
PubMed Web of Science ®Google Scholar
Zamore PD, Haley B. Ribo-genome: the big world of small RNAs. Science 2005;309:1519-24
PubMed Web of Science ®Google Scholar
Meister G. miRNAs get an early start on translational silencing. Cell 2007;131:25-8
PubMed Web of Science ®Google Scholar
Lewis BP, Shih IH, Jones-Rhoades MW, et al. Prediction of mammalian microRNA targets. Cell 2003;115:787-98
PubMed Web of Science ®Google Scholar
Xie X, Mikkelsen TS, Gnirke A, et al. Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites. Proc Natl Acad Sci USA 2007;104:7145-50
PubMed Web of Science ®Google Scholar
Krek A, Grun D, Poy MN, et al. Combinatorial microRNA target predictions. Nat Genet 2005;37:495-500
PubMed Web of Science ®Google Scholar
Lall S, Grun D, Krek A, et al. A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol 2006;16:460-71
PubMed Web of Science ®Google Scholar
Lee Y, Jeon K, Lee JT, et al. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J 2002;21:4663-70
PubMed Web of Science ®Google Scholar
Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci USA 2003;100:9779-84
PubMed Web of Science ®Google Scholar
Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003;425:415-19
PubMed Web of Science ®Google Scholar
Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003;17:3011-16
PubMed Web of Science ®Google Scholar
Lund E, Guttinger S, Calado A, et al. Nuclear export of microRNA precursors. Science 2004;303:95-8
PubMed Web of Science ®Google Scholar
Bohnsack MT, Czaplinski K, Gorlich D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 2004;10:185-91
PubMed Web of Science ®Google Scholar
Miska EA. How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 2005;15:563-8
PubMed Web of Science ®Google Scholar
Jannot G, Simard MJ. Tumour-related microRNA functions in Caenorhabditis elegans. Oncogene 2006;25:6197-201
PubMed Web of Science ®Google Scholar
Umbach JL, Kramer MF, Jurak I, et al. MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature 2008;454:780-3
PubMed Web of Science ®Google Scholar
Thum T, Catalucci D, Bauersachs J. MicroRNAs: novel regulators in cardiac development and disease. Cardiovasc Res 2008;79:562-70
PubMed Web of Science ®Google Scholar
Calin GA, Liu CG, Sevignani C, et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA 2004;101:11755-60
PubMed Web of Science ®Google Scholar
Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002;99:15524-9
PubMed Web of Science ®Google Scholar
Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005;102:13944-9
PubMed Web of Science ®Google Scholar
Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834-8
PubMed Web of Science ®Google Scholar
Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006;9:189-98
PubMed Web of Science ®Google Scholar
Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-66
PubMed Web of Science ®Google Scholar
McManus MT. MicroRNAs and cancer. Semin Cancer Biol 2003;13:253-8
PubMed Web of Science ®Google Scholar
Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005;122:6-7
PubMed Web of Science ®Google Scholar
Chin LJ, Slack FJ. A truth serum for cancer – microRNAs have major potential as cancer biomarkers. Cell Res 2008;18:983-4
PubMed Web of Science ®Google Scholar
Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005;65:7065-70
PubMed Web of Science ®Google Scholar
Ciafre SA, Galardi S, Mangiola A, et al. Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 2005;334:1351-8
PubMed Web of Science ®Google Scholar
Murakami Y, Yasuda T, Saigo K, et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006;25:2537-45
PubMed Web of Science ®Google Scholar
He H, Jazdzewski K, Li W, et al. The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA 2005;102:19075-80
PubMed Web of Science ®Google Scholar
Michael MZ, O'Connor SM, van Holst Pellekaan NG, et al. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 2003;1:882-91
PubMed Web of Science ®Google Scholar
Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006;103:2257-61
PubMed Web of Science ®Google Scholar
Rosenfeld N, Aharonov R, Meiri E, et al. MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol 2008;26:462-9
PubMed Web of Science ®Google Scholar
Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101:2999-3004
PubMed Web of Science ®Google Scholar
Zhang L, Huang J, Yang N, et al. microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci USA 2006;103:9136-41
PubMed Web of Science ®Google Scholar
Garzon R, Croce CM. MicroRNAs in normal and malignant hematopoiesis. Curr Opin Hematol 2008;15:352-8
PubMed Web of Science ®Google Scholar
Jongen-Lavrencic M, Sun SM, Dijkstra MK, et al. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 2008;111:5078-85
PubMed Web of Science ®Google Scholar
Dixon-McIver A, East P, Mein CA, et al. Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS ONE 2008;3:e2141
PubMed Web of Science ®Google Scholar
Varambally S, Cao Q, Mani RS, et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008;322:1695-9
PubMed Web of Science ®Google Scholar
Esquela-Kerscher A, Slack FJ. Oncomirs – microRNAs with a role in cancer. Nat Rev Cancer 2006;6:259-69
PubMed Web of Science ®Google Scholar
He L, He X, Lowe SW, Hannon GJ. microRNAs join the p53 network – another piece in the tumour-suppression puzzle. Nat Rev Cancer 2007;7:819-22
PubMed Web of Science ®Google Scholar
Bommer GT, Gerin I, Feng Y, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 2007;17:1298-307
PubMed Web of Science ®Google Scholar
Chang TC, Wentzel EA, Kent OA, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007;26:745-52
PubMed Web of Science ®Google Scholar
Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005;120:635-47
PubMed Web of Science ®Google Scholar
Meng F, Henson R, Wehbe-Janek H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133:647-58
PubMed Web of Science ®Google Scholar
Mendell JT. miRiad roles for the miR-17-92 cluster in development and disease. Cell 2008;133:217-22
PubMed Web of Science ®Google Scholar
Ikeda S, Kong SW, Lu J, et al. Altered microRNA expression in human heart disease. Physiol Genomics 2007;31:367-73
PubMed Web of Science ®Google Scholar
Pauley KM, Satoh M, Chan AL, et al. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther 2008;10:R101
Google Scholar
Sheedy FJ, O'neill LA. Adding fuel to fire: microRNAs as a new class of mediators of inflammation. Ann Rheum Dis 2008;67(Suppl 3):iii50-5
PubMed Web of Science ®Google Scholar
Tang X, Tang G, Ozcan S. Role of microRNAs in diabetes. Biochim Biophys Acta 2008;1779:697-701
PubMed Web of Science ®Google Scholar
Chen JF, Callis TE, Wang DZ. microRNAs and muscle disorders. J Cell Sci 2009;122:13-20
PubMed Web of Science ®Google Scholar
Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 2008;141:672-5
PubMed Web of Science ®Google Scholar
Meng F, Henson R, Wehbe-Janek H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133:647-58
PubMed Web of Science ®Google Scholar
Asangani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008;27:2128-36
PubMed Web of Science ®Google Scholar
Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008;105:10513-18
PubMed Web of Science ®Google Scholar
Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008;18:997-1006
PubMed Web of Science ®Google Scholar
Resnick KE, Alder H, Hagan JP, et al. The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol Oncol 2009;112:55-9
PubMed Web of Science ®Google Scholar
Feng G, Li G, Gentil-Perret A, et al. Elevated serum-circulating RNA in patients with conventional renal cell cancer. Anticancer Res 2008;28:321-6
PubMed Web of Science ®Google Scholar
Wong TS, Liu XB, Wong BY, et al. Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 2008;14:2588-92
PubMed Web of Science ®Google Scholar
Skog J, Wurdinger T, van RS, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008;10:1470-6
PubMed Web of Science ®Google Scholar
Ng EK, Chong WW, Jin H, et al. Differential expression of microRNAs in plasma of colorectal cancer patients: a potential marker for colorectal cancer screening. Gut 2009. [Epub 6 Feb 2009; doi: 10.1136/gut.2008.167817 ]
PubMedGoogle Scholar
O'Donnell KA, Wentzel EA, Zeller KI, et al. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005;435:839-43
PubMed Web of Science ®Google Scholar
Wang K, Zhang S, Marzolf B, et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci USA 2009;106:4402-7
PubMed Web of Science ®Google Scholar
Hunter MP, Ismail N, Zhang X, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS ONE 2008;3:e3694
PubMed Web of Science ®Google Scholar
Chim SS, Shing TK, Hung EC, et al. Detection and characterization of placental microRNAs in maternal plasma. Clin Chem 2008;54:482-90
PubMed Web of Science ®Google Scholar
Gilad S, Meiri E, Yogev Y, et al. Serum microRNAs are promising novel biomarkers. PLoS ONE 2008;3:e3148
PubMed Web of Science ®Google Scholar
Yu CH, Xu CF, Li YM. Association of microRNA-223 expression with hepatic ischemia/reperfusion injury in mice. Dig Dis Sci 2008 [doi: 10.1007/s10620-008-0629-8]
Google Scholar
Slaby O, Svoboda M, Fabian P, et al. Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer. Oncology 2007;72:397-402
PubMed Web of Science ®Google Scholar
Kamm RC, Smith AG. Nucleic acid concentrations in normal human plasma. Clin Chem 1972;18:519-22
PubMed Web of Science ®Google Scholar
Stroun M, Anker P, Maurice P, Gahan PB. Circulating nucleic acids in higher organisms. Int Rev Cytol 1977;51:1-48
PubMedGoogle Scholar
El-Hefnawy T, Raja S, Kelly L, et al. Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin Chem 2004;50:564-73
PubMed Web of Science ®Google Scholar
Tsui NB, Ng EK, Lo YM. Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin Chem 2002;48:1647-53
PubMed Web of Science ®Google Scholar
Sisco KL. Is RNA in serum bound to nucleoprotein complexes? Clin Chem 2001;47:1744-5
PubMed Web of Science ®Google Scholar
Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007;9:654-9
PubMed Web of Science ®Google Scholar
Ratajczak J, Miekus K, Kucia M, et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 2006;20:847-56
PubMed Web of Science ®Google Scholar
Smalheiser NR. Exosomal transfer of proteins and RNAs at synapses in the nervous system. Biol Direct 2007;2:35-49
Google Scholar
Yuan A, Farber EL, Rapoport AL, et al. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS ONE 2009;4:e4722
PubMed Web of Science ®Google Scholar
Taylor DD, Homesley HD, Doellgast GJ. Binding of specific peroxidase-labeled antibody to placental-type phosphatase on tumor-derived membrane fragments. Cancer Res 1980;40:4064-9
PubMed Web of Science ®Google Scholar
Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 2008;110:13-21
PubMed Web of Science ®Google Scholar
Rabinowits G, Gercel-Taylor C, Day JM, et al. Exosomal microRNA: a diagnostic marker for lung cancer. Clin Lung Cancer 2009;10:42-6
PubMed Web of Science ®Google Scholar
Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65:6029-33
PubMed Web of Science ®Google Scholar
Lotvall J, Valadi H. Cell to cell signalling via exosomes through esRNA. Cell Adh Migr 2007;1:156-8
PubMed Web of Science ®Google Scholar
Davoren PA, McNeill RE, Lowery AJ, et al. Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer. BMC Mol Biol 2008;9:76-86
Google Scholar
Peltier HJ, Latham GJ. Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA 2008;14:844-52
PubMed Web of Science ®Google Scholar
Shell S, Park SM, Radjabi AR, et al. Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci USA 2007;104:11400-5
PubMed Web of Science ®Google Scholar
Corney DC, Flesken-Nikitin A, Godwin AK, et al. microRNA-34b and microRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 2007;67:8433-8
PubMed Web of Science ®Google Scholar
Jackson DB. Serum-based microRNAs: are we blinded by potential? Proc Natl Acad Sci USA 2008;106:E5
Google Scholar
Sethupathy P, Megraw M, Hatzigeorgiou AG. A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods 2006;3:881-6
PubMed Web of Science ®Google Scholar
Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with ‘antagomirs’. Nature 2005;438:685-9
PubMed Web of Science ®Google Scholar
Esau C, Davis S, Murray SF, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006;3:87-98
PubMed Web of Science ®Google Scholar
Elmen J, Lindow M, Silahtaroglu A, et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 2008;36:1153-62
PubMed Web of Science ®Google Scholar
Bhat B, Esau C, Davis S, et al. 2′-O-methoxyethyl/2′-fluoro modified oligonucleotides result in more potent inhibition of microRNA-122 in vivo: a target implicated in HCV replication. Nucleic Acids Symp Ser (Oxf) 2008;52-69
Google Scholar
Mercatelli N, Coppola V, Bonci D, et al. The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS ONE 2008;3:e4029
PubMed Web of Science ®Google Scholar

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